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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (pyK)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei160 – 1601SubstrateBy similarity
Binding sitei331 – 3311ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi357 – 3604ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-507-MONOMER.
BRENDAi2.7.2.3. 6163.
SABIO-RKP50317.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:SSO0527
ORF Names:C22_024
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Phosphoglycerate kinasePRO_0000146071Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0527.

Structurei

3D structure databases

ProteinModelPortaliP50317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
InParanoidiP50317.
KOiK00927.
OMAiFPVDYVT.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLTIPTMD DIDIQSKKVL LRIDINSPVD ENGKIIDDSR IKAHIGTIKE
60 70 80 90 100
LINKGNSVVL ISHQGRPGDK DFTSLEEHAK LISKYLDREV IFVDDVIGPY
110 120 130 140 150
AREMIKKLEN NGILLLDNIR LISEELIEAP PQQHVKSFLV KKLAPLFDIY
160 170 180 190 200
INDAFATAHR SQPSIVGFPL ALPSAAGRVM EREVSALAKI FNAEDTPKIF
210 220 230 240 250
TLGGGKVHDT IRIIENLVRK RIADRILTGG LVAELFSVAK GMNLNPKNME
260 270 280 290 300
ILEKLGILSL IPRARKLLLS GAPIEIPVDY KVEINGNVIE EPASKVTGII
310 320 330 340 350
KDIGSTTAEI YSSFIKDAKV VVLRGPMGVI EDERFKSGSK SVLKASLEGQ
360 370 380 390 400
GYVIIGGGHM ISALDEDMKI DSSKVHISTG GGALLLFLSG ERLPALEALS

MSVVNSGD
Length:408
Mass (Da):44,396
Last modified:October 1, 1996 - v1
Checksum:i9EBF90068315C099
GO

Sequence cautioni

The sequence AAK40847.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB57772.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80178 Genomic DNA. Translation: CAA56459.1.
Y18930 Genomic DNA. Translation: CAB57772.1. Different initiation.
AE006641 Genomic DNA. Translation: AAK40847.1. Different initiation.
PIRiH90198.
S63528.
RefSeqiNP_342057.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40847; AAK40847; SSO0527.
GeneIDi1454814.
KEGGisso:SSO0527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80178 Genomic DNA. Translation: CAA56459.1.
Y18930 Genomic DNA. Translation: CAB57772.1. Different initiation.
AE006641 Genomic DNA. Translation: AAK40847.1. Different initiation.
PIRiH90198.
S63528.
RefSeqiNP_342057.1. NC_002754.1.

3D structure databases

ProteinModelPortaliP50317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40847; AAK40847; SSO0527.
GeneIDi1454814.
KEGGisso:SSO0527.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
InParanoidiP50317.
KOiK00927.
OMAiFPVDYVT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciSSOL273057:GCH2-507-MONOMER.
BRENDAi2.7.2.3. 6163.
SABIO-RKP50317.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-bp. Isolation, sequencing of the genes and expression in Escherichia coli."
    Jones C.E., Fleming T.M., Cowan D.A., Littlechild J.A., Piper P.W.
    Eur. J. Biochem. 233:800-808(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiPGK_SULSO
AccessioniPrimary (citable) accession number: P50317
Secondary accession number(s): Q9UWT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.