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Protein

Follistatin

Gene

FST

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-2473224. Antagonism of Activin by Follistatin.

Protein family/group databases

MEROPSiI01.966.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:FST
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 344315FollistatinPRO_0000010101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 55PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
Disulfide bondi56 ↔ 91PROSITE-ProRule annotation
Disulfide bondi95 ↔ 106PROSITE-ProRule annotation
Disulfide bondi100 ↔ 116PROSITE-ProRule annotation
Disulfide bondi118 ↔ 150PROSITE-ProRule annotation
Disulfide bondi122 ↔ 143PROSITE-ProRule annotation
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi132 ↔ 164PROSITE-ProRule annotation
Disulfide bondi192 ↔ 225PROSITE-ProRule annotation
Disulfide bondi196 ↔ 218PROSITE-ProRule annotation
Disulfide bondi207 ↔ 239PROSITE-ProRule annotation
Disulfide bondi270 ↔ 302PROSITE-ProRule annotation
Disulfide bondi274 ↔ 295PROSITE-ProRule annotation
Disulfide bondi284 ↔ 316PROSITE-ProRule annotation
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50291.
PRIDEiP50291.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004318.

Structurei

3D structure databases

ProteinModelPortaliP50291.
SMRiP50291. Positions 30-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 10374TBAdd
BLAST
Domaini94 – 11724Follistatin-like 1Add
BLAST
Domaini112 – 16655Kazal-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini167 – 19024Follistatin-like 2Add
BLAST
Domaini186 – 24156Kazal-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 26825Follistatin-like 3Add
BLAST
Domaini261 – 31858Kazal-like 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi321 – 33313Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Contains 3 follistatin-like domains.Curated
Contains 3 Kazal-like domains.PROSITE-ProRule annotation
Contains 1 TB (TGF-beta binding) domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP50291.
KOiK04661.
OMAiEAVCASD.
OrthoDBiEOG7GBFXR.
TreeFamiTF106409.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELQVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPT
210 220 230 240 250
SSEQYLCGND GVTYPSACHL RKATCLLGRS IGLAYEGKCI KAKSCDDIQC
260 270 280 290 300
TGGKKCLWDF KVGRGRCSLC GELCPESKSE EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EDTEDEEEDE DQDYSFPISS ILEW
Length:344
Mass (Da):37,958
Last modified:February 5, 2008 - v2
Checksum:iA84FF34350F1AAD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571Q → E in AAA30522 (PubMed:8011323).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21716 mRNA. Translation: AAA30522.1.
AY775795 Genomic DNA. Translation: AAX19140.1.
BC133637 mRNA. Translation: AAI33638.1.
PIRiI45894.
RefSeqiNP_786995.2. NM_175801.3.
UniGeneiBt.405.

Genome annotation databases

EnsembliENSBTAT00000004318; ENSBTAP00000004318; ENSBTAG00000003329.
GeneIDi327681.
KEGGibta:327681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21716 mRNA. Translation: AAA30522.1.
AY775795 Genomic DNA. Translation: AAX19140.1.
BC133637 mRNA. Translation: AAI33638.1.
PIRiI45894.
RefSeqiNP_786995.2. NM_175801.3.
UniGeneiBt.405.

3D structure databases

ProteinModelPortaliP50291.
SMRiP50291. Positions 30-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004318.

Protein family/group databases

MEROPSiI01.966.

Proteomic databases

PaxDbiP50291.
PRIDEiP50291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004318; ENSBTAP00000004318; ENSBTAG00000003329.
GeneIDi327681.
KEGGibta:327681.

Organism-specific databases

CTDi10468.

Phylogenomic databases

eggNOGiENOG410IP0F. Eukaryota.
ENOG410YM8Q. LUCA.
GeneTreeiENSGT00440000033501.
HOGENOMiHOG000261649.
HOVERGENiHBG051666.
InParanoidiP50291.
KOiK04661.
OMAiEAVCASD.
OrthoDBiEOG7GBFXR.
TreeFamiTF106409.

Enzyme and pathway databases

ReactomeiR-BTA-2473224. Antagonism of Activin by Follistatin.

Miscellaneous databases

NextBioi20810146.

Family and domain databases

InterProiIPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR017878. TB_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 3 hits.
[Graphical view]
SMARTiSM00274. FOLN. 3 hits.
SM00280. KAZAL. 3 hits.
[Graphical view]
SUPFAMiSSF57581. SSF57581. 1 hit.
PROSITEiPS51465. KAZAL_2. 3 hits.
PS51364. TB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Ovary and Testis.
  2. "The myostatin signalling pathway: structure, expression and polymorphisms of the ACVR2B and FST genes in cattle."
    Rouhaud L., Forestier F., Laforet M.P., Julien R., Amarger V.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal spinal cord.

Entry informationi

Entry nameiFST_BOVIN
AccessioniPrimary (citable) accession number: P50291
Secondary accession number(s): Q32XW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 5, 2008
Last modified: December 9, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.