Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P50391

- NPY4R_HUMAN

UniProt

P50391 - NPY4R_HUMAN

Protein

Neuropeptide Y receptor type 4

Gene

NPY4R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. pancreatic polypeptide receptor activity Source: Ensembl
    3. peptide binding Source: Ensembl
    4. peptide YY receptor activity Source: Ensembl

    GO - Biological processi

    1. blood circulation Source: ProtInc
    2. digestion Source: ProtInc
    3. feeding behavior Source: ProtInc
    4. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide Y receptor type 4
    Short name:
    NPY4-R
    Alternative name(s):
    Pancreatic polypeptide receptor 1
    Short name:
    PP1
    Gene namesi
    Name:NPY4R
    Synonyms:PPYR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9329. NPY4R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33692.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Neuropeptide Y receptor type 4PRO_0000069935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Lipidationi340 – 3401S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP50391.
    PRIDEiP50391.

    PTM databases

    PhosphoSiteiP50391.

    Expressioni

    Tissue specificityi

    Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

    Gene expression databases

    BgeeiP50391.
    CleanExiHS_PPYR1.
    GenevestigatoriP50391.

    Organism-specific databases

    HPAiHPA027863.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000363431.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IK5model-@1-375[»]
    ProteinModelPortaliP50391.
    SMRiP50391. Positions 22-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 8727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 1168ExtracellularSequence Analysis
    Topological domaini138 – 15518CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 26330CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 30117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 37553CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG261951.
    HOGENOMiHOG000050229.
    HOVERGENiHBG105676.
    InParanoidiP50391.
    KOiK04204.
    OMAiCYVRIYL.
    OrthoDBiEOG773XGC.
    PhylomeDBiP50391.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001933. NPY4_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01015. NRPEPTIDEY4R.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI    50
    ETVVGVLGNL CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV 100
    YTIMDYWIFG ETLCKMSAFI QCMSVTVSIL SLVLVALERH QLIINPTGWK 150
    PSISQAYLGI VLIWVIACVL SLPFLANSIL ENVFHKNHSK ALEFLADKVV 200
    CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR LQRQGRVFHK 250
    GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG 300
    NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE 350
    HLPLSTVHTE VSKGSLRLSG RSNPI 375
    Length:375
    Mass (Da):42,195
    Last modified:October 1, 1996 - v1
    Checksum:i0081DBA51436EE22
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti99 – 991A → S.3 Publications
    Corresponds to variant rs2229967 [ dbSNP | Ensembl ].
    VAR_030337
    Natural varianti240 – 2401R → C.1 Publication
    Corresponds to variant rs3824733 [ dbSNP | Ensembl ].
    VAR_030338

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35232 Genomic DNA. Translation: AAC50280.1.
    Z66526 Genomic DNA. Translation: CAA91433.1.
    U42387 mRNA. Translation: AAB07759.1.
    AY649985 mRNA. Translation: AAV68196.1.
    AY649986 mRNA. Translation: AAV68197.1.
    AY268432 Genomic DNA. Translation: AAP23199.1.
    CR541950 mRNA. Translation: CAG46748.1.
    AL390716 Genomic DNA. Translation: CAI13318.1.
    BC096238 mRNA. Translation: AAH96238.1.
    CCDSiCCDS31193.1.
    PIRiG02300.
    I39182.
    RefSeqiNP_001265723.1. NM_001278794.1.
    NP_001265724.1. NM_001278795.1.
    NP_005963.4. NM_005972.5.
    XP_005277701.1. XM_005277644.1.
    XP_006717608.1. XM_006717545.1.
    UniGeneiHs.524719.

    Genome annotation databases

    EnsembliENST00000374312; ENSP00000363431; ENSG00000204174.
    ENST00000395716; ENSP00000379066; ENSG00000204174.
    GeneIDi100996758.
    5540.
    KEGGihsa:100996758.
    hsa:5540.
    UCSCiuc001jee.3. human.

    Polymorphism databases

    DMDMi1709423.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35232 Genomic DNA. Translation: AAC50280.1 .
    Z66526 Genomic DNA. Translation: CAA91433.1 .
    U42387 mRNA. Translation: AAB07759.1 .
    AY649985 mRNA. Translation: AAV68196.1 .
    AY649986 mRNA. Translation: AAV68197.1 .
    AY268432 Genomic DNA. Translation: AAP23199.1 .
    CR541950 mRNA. Translation: CAG46748.1 .
    AL390716 Genomic DNA. Translation: CAI13318.1 .
    BC096238 mRNA. Translation: AAH96238.1 .
    CCDSi CCDS31193.1.
    PIRi G02300.
    I39182.
    RefSeqi NP_001265723.1. NM_001278794.1.
    NP_001265724.1. NM_001278795.1.
    NP_005963.4. NM_005972.5.
    XP_005277701.1. XM_005277644.1.
    XP_006717608.1. XM_006717545.1.
    UniGenei Hs.524719.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IK5 model - @ 1-375 [» ]
    ProteinModelPortali P50391.
    SMRi P50391. Positions 22-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000363431.

    Chemistry

    BindingDBi P50391.
    ChEMBLi CHEMBL4877.
    GuidetoPHARMACOLOGYi 307.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P50391.

    Polymorphism databases

    DMDMi 1709423.

    Proteomic databases

    PaxDbi P50391.
    PRIDEi P50391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374312 ; ENSP00000363431 ; ENSG00000204174 .
    ENST00000395716 ; ENSP00000379066 ; ENSG00000204174 .
    GeneIDi 100996758.
    5540.
    KEGGi hsa:100996758.
    hsa:5540.
    UCSCi uc001jee.3. human.

    Organism-specific databases

    CTDi 5540.
    GeneCardsi GC10P047084.
    H-InvDB HIX0170461.
    HGNCi HGNC:9329. NPY4R.
    HPAi HPA027863.
    MIMi 601790. gene.
    neXtProti NX_P50391.
    PharmGKBi PA33692.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261951.
    HOGENOMi HOG000050229.
    HOVERGENi HBG105676.
    InParanoidi P50391.
    KOi K04204.
    OMAi CYVRIYL.
    OrthoDBi EOG773XGC.
    PhylomeDBi P50391.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Pancreatic_polypeptide_receptor_1.
    NextBioi 21462.
    PROi P50391.
    SOURCEi Search...

    Gene expression databases

    Bgeei P50391.
    CleanExi HS_PPYR1.
    Genevestigatori P50391.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001933. NPY4_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01015. NRPEPTIDEY4R.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY."
      Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L.
      J. Biol. Chem. 270:26762-26765(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY."
      Lundell I., Blomqvist A.G., Berglund M.M., Schober D.A., Johnson D., Statnick M.A., Gadski R.A., Gehlert D.R., Larhammar D.
      J. Biol. Chem. 270:29123-29128(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
      Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
      Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
    4. "PPYR1: identification of new untranslated 5' exon by in silico and experimental evaluation of gene structure."
      Reichwald K., Petz U., Roschmann E., Platzer M.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-240.
    7. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-99.

    Entry informationi

    Entry nameiNPY4R_HUMAN
    AccessioniPrimary (citable) accession number: P50391
    Secondary accession number(s): Q13456
    , Q5ISU3, Q5T2X9, Q6FH06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3