P50317 (PGK_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	SSO0527
ORF Names:	C22_024

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus solfataricus

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subcellular location	Cytoplasm HAMAP-Rule MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.
Sequence caution	The sequence AAK40847.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB57772.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_0000146071
Regions
	Nucleotide binding	357 – 360	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	63 – 66	4	Substrate binding By similarity
Sites
	Binding site	40	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	331	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50317 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 9EBF90068315C099	FASTA	408	44,396
	10 20 30 40 50 60 MGDLTIPTMD DIDIQSKKVL LRIDINSPVD ENGKIIDDSR IKAHIGTIKE LINKGNSVVL 70 80 90 100 110 120 ISHQGRPGDK DFTSLEEHAK LISKYLDREV IFVDDVIGPY AREMIKKLEN NGILLLDNIR 130 140 150 160 170 180 LISEELIEAP PQQHVKSFLV KKLAPLFDIY INDAFATAHR SQPSIVGFPL ALPSAAGRVM 190 200 210 220 230 240 EREVSALAKI FNAEDTPKIF TLGGGKVHDT IRIIENLVRK RIADRILTGG LVAELFSVAK 250 260 270 280 290 300 GMNLNPKNME ILEKLGILSL IPRARKLLLS GAPIEIPVDY KVEINGNVIE EPASKVTGII 310 320 330 340 350 360 KDIGSTTAEI YSSFIKDAKV VVLRGPMGVI EDERFKSGSK SVLKASLEGQ GYVIIGGGHM 370 380 390 400 ISALDEDMKI DSSKVHISTG GGALLLFLSG ERLPALEALS MSVVNSGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-bp. Isolation, sequencing of the genes and expression in Escherichia coli." Jones C.E., Fleming T.M., Cowan D.A., Littlechild J.A., Piper P.W. Eur. J. Biochem. 233:800-808(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2." Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. , Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W. Genome 43:116-136(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[3]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80178 Genomic DNA. Translation: CAA56459.1. Y18930 Genomic DNA. Translation: CAB57772.1. Different initiation. AE006641 Genomic DNA. Translation: AAK40847.1. Different initiation.
PIR	H90198. S63528.
RefSeq	NP_342057.1. NC_002754.1.
3D structure databases
ProteinModelPortal	P50317.
ModBase	Search...
Protein-protein interaction databases
STRING	273057.SSO0527.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK40847; AAK40847; SSO0527.
GeneID	1454814.
KEGG	sso:SSO0527.
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227108.
KO	K00927.
OMA	NSCIGDE.
ProtClustDB	PRK00073.
Enzyme and pathway databases
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_SULSO

Accession

Primary (citable) accession number: P50317
Secondary accession number(s): Q9UWT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program