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P50284

- TNR3_MOUSE

UniProt

P50284 - TNR3_MOUSE

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Protein

Tumor necrosis factor receptor superfamily member 3

Gene

Ltbr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity).By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to mechanical stimulus Source: Ensembl
  3. lymph node development Source: MGI
  4. myeloid dendritic cell differentiation Source: MGI
  5. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  7. positive regulation of JNK cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
Lymphotoxin-beta receptor
Gene namesi
Name:Ltbr
Synonyms:Tnfcr, Tnfrsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104875. Ltbr.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 415385Tumor necrosis factor receptor superfamily member 3PRO_0000034553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi126 ↔ 132PROSITE-ProRule annotation
Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
Disulfide bondi142 ↔ 169PROSITE-ProRule annotation
Disulfide bondi172 ↔ 187PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Modified residuei315 – 3151PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP50284.
PRIDEiP50284.

PTM databases

PhosphoSiteiP50284.

Expressioni

Gene expression databases

BgeeiP50284.
CleanExiMM_LTBR.
ExpressionAtlasiP50284. baseline and differential.
GenevestigatoriP50284.

Interactioni

Subunit structurei

Self-associates (By similarity). Associates with TRAF5. Associates with TRAF3 and TRAF4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201222. 5 interactions.
DIPiDIP-49695N.
IntActiP50284. 2 interactions.
MINTiMINT-4138161.

Structurei

3D structure databases

ProteinModelPortaliP50284.
SMRiP50284. Positions 43-213.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 223193ExtracellularSequence AnalysisAdd
BLAST
Topological domaini245 – 415171CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 8140TNFR-Cys 1Add
BLAST
Repeati82 – 12443TNFR-Cys 2Add
BLAST
Repeati125 – 17046TNFR-Cys 3Add
BLAST
Repeati171 – 21343TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38845.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000294180.
HOVERGENiHBG023187.
InParanoidiP50284.
KOiK03159.
OMAiTVTGNIY.
OrthoDBiEOG786H2Q.
PhylomeDBiP50284.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSiPR01920. TNFACTORR3.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50284 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY
60 70 80 90 100
YEPMHDVCCS RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL
110 120 130 140 150
CRPCDIVLGF EEVAPCTSDR KAECRCQPGM SCVYLDNECV HCEEERLVLC
160 170 180 190 200
QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT SSPRARCQPH TRCEIQGLVE
210 220 230 240 250
AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL ACAWMRHPSL
260 270 280 290 300
CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP
310 320 330 340 350
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT
360 370 380 390 400
GNIYIYNGPV LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK
410
AWHLAETETL GCQDL
Length:415
Mass (Da):44,956
Last modified:October 1, 1996 - v1
Checksum:i29B326A566AEF661
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29173 mRNA. Translation: AAA68964.1.
L38423 mRNA. Translation: AAB00846.1.
U30798 Genomic DNA. Translation: AAA81334.1.
CCDSiCCDS20549.1.
RefSeqiNP_034866.1. NM_010736.3.
UniGeneiMm.3122.

Genome annotation databases

EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
GeneIDi17000.
KEGGimmu:17000.
UCSCiuc009duj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29173 mRNA. Translation: AAA68964.1 .
L38423 mRNA. Translation: AAB00846.1 .
U30798 Genomic DNA. Translation: AAA81334.1 .
CCDSi CCDS20549.1.
RefSeqi NP_034866.1. NM_010736.3.
UniGenei Mm.3122.

3D structure databases

ProteinModelPortali P50284.
SMRi P50284. Positions 43-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201222. 5 interactions.
DIPi DIP-49695N.
IntActi P50284. 2 interactions.
MINTi MINT-4138161.

PTM databases

PhosphoSitei P50284.

Proteomic databases

PaxDbi P50284.
PRIDEi P50284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032489 ; ENSMUSP00000032489 ; ENSMUSG00000030339 .
GeneIDi 17000.
KEGGi mmu:17000.
UCSCi uc009duj.1. mouse.

Organism-specific databases

CTDi 4055.
MGIi MGI:104875. Ltbr.

Phylogenomic databases

eggNOGi NOG38845.
GeneTreei ENSGT00760000119204.
HOGENOMi HOG000294180.
HOVERGENi HBG023187.
InParanoidi P50284.
KOi K03159.
OMAi TVTGNIY.
OrthoDBi EOG786H2Q.
PhylomeDBi P50284.
TreeFami TF331157.

Miscellaneous databases

ChiTaRSi LTBR. mouse.
NextBioi 291108.
PROi P50284.
SOURCEi Search...

Gene expression databases

Bgeei P50284.
CleanExi MM_LTBR.
ExpressionAtlasi P50284. baseline and differential.
Genevestigatori P50284.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PIRSFi PIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSi PR01920. TNFACTORR3.
SMARTi SM00208. TNFR. 3 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression."
    Force W.R., Walter B.N., Hession C., Tizard R., Kozak C.A., Browning J.L., Ware C.F.
    J. Immunol. 155:5280-5288(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CVB.
    Tissue: Lung.
  2. "The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping."
    Nakamura T., Tashiro K., Nazarea M., Nakano T., Sasayama S., Honjo T.
    Genomics 30:312-319(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
    Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K.
    J. Biol. Chem. 271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF5.
    Strain: BALB/c.

Entry informationi

Entry nameiTNR3_MOUSE
AccessioniPrimary (citable) accession number: P50284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3