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Protein

Rab GDP dissociation inhibitor beta

Gene

Gdi2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

  • GTPase activator activity Source: RGD
  • Rab GDP-dissociation inhibitor activity Source: RGD
  • RNA binding Source: RGD
  • small GTPase binding Source: RGD

GO - Biological processi

  • protein transport Source: RGD
  • small GTPase mediated signal transduction Source: RGD
  • vesicle-mediated transport Source: RGD

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-RNO-194840 Rho GTPase cycle
R-RNO-6798695 Neutrophil degranulation
R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
GDI-3
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:Gdi2
Synonyms:Gdi3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi61802 Gdi2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566831 – 445Rab GDP dissociation inhibitor betaAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei112N6-acetyllysineBy similarity1
Modified residuei130PhosphoserineCombined sources1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei382PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50399
PRIDEiP50399

PTM databases

iPTMnetiP50399
PhosphoSitePlusiP50399

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSRNOG00000018091
GenevisibleiP50399 RN

Interactioni

Subunit structurei

Interacts with RHOH.By similarity

GO - Molecular functioni

  • small GTPase binding Source: RGD

Protein-protein interaction databases

BioGridi248284, 2 interactors
IntActiP50399, 1 interactor
STRINGi10116.ENSRNOP00000024952

Structurei

3D structure databases

ProteinModelPortaliP50399
SMRiP50399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439 Eukaryota
COG5044 LUCA
GeneTreeiENSGT00530000063044
HOGENOMiHOG000163825
HOVERGENiHBG000839
InParanoidiP50399
KOiK17255
OMAiRMMGSEF
OrthoDBiEOG091G06PV
PhylomeDBiP50399
TreeFamiTF300449

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P50399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDQNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKLPG QPPASMGRGR DWNVDLIPKF LMANGQLVKM LLFTEVTRYM
110 120 130 140 150
DFKVIEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG VDPKKTSMRD VYKKFDLGQD VIDFTGHSLA LYRTDDYLDQ
210 220 230 240 250
PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVVGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLFVPK DLGTDSQIFI
410 420 430 440
SRAYDATTHF ETTCDDIKDI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,537
Last modified:January 23, 2007 - v2
Checksum:i483B7C7456B30525
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205 – 211TINRIKL → RLTELNF in CAA52412 (PubMed:8188702).Curated7
Sequence conflicti231 – 232LG → PW in CAA52412 (PubMed:8188702).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74401 mRNA Translation: CAA52412.1
BC061767 mRNA Translation: AAH61767.1
PIRiB54091
RefSeqiNP_058972.2, NM_017276.2
UniGeneiRn.1441

Genome annotation databases

EnsembliENSRNOT00000024952; ENSRNOP00000024952; ENSRNOG00000018091
GeneIDi29662
KEGGirno:29662
UCSCiRGD:61802 rat

Similar proteinsi

Entry informationi

Entry nameiGDIB_RAT
AccessioniPrimary (citable) accession number: P50399
Secondary accession number(s): Q6P797
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health