Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropeptide Y receptor type 4

Gene

NPY4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • pancreatic polypeptide receptor activity Source: GO_Central

GO - Biological processi

  • blood circulation Source: ProtInc
  • cell surface receptor signaling pathway Source: GO_Central
  • digestion Source: ProtInc
  • feeding behavior Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • neuropeptide signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31272-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP50391.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:NPY4R
Synonyms:PPYR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9329. NPY4R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 87CytoplasmicSequence analysisAdd BLAST27
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini109 – 116ExtracellularSequence analysis8
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 155CytoplasmicSequence analysisAdd BLAST18
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 212ExtracellularSequence analysisAdd BLAST36
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 263CytoplasmicSequence analysisAdd BLAST30
Transmembranei264 – 284Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini285 – 301ExtracellularSequence analysisAdd BLAST17
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 375CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100996758.
5540.
OpenTargetsiENSG00000264717.
PharmGKBiPA33692.

Chemistry databases

ChEMBLiCHEMBL4877.
GuidetoPHARMACOLOGYi307.

Polymorphism and mutation databases

DMDMi1709423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699351 – 375Neuropeptide Y receptor type 4Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Lipidationi340S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP50391.
PRIDEiP50391.

PTM databases

iPTMnetiP50391.
PhosphoSitePlusiP50391.

Expressioni

Tissue specificityi

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Gene expression databases

BgeeiENSG00000204174.
CleanExiHS_PPYR1.
GenevisibleiP50391. HS.

Organism-specific databases

HPAiHPA027863.

Interactioni

Protein-protein interaction databases

BioGridi111532. 1 interactor.
STRINGi9606.ENSP00000363431.

Chemistry databases

BindingDBiP50391.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK5model-@1-375[»]
ProteinModelPortaliP50391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP50391.
KOiK04206.
OrthoDBiEOG091G0HOS.
PhylomeDBiP50391.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI
60 70 80 90 100
ETVVGVLGNL CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV
110 120 130 140 150
YTIMDYWIFG ETLCKMSAFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSISQAYLGI VLIWVIACVL SLPFLANSIL ENVFHKNHSK ALEFLADKVV
210 220 230 240 250
CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR LQRQGRVFHK
260 270 280 290 300
GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
310 320 330 340 350
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE
360 370
HLPLSTVHTE VSKGSLRLSG RSNPI
Length:375
Mass (Da):42,195
Last modified:October 1, 1996 - v1
Checksum:i0081DBA51436EE22
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03033799A → S.3 PublicationsCorresponds to variant rs2229967dbSNPEnsembl.1
Natural variantiVAR_030338240R → C.1 PublicationCorresponds to variant rs3824733dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35232 Genomic DNA. Translation: AAC50280.1.
Z66526 Genomic DNA. Translation: CAA91433.1.
U42387 mRNA. Translation: AAB07759.1.
AY649985 mRNA. Translation: AAV68196.1.
AY649986 mRNA. Translation: AAV68197.1.
AY268432 Genomic DNA. Translation: AAP23199.1.
CR541950 mRNA. Translation: CAG46748.1.
AL390716 Genomic DNA. Translation: CAI13318.1.
BC096238 mRNA. Translation: AAH96238.1.
CCDSiCCDS73100.1.
PIRiG02300.
I39182.
RefSeqiNP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.3.
XP_006717608.1. XM_006717545.3.
XP_011537416.1. XM_011539114.2.
XP_011537417.1. XM_011539115.2.
XP_011538238.1. XM_011539936.2.
XP_011538239.1. XM_011539937.2.
XP_011547675.1. XM_011549373.2.
XP_011547676.1. XM_011549374.2.
XP_011547677.1. XM_011549375.2.
XP_011547678.1. XM_011549376.2.
XP_016854962.1. XM_016999473.1.
XP_016854963.1. XM_016999474.1.
XP_016870952.1. XM_017015463.1.
XP_016870953.1. XM_017015464.1.
XP_016871875.1. XM_017016386.1.
XP_016871876.1. XM_017016387.1.
UniGeneiHs.524719.

Genome annotation databases

EnsembliENST00000374312; ENSP00000363431; ENSG00000204174.
ENST00000395716; ENSP00000379066; ENSG00000204174.
ENST00000612632; ENSP00000480883; ENSG00000204174.
GeneIDi100996758.
105379861.
5540.
KEGGihsa:100996758.
hsa:105379861.
hsa:5540.
UCSCiuc031wfc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35232 Genomic DNA. Translation: AAC50280.1.
Z66526 Genomic DNA. Translation: CAA91433.1.
U42387 mRNA. Translation: AAB07759.1.
AY649985 mRNA. Translation: AAV68196.1.
AY649986 mRNA. Translation: AAV68197.1.
AY268432 Genomic DNA. Translation: AAP23199.1.
CR541950 mRNA. Translation: CAG46748.1.
AL390716 Genomic DNA. Translation: CAI13318.1.
BC096238 mRNA. Translation: AAH96238.1.
CCDSiCCDS73100.1.
PIRiG02300.
I39182.
RefSeqiNP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.3.
XP_006717608.1. XM_006717545.3.
XP_011537416.1. XM_011539114.2.
XP_011537417.1. XM_011539115.2.
XP_011538238.1. XM_011539936.2.
XP_011538239.1. XM_011539937.2.
XP_011547675.1. XM_011549373.2.
XP_011547676.1. XM_011549374.2.
XP_011547677.1. XM_011549375.2.
XP_011547678.1. XM_011549376.2.
XP_016854962.1. XM_016999473.1.
XP_016854963.1. XM_016999474.1.
XP_016870952.1. XM_017015463.1.
XP_016870953.1. XM_017015464.1.
XP_016871875.1. XM_017016386.1.
XP_016871876.1. XM_017016387.1.
UniGeneiHs.524719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK5model-@1-375[»]
ProteinModelPortaliP50391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111532. 1 interactor.
STRINGi9606.ENSP00000363431.

Chemistry databases

BindingDBiP50391.
ChEMBLiCHEMBL4877.
GuidetoPHARMACOLOGYi307.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP50391.
PhosphoSitePlusiP50391.

Polymorphism and mutation databases

DMDMi1709423.

Proteomic databases

PaxDbiP50391.
PRIDEiP50391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374312; ENSP00000363431; ENSG00000204174.
ENST00000395716; ENSP00000379066; ENSG00000204174.
ENST00000612632; ENSP00000480883; ENSG00000204174.
GeneIDi100996758.
105379861.
5540.
KEGGihsa:100996758.
hsa:105379861.
hsa:5540.
UCSCiuc031wfc.1. human.

Organism-specific databases

CTDi100996758.
5540.
DisGeNETi100996758.
5540.
GeneCardsiNPY4R.
H-InvDBHIX0170461.
HGNCiHGNC:9329. NPY4R.
HPAiHPA027863.
MIMi601790. gene.
neXtProtiNX_P50391.
OpenTargetsiENSG00000264717.
PharmGKBiPA33692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP50391.
KOiK04206.
OrthoDBiEOG091G0HOS.
PhylomeDBiP50391.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:G66-31272-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP50391.

Miscellaneous databases

GeneWikiiPancreatic_polypeptide_receptor_1.
PROiP50391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204174.
CleanExiHS_PPYR1.
GenevisibleiP50391. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY4R_HUMAN
AccessioniPrimary (citable) accession number: P50391
Secondary accession number(s): Q13456
, Q5ISU3, Q5T2X9, Q6FH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.