Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P50400

- GUND_CELFI

UniProt

P50400 - GUND_CELFI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Endoglucanase D

Gene

cenD

Organism
Cellulomonas fimi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081Proton donorBy similarity
Active sitei349 – 3491NucleophileBy similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase D (EC:3.2.1.4)
Alternative name(s):
Cellulase D
Endo-1,4-beta-glucanase D
Gene namesi
Name:cenD
OrganismiCellulomonas fimi
Taxonomic identifieri1708 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeCellulomonadaceaeCellulomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 747708Endoglucanase DPRO_0000007843Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini456 – 54388Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini552 – 63988Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini638 – 747110CBM2Add
BLAST

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR003961. Fibronectin_type3.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
PF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS50853. FN3. 2 hits.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHSASRTRAR TRVRTAVSGL LAATVLAAPL TLVAAPAQAA TGDDWLHVEG
60 70 80 90 100
NTIVDSTGKE AILSGVNWFG FNASERVFHG LWSGNITQIT QQMAQRGINV
110 120 130 140 150
VRVPVSTQLL LEWKAGTFLK PNVNTYANPE LEGKNSLQIF EYWLTLCQKY
160 170 180 190 200
GIKVFLDVHS AEADNSGHVY NMWWKGDITT EDVYEGWEWA ATRWKDDDTI
210 220 230 240 250
VGADIKNEPH GTQGSTERAK WDGTTDKDNF KHFAETASKK ILAINPNWLV
260 270 280 290 300
FVEGVEIYPK PGVPWTSTGL TDYYGTWWGG NLRGVRDHPI DLGAHQDQLV
310 320 330 340 350
YSPHDYGPLV FDQKWFQKDF DKASLTADVW GPNWLFIHDE DIAPLLIGEW
360 370 380 390 400
GGRLGQDPRQ DKWMAALRDL VAERRLSQTF WVLNPNSGDT GGLLLDDWKT
410 420 430 440 450
WDEVKYSTML EPTLWKHGGK YVGLDHQVPL GGVGSTTGTS ISQVGGGTPD
460 470 480 490 500
TTAPTAPTGL RAGTPTASTV PLTWSASTDT GGSGVAGYEV YRGTTLVGTT
510 520 530 540 550
TATSYTVTGL AADSAYTFSV RAKDGAGNTS AASAAVTART AAGGGDVTAP
560 570 580 590 600
SVPTGLTAGT PTATSVPLTW TASTDTGGSG VTGYEVYRGS TLVARPTGTS
610 620 630 640 650
HTVTGLSAAT AYTFTVRAVD AAGNVSAASA PVGVTTAPDP TTGSCAVTYT
660 670 680 690 700
ANGWSGGFTA AVTLTNTGTT ALSGWTLGFA FPSGQTLTQG WSARWAQSGS
710 720 730 740
SVTATNEAWN AVLAPGASVE IGFSGTHTGT NTAPATFTVG GATCTTR
Length:747
Mass (Da):78,937
Last modified:October 1, 1996 - v1
Checksum:iBD15473C9D8B42BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02544 Genomic DNA. Translation: AAA23089.1.
PIRiB47093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02544 Genomic DNA. Translation: AAA23089.1 .
PIRi B47093.

3D structure databases

ProteinModelPortali P50400.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR003961. Fibronectin_type3.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
PF00041. fn3. 2 hits.
[Graphical view ]
SMARTi SM00637. CBD_II. 1 hit.
SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS51173. CBM2. 1 hit.
PS50853. FN3. 2 hits.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cellulose-binding polypeptides from Cellulomonas fimi: endoglucanase D (CenD), a family A beta-1,4-glucanase."
    Meinke A., Gilkes N.R., Kilburn D.G., Miller R.C. Jr., Warren R.A.J.
    J. Bacteriol. 175:1910-1918(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGUND_CELFI
AccessioniPrimary (citable) accession number: P50400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3