Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P50312 (PGKC_LEIMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase, glycosomal

EC=2.7.2.3
Alternative name(s):
Phosphoglycerate kinase C
gPGK
Gene names
Name:PGKC
OrganismLeishmania major
Taxonomic identifier5664 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Glycosome HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentGlycosome
Peroxisome
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentglycosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Phosphoglycerate kinase, glycosomal HAMAP-Rule MF_00145
PRO_0000145854

Regions

Nucleotide binding372 – 3754ATP By similarity
Region24 – 263Substrate binding By similarity
Region62 – 654Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1321Substrate By similarity
Binding site1691Substrate By similarity
Binding site2201ATP By similarity
Binding site3421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P50312 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: ADEAC5489E9F8393

FASTA47951,576
        10         20         30         40         50         60 
MSLVLKKSID DATVRDKKVL IRVDFNVPVK NGKITNDFRI RSALPTIQKV LKEGGSCILM 

        70         80         90        100        110        120 
SHLGRPKGAR MSDPSPEKGV RGYEEAATLR PVAARISELL GQKVEFAPDC LDAASYASKL 

       130        140        150        160        170        180 
KNADVLLLEN VRFYAEEGSK KEEERDAMAK VLASYGDVYV SDAFGTAHRD SATMTGIPKV 

       190        200        210        220        230        240 
LGAGYAGYLM EKEINYFSRV LNNPPRPLVA IVGGAKVSDK IQLLDNMLGR INYLVIGGAM 

       250        260        270        280        290        300 
AYTFQKAQGR KIGISMCEED KLDLAKSLLK KAQERNVQVF LPVDHVCNKE FKAADSPLVT 

       310        320        330        340        350        360 
ESVDVPDGYM ALDIGPRTIH MYEEVIGRCK SAIWNGPMGV FEMPCYSKGT FAVAKAMGTG 

       370        380        390        400        410        420 
TQKNGLMSII GGGDSASAAE LSGEAKNMSH VSTGGGASLE LLEGKTLPGV AILTDKDVKE 

       430        440        450        460        470 
RGASCKFAFG VGSPSREACP LRCGHIFGGA SIVREIVKIV VALLIGIFIG RRMSTKLIR 

« Hide

References

[1]"Characterisation of phosphoglycerate kinase genes in Leishmania major and evidence for the absence of a third closely related gene or isoenzyme."
McKoy G.E.M., Badal M., Prescott Q., Lux H., Hart D.T.
Mol. Biochem. Parasitol. 90:169-181(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MHOM/IL/81/Friedlin.
[2]Erratum
McKoy G.E.M., Badal M., Prescott Q., Lux H., Hart D.T.
Mol. Biochem. Parasitol. 93:161-161(1998)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25121 Genomic DNA. Translation: AAC12659.1.

3D structure databases

ProteinModelPortalP50312.
SMRP50312. Positions 6-416.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGKC_LEIMA
AccessionPrimary (citable) accession number: P50312
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways