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P50311 (PGK_OPISI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK
OrganismOpisthorchis sinensis (Clonorchis sinensis)
Taxonomic identifier41765 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphoglycerate kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145845

Regions

Nucleotide binding371 – 3744ATP By similarity
Region23 – 253Substrate binding By similarity
Region62 – 654Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1211Substrate By similarity
Binding site1691Substrate By similarity
Binding site2181ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity
Binding site3421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P50311 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 13168A6FB1FB20A0

FASTA41544,658
        10         20         30         40         50         60 
MGLRKLSIAN VDLKDKRVLM RVDFNVPMKD GKVTNTQRIV GASPTIKYAL DKGAKSIVLM 

        70         80         90        100        110        120 
SHLGGRVGNK VARYSLNPVG EEVSKLLGKP VKFLPDCVGP ETTEGMCQSS AGSVFLLENL 

       130        140        150        160        170        180 
RFHVEEEGKG VSPTGEKIKA TPEQVKAFSE NLTKLGDVYL NDAFGTAHRA HASMVGCRLT 

       190        200        210        220        230        240 
QRACGFLMDK ELTYFSKLLD QPQHPFLAII GGAKVSDKIQ LIKNMLDKVD ELIITGGMAF 

       250        260        270        280        290        300 
TFLKKLHNMK IGKSLYDEPG AAIVDEWMQL AKSKNVKIHL PVDFITGDKF AEDANTGTAT 

       310        320        330        340        350        360 
VEPGIRDTHM GLDGGPKTME EFCKVISRAK TIVWNGPMGV FEMEKFAGGT KAAMDAVVAA 

       370        380        390        400        410 
TTKGVTNNNG GGDTATCCPK WKTEAQVSHV STGVGASLEL LEGKQLPGIL ALSDA 

« Hide

References

[1]Hong S.J.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47982 mRNA. Translation: AAD10200.1.

3D structure databases

ProteinModelPortalP50311.
SMRP50311. Positions 5-414.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP50311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.2.3. 1449.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_OPISI
AccessionPrimary (citable) accession number: P50311
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways