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P50285

- FMO1_MOUSE

UniProt

P50285 - FMO1_MOUSE

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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

Fmo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei208 – 2081Important for substrate bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADSequence Analysis
Nucleotide bindingi191 – 1966NADPSequence Analysis

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. monooxygenase activity Source: MGI
  3. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
  4. NADP binding Source: InterPro

GO - Biological processi

  1. drug metabolic process Source: MGI
  2. NADPH oxidation Source: Ensembl
  3. organic acid metabolic process Source: Ensembl
  4. response to lipopolysaccharide Source: Ensembl
  5. response to osmotic stress Source: Ensembl
  6. toxin metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 1
Hepatic flavin-containing monooxygenase 1
Short name:
FMO 1
Gene namesi
Name:Fmo1
Synonyms:Fmo-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1310002. Fmo1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 532531Dimethylaniline monooxygenase [N-oxide-forming] 1PRO_0000147640Add
BLAST

Proteomic databases

MaxQBiP50285.
PaxDbiP50285.
PRIDEiP50285.

PTM databases

PhosphoSiteiP50285.

Expressioni

Tissue specificityi

Liver.

Gene expression databases

BgeeiP50285.
CleanExiMM_FMO1.
ExpressionAtlasiP50285. baseline and differential.
GenevestigatoriP50285.

Interactioni

Protein-protein interaction databases

IntActiP50285. 3 interactions.
MINTiMINT-1838390.

Structurei

3D structure databases

ProteinModelPortaliP50285.
SMRiP50285. Positions 4-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiCOG2072.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiP50285.
KOiK00485.
OMAiTRFQNML.
OrthoDBiEOG7GXPB6.
PhylomeDBiP50285.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50285-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSSDLGGL WRFTEHVEEG
60 70 80 90 100
RASLYKSVVS NSSREMSCYP DFPFPEDYPN FVPNSLFLEY LKLYSTQFNL
110 120 130 140 150
QRCIYFNTKV CSITKRPDFA VSGQWEVVTV TNGKQNSAIF DAVMVCTGFL
160 170 180 190 200
TNPHLPLDSF PGILTFKGEY FHSRQYKHPD IFKDKRVLVV GMGNSGTDIA
210 220 230 240 250
VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMIFMTRFQ NMLRNLLPTP
260 270 280 290 300
IVSWLISKKM NSWFNHVNYG VAPEDRTQLR EPVLNDELPG RIITGKVFIK
310 320 330 340 350
PSIKEVKENS VVFNNTPKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA
360 370 380 390 400
SLYKYIFPAH LPKPTLAVIG LIKPLGSMVP TGETQARWVV QVLKGATTLP
410 420 430 440 450
PPSVMMEEVN ERKKNKHSGF GLCYCKALQT DYITYIDDLL TSINAKPDLR
460 470 480 490 500
AMLLTDPRLA LSIFFGPCTP YHFRLTGPGK WEGARKAILT QWDRTVKVTK
510 520 530
TRTIQESPSS FETLLKLFSF LALLIAVFLI FL
Length:532
Mass (Da):59,915
Last modified:October 1, 1996 - v1
Checksum:iC3CEDC7FC82DAC59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16215 mRNA. Translation: BAA03745.1.
U87456 mRNA. Translation: AAB47569.1.
BC011229 mRNA. Translation: AAH11229.1.
CCDSiCCDS15424.1.
PIRiB61243.
RefSeqiNP_034361.1. NM_010231.2.
XP_006496725.1. XM_006496662.1.
XP_006496726.1. XM_006496663.1.
UniGeneiMm.976.

Genome annotation databases

EnsembliENSMUST00000046049; ENSMUSP00000037259; ENSMUSG00000040181.
GeneIDi14261.
KEGGimmu:14261.
UCSCiuc007dgx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16215 mRNA. Translation: BAA03745.1 .
U87456 mRNA. Translation: AAB47569.1 .
BC011229 mRNA. Translation: AAH11229.1 .
CCDSi CCDS15424.1.
PIRi B61243.
RefSeqi NP_034361.1. NM_010231.2.
XP_006496725.1. XM_006496662.1.
XP_006496726.1. XM_006496663.1.
UniGenei Mm.976.

3D structure databases

ProteinModelPortali P50285.
SMRi P50285. Positions 4-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50285. 3 interactions.
MINTi MINT-1838390.

PTM databases

PhosphoSitei P50285.

Proteomic databases

MaxQBi P50285.
PaxDbi P50285.
PRIDEi P50285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046049 ; ENSMUSP00000037259 ; ENSMUSG00000040181 .
GeneIDi 14261.
KEGGi mmu:14261.
UCSCi uc007dgx.1. mouse.

Organism-specific databases

CTDi 2326.
MGIi MGI:1310002. Fmo1.

Phylogenomic databases

eggNOGi COG2072.
GeneTreei ENSGT00760000119232.
HOGENOMi HOG000076537.
HOVERGENi HBG002037.
InParanoidi P50285.
KOi K00485.
OMAi TRFQNML.
OrthoDBi EOG7GXPB6.
PhylomeDBi P50285.
TreeFami TF105285.

Miscellaneous databases

NextBioi 285603.
PROi P50285.
SOURCEi Search...

Gene expression databases

Bgeei P50285.
CleanExi MM_FMO1.
ExpressionAtlasi P50285. baseline and differential.
Genevestigatori P50285.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00743. FMO-like. 1 hit.
[Graphical view ]
PIRSFi PIRSF000332. FMO. 1 hit.
PRINTSi PR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Itoh K., Nakamura K., Kimura T., Itoh S., Kamataki T.
    Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)."
    Cherrington N.J., Falls J.G., Rose R.L., Clements K.M., Philpot R.M., Levi P.E., Hodgson E.
    J. Biochem. Mol. Toxicol. 12:205-212(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 297-307, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiFMO1_MOUSE
AccessioniPrimary (citable) accession number: P50285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3