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P50400

- GUND_CELFI

UniProt

P50400 - GUND_CELFI

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Protein

Endoglucanase D

Gene
cenD
Organism
Cellulomonas fimi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081Proton donor By similarity
Active sitei349 – 3491Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Protein family/group databases

CAZyiCBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase D (EC:3.2.1.4)
Alternative name(s):
Cellulase D
Endo-1,4-beta-glucanase D
Gene namesi
Name:cenD
OrganismiCellulomonas fimi
Taxonomic identifieri1708 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeCellulomonadaceaeCellulomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 Reviewed predictionAdd
BLAST
Chaini40 – 747708Endoglucanase DPRO_0000007843Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini456 – 54388Fibronectin type-III 1Add
BLAST
Domaini552 – 63988Fibronectin type-III 2Add
BLAST
Domaini638 – 747110CBM2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR003961. Fibronectin_type3.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
PF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00637. CBD_II. 1 hit.
SM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS51173. CBM2. 1 hit.
PS50853. FN3. 2 hits.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50400-1 [UniParc]FASTAAdd to Basket

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MHSASRTRAR TRVRTAVSGL LAATVLAAPL TLVAAPAQAA TGDDWLHVEG    50
NTIVDSTGKE AILSGVNWFG FNASERVFHG LWSGNITQIT QQMAQRGINV 100
VRVPVSTQLL LEWKAGTFLK PNVNTYANPE LEGKNSLQIF EYWLTLCQKY 150
GIKVFLDVHS AEADNSGHVY NMWWKGDITT EDVYEGWEWA ATRWKDDDTI 200
VGADIKNEPH GTQGSTERAK WDGTTDKDNF KHFAETASKK ILAINPNWLV 250
FVEGVEIYPK PGVPWTSTGL TDYYGTWWGG NLRGVRDHPI DLGAHQDQLV 300
YSPHDYGPLV FDQKWFQKDF DKASLTADVW GPNWLFIHDE DIAPLLIGEW 350
GGRLGQDPRQ DKWMAALRDL VAERRLSQTF WVLNPNSGDT GGLLLDDWKT 400
WDEVKYSTML EPTLWKHGGK YVGLDHQVPL GGVGSTTGTS ISQVGGGTPD 450
TTAPTAPTGL RAGTPTASTV PLTWSASTDT GGSGVAGYEV YRGTTLVGTT 500
TATSYTVTGL AADSAYTFSV RAKDGAGNTS AASAAVTART AAGGGDVTAP 550
SVPTGLTAGT PTATSVPLTW TASTDTGGSG VTGYEVYRGS TLVARPTGTS 600
HTVTGLSAAT AYTFTVRAVD AAGNVSAASA PVGVTTAPDP TTGSCAVTYT 650
ANGWSGGFTA AVTLTNTGTT ALSGWTLGFA FPSGQTLTQG WSARWAQSGS 700
SVTATNEAWN AVLAPGASVE IGFSGTHTGT NTAPATFTVG GATCTTR 747
Length:747
Mass (Da):78,937
Last modified:October 1, 1996 - v1
Checksum:iBD15473C9D8B42BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02544 Genomic DNA. Translation: AAA23089.1.
PIRiB47093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02544 Genomic DNA. Translation: AAA23089.1 .
PIRi B47093.

3D structure databases

ProteinModelPortali P50400.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM2. Carbohydrate-Binding Module Family 2.
GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR001919. Cellulose-bd_dom_fam2_bac.
IPR003961. Fibronectin_type3.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00553. CBM_2. 1 hit.
PF00150. Cellulase. 1 hit.
PF00041. fn3. 2 hits.
[Graphical view ]
SMARTi SM00637. CBD_II. 1 hit.
SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS51173. CBM2. 1 hit.
PS50853. FN3. 2 hits.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cellulose-binding polypeptides from Cellulomonas fimi: endoglucanase D (CenD), a family A beta-1,4-glucanase."
    Meinke A., Gilkes N.R., Kilburn D.G., Miller R.C. Jr., Warren R.A.J.
    J. Bacteriol. 175:1910-1918(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGUND_CELFI
AccessioniPrimary (citable) accession number: P50400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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