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P50309

- G6PI_CRIGR

UniProt

P50309 - G6PI_CRIGR

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Protein
Glucose-6-phosphate isomerase
Gene
GPI
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei358 – 3581Proton donor By similarity
Active sitei389 – 3891 By similarity
Active sitei519 – 5191 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. gluconeogenesis Source: UniProtKB-KW
  3. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Isomerase

Keywords - Biological processi

Angiogenesis, Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Autocrine motility factor
Short name:
AMF
Neuroleukin
Short name:
NLK
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:GPI
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cytoplasm. Secreted By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 558557Glucose-6-phosphate isomeraseUniRule annotation
PRO_0000180536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121N6-acetyllysine By similarity
Modified residuei142 – 1421N6-acetyllysine By similarity
Modified residuei185 – 1851Phosphoserine; by CK2 By similarity
Modified residuei454 – 4541N6-malonyllysine By similarity

Post-translational modificationi

ISGylated By similarity.UniRule annotation

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP50309.

Interactioni

Subunit structurei

Homodimer in the catalytically active form, monomer in the secreted form By similarity.

Structurei

3D structure databases

ProteinModelPortaliP50309.
SMRiP50309. Positions 3-557.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

HOVERGENiHBG002877.
KOiK01810.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50309-1 [UniParc]FASTAAdd to Basket

« Hide

MTSLTQNRYF QKLQDWHRDN SADINLRSLF DADPERFNNF SLNLNTTHGH    50
ILVDYSKNLV NKEVMQMLVD LARSRGVETM RDNMFSGVKI NYTEDRAVLH 100
VALRNRSNSP IVVDSRDVMP EVNRVLEKMR SFCQRVRSGE WKGYSGKPIT 150
DIVNIGIGGS DLGPLMVTEA LKPYASGGPR IWFVSNIDGT HIAKTLANLT 200
PESSLFIVAS KTFTTQETIT NAETAKEWFL GASRDPSTVA KHFIALSTNT 250
SKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHIGF DNFEQLLSGA 300
HWMDQHFRKT PLEKNAPVLL ALLGIWYINF YGCETHALLP YDQYMHRFAA 350
YFQQGDMESN GKSITRSGTR VDHHTGPIVW GEPGTNGQHA FYQLIHQGTK 400
MIPCDFLIPV QTQHPIRKGL HHKILLANFL AQTEALMKGK SNEEAKKELQ 450
AAGKSPEDLE KLLPHKVFEG NRPTNSIVFT KLTPFILGAL IALYEHKIFV 500
QGVIWDINSF DQWGVELGKQ LAKNIEPELD GSAPVTSHDS STNGLIKFIK 550
QQRDIRIE 558
Length:558
Mass (Da):63,059
Last modified:October 1, 1996 - v1
Checksum:i262C454F01CE047F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37977 mRNA. Translation: CAA86031.1.
PIRiI48073.
RefSeqiNP_001233655.1. NM_001246726.1.

Genome annotation databases

GeneIDi100689468.
KEGGicge:100689468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z37977 mRNA. Translation: CAA86031.1 .
PIRi I48073.
RefSeqi NP_001233655.1. NM_001246726.1.

3D structure databases

ProteinModelPortali P50309.
SMRi P50309. Positions 3-557.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P50309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689468.
KEGGi cge:100689468.

Organism-specific databases

CTDi 2821.

Phylogenomic databases

HOVERGENi HBG002877.
KOi K01810.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of cDNAs coding for glucose phosphate isomerase and phosphoglycerate kinase in Chinese hamster ovary cell line CHO-K1 and identification of defects in R1.1.7, a glycolysis-deficient variant of CHO-K1."
    Hassan A.F., Morgan M.J., Faik P.
    Somat. Cell Mol. Genet. 21:75-81(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiG6PI_CRIGR
AccessioniPrimary (citable) accession number: P50309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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