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P50313 (PGK_TETTH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK
OrganismTetrahymena thermophila
Taxonomic identifier5911 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145861

Regions

Nucleotide binding373 – 3764ATP By similarity
Region25 – 273Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P50313 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FCCE8F842FEA8016

FASTA42045,914
        10         20         30         40         50         60 
MLSRKIGIDH ILKHIENKRV LMRVDFNVPL KEGKVKDPTR IQGSVPSIKK ILEQNPKGLV 

        70         80         90        100        110        120 
LMSHLGRPDG NRVEKHSMKP VVPKLEELLG TKVTFLNDCV GKDVEEAVKS SRNGEIILLE 

       130        140        150        160        170        180 
NLRFHPEEEG KYIDAAGNKV KADSKAVKEF RKSLTSLGDL FVNDAFGTAH RAHSSMVGVD 

       190        200        210        220        230        240 
HKIRAAGYLL KRELDYFSKA LESPNRPFLV VLGGAKVKDK IQLIESMLDK VDEMIIGGGM 

       250        260        270        280        290        300 
AFTFLKKIHN IEIGNSLFDE EGYKIVDQLL EKAKAKNVKI HLPVDFLCGD SLEANANTRS 

       310        320        330        340        350        360 
FDLKSGIPAG WIGLDAGPKT MAENAEAVAR ANTIVWNGPQ GRFEVDKFKV GSSDLLKHVA 

       370        380        390        400        410        420 
TRTSQGATSI IGGGDTVNLV QQEKATQKVS HVSTGGGASL ELLEGKVLPG VAYLTDIDQL 

« Hide

References

[1]"A phylogenetic analysis based on the gene encoding phosphoglycerate kinase."
Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
J. Mol. Evol. 34:383-395(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: CU329.
[2]Erratum
Vohra G.B., Golding G.B., Tsao N., Pearlman R.E.
J. Mol. Evol. 35:466-466(1992) [PubMed] [Europe PMC] [Abstract]

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63529 mRNA. Translation: CAA45092.1.
X63528 Genomic DNA. Translation: CAA45091.1.
RefSeqXP_001025708.1. XM_001025708.2.
UniGeneTth.90.

3D structure databases

ProteinModelPortalP50313.
SMRP50313. Positions 5-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5911.P50313.

Proteomic databases

PRIDEP50313.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7824345.
KEGGtet:TTHERM_00929450.

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
ProtClustDBPTZ00005.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_TETTH
AccessionPrimary (citable) accession number: P50313
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways