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P50396

- GDIA_MOUSE

UniProt

P50396 - GDIA_MOUSE

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Protein

Rab GDP dissociation inhibitor alpha

Gene

Gdi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. Rab GDP-dissociation inhibitor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of axonogenesis Source: UniProtKB
  2. negative regulation of protein targeting to membrane Source: UniProtKB
  3. protein transport Source: InterPro
  4. Rab protein signal transduction Source: UniProtKB
  5. regulation of catalytic activity Source: GOC
  6. response to calcium ion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor alpha
Short name:
Rab GDI alpha
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 1
Short name:
GDI-1
Gene namesi
Name:Gdi1
Synonyms:Rabgdia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:99846. Gdi1.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatustrans-Golgi network By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. midbody Source: Ensembl
  3. neuron projection Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Rab GDP dissociation inhibitor alphaPRO_0000056673Add
BLAST

Proteomic databases

MaxQBiP50396.
PaxDbiP50396.
PRIDEiP50396.

PTM databases

PhosphoSiteiP50396.

Expressioni

Tissue specificityi

High expression in brain, lower in other tissues.

Gene expression databases

BgeeiP50396.
ExpressionAtlasiP50396. baseline and differential.
GenevestigatoriP50396.

Interactioni

Subunit structurei

Interacts with RHOH, RAB1A, RAB3A and RAB5A By similarity. Interacts with RAB10.By similarity1 Publication

Protein-protein interaction databases

IntActiP50396. 7 interactions.
MINTiMINT-1869124.

Structurei

3D structure databases

ProteinModelPortaliP50396.
SMRiP50396. Positions 1-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiCOG5044.
GeneTreeiENSGT00530000063044.
HOVERGENiHBG000839.
InParanoidiP50396.
KOiK17255.
OMAiKTWKDFD.
OrthoDBiEOG7PP56D.
PhylomeDBiP50396.
TreeFamiTF300449.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR018203. GDP_dissociation_inhibitor.
IPR016040. NAD(P)-bd_dom.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.

Sequencei

Sequence statusi: Complete.

P50396-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE
60 70 80 90 100
ELYKRFQILE GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVVEGSFV YKGGKIYKVP STETEALASN LMGMFEKRRF RKFLVFVANF
160 170 180 190 200
DENDPKTFEG VDPQNTSMRD VYRKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCLETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VQKAGQVIRI
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI
360 370 380 390 400
AIASTTVETA EPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGSESQVFC
410 420 430 440
SCSYDATTHF ETTCNDIKDI YKRMAGSAFD FENMKRKQND VFGEADQ
Length:447
Mass (Da):50,522
Last modified:May 10, 2004 - v3
Checksum:iF7B9BC942B35DF58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581I → M in AAK49815. (PubMed:11027356)Curated
Sequence conflicti58 – 581I → M in BAE33632. (PubMed:16141072)Curated
Sequence conflicti58 – 581I → M in BAE42320. (PubMed:16141072)Curated
Sequence conflicti128 – 1281A → R in AAB16907. (PubMed:7513052)Curated
Sequence conflicti165 – 1651N → T in AAK49815. (PubMed:11027356)Curated
Sequence conflicti196 – 1961D → E in AAB16907. (PubMed:7513052)Curated
Sequence conflicti223 – 2231P → S in AAL60197. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251042 mRNA. Translation: AAK49815.1.
AF441240 Genomic DNA. Translation: AAL60197.1.
AK028880 mRNA. Translation: BAC26169.1.
AK156224 mRNA. Translation: BAE33632.1.
AK171216 mRNA. Translation: BAE42320.1.
AL807376 Genomic DNA. Translation: CAM24345.1.
BC010220 mRNA. Translation: AAH10220.1.
BC013758 mRNA. Translation: AAH13758.1.
BC037598 mRNA. Translation: AAH37598.1.
U07950 mRNA. Translation: AAB16907.1.
CCDSiCCDS30227.1.
PIRiC56024.
RefSeqiNP_034403.1. NM_010273.4.
UniGeneiMm.205830.

Genome annotation databases

EnsembliENSMUST00000015435; ENSMUSP00000015435; ENSMUSG00000015291.
GeneIDi14567.
KEGGimmu:14567.
UCSCiuc009tom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF251042 mRNA. Translation: AAK49815.1 .
AF441240 Genomic DNA. Translation: AAL60197.1 .
AK028880 mRNA. Translation: BAC26169.1 .
AK156224 mRNA. Translation: BAE33632.1 .
AK171216 mRNA. Translation: BAE42320.1 .
AL807376 Genomic DNA. Translation: CAM24345.1 .
BC010220 mRNA. Translation: AAH10220.1 .
BC013758 mRNA. Translation: AAH13758.1 .
BC037598 mRNA. Translation: AAH37598.1 .
U07950 mRNA. Translation: AAB16907.1 .
CCDSi CCDS30227.1.
PIRi C56024.
RefSeqi NP_034403.1. NM_010273.4.
UniGenei Mm.205830.

3D structure databases

ProteinModelPortali P50396.
SMRi P50396. Positions 1-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50396. 7 interactions.
MINTi MINT-1869124.

PTM databases

PhosphoSitei P50396.

Proteomic databases

MaxQBi P50396.
PaxDbi P50396.
PRIDEi P50396.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015435 ; ENSMUSP00000015435 ; ENSMUSG00000015291 .
GeneIDi 14567.
KEGGi mmu:14567.
UCSCi uc009tom.2. mouse.

Organism-specific databases

CTDi 2664.
MGIi MGI:99846. Gdi1.

Phylogenomic databases

eggNOGi COG5044.
GeneTreei ENSGT00530000063044.
HOVERGENi HBG000839.
InParanoidi P50396.
KOi K17255.
OMAi KTWKDFD.
OrthoDBi EOG7PP56D.
PhylomeDBi P50396.
TreeFami TF300449.

Enzyme and pathway databases

Reactomei REACT_210090. Rho GTPase cycle.

Miscellaneous databases

NextBioi 286278.
PROi P50396.
SOURCEi Search...

Gene expression databases

Bgeei P50396.
ExpressionAtlasi P50396. baseline and differential.
Genevestigatori P50396.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR018203. GDP_dissociation_inhibitor.
IPR016040. NAD(P)-bd_dom.
IPR000806. RabGDI.
[Graphical view ]
Pfami PF00996. GDI. 1 hit.
[Graphical view ]
PRINTSi PR00892. RABGDI.
PR00891. RABGDIREP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission."
    Ishizaki H., Miyoshi J., Kamiya H., Togawa A., Tanaka M., Sasaki T., Endo K., Mizoguchi A., Ozawa S., Takai Y.
    Proc. Natl. Acad. Sci. U.S.A. 97:11587-11592(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Knockout mice carrying a deletion of the mental retardation gene Gdi1 show impaired associative memory and inappropriate social behavior."
    D'Adamo P., Welzl H., Papadimitriou S., Raffaele di Barletta M., Tiveron C., Tatangelo L., Chapman P.F., Knevett S.G., Ramsay M.F., Valtorta F., Leoni C., Menegon A., Wolfer D.P., Lipp H.-P., Toniolo D.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvEv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin and Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Eye and Mammary tumor.
  6. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 36-54; 56-68; 104-112; 119-137; 143-169; 174-208; 211-218; 222-240; 300-328; 349-379 AND 424-447, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  7. "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle."
    Shisheva A., Suedhof T.C., Czech M.P.
    Mol. Cell. Biol. 14:3459-3468(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-447.
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  8. "GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation."
    Chen Y., Deng Y., Zhang J., Yang L., Xie X., Xu T.
    Biochem. J. 422:229-235(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB10.

Entry informationi

Entry nameiGDIA_MOUSE
AccessioniPrimary (citable) accession number: P50396
Secondary accession number(s): A2AMA8
, Q3TBI9, Q8VHM3, Q91Y71, Q91Z41, Q96CX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3