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P50285

- FMO1_MOUSE

UniProt

P50285 - FMO1_MOUSE

Protein

Dimethylaniline monooxygenase [N-oxide-forming] 1

Gene

Fmo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

    Catalytic activityi

    N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

    Cofactori

    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei208 – 2081Important for substrate bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146FADSequence Analysis
    Nucleotide bindingi191 – 1966NADPSequence Analysis

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. monooxygenase activity Source: MGI
    3. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. drug metabolic process Source: MGI
    2. NADPH oxidation Source: Ensembl
    3. organic acid metabolic process Source: Ensembl
    4. response to lipopolysaccharide Source: Ensembl
    5. response to osmotic stress Source: Ensembl
    6. toxin metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1 (EC:1.14.13.8)
    Alternative name(s):
    Dimethylaniline oxidase 1
    Hepatic flavin-containing monooxygenase 1
    Short name:
    FMO 1
    Gene namesi
    Name:Fmo1
    Synonyms:Fmo-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1310002. Fmo1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 532531Dimethylaniline monooxygenase [N-oxide-forming] 1PRO_0000147640Add
    BLAST

    Proteomic databases

    MaxQBiP50285.
    PaxDbiP50285.
    PRIDEiP50285.

    PTM databases

    PhosphoSiteiP50285.

    Expressioni

    Tissue specificityi

    Liver.

    Gene expression databases

    ArrayExpressiP50285.
    BgeeiP50285.
    CleanExiMM_FMO1.
    GenevestigatoriP50285.

    Interactioni

    Protein-protein interaction databases

    IntActiP50285. 3 interactions.
    MINTiMINT-1838390.

    Structurei

    3D structure databases

    ProteinModelPortaliP50285.
    SMRiP50285. Positions 2-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FMO family.Curated

    Keywords - Domaini

    Transmembrane

    Phylogenomic databases

    eggNOGiCOG2072.
    GeneTreeiENSGT00740000115433.
    HOGENOMiHOG000076537.
    HOVERGENiHBG002037.
    InParanoidiP50285.
    KOiK00485.
    OMAiTRFQNML.
    OrthoDBiEOG7GXPB6.
    PhylomeDBiP50285.
    TreeFamiTF105285.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002253. Flavin_mOase_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00743. FMO-like. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000332. FMO. 1 hit.
    PRINTSiPR00370. FMOXYGENASE.
    PR01121. FMOXYGENASE1.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50285-1 [UniParc]FASTAAdd to Basket

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    MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSSDLGGL WRFTEHVEEG    50
    RASLYKSVVS NSSREMSCYP DFPFPEDYPN FVPNSLFLEY LKLYSTQFNL 100
    QRCIYFNTKV CSITKRPDFA VSGQWEVVTV TNGKQNSAIF DAVMVCTGFL 150
    TNPHLPLDSF PGILTFKGEY FHSRQYKHPD IFKDKRVLVV GMGNSGTDIA 200
    VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMIFMTRFQ NMLRNLLPTP 250
    IVSWLISKKM NSWFNHVNYG VAPEDRTQLR EPVLNDELPG RIITGKVFIK 300
    PSIKEVKENS VVFNNTPKEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA 350
    SLYKYIFPAH LPKPTLAVIG LIKPLGSMVP TGETQARWVV QVLKGATTLP 400
    PPSVMMEEVN ERKKNKHSGF GLCYCKALQT DYITYIDDLL TSINAKPDLR 450
    AMLLTDPRLA LSIFFGPCTP YHFRLTGPGK WEGARKAILT QWDRTVKVTK 500
    TRTIQESPSS FETLLKLFSF LALLIAVFLI FL 532
    Length:532
    Mass (Da):59,915
    Last modified:October 1, 1996 - v1
    Checksum:iC3CEDC7FC82DAC59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16215 mRNA. Translation: BAA03745.1.
    U87456 mRNA. Translation: AAB47569.1.
    BC011229 mRNA. Translation: AAH11229.1.
    CCDSiCCDS15424.1.
    PIRiB61243.
    RefSeqiNP_034361.1. NM_010231.2.
    XP_006496725.1. XM_006496662.1.
    XP_006496726.1. XM_006496663.1.
    UniGeneiMm.976.

    Genome annotation databases

    EnsembliENSMUST00000046049; ENSMUSP00000037259; ENSMUSG00000040181.
    GeneIDi14261.
    KEGGimmu:14261.
    UCSCiuc007dgx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16215 mRNA. Translation: BAA03745.1 .
    U87456 mRNA. Translation: AAB47569.1 .
    BC011229 mRNA. Translation: AAH11229.1 .
    CCDSi CCDS15424.1.
    PIRi B61243.
    RefSeqi NP_034361.1. NM_010231.2.
    XP_006496725.1. XM_006496662.1.
    XP_006496726.1. XM_006496663.1.
    UniGenei Mm.976.

    3D structure databases

    ProteinModelPortali P50285.
    SMRi P50285. Positions 2-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P50285. 3 interactions.
    MINTi MINT-1838390.

    PTM databases

    PhosphoSitei P50285.

    Proteomic databases

    MaxQBi P50285.
    PaxDbi P50285.
    PRIDEi P50285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046049 ; ENSMUSP00000037259 ; ENSMUSG00000040181 .
    GeneIDi 14261.
    KEGGi mmu:14261.
    UCSCi uc007dgx.1. mouse.

    Organism-specific databases

    CTDi 2326.
    MGIi MGI:1310002. Fmo1.

    Phylogenomic databases

    eggNOGi COG2072.
    GeneTreei ENSGT00740000115433.
    HOGENOMi HOG000076537.
    HOVERGENi HBG002037.
    InParanoidi P50285.
    KOi K00485.
    OMAi TRFQNML.
    OrthoDBi EOG7GXPB6.
    PhylomeDBi P50285.
    TreeFami TF105285.

    Miscellaneous databases

    NextBioi 285603.
    PROi P50285.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50285.
    Bgeei P50285.
    CleanExi MM_FMO1.
    Genevestigatori P50285.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002253. Flavin_mOase_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00743. FMO-like. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000332. FMO. 1 hit.
    PRINTSi PR00370. FMOXYGENASE.
    PR01121. FMOXYGENASE1.
    ProtoNeti Search...

    Publicationsi

    1. Itoh K., Nakamura K., Kimura T., Itoh S., Kamataki T.
      Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)."
      Cherrington N.J., Falls J.G., Rose R.L., Clements K.M., Philpot R.M., Levi P.E., Hodgson E.
      J. Biochem. Mol. Toxicol. 12:205-212(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 297-307, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiFMO1_MOUSE
    AccessioniPrimary (citable) accession number: P50285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3