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P50391

- NPY4R_HUMAN

UniProt

P50391 - NPY4R_HUMAN

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Protein

Neuropeptide Y receptor type 4

Gene

NPY4R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. pancreatic polypeptide receptor activity Source: Ensembl
  3. peptide binding Source: Ensembl
  4. peptide YY receptor activity Source: Ensembl

GO - Biological processi

  1. blood circulation Source: ProtInc
  2. digestion Source: ProtInc
  3. feeding behavior Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 4
Short name:
NPY4-R
Alternative name(s):
Pancreatic polypeptide receptor 1
Short name:
PP1
Gene namesi
Name:NPY4R
Synonyms:PPYR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:9329. NPY4R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 8727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini109 – 1168ExtracellularSequence Analysis
Transmembranei117 – 13721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini138 – 15518CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 21236ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 26330CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini285 – 30117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini323 – 37553CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Neuropeptide Y receptor type 4PRO_0000069935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 201PROSITE-ProRule annotation
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Lipidationi340 – 3401S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP50391.
PRIDEiP50391.

PTM databases

PhosphoSiteiP50391.

Expressioni

Tissue specificityi

Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.

Gene expression databases

BgeeiP50391.
CleanExiHS_PPYR1.
GenevestigatoriP50391.

Organism-specific databases

HPAiHPA027863.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363431.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IK5model-@1-375[»]
ProteinModelPortaliP50391.
SMRiP50391. Positions 22-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG261951.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP50391.
KOiK04206.
OMAiCYVRIYL.
OrthoDBiEOG773XGC.
PhylomeDBiP50391.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTSHLLALL LPKSPQGENR SKPLGTPYNF SEHCQDSVDV MVFIVTSYSI
60 70 80 90 100
ETVVGVLGNL CLMCVTVRQK EKANVTNLLI ANLAFSDFLM CLLCQPLTAV
110 120 130 140 150
YTIMDYWIFG ETLCKMSAFI QCMSVTVSIL SLVLVALERH QLIINPTGWK
160 170 180 190 200
PSISQAYLGI VLIWVIACVL SLPFLANSIL ENVFHKNHSK ALEFLADKVV
210 220 230 240 250
CTESWPLAHH RTIYTTFLLL FQYCLPLGFI LVCYARIYRR LQRQGRVFHK
260 270 280 290 300
GTYSLRAGHM KQVNVVLVVM VVAFAVLWLP LHVFNSLEDW HHEAIPICHG
310 320 330 340 350
NLIFLVCHLL AMASTCVNPF IYGFLNTNFK KEIKALVLTC QQSAPLEESE
360 370
HLPLSTVHTE VSKGSLRLSG RSNPI
Length:375
Mass (Da):42,195
Last modified:October 1, 1996 - v1
Checksum:i0081DBA51436EE22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991A → S.3 Publications
Corresponds to variant rs2229967 [ dbSNP | Ensembl ].
VAR_030337
Natural varianti240 – 2401R → C.1 Publication
Corresponds to variant rs3824733 [ dbSNP | Ensembl ].
VAR_030338

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35232 Genomic DNA. Translation: AAC50280.1.
Z66526 Genomic DNA. Translation: CAA91433.1.
U42387 mRNA. Translation: AAB07759.1.
AY649985 mRNA. Translation: AAV68196.1.
AY649986 mRNA. Translation: AAV68197.1.
AY268432 Genomic DNA. Translation: AAP23199.1.
CR541950 mRNA. Translation: CAG46748.1.
AL390716 Genomic DNA. Translation: CAI13318.1.
BC096238 mRNA. Translation: AAH96238.1.
CCDSiCCDS73100.1.
PIRiG02300.
I39182.
RefSeqiNP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.1.
XP_006717608.1. XM_006717545.1.
UniGeneiHs.524719.

Genome annotation databases

EnsembliENST00000374312; ENSP00000363431; ENSG00000204174.
ENST00000395716; ENSP00000379066; ENSG00000204174.
ENST00000612632; ENSP00000480883; ENSG00000204174.
GeneIDi100996758.
5540.
KEGGihsa:100996758.
hsa:5540.
UCSCiuc001jee.3. human.

Polymorphism databases

DMDMi1709423.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35232 Genomic DNA. Translation: AAC50280.1 .
Z66526 Genomic DNA. Translation: CAA91433.1 .
U42387 mRNA. Translation: AAB07759.1 .
AY649985 mRNA. Translation: AAV68196.1 .
AY649986 mRNA. Translation: AAV68197.1 .
AY268432 Genomic DNA. Translation: AAP23199.1 .
CR541950 mRNA. Translation: CAG46748.1 .
AL390716 Genomic DNA. Translation: CAI13318.1 .
BC096238 mRNA. Translation: AAH96238.1 .
CCDSi CCDS73100.1.
PIRi G02300.
I39182.
RefSeqi NP_001265723.1. NM_001278794.1.
NP_001265724.1. NM_001278795.1.
NP_005963.4. NM_005972.5.
XP_005277701.1. XM_005277644.1.
XP_006717608.1. XM_006717545.1.
UniGenei Hs.524719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IK5 model - @ 1-375 [» ]
ProteinModelPortali P50391.
SMRi P50391. Positions 22-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000363431.

Chemistry

BindingDBi P50391.
ChEMBLi CHEMBL4877.
GuidetoPHARMACOLOGYi 307.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P50391.

Polymorphism databases

DMDMi 1709423.

Proteomic databases

PaxDbi P50391.
PRIDEi P50391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374312 ; ENSP00000363431 ; ENSG00000204174 .
ENST00000395716 ; ENSP00000379066 ; ENSG00000204174 .
ENST00000612632 ; ENSP00000480883 ; ENSG00000204174 .
GeneIDi 100996758.
5540.
KEGGi hsa:100996758.
hsa:5540.
UCSCi uc001jee.3. human.

Organism-specific databases

CTDi 5540.
GeneCardsi GC10P047084.
H-InvDB HIX0170461.
HGNCi HGNC:9329. NPY4R.
HPAi HPA027863.
MIMi 601790. gene.
neXtProti NX_P50391.
PharmGKBi PA33692.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261951.
GeneTreei ENSGT00760000118781.
HOGENOMi HOG000050229.
HOVERGENi HBG105676.
InParanoidi P50391.
KOi K04206.
OMAi CYVRIYL.
OrthoDBi EOG773XGC.
PhylomeDBi P50391.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Pancreatic_polypeptide_receptor_1.
NextBioi 21462.
PROi P50391.
SOURCEi Search...

Gene expression databases

Bgeei P50391.
CleanExi HS_PPYR1.
Genevestigatori P50391.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001933. NPY4_rcpt.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01015. NRPEPTIDEY4R.
PR01012. NRPEPTIDEYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY."
    Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L.
    J. Biol. Chem. 270:26762-26765(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY."
    Lundell I., Blomqvist A.G., Berglund M.M., Schober D.A., Johnson D., Statnick M.A., Gadski R.A., Gehlert D.R., Larhammar D.
    J. Biol. Chem. 270:29123-29128(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
    Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
    Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
  4. "PPYR1: identification of new untranslated 5' exon by in silico and experimental evaluation of gene structure."
    Reichwald K., Petz U., Roschmann E., Platzer M.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-99.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-240.
  7. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-99.

Entry informationi

Entry nameiNPY4R_HUMAN
AccessioniPrimary (citable) accession number: P50391
Secondary accession number(s): Q13456
, Q5ISU3, Q5T2X9, Q6FH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3