P50388 (BGAL_SULSH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-galactosidase
Short name=Lactase
EC=3.2.1.23

Gene names

Name:

bglY

Organism

Sulfolobus shibatae

Taxonomic identifier

2286 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
PTM	Methylation
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	beta-galactosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Beta-galactosidase		PRO_0000063868
Sites
	Active site	206	1	Proton donor Potential
	Active site	387	1	Nucleophile By similarity
Amino acid modifications
	Modified residue	135	1	N6-methyllysine By similarity
	Modified residue	273	1	N6-methyllysine By similarity
	Modified residue	332	1	N6-methyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50388 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 32412B88F478842E	FASTA	489	56,565
	10 20 30 40 50 60 MYSFPKNFRF GWSQAGFQSE MGTPGSEDPN TDWYKWVHDP ENISAGLVSG DLPENGPGYW 70 80 90 100 110 120 GNYKTFHDNA QKMGLKIARL NVEWSRIFPN QLPKPQNFDD SKQDVTEVEI NQNELRRLDE 130 140 150 160 170 180 HANKDALNHY REIFKDLKSR GIYFILNMYH WPLPLWLHDP IRVRRGDLSG PTGWLSTRTV 190 200 210 220 230 240 YEFARFSAYI AWKFDDLVDE YSTMNEPNVV GGLGYVGVKS GFPPGYLSFE LSRKAMYNII 250 260 270 280 290 300 QAHARAYDGI KSVSKKPIGI IYANSSFQPL TEKDVEAVEM AEYDNRWAFF DAIIRGEIMR 310 320 330 340 350 360 GSEKVVRDDL RGRLDWIGVN YYTRTVVKKT EKGYTSLGGY GHGCERNSVS LAGLPTSDFG 370 380 390 400 410 420 WEFFPEGLYD VLTKYWNRYH LYMYVTENGI ADDADYQRPY YLVSHVYQVH RAINSGADVR 430 440 450 460 470 480 GYLHWSLADN YEWASGFSMR FGLLKVDYGT KRLYWRPSAL VYREIATNGG ITDEIEHLNT VPPIRPLRH

References

[1]

"The development and application of genetical techniques for the extremely thermoacidophilic archaeon Sulfolobus shibatae." Connaris H., Charalambous B.M. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51178 / DSM 5389 / JCM 8931 / NBRC 15437 / B12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L47841 Genomic DNA. Translation: AAA79030.1.
3D structure databases
ProteinModelPortal	P50388.
SMR	P50388. Positions 1-489.
ModBase	Search...
Protein family/group databases
CAZy	GH1. Glycoside Hydrolase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.20.20.80. 1 hit.
InterPro	IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_catalytic_dom. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
PANTHER	PTHR10353. PTHR10353. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 2 hits. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BGAL_SULSH

Accession

Primary (citable) accession number: P50388

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program