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P50396 (GDIA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rab GDP dissociation inhibitor alpha

Short name=Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name=GDI-1
Gene names
Name:Gdi1
Synonyms:Rabgdia
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

Subunit structure

Interacts with RHOH, RAB1A, RAB3A and RAB5A By similarity. Interacts with RAB10. Ref.8

Subcellular location

Cytoplasm By similarity. Golgi apparatustrans-Golgi network By similarity.

Tissue specificity

High expression in brain, lower in other tissues.

Sequence similarities

Belongs to the Rab GDI family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Rab GDP dissociation inhibitor alpha
PRO_0000056673

Experimental info

Sequence conflict581I → M in AAK49815. Ref.1
Sequence conflict581I → M in BAE33632. Ref.3
Sequence conflict581I → M in BAE42320. Ref.3
Sequence conflict1281A → R in AAB16907. Ref.7
Sequence conflict1651N → T in AAK49815. Ref.1
Sequence conflict1961D → E in AAB16907. Ref.7
Sequence conflict2231P → S in AAL60197. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50396 [UniParc].

Last modified May 10, 2004. Version 3.
Checksum: F7B9BC942B35DF58

FASTA44750,522
        10         20         30         40         50         60 
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE ELYKRFQILE 

        70         80         90        100        110        120 
GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVVEGSFV YKGGKIYKVP 

       130        140        150        160        170        180 
STETEALASN LMGMFEKRRF RKFLVFVANF DENDPKTFEG VDPQNTSMRD VYRKFDLGQD 

       190        200        210        220        230        240 
VIDFTGHALA LYRTDDYLDQ PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR 

       250        260        270        280        290        300 
LSAIYGGTYM LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VQKAGQVIRI 

       310        320        330        340        350        360 
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI AIASTTVETA 

       370        380        390        400        410        420 
EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC SCSYDATTHF ETTCNDIKDI 

       430        440 
YKRMAGSAFD FENMKRKQND VFGEADQ 

« Hide

References

« Hide 'large scale' references
[1]"Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission."
Ishizaki H., Miyoshi J., Kamiya H., Togawa A., Tanaka M., Sasaki T., Endo K., Mizoguchi A., Ozawa S., Takai Y.
Proc. Natl. Acad. Sci. U.S.A. 97:11587-11592(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Knockout mice carrying a deletion of the mental retardation gene Gdi1 show impaired associative memory and inappropriate social behavior."
D'Adamo P., Welzl H., Papadimitriou S., Raffaele di Barletta M., Tiveron C., Tatangelo L., Chapman P.F., Knevett S.G., Ramsay M.F., Valtorta F., Leoni C., Menegon A., Wolfer D.P., Lipp H.-P., Toniolo D.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvEv.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Skin and Spleen.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and FVB/N.
Tissue: Eye and Mammary tumor.
[6]Lubec G., Klug S., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 36-54; 56-68; 104-112; 119-137; 143-169; 174-208; 211-218; 222-240; 300-328; 349-379 AND 424-447, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain and Hippocampus.
[7]"Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle."
Shisheva A., Suedhof T.C., Czech M.P.
Mol. Cell. Biol. 14:3459-3468(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-447.
Strain: BALB/c.
Tissue: Skeletal muscle.
[8]"GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation."
Chen Y., Deng Y., Zhang J., Yang L., Xie X., Xu T.
Biochem. J. 422:229-235(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB10.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF251042 mRNA. Translation: AAK49815.1.
AF441240 Genomic DNA. Translation: AAL60197.1.
AK028880 mRNA. Translation: BAC26169.1.
AK156224 mRNA. Translation: BAE33632.1.
AK171216 mRNA. Translation: BAE42320.1.
AL807376 Genomic DNA. Translation: CAM24345.1.
BC010220 mRNA. Translation: AAH10220.1.
BC013758 mRNA. Translation: AAH13758.1.
BC037598 mRNA. Translation: AAH37598.1.
U07950 mRNA. Translation: AAB16907.1.
CCDSCCDS30227.1.
PIRC56024.
RefSeqNP_034403.1. NM_010273.4.
UniGeneMm.205830.

3D structure databases

ProteinModelPortalP50396.
SMRP50396. Positions 1-430.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP50396. 7 interactions.
MINTMINT-1869124.

PTM databases

PhosphoSiteP50396.

Proteomic databases

MaxQBP50396.
PaxDbP50396.
PRIDEP50396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015435; ENSMUSP00000015435; ENSMUSG00000015291.
GeneID14567.
KEGGmmu:14567.
UCSCuc009tom.2. mouse.

Organism-specific databases

CTD2664.
MGIMGI:99846. Gdi1.

Phylogenomic databases

eggNOGCOG5044.
GeneTreeENSGT00530000063044.
HOVERGENHBG000839.
InParanoidP50396.
KOK17255.
OMAKTWKDFD.
OrthoDBEOG7PP56D.
PhylomeDBP50396.
TreeFamTF300449.

Gene expression databases

ArrayExpressP50396.
BgeeP50396.
GenevestigatorP50396.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR018203. GDP_dissociation_inhibitor.
IPR016040. NAD(P)-bd_dom.
IPR000806. RabGDI.
[Graphical view]
PfamPF00996. GDI. 1 hit.
[Graphical view]
PRINTSPR00892. RABGDI.
PR00891. RABGDIREP.
ProtoNetSearch...

Other

NextBio286278.
PROP50396.
SOURCESearch...

Entry information

Entry nameGDIA_MOUSE
AccessionPrimary (citable) accession number: P50396
Secondary accession number(s): A2AMA8 expand/collapse secondary AC list , Q3TBI9, Q8VHM3, Q91Y71, Q91Z41, Q96CX5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot