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P50284

- TNR3_MOUSE

UniProt

P50284 - TNR3_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 3

Gene

Ltbr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cellular response to mechanical stimulus Source: Ensembl
    3. lymph node development Source: MGI
    4. myeloid dendritic cell differentiation Source: MGI
    5. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    7. positive regulation of JNK cascade Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 3
    Alternative name(s):
    Lymphotoxin-beta receptor
    Gene namesi
    Name:Ltbr
    Synonyms:Tnfcr, Tnfrsf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:104875. Ltbr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 415385Tumor necrosis factor receptor superfamily member 3PRO_0000034553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi62 ↔ 80PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
    Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi126 ↔ 132PROSITE-ProRule annotation
    Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
    Disulfide bondi142 ↔ 169PROSITE-ProRule annotation
    Disulfide bondi172 ↔ 187PROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Modified residuei315 – 3151PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP50284.
    PRIDEiP50284.

    PTM databases

    PhosphoSiteiP50284.

    Expressioni

    Gene expression databases

    ArrayExpressiP50284.
    BgeeiP50284.
    CleanExiMM_LTBR.
    GenevestigatoriP50284.

    Interactioni

    Subunit structurei

    Self-associates By similarity. Associates with TRAF5. Associates with TRAF3 and TRAF4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201222. 5 interactions.
    DIPiDIP-49695N.
    IntActiP50284. 2 interactions.
    MINTiMINT-4138161.

    Structurei

    3D structure databases

    ProteinModelPortaliP50284.
    SMRiP50284. Positions 43-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 223193ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 415171CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 8140TNFR-Cys 1Add
    BLAST
    Repeati82 – 12443TNFR-Cys 2Add
    BLAST
    Repeati125 – 17046TNFR-Cys 3Add
    BLAST
    Repeati171 – 21343TNFR-Cys 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38845.
    GeneTreeiENSGT00740000115372.
    HOGENOMiHOG000294180.
    HOVERGENiHBG023187.
    InParanoidiP50284.
    KOiK03159.
    OMAiTVTGNIY.
    OrthoDBiEOG786H2Q.
    PhylomeDBiP50284.
    TreeFamiTF331157.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR017349. TNFR_3_LTBR.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
    PRINTSiPR01920. TNFACTORR3.
    SMARTiSM00208. TNFR. 3 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50284-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY    50
    YEPMHDVCCS RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL 100
    CRPCDIVLGF EEVAPCTSDR KAECRCQPGM SCVYLDNECV HCEEERLVLC 150
    QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT SSPRARCQPH TRCEIQGLVE 200
    AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL ACAWMRHPSL 250
    CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP 300
    PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT 350
    GNIYIYNGPV LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK 400
    AWHLAETETL GCQDL 415
    Length:415
    Mass (Da):44,956
    Last modified:October 1, 1996 - v1
    Checksum:i29B326A566AEF661
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29173 mRNA. Translation: AAA68964.1.
    L38423 mRNA. Translation: AAB00846.1.
    U30798 Genomic DNA. Translation: AAA81334.1.
    CCDSiCCDS20549.1.
    RefSeqiNP_034866.1. NM_010736.3.
    UniGeneiMm.3122.

    Genome annotation databases

    EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
    GeneIDi17000.
    KEGGimmu:17000.
    UCSCiuc009duj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U29173 mRNA. Translation: AAA68964.1 .
    L38423 mRNA. Translation: AAB00846.1 .
    U30798 Genomic DNA. Translation: AAA81334.1 .
    CCDSi CCDS20549.1.
    RefSeqi NP_034866.1. NM_010736.3.
    UniGenei Mm.3122.

    3D structure databases

    ProteinModelPortali P50284.
    SMRi P50284. Positions 43-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201222. 5 interactions.
    DIPi DIP-49695N.
    IntActi P50284. 2 interactions.
    MINTi MINT-4138161.

    PTM databases

    PhosphoSitei P50284.

    Proteomic databases

    PaxDbi P50284.
    PRIDEi P50284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032489 ; ENSMUSP00000032489 ; ENSMUSG00000030339 .
    GeneIDi 17000.
    KEGGi mmu:17000.
    UCSCi uc009duj.1. mouse.

    Organism-specific databases

    CTDi 4055.
    MGIi MGI:104875. Ltbr.

    Phylogenomic databases

    eggNOGi NOG38845.
    GeneTreei ENSGT00740000115372.
    HOGENOMi HOG000294180.
    HOVERGENi HBG023187.
    InParanoidi P50284.
    KOi K03159.
    OMAi TVTGNIY.
    OrthoDBi EOG786H2Q.
    PhylomeDBi P50284.
    TreeFami TF331157.

    Miscellaneous databases

    ChiTaRSi LTBR. mouse.
    NextBioi 291108.
    PROi P50284.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50284.
    Bgeei P50284.
    CleanExi MM_LTBR.
    Genevestigatori P50284.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR017349. TNFR_3_LTBR.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037999. TNFR_3_LTBR. 1 hit.
    PRINTSi PR01920. TNFACTORR3.
    SMARTi SM00208. TNFR. 3 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression."
      Force W.R., Walter B.N., Hession C., Tizard R., Kozak C.A., Browning J.L., Ware C.F.
      J. Immunol. 155:5280-5288(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CVB.
      Tissue: Lung.
    2. "The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping."
      Nakamura T., Tashiro K., Nazarea M., Nakano T., Sasayama S., Honjo T.
      Genomics 30:312-319(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
      Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K.
      J. Biol. Chem. 271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF5.
      Strain: BALB/c.

    Entry informationi

    Entry nameiTNR3_MOUSE
    AccessioniPrimary (citable) accession number: P50284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3