Probable S-adenosylmethionine synthase 3

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P50305 (METK3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable S-adenosylmethionine synthase 3
Short name=AdoMet synthase 3
EC=2.5.1.6

Alternative name(s):
Methionine adenosyltransferase 3
Short name=MAT 3

Gene names

Name:	sams-3
ORF Names:	C06E7.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the formation of S-adenosylmethionine from methionine and ATP By similarity.
Catalytic activity	ATP + L-methionine + H₂O = phosphate + diphosphate + S-adenosyl-L-methionine.
Cofactor	Binds 2 divalent ions per subunit. Magnesium or cobalt By similarity. Binds 1 potassium ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Sequence similarities	Belongs to the AdoMet synthase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Cobalt Magnesium Metal-binding Nucleotide-binding Potassium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA interference Inferred from mutant phenotype. Source: WormBase S-adenosylmethionine biosynthetic process Inferred from electronic annotation. Source: InterPro growth Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase negative regulation of vulval development Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase positive regulation of locomotion Inferred from mutant phenotype. Source: WormBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW methionine adenosyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
sams-1	O17680	4	EBI-2412743,EBI-2412749

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 404

404

Probable S-adenosylmethionine synthase 3

PRO_0000174442

Regions

Nucleotide binding

119 – 124

ATP Potential

Sites

Metal binding

Magnesium By similarity

Metal binding

Potassium By similarity

Metal binding

271

Potassium By similarity

Metal binding

279

Magnesium By similarity

Binding site

147

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P50305 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4F7891933B46E26B
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FASTA

404

44,034

        10         20         30         40         50         60 
MSQHKFLFTS ESVSEGHPDK MCDQISDAVL DAHLAQDPHA KVACETVTKT GMIMLCGEIT 

        70         80         90        100        110        120 
SKAVVDYQVL VRNVIKKIGY DDSSKGFDYK TCNVLVALEQ QSPEIAAGVH VDKDSDDVGA 

       130        140        150        160        170        180 
GDQGIMFGYA TDETEEAMPL TLLLSHKLNR KLHELRRSGE LEWVRPDSKT QVTIEYASEG 

       190        200        210        220        230        240 
GACVPLRVHT VVISTQHSPD ISLDDLRKEL IEKVIKAVIP ANLIDDKTIY HLNPCGSFII 

       250        260        270        280        290        300 
GGPMGDAGLT GRKIIVDTYG GWGAHGGGAF SGKDPTKVDR SAAYAARWVA KSLVKSGLCR 

       310        320        330        340        350        360 
RCLVQVSYAI GVAKPLSVMV FSFGTSALNE GELLKIVNDN FDLRPGMIIK DLDLKKPIYE 

       370        380        390        400 
PTAENGHFGH NEFPWEQPRH LQIDVELLKK IGGKTISNGN GIAH

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References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080387 Genomic DNA. Translation: CCD63366.1.
PIR	T34085.
RefSeq	NP_500872.1. NM_068471.4.
UniGene	Cel.13577.
3D structure databases
ProteinModelPortal	P50305.
SMR	P50305. Positions 6-382.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50305. 1 interaction.
STRING	P50305.
Proteomic databases
PRIDE	P50305.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C06E7.1a; C06E7.1a; C06E7.1.
GeneID	177355.
KEGG	cel:C06E7.1.
UCSC	C06E7.1a. c. elegans.
Organism-specific databases
CTD	177355.
WormBase	C06E7.1a; CE03957; WBGene00015538; sams-3.
Phylogenomic databases
GeneTree	EMGT00050000000100.
HOGENOM	HBG443662.
InParanoid	P50305.
OMA	FHDAFIE.
PhylomeDB	P50305.
Gene expression databases
ArrayExpress	P50305.
Family and domain databases
InterPro	IPR022631. ADOMET_SYNTHASE_CS. IPR022630. S-AdoMet_synt_C. IPR022629. S-AdoMet_synt_central. IPR022628. S-AdoMet_synt_N. IPR002133. S-AdoMet_synthetase. IPR022636. S-AdoMet_synthetase_sfam. [Graphical view]
KO	K00789.
PANTHER	PTHR11964. S-AdoMet_synt. 1 hit.
Pfam	PF02773. S-AdoMet_synt_C. 1 hit. PF02772. S-AdoMet_synt_M. 1 hit. PF00438. S-AdoMet_synt_N. 1 hit. [Graphical view]
PIRSF	PIRSF000497. MAT. 1 hit.
SUPFAM	SSF55973. S-AdoMet_synt. 3 hits.
TIGRFAMs	TIGR01034. MetK. 1 hit.
PROSITE	PS00376. ADOMET_SYNTHASE_1. 1 hit. PS00377. ADOMET_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	896422.

Entry information

Entry name

METK3_CAEEL

Accession

Primary (citable) accession number: P50305

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents