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Protein

Rab GDP dissociation inhibitor alpha

Gene

Gdi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Rab GDP-dissociation inhibitor activity Source: RGD
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of axonogenesis Source: UniProtKB
  • negative regulation of protein targeting to membrane Source: UniProtKB
  • positive regulation of axon extension Source: RGD
  • protein transport Source: InterPro
  • Rab protein signal transduction Source: UniProtKB
  • response to calcium ion Source: RGD

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-RNO-194840. Rho GTPase cycle.
R-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor alpha
Short name:
Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name:
GDI-1
Gene namesi
Name:Gdi1
Synonyms:Rabgdia
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2676. Gdi1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566761 – 447Rab GDP dissociation inhibitor alphaAdd BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei427PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50398.
PRIDEiP50398.

2D gel databases

World-2DPAGEi0004:P50398.

PTM databases

iPTMnetiP50398.
PhosphoSitePlusiP50398.

Expressioni

Tissue specificityi

High expression in brain, lower in other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000056870.
GenevisibleiP50398. RN.

Interactioni

Subunit structurei

Interacts with RHOH, RAB1A, RAB3A, RAB5A and RAB10.By similarity

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi247236. 1 interactor.
CORUMiP50398.
IntActiP50398. 1 interactor.
STRINGi10116.ENSRNOP00000053135.

Structurei

3D structure databases

ProteinModelPortaliP50398.
SMRiP50398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiP50398.
KOiK17255.
OMAiEDPATHQ.
OrthoDBiEOG091G06PV.
PhylomeDBiP50398.
TreeFamiTF300449.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
PANTHERiPTHR11787. PTHR11787. 1 hit.
PfamiView protein in Pfam
PF00996. GDI. 1 hit.
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P50398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQLLE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQTTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETA EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGSAFD FENMKRKQND VFGEADQ
Length:447
Mass (Da):50,537
Last modified:October 1, 1996 - v1
Checksum:i58384671991DF793
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199D → Y in CAA52413 (PubMed:8188702).Curated1
Sequence conflicti230G → S in AAB16909 (PubMed:7513052).Curated1
Sequence conflicti330S → P in AAB16909 (PubMed:7513052).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74402 mRNA. Translation: CAA52413.1.
U07952 mRNA. Translation: AAB16909.1.
BC099763 mRNA. Translation: AAH99763.1.
AF130987 mRNA. Translation: AAD25536.1.
PIRiA54091.
B56024.
RefSeqiNP_058784.2. NM_017088.2.
UniGeneiRn.4000.

Genome annotation databases

EnsembliENSRNOT00000089814; ENSRNOP00000070171; ENSRNOG00000056870.
GeneIDi25183.
KEGGirno:25183.

Similar proteinsi

Entry informationi

Entry nameiGDIA_RAT
AccessioniPrimary (citable) accession number: P50398
Secondary accession number(s): Q499U0, Q9R274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families