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Protein

Beta-galactosidase

Gene

bglY

Organism
Sulfolobus shibatae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei206Proton donorSequence analysis1
Active sitei387NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.B33. 6162.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Lactase
Gene namesi
Name:bglY
OrganismiSulfolobus shibatae
Taxonomic identifieri2286 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638681 – 489Beta-galactosidaseAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135N6-methyllysineBy similarity1
Modified residuei273N6-methyllysineBy similarity1
Modified residuei332N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP50388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 2 hits.
PfamiPF00232. Glyco_hydro_1. 2 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSFPKNFRF GWSQAGFQSE MGTPGSEDPN TDWYKWVHDP ENISAGLVSG
60 70 80 90 100
DLPENGPGYW GNYKTFHDNA QKMGLKIARL NVEWSRIFPN QLPKPQNFDD
110 120 130 140 150
SKQDVTEVEI NQNELRRLDE HANKDALNHY REIFKDLKSR GIYFILNMYH
160 170 180 190 200
WPLPLWLHDP IRVRRGDLSG PTGWLSTRTV YEFARFSAYI AWKFDDLVDE
210 220 230 240 250
YSTMNEPNVV GGLGYVGVKS GFPPGYLSFE LSRKAMYNII QAHARAYDGI
260 270 280 290 300
KSVSKKPIGI IYANSSFQPL TEKDVEAVEM AEYDNRWAFF DAIIRGEIMR
310 320 330 340 350
GSEKVVRDDL RGRLDWIGVN YYTRTVVKKT EKGYTSLGGY GHGCERNSVS
360 370 380 390 400
LAGLPTSDFG WEFFPEGLYD VLTKYWNRYH LYMYVTENGI ADDADYQRPY
410 420 430 440 450
YLVSHVYQVH RAINSGADVR GYLHWSLADN YEWASGFSMR FGLLKVDYGT
460 470 480
KRLYWRPSAL VYREIATNGG ITDEIEHLNT VPPIRPLRH
Length:489
Mass (Da):56,565
Last modified:October 1, 1996 - v1
Checksum:i32412B88F478842E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47841 Genomic DNA. Translation: AAA79030.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47841 Genomic DNA. Translation: AAA79030.1.

3D structure databases

ProteinModelPortaliP50388.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.2.1.B33. 6162.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 2 hits.
PfamiPF00232. Glyco_hydro_1. 2 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL_SULSH
AccessioniPrimary (citable) accession number: P50388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.