P50296 (ARY3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 3
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 3
N-acetyltransferase type 3
Short name=NAT-3

Gene names

Name:	Nat3
Synonyms:	Aac3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: MGI
Molecular function	L-amino acid transmembrane transporter activity Inferred from direct assay. Source: MGI arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Arylamine N-acetyltransferase 3		PRO_0000107910
Regions
	Region	106 – 107	2	Substrate binding By similarity
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity
	Binding site	208	1	Coenzyme A By similarity
	Binding site	214	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50296 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: AB6477F3DA3B0A9E	FASTA	290	33,686
	10 20 30 40 50 60 MDIEAYFERI GYQKSSNKLD LQTLTEILQH QIRAIPFENL NIHCGKTMEL SLEDTFHQIV 70 80 90 100 110 120 RKKRGGWCLQ VNHLLYWALA MIGFETTMLG GCVYVPSACK YSNTMIHLLL QVTISGKTYI 130 140 150 160 170 180 VDSAFPFSCQ LWEPLELTSG KDQPQVPAIF HLREENGTWY LEQTKRQEYV SNQEFIDSNF 190 200 210 220 230 240 LEKNTHRKIY SFTLEPRTIE DFWSISTYYQ VSRTSVMTNT SLCSLHTKDG VHGLMGTILA 250 260 270 280 290 YKKFNYKDNI DLVEFKTLKE EEIEEVLKSV FGIHLETKLV PKCGNVFFTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro." Kelly S.L., Sim E. Biochem. J. 302:347-353(1994) [PubMed: 7545952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X72959 Genomic DNA. Translation: CAA51461.1. AK077364 mRNA. Translation: BAC36769.1.
IPI	IPI00116460.
PIR	S55276.
RefSeq	NP_032700.1. NM_008674.2.
UniGene	Mm.57193.
3D structure databases
ProteinModelPortal	P50296.
SMR	P50296. Positions 2-290.
ModBase	Search...
Protein-protein interaction databases
STRING	P50296.
Proteomic databases
PRIDE	P50296.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000070514; ENSMUSP00000069359; ENSMUSG00000056426.
GeneID	17962.
KEGG	mmu:17962.
Organism-specific databases
CTD	17962.
MGI	MGI:102537. Nat3.
Phylogenomic databases
eggNOG	roNOG04860.
HOGENOM	HBG544563.
HOVERGEN	HBG000165.
InParanoid	P50296.
OrthoDB	EOG4SN1QM.
PhylomeDB	P50296.
Gene expression databases
ArrayExpress	P50296.
Bgee	P50296.
CleanEx	MM_NAT3.
Genevestigator	P50296.
GermOnline	ENSMUSG00000056426. Mus musculus.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
KO	K00622.
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...
Other
NextBio	292891.
SOURCE	Search...

Entry information

Entry name

ARY3_MOUSE

Accession

Primary (citable) accession number: P50296

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program