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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26SubstrateUniRule annotation1
Binding sitei40SubstrateUniRule annotation1
Binding sitei52SubstrateUniRule annotation1
Metal bindingi62Magnesium 1UniRule annotation1
Metal bindingi67Magnesium 1UniRule annotation1
Metal bindingi67Magnesium 2UniRule annotation1
Metal bindingi99Magnesium 1UniRule annotation1
Binding sitei138SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.1. 6160.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:Saci_0955
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375591 – 173Inorganic pyrophosphataseAdd BLAST173

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi330779.Saci_0955.

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni7 – 11Combined sources5
Beta strandi12 – 19Combined sources8
Beta strandi25 – 30Combined sources6
Turni31 – 34Combined sources4
Beta strandi35 – 41Combined sources7
Beta strandi43 – 46Combined sources4
Beta strandi49 – 54Combined sources6
Beta strandi67 – 70Combined sources4
Beta strandi81 – 94Combined sources14
Beta strandi97 – 106Combined sources10
Turni108 – 110Combined sources3
Helixi112 – 114Combined sources3
Helixi120 – 122Combined sources3
Helixi125 – 137Combined sources13
Turni138 – 141Combined sources4
Beta strandi147 – 153Combined sources7
Helixi155 – 169Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QEZX-ray2.70A/B/C/D/E/F1-173[»]
ProteinModelPortaliP50308.
SMRiP50308.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50308.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01711. Archaea.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiDGVANYK.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSPGKNAP DVVNVLVEIP QGSNIKYEYD DEEGVIKVDR VLYTSMNYPF
60 70 80 90 100
NYGFIPGTLE EDGDPLDVLV ITNYQLYPGS VIEVRPIGIL YMKDEEGEDA
110 120 130 140 150
KIVAVPKDKT DPSFSNIKDI NDLPQATKNK IVHFFEHYKE LEPGKYVKIS
160 170
GWGSATEAKN RIQLAIKRVS GGQ
Length:173
Mass (Da):19,381
Last modified:October 1, 1996 - v1
Checksum:i15FF27EED2B79D72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81842 Genomic DNA. Translation: CAA57434.1.
CP000077 Genomic DNA. Translation: AAY80317.1.
PIRiS65965. S57617.
RefSeqiWP_011277819.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80317; AAY80317; Saci_0955.
GeneIDi3472897.
KEGGisai:Saci_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81842 Genomic DNA. Translation: CAA57434.1.
CP000077 Genomic DNA. Translation: AAY80317.1.
PIRiS65965. S57617.
RefSeqiWP_011277819.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QEZX-ray2.70A/B/C/D/E/F1-173[»]
ProteinModelPortaliP50308.
SMRiP50308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_0955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80317; AAY80317; Saci_0955.
GeneIDi3472897.
KEGGisai:Saci_0955.

Phylogenomic databases

eggNOGiarCOG01711. Archaea.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiDGVANYK.

Enzyme and pathway databases

BRENDAi3.6.1.1. 6160.

Miscellaneous databases

EvolutionaryTraceiP50308.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_SULAC
AccessioniPrimary (citable) accession number: P50308
Secondary accession number(s): Q4JA63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.