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P50313

- PGK_TETTH

UniProt

P50313 - PGK_TETTH

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Protein
Phosphoglycerate kinase
Gene
PGK
Organism
Tetrahymena thermophila
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei313 – 3131ATP; via carbonyl oxygen By similarity
Binding sitei344 – 3441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Phosphoglycerate kinaseUniRule annotation
PRO_0000145861Add
BLAST

Proteomic databases

PRIDEiP50313.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi5911.P50313.

Structurei

3D structure databases

ProteinModelPortaliP50313.
SMRiP50313. Positions 5-418.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 273Substrate binding By similarity
Regioni64 – 674Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50313-1 [UniParc]FASTAAdd to Basket

« Hide

MLSRKIGIDH ILKHIENKRV LMRVDFNVPL KEGKVKDPTR IQGSVPSIKK    50
ILEQNPKGLV LMSHLGRPDG NRVEKHSMKP VVPKLEELLG TKVTFLNDCV 100
GKDVEEAVKS SRNGEIILLE NLRFHPEEEG KYIDAAGNKV KADSKAVKEF 150
RKSLTSLGDL FVNDAFGTAH RAHSSMVGVD HKIRAAGYLL KRELDYFSKA 200
LESPNRPFLV VLGGAKVKDK IQLIESMLDK VDEMIIGGGM AFTFLKKIHN 250
IEIGNSLFDE EGYKIVDQLL EKAKAKNVKI HLPVDFLCGD SLEANANTRS 300
FDLKSGIPAG WIGLDAGPKT MAENAEAVAR ANTIVWNGPQ GRFEVDKFKV 350
GSSDLLKHVA TRTSQGATSI IGGGDTVNLV QQEKATQKVS HVSTGGGASL 400
ELLEGKVLPG VAYLTDIDQL 420
Length:420
Mass (Da):45,914
Last modified:October 1, 1996 - v1
Checksum:iFCCE8F842FEA8016
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63529 mRNA. Translation: CAA45092.1.
X63528 Genomic DNA. Translation: CAA45091.1.
RefSeqiXP_001025708.1. XM_001025708.2.
UniGeneiTth.90.

Genome annotation databases

GeneIDi7824345.
KEGGitet:TTHERM_00929450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63529 mRNA. Translation: CAA45092.1 .
X63528 Genomic DNA. Translation: CAA45091.1 .
RefSeqi XP_001025708.1. XM_001025708.2.
UniGenei Tth.90.

3D structure databases

ProteinModelPortali P50313.
SMRi P50313. Positions 5-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.P50313.

Proteomic databases

PRIDEi P50313.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7824345.
KEGGi tet:TTHERM_00929450.

Phylogenomic databases

eggNOGi COG0126.
KOi K00927.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phylogenetic analysis based on the gene encoding phosphoglycerate kinase."
    Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
    J. Mol. Evol. 34:383-395(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: CU329.
  2. Erratum
    Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
    J. Mol. Evol. 35:466-466(1992) [PubMed] [Europe PMC] [Abstract]

Entry informationi

Entry nameiPGK_TETTH
AccessioniPrimary (citable) accession number: P50313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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