Reviewed, UniProtKB/Swiss-Prot P50296 (ARY3_MOUSE)

Names and origin

Protein names

Recommended name:
    Arylamine N-acetyltransferase 3
    EC=2.3.1.5
Alternative name(s):
    Arylamide acetylase 3
    N-acetyltransferase type 3
      Short name=NAT-3

Gene names

Name:	Nat3
Synonyms:	Aac3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	L-amino acid transport Inferred from direct assay. Source: MGI metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: MGI
Molecular function	L-amino acid transmembrane transporter activity Inferred from direct assay. Source: MGI arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Arylamine N-acetyltransferase 3		PRO_0000107910
Regions
	Region	106 – 107	2	Substrate binding By similarity
Sites
	Active site	68	1	Acyl-thioester intermediate By similarity
	Active site	107	1	By similarity
	Active site	122	1	By similarity
	Binding site	208	1	Coenzyme A By similarity
	Binding site	214	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50296-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: AB6477F3DA3B0A9E	FASTA	290	33,686
	10 20 30 40 50 60 MDIEAYFERI GYQKSSNKLD LQTLTEILQH QIRAIPFENL NIHCGKTMEL SLEDTFHQIV 70 80 90 100 110 120 RKKRGGWCLQ VNHLLYWALA MIGFETTMLG GCVYVPSACK YSNTMIHLLL QVTISGKTYI 130 140 150 160 170 180 VDSAFPFSCQ LWEPLELTSG KDQPQVPAIF HLREENGTWY LEQTKRQEYV SNQEFIDSNF 190 200 210 220 230 240 LEKNTHRKIY SFTLEPRTIE DFWSISTYYQ VSRTSVMTNT SLCSLHTKDG VHGLMGTILA 250 260 270 280 290 YKKFNYKDNI DLVEFKTLKE EEIEEVLKSV FGIHLETKLV PKCGNVFFTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro." Kelly S.L., Sim E. Biochem. J. 302:347-353(1994) [PubMed: 7545952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X72959 Genomic DNA. Translation: CAA51461.1. AK077364 mRNA. Translation: BAC36769.1.
IPI	IPI00116460.
PIR	S55276.
RefSeq	NP_032700.1.
UniGene	Mm.57193
3D structure databases
HSSP	HSSP built from PDB template 1GX3 based on UniProtKB O86309.
ModBase	Search...
Protein-protein interaction databases
STRING	P50296.
Proteomic databases
PRIDE	P50296.
Genome annotation databases
Ensembl	ENSMUST00000070514; ENSMUSP00000069359; ENSMUSG00000056426; Mus musculus. [Genome view]
GeneID	17962.
KEGG	mmu:17962.
UCSC	uc009lvy.1. mouse.
Organism-specific databases
CTD	17962.
MGI	MGI:102537. Nat3.
Phylogenomic databases
HOGENOM	P50296.
HOVERGEN	P50296.
OMA	PATHTLM.
Enzyme and pathway databases
BRENDA	2.3.1.5. 244.
Gene expression databases
ArrayExpress	P50296.
Bgee	P50296.
CleanEx	MM_NAT3.
Genevestigator	P50296.
GermOnline	ENSMUSG00000056426. Mus musculus.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProDom	PD002783. Acetyltransf2. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	292891.
SOURCE	Search...

Entry information

Entry name

ARY3_MOUSE

Accession

Primary (citable) accession number: P50296

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)