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P50388

- BGAL_SULSH

UniProt

P50388 - BGAL_SULSH

Protein

Beta-galactosidase

Gene

bglY

Organism
Sulfolobus shibatae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061Proton donorSequence Analysis
    Active sitei387 – 3871NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Lactase
    Gene namesi
    Name:bglY
    OrganismiSulfolobus shibatae
    Taxonomic identifieri2286 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Beta-galactosidasePRO_0000063868Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei135 – 1351N6-methyllysineBy similarity
    Modified residuei273 – 2731N6-methyllysineBy similarity
    Modified residuei332 – 3321N6-methyllysineBy similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    3D structure databases

    ProteinModelPortaliP50388.
    SMRiP50388. Positions 1-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 2 hits.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50388-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSFPKNFRF GWSQAGFQSE MGTPGSEDPN TDWYKWVHDP ENISAGLVSG    50
    DLPENGPGYW GNYKTFHDNA QKMGLKIARL NVEWSRIFPN QLPKPQNFDD 100
    SKQDVTEVEI NQNELRRLDE HANKDALNHY REIFKDLKSR GIYFILNMYH 150
    WPLPLWLHDP IRVRRGDLSG PTGWLSTRTV YEFARFSAYI AWKFDDLVDE 200
    YSTMNEPNVV GGLGYVGVKS GFPPGYLSFE LSRKAMYNII QAHARAYDGI 250
    KSVSKKPIGI IYANSSFQPL TEKDVEAVEM AEYDNRWAFF DAIIRGEIMR 300
    GSEKVVRDDL RGRLDWIGVN YYTRTVVKKT EKGYTSLGGY GHGCERNSVS 350
    LAGLPTSDFG WEFFPEGLYD VLTKYWNRYH LYMYVTENGI ADDADYQRPY 400
    YLVSHVYQVH RAINSGADVR GYLHWSLADN YEWASGFSMR FGLLKVDYGT 450
    KRLYWRPSAL VYREIATNGG ITDEIEHLNT VPPIRPLRH 489
    Length:489
    Mass (Da):56,565
    Last modified:October 1, 1996 - v1
    Checksum:i32412B88F478842E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47841 Genomic DNA. Translation: AAA79030.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47841 Genomic DNA. Translation: AAA79030.1 .

    3D structure databases

    ProteinModelPortali P50388.
    SMRi P50388. Positions 1-489.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The development and application of genetical techniques for the extremely thermoacidophilic archaeon Sulfolobus shibatae."
      Connaris H., Charalambous B.M.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 51178 / DSM 5389 / JCM 8931 / NBRC 15437 / B12.

    Entry informationi

    Entry nameiBGAL_SULSH
    AccessioniPrimary (citable) accession number: P50388
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3