Reviewed,
UniProtKB/Swiss-Prot P50296 (ARY3_MOUSE)
Last modified
November 3, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Arylamine N-acetyltransferase 3 EC=2.3.1.5 Alternative name(s): Arylamide acetylase 3 N-acetyltransferase type 3 Short name=NAT-3 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 290 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Participates in the detoxification of a plethora of hydrazine and arylamine drugs. |
| Catalytic activity | Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| Subcellular location | |
| Sequence similarities | Belongs to the arylamine N-acetyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | L-amino acid transport Inferred from direct assay. Source: MGI metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from direct assay. Source: MGI |
| Molecular function | L-amino acid transmembrane transporter activity Inferred from direct assay. Source: MGI arylamine N-acetyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 290 | 290 | Arylamine N-acetyltransferase 3 | PRO_0000107910 | |||||
Regions | |||||||||
| Region | 106 – 107 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 68 | 1 | Acyl-thioester intermediate By similarity | ||||||
| Active site | 107 | 1 | By similarity | ||||||
| Active site | 122 | 1 | By similarity | ||||||
| Binding site | 208 | 1 | Coenzyme A By similarity | ||||||
| Binding site | 214 | 1 | Coenzyme A By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro." Kelly S.L., Sim E. Biochem. J. 302:347-353(1994) [PubMed: 7545952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pituitary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X72959 Genomic DNA. Translation: CAA51461.1. AK077364 mRNA. Translation: BAC36769.1. | |
| IPI | IPI00116460. |
| PIR | S55276. |
| RefSeq | NP_032700.1. |
| UniGene | Mm.57193 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GX3 based on UniProtKB O86309. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P50296. |
Proteomic databases | |
| PRIDE | P50296. |
Genome annotation databases | |
| Ensembl | ENSMUST00000070514; ENSMUSP00000069359; ENSMUSG00000056426; Mus musculus. [Genome view] |
| GeneID | 17962. |
| KEGG | mmu:17962. |
| UCSC | uc009lvy.1. mouse. |
Organism-specific databases | |
| CTD | 17962. |
| MGI | MGI:102537. Nat3. |
Phylogenomic databases | |
| HOGENOM | P50296. |
| HOVERGEN | P50296. |
| OMA | PATHTLM. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.5. 244. |
Gene expression databases | |
| ArrayExpress | P50296. |
| Bgee | P50296. |
| CleanEx | MM_NAT3. |
| Genevestigator | P50296. |
| GermOnline | ENSMUSG00000056426. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001447. N-AcTrfase. [Graphical view] |
| PANTHER | PTHR11786. Acetyltransf2. 1 hit. |
| Pfam | PF00797. Acetyltransf_2. 1 hit. [Graphical view] |
| PRINTS | PR01543. ANATRNSFRASE. |
| ProDom | PD002783. Acetyltransf2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 292891. |
| SOURCE | Search... |
Entry information
| Entry name | ARY3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P50296 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


