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Protein

Neuropeptide Y receptor type 4

Gene

NPY4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • pancreatic polypeptide receptor activity Source: GO_Central

GO - Biological processi

  • blood circulation Source: ProtInc
  • chemical synaptic transmission Source: GO_Central
  • digestion Source: ProtInc
  • feeding behavior Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • neuropeptide signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP50391.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:NPY4R
Synonyms:PPYR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204174.6.
HGNCiHGNC:9329. NPY4R.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 87CytoplasmicSequence analysisAdd BLAST27
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini109 – 116ExtracellularSequence analysis8
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 155CytoplasmicSequence analysisAdd BLAST18
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 212ExtracellularSequence analysisAdd BLAST36
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 263CytoplasmicSequence analysisAdd BLAST30
Transmembranei264 – 284Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini285 – 301ExtracellularSequence analysisAdd BLAST17
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 375CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100996758.
105379861.
5540.
PharmGKBiPA33692.

Chemistry databases

ChEMBLiCHEMBL4877.
DrugBankiDB05004. AC162352.
DB05045. TM30338.
GuidetoPHARMACOLOGYi307.

Polymorphism and mutation databases

DMDMi1709423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699351 – 375Neuropeptide Y receptor type 4Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 201
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi340S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP50391.
PRIDEiP50391.

PTM databases

iPTMnetiP50391.
PhosphoSitePlusiP50391.

Expressioni

Tissue specificityi

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Gene expression databases

BgeeiENSG00000204174.
CleanExiHS_PPYR1.
GenevisibleiP50391. HS.

Organism-specific databases

HPAiHPA027863.

Interactioni

Protein-protein interaction databases

BioGridi111532. 1 interactor.
STRINGi9606.ENSP00000363431.

Chemistry databases

BindingDBiP50391.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IK5model-@1-375[»]
ProteinModelPortaliP50391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP50391.
KOiK04206.
OrthoDBiEOG091G0HOS.
PhylomeDBiP50391.
TreeFamiTF315303.

Family and domain databases

CDDicd15397. 7tmA_NPY4R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
PANTHERiPTHR43916:SF4. PTHR43916:SF4. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P50391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI
60 70 80 90 100
ETVVGVLGNL CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV
110 120 130 140 150
YTIMDYWIFG ETLCKMSAFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSISQAYLGI VLIWVIACVL SLPFLANSIL ENVFHKNHSK ALEFLADKVV
210 220 230 240 250
CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR LQRQGRVFHK
260 270 280 290 300
GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
310 320 330 340 350
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE
360 370
HLPLSTVHTE VSKGSLRLSG RSNPI
Length:375
Mass (Da):42,195
Last modified:October 1, 1996 - v1
Checksum:i0081DBA51436EE22
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03033799A → S3 PublicationsCorresponds to variant dbSNP:rs2229967Ensembl.1
Natural variantiVAR_030338240R → C1 PublicationCorresponds to variant dbSNP:rs3824733Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35232 Genomic DNA. Translation: AAC50280.1.
Z66526 Genomic DNA. Translation: CAA91433.1.
U42387 mRNA. Translation: AAB07759.1.
AY649985 mRNA. Translation: AAV68196.1.
AY649986 mRNA. Translation: AAV68197.1.
AY268432 Genomic DNA. Translation: AAP23199.1.
CR541950 mRNA. Translation: CAG46748.1.
AL390716 Genomic DNA. Translation: CAI13318.1.
BC096238 mRNA. Translation: AAH96238.1.
CCDSiCCDS73100.1.
PIRiG02300.
I39182.
RefSeqiNP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.3.
XP_006717608.1. XM_006717545.3.
XP_011537416.1. XM_011539114.2.
XP_011537417.1. XM_011539115.2.
XP_011538238.1. XM_011539936.2.
XP_011538239.1. XM_011539937.2.
XP_011547675.1. XM_011549373.2.
XP_011547676.1. XM_011549374.2.
XP_011547677.1. XM_011549375.2.
XP_011547678.1. XM_011549376.2.
XP_016854962.1. XM_016999473.1.
XP_016854963.1. XM_016999474.1.
XP_016870952.1. XM_017015463.1.
XP_016870953.1. XM_017015464.1.
XP_016871875.1. XM_017016386.1.
XP_016871876.1. XM_017016387.1.
UniGeneiHs.524719.

Genome annotation databases

EnsembliENST00000374312; ENSP00000363431; ENSG00000204174.
ENST00000395716; ENSP00000379066; ENSG00000204174.
ENST00000612632; ENSP00000480883; ENSG00000204174.
GeneIDi100996758.
105379861.
5540.
KEGGihsa:100996758.
hsa:105379861.
hsa:5540.
UCSCiuc031wfc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPY4R_HUMAN
AccessioniPrimary (citable) accession number: P50391
Secondary accession number(s): Q13456
, Q5ISU3, Q5T2X9, Q6FH06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families