ID   TNR3_MOUSE              Reviewed;         415 AA.
AC   P50284;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   24-JAN-2024, entry version 167.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 3;
DE   AltName: Full=Lymphotoxin-beta receptor;
DE   Flags: Precursor;
GN   Name=Ltbr; Synonyms=Tnfcr, Tnfrsf3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CVB; TISSUE=Lung;
RX   PubMed=7594541;
RA   Force W.R., Walter B.N., Hession C., Tizard R., Kozak C.A., Browning J.L.,
RA   Ware C.F.;
RT   "Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and
RT   expression.";
RL   J. Immunol. 155:5280-5288(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8586432; DOI=10.1006/geno.1995.9872;
RA   Nakamura T., Tashiro K., Nazarea M., Nakano T., Sasayama S., Honjo T.;
RT   "The murine lymphotoxin-beta receptor cDNA: isolation by the signal
RT   sequence trap and chromosomal mapping.";
RL   Genomics 30:312-319(1995).
RN   [3]
RP   INTERACTION WITH TRAF5.
RC   STRAIN=BALB/cJ;
RX   PubMed=8663299; DOI=10.1074/jbc.271.25.14661;
RA   Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H.,
RA   Okumura K.;
RT   "TRAF5, an activator of NF-kappaB and putative signal transducer for the
RT   lymphotoxin-beta receptor.";
RL   J. Biol. Chem. 271:14661-14664(1996).
CC   -!- FUNCTION: Receptor for the heterotrimeric lymphotoxin containing LTA
CC       and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5.
CC       May play a role in the development of lymphoid organs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates (By similarity). Associates with TRAF5.
CC       Associates with TRAF3 and TRAF4 (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P50284; P39429: Traf2; NbExp=3; IntAct=EBI-647023, EBI-520016;
CC       P50284; O43557: TNFSF14; Xeno; NbExp=2; IntAct=EBI-647023, EBI-524131;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U29173; AAA68964.1; -; mRNA.
DR   EMBL; L38423; AAB00846.1; -; mRNA.
DR   EMBL; U30798; AAA81334.1; -; Genomic_DNA.
DR   CCDS; CCDS20549.1; -.
DR   RefSeq; NP_034866.1; NM_010736.3.
DR   AlphaFoldDB; P50284; -.
DR   SMR; P50284; -.
DR   BioGRID; 201222; 5.
DR   DIP; DIP-49695N; -.
DR   IntAct; P50284; 7.
DR   STRING; 10090.ENSMUSP00000032489; -.
DR   GlyCosmos; P50284; 2 sites, No reported glycans.
DR   GlyGen; P50284; 2 sites.
DR   PhosphoSitePlus; P50284; -.
DR   MaxQB; P50284; -.
DR   PaxDb; 10090-ENSMUSP00000032489; -.
DR   ProteomicsDB; 258811; -.
DR   Antibodypedia; 10740; 964 antibodies from 37 providers.
DR   DNASU; 17000; -.
DR   Ensembl; ENSMUST00000032489.8; ENSMUSP00000032489.8; ENSMUSG00000030339.8.
DR   GeneID; 17000; -.
DR   KEGG; mmu:17000; -.
DR   UCSC; uc009duj.1; mouse.
DR   AGR; MGI:104875; -.
DR   CTD; 4055; -.
DR   MGI; MGI:104875; Ltbr.
DR   VEuPathDB; HostDB:ENSMUSG00000030339; -.
DR   eggNOG; ENOG502S4WF; Eukaryota.
DR   GeneTree; ENSGT00940000162178; -.
DR   HOGENOM; CLU_052594_0_0_1; -.
DR   InParanoid; P50284; -.
DR   OMA; NNCVPCK; -.
DR   OrthoDB; 5320298at2759; -.
DR   PhylomeDB; P50284; -.
DR   TreeFam; TF331157; -.
DR   Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
DR   Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR   BioGRID-ORCS; 17000; 2 hits in 81 CRISPR screens.
DR   ChiTaRS; Ltbr; mouse.
DR   PRO; PR:P50284; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P50284; Protein.
DR   Bgee; ENSMUSG00000030339; Expressed in granulocyte and 217 other cell types or tissues.
DR   ExpressionAtlas; P50284; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0048535; P:lymph node development; TAS:MGI.
DR   GO; GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR   GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; ISO:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR   CDD; cd10578; TNFRSF3; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR017349; TNFR_3_LTBR.
DR   InterPro; IPR033997; TNFRSF3_N.
DR   PANTHER; PTHR47607; TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3; 1.
DR   PANTHER; PTHR47607:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3; 1.
DR   Pfam; PF00020; TNFR_c6; 3.
DR   PIRSF; PIRSF037999; TNFR_3_LTBR; 1.
DR   PRINTS; PR01920; TNFACTORR3.
DR   SMART; SM00208; TNFR; 3.
DR   SUPFAM; SSF57586; TNF receptor-like; 2.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 3.
DR   Genevisible; P50284; MM.
PE   1: Evidence at protein level;
KW   Apoptosis; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein;
KW   Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..415
FT                   /note="Tumor necrosis factor receptor superfamily member 3"
FT                   /id="PRO_0000034553"
FT   TOPO_DOM        31..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..415
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          42..81
FT                   /note="TNFR-Cys 1"
FT   REPEAT          82..124
FT                   /note="TNFR-Cys 2"
FT   REPEAT          125..170
FT                   /note="TNFR-Cys 3"
FT   REPEAT          171..213
FT                   /note="TNFR-Cys 4"
FT   REGION          261..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..384
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         315
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P36941"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        59..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        62..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        83..98
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        101..116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        104..124
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        126..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        139..150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        142..169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        172..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   415 AA;  44956 MW;  29B326A566AEF661 CRC64;
     MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY YEPMHDVCCS
     RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL CRPCDIVLGF EEVAPCTSDR
     KAECRCQPGM SCVYLDNECV HCEEERLVLC QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT
     SSPRARCQPH TRCEIQGLVE AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL
     ACAWMRHPSL CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP
     PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT GNIYIYNGPV
     LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK AWHLAETETL GCQDL
//