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P50311

- PGK_OPISI

UniProt

P50311 - PGK_OPISI

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Opisthorchis sinensis (Clonorchis sinensis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei169 – 1691SubstrateBy similarity
    Binding sitei218 – 2181ATPBy similarity
    Binding sitei311 – 3111ATP; via carbonyl oxygenBy similarity
    Binding sitei342 – 3421ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi371 – 3744ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.2.3. 1449.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiOpisthorchis sinensis (Clonorchis sinensis)
    Taxonomic identifieri41765 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Phosphoglycerate kinasePRO_0000145845Add
    BLAST

    Proteomic databases

    PRIDEiP50311.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP50311.
    SMRiP50311. Positions 5-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 253Substrate bindingBy similarity
    Regioni62 – 654Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLRKLSIAN VDLKDKRVLM RVDFNVPMKD GKVTNTQRIV GASPTIKYAL    50
    DKGAKSIVLM SHLGGRVGNK VARYSLNPVG EEVSKLLGKP VKFLPDCVGP 100
    ETTEGMCQSS AGSVFLLENL RFHVEEEGKG VSPTGEKIKA TPEQVKAFSE 150
    NLTKLGDVYL NDAFGTAHRA HASMVGCRLT QRACGFLMDK ELTYFSKLLD 200
    QPQHPFLAII GGAKVSDKIQ LIKNMLDKVD ELIITGGMAF TFLKKLHNMK 250
    IGKSLYDEPG AAIVDEWMQL AKSKNVKIHL PVDFITGDKF AEDANTGTAT 300
    VEPGIRDTHM GLDGGPKTME EFCKVISRAK TIVWNGPMGV FEMEKFAGGT 350
    KAAMDAVVAA TTKGVTNNNG GGDTATCCPK WKTEAQVSHV STGVGASLEL 400
    LEGKQLPGIL ALSDA 415
    Length:415
    Mass (Da):44,658
    Last modified:May 30, 2000 - v2
    Checksum:i13168A6FB1FB20A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47982 mRNA. Translation: AAD10200.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47982 mRNA. Translation: AAD10200.1 .

    3D structure databases

    ProteinModelPortali P50311.
    SMRi P50311. Positions 5-414.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P50311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BRENDAi 2.7.2.3. 1449.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hong S.J.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPGK_OPISI
    AccessioniPrimary (citable) accession number: P50311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3