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Protein

NAD-dependent alcohol dehydrogenase

Gene

adh

Organism
Sulfolobus sp. (strain RC3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 6164.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adh
OrganismiSulfolobus sp. (strain RC3)
Taxonomic identifieri165757 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607541 – 347NAD-dependent alcohol dehydrogenaseAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-methyllysineBy similarity1
Modified residuei213N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP50381.
SMRiP50381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 2 hits.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P50381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVRLVEIG KPLVLKDIDI PKPKGAQVLI KVEAAGVCHS DVHMRQGRFG
60 70 80 90 100
NLRIVEDLGV KLPVTLGHEI AGKIEEMGDE VVGYSKGDLV AVNPWQGEGN
110 120 130 140 150
CYYCRIGEEH LCDSPRWLGI NFDGAYAEYV LNPHYKYMYK LRRLNAVEAS
160 170 180 190 200
PLTCSGITTY RAVRKASLDP TKTLVVVGAG GGLGTMAVQI AKAVGGATII
210 220 230 240 250
GVDVREEAVE TAKRAGADYV INASVQDPLA EIRRITEGKG VDAVIDLNNS
260 270 280 290 300
EKTLSVYPKA LAKQGKYIMV GLFGADLHFH APLITLSEIQ FVGSLVGNQS
310 320 330 340
DFLGIMRLAE AGKVKPMITK TMKLEEANEA IDNLENFKAV GRQVLIP
Length:347
Mass (Da):37,584
Last modified:October 1, 1996 - v1
Checksum:i55D3C003792DE60D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47543 Genomic DNA. Translation: CAA87591.1.
PIRiS51120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47543 Genomic DNA. Translation: CAA87591.1.
PIRiS51120.

3D structure databases

ProteinModelPortaliP50381.
SMRiP50381.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.1. 6164.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 2 hits.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_SULSR
AccessioniPrimary (citable) accession number: P50381
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 12, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.