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Protein

Rab GDP dissociation inhibitor beta

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • oxidoreductase activity Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • Rab GDP-dissociation inhibitor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000057608-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitor beta
Short name:
Rab GDI beta
Alternative name(s):
Guanosine diphosphate dissociation inhibitor 2
Short name:
GDI-2
Gene namesi
Name:GDI2
Synonyms:RABGDIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4227. GDI2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • membrane Source: UniProtKB-SubCell
  • myelin sheath Source: Ensembl
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2665.
OpenTargetsiENSG00000057608.
PharmGKBiPA28642.

Polymorphism and mutation databases

BioMutaiGDI2.
DMDMi13638228.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566791 – 445Rab GDP dissociation inhibitor betaAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei61PhosphoserineCombined sources1
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei130PhosphoserineBy similarity1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP50395.
PaxDbiP50395.
PeptideAtlasiP50395.
PRIDEiP50395.

2D gel databases

OGPiP50395.
REPRODUCTION-2DPAGEIPI00031461.
P50395.

PTM databases

iPTMnetiP50395.
PhosphoSitePlusiP50395.
SwissPalmiP50395.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000057608.
CleanExiHS_GDI2.
ExpressionAtlasiP50395. baseline and differential.
GenevisibleiP50395. HS.

Organism-specific databases

HPAiHPA049290.
HPA057668.

Interactioni

Subunit structurei

Interacts with RHOH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab10P610273EBI-1049143,EBI-911581From a different organism.
RAB4AP203382EBI-1049143,EBI-722284

Protein-protein interaction databases

BioGridi108933. 54 interactors.
DIPiDIP-50593N.
IntActiP50395. 23 interactors.
MINTiMINT-4999214.
STRINGi9606.ENSP00000369538.

Structurei

3D structure databases

ProteinModelPortaliP50395.
SMRiP50395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.Curated

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiP50395.
KOiK17255.
OMAiPAMNEEY.
OrthoDBiEOG091G06PV.
PhylomeDBiP50395.
TreeFamiTF300449.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50395-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESASITPLE
60 70 80 90 100
DLYKRFKIPG SPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL
110 120 130 140 150
DFKVTEGSFV YKGGKIYKVP STEAEALASS LMGLFEKRRF RKFLVYVANF
160 170 180 190 200
DEKDPRTFEG IDPKKTTMRD VYKKFDLGQD VIDFTGHALA LYRTDDYLDQ
210 220 230 240 250
PCYETINRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR LSAIYGGTYM
260 270 280 290 300
LNKPIEEIIV QNGKVIGVKS EGEIARCKQL ICDPSYVKDR VEKVGQVIRV
310 320 330 340 350
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISFA HNVAAQGKYI
360 370 380 390 400
AIVSTTVETK EPEKEIRPAL ELLEPIEQKF VSISDLLVPK DLGTESQIFI
410 420 430 440
SRTYDATTHF ETTCDDIKNI YKRMTGSEFD FEEMKRKKND IYGED
Length:445
Mass (Da):50,663
Last modified:April 27, 2001 - v2
Checksum:iCE186A2E3A47FCC9
GO
Isoform 2 (identifier: P50395-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-130: Missing.

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):45,619
Checksum:i9B80298F66BA048B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2N → D in BAA03095 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04346986 – 130Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13988 mRNA. Translation: BAA03095.1.
Y13286 mRNA. Translation: CAA73734.1.
Y13287
, Y13288, Y13289, Y13290, Y13291, Y13292, Y13293, Y13294, Y13295, Y13296, Y13297 Genomic DNA. Translation: CAA73735.1.
BT006868 mRNA. Translation: AAP35514.1.
AK297554 mRNA. Translation: BAG59947.1.
AL596094 Genomic DNA. Translation: CAI13363.1.
BC005145 mRNA. Translation: AAH05145.1.
AF144713 mRNA. Translation: AAD34588.1.
CCDSiCCDS44352.1. [P50395-2]
CCDS7071.1. [P50395-1]
RefSeqiNP_001108628.1. NM_001115156.1. [P50395-2]
NP_001485.2. NM_001494.3. [P50395-1]
UniGeneiHs.299055.

Genome annotation databases

EnsembliENST00000380181; ENSP00000369528; ENSG00000057608. [P50395-2]
ENST00000380191; ENSP00000369538; ENSG00000057608. [P50395-1]
GeneIDi2665.
KEGGihsa:2665.
UCSCiuc001iim.5. human. [P50395-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13988 mRNA. Translation: BAA03095.1.
Y13286 mRNA. Translation: CAA73734.1.
Y13287
, Y13288, Y13289, Y13290, Y13291, Y13292, Y13293, Y13294, Y13295, Y13296, Y13297 Genomic DNA. Translation: CAA73735.1.
BT006868 mRNA. Translation: AAP35514.1.
AK297554 mRNA. Translation: BAG59947.1.
AL596094 Genomic DNA. Translation: CAI13363.1.
BC005145 mRNA. Translation: AAH05145.1.
AF144713 mRNA. Translation: AAD34588.1.
CCDSiCCDS44352.1. [P50395-2]
CCDS7071.1. [P50395-1]
RefSeqiNP_001108628.1. NM_001115156.1. [P50395-2]
NP_001485.2. NM_001494.3. [P50395-1]
UniGeneiHs.299055.

3D structure databases

ProteinModelPortaliP50395.
SMRiP50395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108933. 54 interactors.
DIPiDIP-50593N.
IntActiP50395. 23 interactors.
MINTiMINT-4999214.
STRINGi9606.ENSP00000369538.

PTM databases

iPTMnetiP50395.
PhosphoSitePlusiP50395.
SwissPalmiP50395.

Polymorphism and mutation databases

BioMutaiGDI2.
DMDMi13638228.

2D gel databases

OGPiP50395.
REPRODUCTION-2DPAGEIPI00031461.
P50395.

Proteomic databases

EPDiP50395.
PaxDbiP50395.
PeptideAtlasiP50395.
PRIDEiP50395.

Protocols and materials databases

DNASUi2665.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380181; ENSP00000369528; ENSG00000057608. [P50395-2]
ENST00000380191; ENSP00000369538; ENSG00000057608. [P50395-1]
GeneIDi2665.
KEGGihsa:2665.
UCSCiuc001iim.5. human. [P50395-1]

Organism-specific databases

CTDi2665.
DisGeNETi2665.
GeneCardsiGDI2.
HGNCiHGNC:4227. GDI2.
HPAiHPA049290.
HPA057668.
MIMi600767. gene.
neXtProtiNX_P50395.
OpenTargetsiENSG00000057608.
PharmGKBiPA28642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1439. Eukaryota.
COG5044. LUCA.
GeneTreeiENSGT00530000063044.
HOGENOMiHOG000163825.
HOVERGENiHBG000839.
InParanoidiP50395.
KOiK17255.
OMAiPAMNEEY.
OrthoDBiEOG091G06PV.
PhylomeDBiP50395.
TreeFamiTF300449.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000057608-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiGDI2. human.
GeneWikiiGDI2.
GenomeRNAii2665.
PROiP50395.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000057608.
CleanExiHS_GDI2.
ExpressionAtlasiP50395. baseline and differential.
GenevisibleiP50395. HS.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR018203. GDP_dissociation_inhibitor.
IPR000806. RabGDI.
[Graphical view]
PfamiPF00996. GDI. 1 hit.
[Graphical view]
PRINTSiPR00892. RABGDI.
PR00891. RABGDIREP.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGDIB_HUMAN
AccessioniPrimary (citable) accession number: P50395
Secondary accession number(s): O43928, Q5SX88, Q9UQM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.