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P50391 (NPY4R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide Y receptor type 4

Short name=NPY4-R
Alternative name(s):
Pancreatic polypeptide receptor 1
Short name=PP1
Gene names
Name:NPY4R
Synonyms:PPYR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Neuropeptide Y receptor type 4
PRO_0000069935

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6021Helical; Name=1; Potential
Topological domain61 – 8727Cytoplasmic Potential
Transmembrane88 – 10821Helical; Name=2; Potential
Topological domain109 – 1168Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15518Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 21236Extracellular Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 26330Cytoplasmic Potential
Transmembrane264 – 28421Helical; Name=6; Potential
Topological domain285 – 30117Extracellular Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 37553Cytoplasmic Potential

Amino acid modifications

Lipidation3401S-palmitoyl cysteine Potential
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 201 By similarity

Natural variations

Natural variant991A → S. Ref.3 Ref.4 Ref.8
Corresponds to variant rs2229967 [ dbSNP | Ensembl ].
VAR_030337
Natural variant2401R → C. Ref.6
Corresponds to variant rs3824733 [ dbSNP | Ensembl ].
VAR_030338

Sequences

Sequence LengthMass (Da)Tools
P50391 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0081DBA51436EE22

FASTA37542,195
        10         20         30         40         50         60 
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI ETVVGVLGNL 

        70         80         90        100        110        120 
CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV YTIMDYWIFG ETLCKMSAFI 

       130        140        150        160        170        180 
QCMSVTVSIL SLVLVALERH QLIINPTGWK PSISQAYLGI VLIWVIACVL SLPFLANSIL 

       190        200        210        220        230        240 
ENVFHKNHSK ALEFLADKVV CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR 

       250        260        270        280        290        300 
LQRQGRVFHK GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG 

       310        320        330        340        350        360 
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE HLPLSTVHTE 

       370 
VSKGSLRLSG RSNPI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY."
Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L.
J. Biol. Chem. 270:26762-26765(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY."
Lundell I., Blomqvist A.G., Berglund M.M., Schober D.A., Johnson D., Statnick M.A., Gadski R.A., Gehlert D.R., Larhammar D.
J. Biol. Chem. 270:29123-29128(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
[4]"PPYR1: identification of new untranslated 5' exon by in silico and experimental evaluation of gene structure."
Reichwald K., Petz U., Roschmann E., Platzer M.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-240.
[7]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-99.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35232 Genomic DNA. Translation: AAC50280.1.
Z66526 Genomic DNA. Translation: CAA91433.1.
U42387 mRNA. Translation: AAB07759.1.
AY649985 mRNA. Translation: AAV68196.1.
AY649986 mRNA. Translation: AAV68197.1.
AY268432 Genomic DNA. Translation: AAP23199.1.
CR541950 mRNA. Translation: CAG46748.1.
AL390716 Genomic DNA. Translation: CAI13318.1.
BC096238 mRNA. Translation: AAH96238.1.
CCDSCCDS31193.1.
PIRG02300.
I39182.
RefSeqNP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.1.
XP_006717608.1. XM_006717545.1.
UniGeneHs.524719.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IK5model-@1-375[»]
ProteinModelPortalP50391.
SMRP50391. Positions 22-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000363431.

Chemistry

BindingDBP50391.
ChEMBLCHEMBL4877.
GuidetoPHARMACOLOGY307.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP50391.

Polymorphism databases

DMDM1709423.

Proteomic databases

PaxDbP50391.
PRIDEP50391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374312; ENSP00000363431; ENSG00000204174.
ENST00000395716; ENSP00000379066; ENSG00000204174.
GeneID100996758.
5540.
KEGGhsa:100996758.
hsa:5540.
UCSCuc001jee.3. human.

Organism-specific databases

CTD5540.
GeneCardsGC10P047084.
H-InvDBHIX0170461.
HGNCHGNC:9329. NPY4R.
HPAHPA027863.
MIM601790. gene.
neXtProtNX_P50391.
PharmGKBPA33692.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG261951.
HOGENOMHOG000050229.
HOVERGENHBG105676.
InParanoidP50391.
KOK04204.
OMACYVRIYL.
OrthoDBEOG773XGC.
PhylomeDBP50391.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP50391.
CleanExHS_PPYR1.
GenevestigatorP50391.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPancreatic_polypeptide_receptor_1.
NextBio21462.
PROP50391.
SOURCESearch...

Entry information

Entry nameNPY4R_HUMAN
AccessionPrimary (citable) accession number: P50391
Secondary accession number(s): Q13456 expand/collapse secondary AC list , Q5ISU3, Q5T2X9, Q6FH06
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries