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Protein

Rab GDP dissociation inhibitor beta

Gene

GDI2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-BTA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:GDI2
Synonyms:RABGDIB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Rab GDP dissociation inhibitor betaPRO_0000056677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei57 – 571N6-succinyllysineBy similarity
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Modified residuei269 – 2691N6-acetyllysineBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50397.
PeptideAtlasiP50397.
PRIDEiP50397.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Interactioni

Subunit structurei

Interacts with RHOH.By similarity

Protein-protein interaction databases

IntActiP50397. 1 interaction.
MINTiMINT-4095964.
STRINGi9913.ENSBTAP00000006992.

Structurei

3D structure databases

ProteinModelPortaliP50397.
SMRiP50397. Positions 1-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiP50397.
KOiK17255.
OMAiFNLPGTP.
OrthoDBiEOG7PP56D.
TreeFamiTF300449.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P50397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG APPASMGRGR DWNVDLIPKF LMANGQLVKM LLFTEVTRYL
110 120 130 140 150
DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DENDPRTFEG IDPKKTSMRE VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCCETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIM QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISSA HNVAAQGKYI
360 370 380 390 400
AIASTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI
410 420 430 440
SRTYDATTHF ETTCDDIKDI YKRMMGSEFD FEEMKRKKND IYGEE
Length:445
Mass (Da):50,488
Last modified:May 30, 2006 - v3
Checksum:iCEEA4DE3CC17D5F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07951 mRNA. Translation: AAB16908.1.
BT030504 mRNA. Translation: ABQ12944.1.
BC105197 mRNA. Translation: AAI05198.1.
PIRiA56024.
RefSeqiNP_001028934.1. NM_001033762.2.
UniGeneiBt.23028.

Genome annotation databases

EnsembliENSBTAT00000006992; ENSBTAP00000006992; ENSBTAG00000005316.
GeneIDi509832.
KEGGibta:509832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07951 mRNA. Translation: AAB16908.1.
BT030504 mRNA. Translation: ABQ12944.1.
BC105197 mRNA. Translation: AAI05198.1.
PIRiA56024.
RefSeqiNP_001028934.1. NM_001033762.2.
UniGeneiBt.23028.

3D structure databases

ProteinModelPortaliP50397.
SMRiP50397. Positions 1-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50397. 1 interaction.
MINTiMINT-4095964.
STRINGi9913.ENSBTAP00000006992.

Proteomic databases

PaxDbiP50397.
PeptideAtlasiP50397.
PRIDEiP50397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006992; ENSBTAP00000006992; ENSBTAG00000005316.
GeneIDi509832.
KEGGibta:509832.

Organism-specific databases

CTDi2665.

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiP50397.
KOiK17255.
OMAiFNLPGTP.
OrthoDBiEOG7PP56D.
TreeFamiTF300449.

Enzyme and pathway databases

ReactomeiR-BTA-194840. Rho GTPase cycle.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle."
    Shisheva A., Suedhof T.C., Czech M.P.
    Mol. Cell. Biol. 14:3459-3468(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiGDIB_BOVIN
AccessioniPrimary (citable) accession number: P50397
Secondary accession number(s): A5D985, Q3MHL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2006
Last modified: July 6, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from mouse.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.