Reviewed,
UniProtKB/Swiss-Prot P50395 (GDIB_HUMAN)
Last modified
November 25, 2008.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Rab GDP dissociation inhibitor beta Short name=Rab GDI beta Alternative name(s): Guanosine diphosphate dissociation inhibitor 2 Short name=GDI-2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 445 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. |
| Subcellular location | CytoplasmBy similarity. Membrane; Peripheral membrane proteinBy similarity. |
| Tissue specificity | Ubiquitous. |
| Sequence similarities | Belongs to the Rab GDI family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Membrane |
| Molecular function | GTPase activation |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: InterPro regulation of GTPase activityInferred from electronic annotation. Source: InterPro signal transductionTraceable author statement. Source: UniProtKB |
| Cellular component | cell surface Inferred from direct assay. Source: UniProtKB cytoplasmTraceable author statement. Source: UniProtKB membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rab GDP-dissociation inhibitor activity Ref.6Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 445 | 445 | Rab GDP dissociation inhibitor beta | PRO_0000056679 | |||||
Amino acid modifications | |||||||||
| Modified residue | 61 | 1 | Phosphoserine | ||||||
| Modified residue | 203 | 1 | Phosphotyrosine | ||||||
Experimental info | |||||||||
| Sequence conflict | 2 | 1 | N → D in BAA03095. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Asada M., Kaibuchi K., Takai Y. Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain. |
| [2] | "The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13." Sedlacek Z., Munstermann E., Mincheva A., Lichter P., Poutska A. Mamm. Genome 9:78-80(1998) [PubMed: 9434952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [5] | "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells." Caillol N., Pasqualini E., Lloubes R., Lombardo D. J. Cell. Biochem. 79:628-647(2000) [PubMed: 10996854] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 81-439. Tissue: Pancreas. |
| [6] | "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport." Bachner D., Sedlacek Z., Korn B., Hameister H., Poustka A. Hum. Mol. Genet. 4:701-708(1995) [PubMed: 7543319] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [7] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-203, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D13988 mRNA. Translation: BAA03095.1. Y13286 mRNA. Translation: CAA73734.1. Y13287 Y13297 Genomic DNA. Translation: CAA73735.1. BT006868 mRNA. Translation: AAP35514.1. BC005145 mRNA. Translation: AAH05145.1. AF144713 mRNA. Translation: AAD34588.1. | |
| RefSeq | NP_001485.2. |
| UniGene | Hs.299055 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1D5T based on UniProtKB P21856. |
| SMR | P50395. Positions 1-431. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P50395. |
PTM databases | |
| PhosphoSite | P50395. |
2-D gel databases | |
| OGP | P50395. |
| REPRODUCTION-2DPAGE | IPI00031461. P50395. |
Genome annotation databases | |
| Ensembl | ENSG00000057608. Homo sapiens. [Contig view] |
| GeneID | 2665. |
Organism-specific databases | |
| H-InvDB | HIX0008614. |
| HGNC | HGNC:4227. GDI2. |
| MIM | 600767. gene. |
| PharmGKB | PA28642. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P50395. |
| HOVERGEN | P50395. |
Enzyme and pathway databases | |
| Reactome | REACT_11044. Signaling by Rho GTPases. |
Gene expression databases | |
| ArrayExpress | P50395. |
| CleanEx | HS_GDI2. |
| GermOnline | ENSG00000057608. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002005. Rab_GDI_REP. IPR000806. RabGDI. [Graphical view] |
| PANTHER | PTHR11787. Rab_GDI_REP. 1 hit. |
| Pfam | PF00996. GDI. 1 hit. [Graphical view] |
| PRINTS | PR00892. RABGDI. PR00891. RABGDIREP. |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P50395. |
| NextBio | 10516. |
| SOURCE | Search... |
Entry information
| Entry name | GDIB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P50395 Secondary accession number(s): O43928, Q9UQM6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


