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Protein

Follistatin

Gene

FST

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-2473224 Antagonism of Activin by Follistatin

Protein family/group databases

MEROPSiI01.966

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:FST
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:29134 FST

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001010130 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
Disulfide bondi56 ↔ 91PROSITE-ProRule annotation
Disulfide bondi95 ↔ 106PROSITE-ProRule annotation
Disulfide bondi100 ↔ 116PROSITE-ProRule annotation
Disulfide bondi118 ↔ 150PROSITE-ProRule annotation
Disulfide bondi122 ↔ 143PROSITE-ProRule annotation
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 164PROSITE-ProRule annotation
Disulfide bondi192 ↔ 225PROSITE-ProRule annotation
Disulfide bondi196 ↔ 218PROSITE-ProRule annotation
Disulfide bondi207 ↔ 239PROSITE-ProRule annotation
Disulfide bondi270 ↔ 302PROSITE-ProRule annotation
Disulfide bondi274 ↔ 295PROSITE-ProRule annotation
Disulfide bondi284 ↔ 316PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50291
PRIDEiP50291

Expressioni

Gene expression databases

BgeeiENSBTAG00000003329

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004318

Structurei

3D structure databases

ProteinModelPortaliP50291
SMRiP50291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini261 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F Eukaryota
ENOG410YM8Q LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiP50291
KOiK04661
OMAiDEAVCAS
OrthoDBiEOG091G09I0
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 3 hits
SMARTiView protein in SMART
SM00274 FOLN, 3 hits
SM00280 KAZAL, 3 hits
SUPFAMiSSF100895 SSF100895, 3 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 3 hits
PS51364 TB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELQVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPT
210 220 230 240 250
SSEQYLCGND GVTYPSACHL RKATCLLGRS IGLAYEGKCI KAKSCDDIQC
260 270 280 290 300
TGGKKCLWDF KVGRGRCSLC GELCPESKSE EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EDTEDEEEDE DQDYSFPISS ILEW
Length:344
Mass (Da):37,958
Last modified:February 5, 2008 - v2
Checksum:iA84FF34350F1AAD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157Q → E in AAA30522 (PubMed:8011323).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21716 mRNA Translation: AAA30522.1
AY775795 Genomic DNA Translation: AAX19140.1
BC133637 mRNA Translation: AAI33638.1
PIRiI45894
RefSeqiNP_786995.2, NM_175801.3
UniGeneiBt.405

Genome annotation databases

EnsembliENSBTAT00000004318; ENSBTAP00000004318; ENSBTAG00000003329
GeneIDi327681
KEGGibta:327681

Similar proteinsi

Entry informationi

Entry nameiFST_BOVIN
AccessioniPrimary (citable) accession number: P50291
Secondary accession number(s): Q32XW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health