P50296 (ARY3_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Arylamine N-acetyltransferase 3 EC=2.3.1.5 Alternative name(s): Arylamide acetylase 3 N-acetyltransferase type 3 Short name=NAT-3 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 290 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Participates in the detoxification of a plethora of hydrazine and arylamine drugs. |
| Catalytic activity | Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| Subcellular location | |
| Sequence similarities | Belongs to the arylamine N-acetyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from direct assay. Source: MGI |
| Molecular function | L-amino acid transmembrane transporter activity Inferred from direct assay. Source: MGI arylamine N-acetyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 290 | 290 | Arylamine N-acetyltransferase 3 | PRO_0000107910 | |||||
Regions | |||||||||
| Region | 106 – 107 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 68 | 1 | Acyl-thioester intermediate By similarity | ||||||
| Active site | 107 | 1 | By similarity | ||||||
| Active site | 122 | 1 | By similarity | ||||||
| Binding site | 208 | 1 | Coenzyme A By similarity | ||||||
| Binding site | 214 | 1 | Coenzyme A By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro." Kelly S.L., Sim E. Biochem. J. 302:347-353(1994) [PubMed: 7545952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pituitary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X72959 Genomic DNA. Translation: CAA51461.1. AK077364 mRNA. Translation: BAC36769.1. |
| IPI | IPI00116460. |
| PIR | S55276. |
| RefSeq | NP_032700.1. NM_008674.2. |
| UniGene | Mm.57193. |
3D structure databases | |
| ProteinModelPortal | P50296. |
| SMR | P50296. Positions 2-290. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P50296. |
Proteomic databases | |
| PRIDE | P50296. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000070514; ENSMUSP00000069359; ENSMUSG00000056426. |
| GeneID | 17962. |
| KEGG | mmu:17962. |
Organism-specific databases | |
| CTD | 17962. |
| MGI | MGI:102537. Nat3. |
Phylogenomic databases | |
| eggNOG | roNOG04860. |
| HOGENOM | HBG544563. |
| HOVERGEN | HBG000165. |
| InParanoid | P50296. |
| OrthoDB | EOG4SN1QM. |
| PhylomeDB | P50296. |
Gene expression databases | |
| ArrayExpress | P50296. |
| Bgee | P50296. |
| CleanEx | MM_NAT3. |
| Genevestigator | P50296. |
| GermOnline | ENSMUSG00000056426. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001447. N-AcTrfase. [Graphical view] |
| KO | K00622. |
| PANTHER | PTHR11786. Acetyltransf2. 1 hit. |
| Pfam | PF00797. Acetyltransf_2. 1 hit. [Graphical view] |
| PRINTS | PR01543. ANATRNSFRASE. |
| ProtoNet | Search... |
Other | |
| NextBio | 292891. |
| SOURCE | Search... |
Entry information
| Entry name | ARY3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P50296 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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