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Protein

Tumor necrosis factor receptor superfamily member 3

Gene

Ltbr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
Lymphotoxin-beta receptor
Gene namesi
Name:Ltbr
Synonyms:Tnfcr, Tnfrsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104875. Ltbr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 223ExtracellularSequence analysisAdd BLAST193
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 415CytoplasmicSequence analysisAdd BLAST171

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003455331 – 415Tumor necrosis factor receptor superfamily member 3Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi62 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi126 ↔ 132PROSITE-ProRule annotation
Disulfide bondi139 ↔ 150PROSITE-ProRule annotation
Disulfide bondi142 ↔ 169PROSITE-ProRule annotation
Disulfide bondi172 ↔ 187PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Modified residuei315PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP50284.
PaxDbiP50284.
PRIDEiP50284.

PTM databases

PhosphoSitePlusiP50284.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030339.
CleanExiMM_LTBR.
ExpressionAtlasiP50284. baseline and differential.
GenevisibleiP50284. MM.

Interactioni

Subunit structurei

Self-associates (By similarity). Associates with TRAF5. Associates with TRAF3 and TRAF4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF14O435572EBI-647023,EBI-524131From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201222. 5 interactors.
DIPiDIP-49695N.
IntActiP50284. 4 interactors.
MINTiMINT-4138161.
STRINGi10090.ENSMUSP00000032489.

Structurei

3D structure databases

ProteinModelPortaliP50284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 81TNFR-Cys 1Add BLAST40
Repeati82 – 124TNFR-Cys 2Add BLAST43
Repeati125 – 170TNFR-Cys 3Add BLAST46
Repeati171 – 213TNFR-Cys 4Add BLAST43

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKNN. Eukaryota.
ENOG410YQJW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000294180.
HOVERGENiHBG023187.
InParanoidiP50284.
KOiK03159.
OMAiQLCRPCD.
OrthoDBiEOG091G03XW.
PhylomeDBiP50284.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSiPR01920. TNFACTORR3.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY
60 70 80 90 100
YEPMHDVCCS RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL
110 120 130 140 150
CRPCDIVLGF EEVAPCTSDR KAECRCQPGM SCVYLDNECV HCEEERLVLC
160 170 180 190 200
QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT SSPRARCQPH TRCEIQGLVE
210 220 230 240 250
AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL ACAWMRHPSL
260 270 280 290 300
CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP
310 320 330 340 350
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT
360 370 380 390 400
GNIYIYNGPV LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK
410
AWHLAETETL GCQDL
Length:415
Mass (Da):44,956
Last modified:October 1, 1996 - v1
Checksum:i29B326A566AEF661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29173 mRNA. Translation: AAA68964.1.
L38423 mRNA. Translation: AAB00846.1.
U30798 Genomic DNA. Translation: AAA81334.1.
CCDSiCCDS20549.1.
RefSeqiNP_034866.1. NM_010736.3.
UniGeneiMm.3122.

Genome annotation databases

EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
GeneIDi17000.
KEGGimmu:17000.
UCSCiuc009duj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29173 mRNA. Translation: AAA68964.1.
L38423 mRNA. Translation: AAB00846.1.
U30798 Genomic DNA. Translation: AAA81334.1.
CCDSiCCDS20549.1.
RefSeqiNP_034866.1. NM_010736.3.
UniGeneiMm.3122.

3D structure databases

ProteinModelPortaliP50284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201222. 5 interactors.
DIPiDIP-49695N.
IntActiP50284. 4 interactors.
MINTiMINT-4138161.
STRINGi10090.ENSMUSP00000032489.

PTM databases

PhosphoSitePlusiP50284.

Proteomic databases

MaxQBiP50284.
PaxDbiP50284.
PRIDEiP50284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
GeneIDi17000.
KEGGimmu:17000.
UCSCiuc009duj.1. mouse.

Organism-specific databases

CTDi4055.
MGIiMGI:104875. Ltbr.

Phylogenomic databases

eggNOGiENOG410IKNN. Eukaryota.
ENOG410YQJW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000294180.
HOVERGENiHBG023187.
InParanoidiP50284.
KOiK03159.
OMAiQLCRPCD.
OrthoDBiEOG091G03XW.
PhylomeDBiP50284.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Miscellaneous databases

ChiTaRSiLtbr. mouse.
PROiP50284.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030339.
CleanExiMM_LTBR.
ExpressionAtlasiP50284. baseline and differential.
GenevisibleiP50284. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSiPR01920. TNFACTORR3.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR3_MOUSE
AccessioniPrimary (citable) accession number: P50284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.