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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Phytophthora infestans (Potato late blight fungus) (Botrytis infestans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:ND5
Synonyms:NAD5
Encoded oniMitochondrion
OrganismiPhytophthora infestans (Potato late blight fungus) (Botrytis infestans)
Taxonomic identifieri4787 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001181321 – 664NADH-ubiquinone oxidoreductase chain 5Add BLAST664

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
PfamiView protein in Pfam
PF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P50366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLTLIFLP FLGSVAAGLF GFYIGRKGSV FITTLTTFLS CIFSLIIIYN
60 70 80 90 100
SITNEYEYII YISNWINSGL FNCNWCFLFD SLTMIMLVVV TSISTLVHLY
110 120 130 140 150
SSQYMAHDPH LSRFMSYLSL FTFFMIILVT GDNFMQMFVG WEGVGFCSYL
160 170 180 190 200
LINFWFTRLQ ANKAAIKAML VNRISDLILL LGVLTIFYNI RTIEYFSTFA
210 220 230 240 250
AISIVKDFKF IFFNYILSII DVACILIFIG AMGKSAQIFL HLWLPDAMEG
260 270 280 290 300
PTPVSALIHA ATMVTAGVYL TARCSPMFEY SMFSLKIITI IGASTAFFAS
310 320 330 340 350
TVGLVQNDFK KIVAYSTCSQ LGYMFFACGL SNYPLAIFHL SNHAYFKALL
360 370 380 390 400
FLCSGAVIHA MGDEQDIRKM GGLRRILPFT YIMFLIGSLS LMGFPFLTGF
410 420 430 440 450
YSKDLILEVA FASFSETGHF AYWLGTIGAF FTAFYSTRLL FFAFLSETNA
460 470 480 490 500
YKNIIKNAHD VPLEMGIPLG LLAFGSIFIG YISKDMFVGL GSDFWNNSIY
510 520 530 540 550
INPFNNQMID AEFLPTFFKL LPVILSFCGL FGAFYLYFFK FKFLYNLKIS
560 570 580 590 600
EYGLYFYNFL NRKWYFDKIY YEFINQYILK IGYNVTYKMI DKGLIEMCGP
610 620 630 640 650
YGLTTIFSFL SQQIILLQTG YIYHYSLLML ISTIFLINII FFSIIYYFNI
660
ITILLFLFIF LLIK
Length:664
Mass (Da):76,150
Last modified:October 1, 1996 - v1
Checksum:i1C94B4E9E9F185C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17009 Genomic DNA. Translation: AAA99061.1.
PIRiT14132.
RefSeqiNP_037615.1. NC_002387.1.

Genome annotation databases

GeneIDi808860.

Similar proteinsi

Entry informationi

Entry nameiNU5M_PHYIN
AccessioniPrimary (citable) accession number: P50366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 16, 2015
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families