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Reviewed, UniProtKB/Swiss-Prot P50285 (FMO1_MOUSE)

Last modified January 19, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1
    EC=1.14.13.8
Alternative name(s):
    Hepatic flavin-containing monooxygenase 1
      Short name=FMO 1
    Dimethylaniline oxidase 1
Gene names
Name: Fmo1
Synonyms: Fmo-1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Catalytic activity

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactor

FAD.

Subcellular location

Microsome membrane. Endoplasmic reticulum membrane.

Tissue specificity

Liver By similarity.

Sequence similarities

Belongs to the FMO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Dimethylaniline monooxygenase [N-oxide-forming] 1
PRO_0000147640

Regions

Nucleotide binding9 – 146FAD Potential
Nucleotide binding191 – 1966NADP Potential

Sites

Site2081Important for substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P50285-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C3CEDC7FC82DAC59

FASTA53259,915
        10         20         30         40         50         60 
MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSSDLGGL WRFTEHVEEG RASLYKSVVS 

        70         80         90        100        110        120 
NSSREMSCYP DFPFPEDYPN FVPNSLFLEY LKLYSTQFNL QRCIYFNTKV CSITKRPDFA 

       130        140        150        160        170        180 
VSGQWEVVTV TNGKQNSAIF DAVMVCTGFL TNPHLPLDSF PGILTFKGEY FHSRQYKHPD 

       190        200        210        220        230        240 
IFKDKRVLVV GMGNSGTDIA VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMIFMTRFQ 

       250        260        270        280        290        300 
NMLRNLLPTP IVSWLISKKM NSWFNHVNYG VAPEDRTQLR EPVLNDELPG RIITGKVFIK 

       310        320        330        340        350        360 
PSIKEVKENS VVFNNTPKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH 

       370        380        390        400        410        420 
LPKPTLAVIG LIKPLGSMVP TGETQARWVV QVLKGATTLP PPSVMMEEVN ERKKNKHSGF 

       430        440        450        460        470        480 
GLCYCKALQT DYITYIDDLL TSINAKPDLR AMLLTDPRLA LSIFFGPCTP YHFRLTGPGK 

       490        500        510        520        530 
WEGARKAILT QWDRTVKVTK TRTIQESPSS FETLLKLFSF LALLIAVFLI FL 

« Hide

References

« Hide 'large scale' references
[1]Itoh K., Nakamura K., Kimura T., Itoh S., Kamataki T.
Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)."
Cherrington N.J., Falls J.G., Rose R.L., Clements K.M., Philpot R.M., Levi P.E., Hodgson E.
J. Biochem. Mol. Toxicol. 12:205-212(1998) [PubMed: 9580872] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 297-307, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16215 mRNA. Translation: BAA03745.1.
U87456 mRNA. Translation: AAB47569.1.
BC011229 mRNA. Translation: AAH11229.1.
IPIIPI00116432.
PIRB61243.
RefSeqNP_034361.1.
UniGeneMm.976

3D structure databases

SMRP50285. Positions 1-467.
ModBaseSearch...

Protein-protein interaction databases

STRINGP50285.

PTM databases

PhosphoSiteP50285.

Proteomic databases

PRIDEP50285.

Genome annotation databases

EnsemblENSMUST00000046049; ENSMUSP00000037259; ENSMUSG00000040181; Mus musculus. [Genome view]
GeneID14261.
KEGGmmu:14261.
UCSCuc007dgx.1. mouse.

Organism-specific databases

CTD14261.
MGIMGI:1310002. Fmo1.

Phylogenomic databases

eggNOGroNOG11485.
HOGENOMHBG700572.
HOVERGENP50285.
InParanoidP50285.
OMAMLLTDPR.
OrthoDBEOG9F7R4X.
PhylomeDBP50285.

Enzyme and pathway databases

BRENDA1.14.13.8. 244.

Gene expression databases

ArrayExpressP50285.
BgeeP50285.
CleanExMM_FMO1.
GenevestigatorP50285.
GermOnlineENSMUSG00000040181. Mus musculus.

Family and domain databases

InterProIPR012143. dManiline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002253. Flavin_mOase_1.
[Graphical view]
PfamPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFPIRSF000332. FMO. 1 hit.
PRINTSPR00370. FMOXYGENASE.
PR01121. FMOXYGENASE1.
ProtoNetSearch...

Other Resources

NextBio285603.
SOURCESearch...

Entry information

Entry nameFMO1_MOUSE
AccessionPrimary (citable) accession number: P50285
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 19, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents