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P50313

- PGK_TETTH

UniProt

P50313 - PGK_TETTH

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Tetrahymena thermophila
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei220 – 2201ATPBy similarity
    Binding sitei313 – 3131ATP; via carbonyl oxygenBy similarity
    Binding sitei344 – 3441ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi373 – 3764ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiTetrahymena thermophila
    Taxonomic identifieri5911 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Phosphoglycerate kinasePRO_0000145861Add
    BLAST

    Proteomic databases

    PRIDEiP50313.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi5911.P50313.

    Structurei

    3D structure databases

    ProteinModelPortaliP50313.
    SMRiP50313. Positions 5-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 273Substrate bindingBy similarity
    Regioni64 – 674Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50313-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRKIGIDH ILKHIENKRV LMRVDFNVPL KEGKVKDPTR IQGSVPSIKK    50
    ILEQNPKGLV LMSHLGRPDG NRVEKHSMKP VVPKLEELLG TKVTFLNDCV 100
    GKDVEEAVKS SRNGEIILLE NLRFHPEEEG KYIDAAGNKV KADSKAVKEF 150
    RKSLTSLGDL FVNDAFGTAH RAHSSMVGVD HKIRAAGYLL KRELDYFSKA 200
    LESPNRPFLV VLGGAKVKDK IQLIESMLDK VDEMIIGGGM AFTFLKKIHN 250
    IEIGNSLFDE EGYKIVDQLL EKAKAKNVKI HLPVDFLCGD SLEANANTRS 300
    FDLKSGIPAG WIGLDAGPKT MAENAEAVAR ANTIVWNGPQ GRFEVDKFKV 350
    GSSDLLKHVA TRTSQGATSI IGGGDTVNLV QQEKATQKVS HVSTGGGASL 400
    ELLEGKVLPG VAYLTDIDQL 420
    Length:420
    Mass (Da):45,914
    Last modified:October 1, 1996 - v1
    Checksum:iFCCE8F842FEA8016
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63529 mRNA. Translation: CAA45092.1.
    X63528 Genomic DNA. Translation: CAA45091.1.
    RefSeqiXP_001025708.1. XM_001025708.2.
    UniGeneiTth.90.

    Genome annotation databases

    GeneIDi7824345.
    KEGGitet:TTHERM_00929450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63529 mRNA. Translation: CAA45092.1 .
    X63528 Genomic DNA. Translation: CAA45091.1 .
    RefSeqi XP_001025708.1. XM_001025708.2.
    UniGenei Tth.90.

    3D structure databases

    ProteinModelPortali P50313.
    SMRi P50313. Positions 5-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5911.P50313.

    Proteomic databases

    PRIDEi P50313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7824345.
    KEGGi tet:TTHERM_00929450.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phylogenetic analysis based on the gene encoding phosphoglycerate kinase."
      Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
      J. Mol. Evol. 34:383-395(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: CU329.
    2. Erratum
      Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
      J. Mol. Evol. 35:466-466(1992) [PubMed] [Europe PMC] [Abstract]

    Entry informationi

    Entry nameiPGK_TETTH
    AccessioniPrimary (citable) accession number: P50313
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3