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P50284

- TNR3_MOUSE

UniProt

P50284 - TNR3_MOUSE

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Protein
Tumor necrosis factor receptor superfamily member 3
Gene
Ltbr, Tnfcr, Tnfrsf3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to mechanical stimulus Source: Ensembl
  3. lymph node development Source: MGI
  4. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  5. positive regulation of JNK cascade Source: Ensembl
  6. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
Lymphotoxin-beta receptor
Gene namesi
Name:Ltbr
Synonyms:Tnfcr, Tnfrsf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104875. Ltbr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 223193Extracellular Reviewed prediction
Add
BLAST
Transmembranei224 – 24421Helical; Reviewed prediction
Add
BLAST
Topological domaini245 – 415171Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 415385Tumor necrosis factor receptor superfamily member 3
PRO_0000034553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi43 ↔ 58 By similarity
Disulfide bondi59 ↔ 72 By similarity
Disulfide bondi62 ↔ 80 By similarity
Disulfide bondi83 ↔ 98 By similarity
Disulfide bondi101 ↔ 116 By similarity
Disulfide bondi104 ↔ 124 By similarity
Disulfide bondi126 ↔ 132 By similarity
Disulfide bondi139 ↔ 150 By similarity
Disulfide bondi142 ↔ 169 By similarity
Disulfide bondi172 ↔ 187 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Modified residuei315 – 3151Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP50284.
PRIDEiP50284.

PTM databases

PhosphoSiteiP50284.

Expressioni

Gene expression databases

ArrayExpressiP50284.
BgeeiP50284.
CleanExiMM_LTBR.
GenevestigatoriP50284.

Interactioni

Subunit structurei

Self-associates By similarity. Associates with TRAF5. Associates with TRAF3 and TRAF4 By similarity.

Protein-protein interaction databases

BioGridi201222. 5 interactions.
DIPiDIP-49695N.
IntActiP50284. 2 interactions.
MINTiMINT-4138161.

Structurei

3D structure databases

ProteinModelPortaliP50284.
SMRiP50284. Positions 43-213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 8140TNFR-Cys 1
Add
BLAST
Repeati82 – 12443TNFR-Cys 2
Add
BLAST
Repeati125 – 17046TNFR-Cys 3
Add
BLAST
Repeati171 – 21343TNFR-Cys 4
Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38845.
GeneTreeiENSGT00740000115372.
HOGENOMiHOG000294180.
HOVERGENiHBG023187.
InParanoidiP50284.
KOiK03159.
OMAiTVTGNIY.
OrthoDBiEOG786H2Q.
PhylomeDBiP50284.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFiPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSiPR01920. TNFACTORR3.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50284-1 [UniParc]FASTAAdd to Basket

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MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY    50
YEPMHDVCCS RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL 100
CRPCDIVLGF EEVAPCTSDR KAECRCQPGM SCVYLDNECV HCEEERLVLC 150
QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT SSPRARCQPH TRCEIQGLVE 200
AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL ACAWMRHPSL 250
CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP 300
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT 350
GNIYIYNGPV LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK 400
AWHLAETETL GCQDL 415
Length:415
Mass (Da):44,956
Last modified:October 1, 1996 - v1
Checksum:i29B326A566AEF661
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29173 mRNA. Translation: AAA68964.1.
L38423 mRNA. Translation: AAB00846.1.
U30798 Genomic DNA. Translation: AAA81334.1.
CCDSiCCDS20549.1.
RefSeqiNP_034866.1. NM_010736.3.
UniGeneiMm.3122.

Genome annotation databases

EnsembliENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
GeneIDi17000.
KEGGimmu:17000.
UCSCiuc009duj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U29173 mRNA. Translation: AAA68964.1 .
L38423 mRNA. Translation: AAB00846.1 .
U30798 Genomic DNA. Translation: AAA81334.1 .
CCDSi CCDS20549.1.
RefSeqi NP_034866.1. NM_010736.3.
UniGenei Mm.3122.

3D structure databases

ProteinModelPortali P50284.
SMRi P50284. Positions 43-213.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201222. 5 interactions.
DIPi DIP-49695N.
IntActi P50284. 2 interactions.
MINTi MINT-4138161.

PTM databases

PhosphoSitei P50284.

Proteomic databases

PaxDbi P50284.
PRIDEi P50284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032489 ; ENSMUSP00000032489 ; ENSMUSG00000030339 .
GeneIDi 17000.
KEGGi mmu:17000.
UCSCi uc009duj.1. mouse.

Organism-specific databases

CTDi 4055.
MGIi MGI:104875. Ltbr.

Phylogenomic databases

eggNOGi NOG38845.
GeneTreei ENSGT00740000115372.
HOGENOMi HOG000294180.
HOVERGENi HBG023187.
InParanoidi P50284.
KOi K03159.
OMAi TVTGNIY.
OrthoDBi EOG786H2Q.
PhylomeDBi P50284.
TreeFami TF331157.

Miscellaneous databases

ChiTaRSi LTBR. mouse.
NextBioi 291108.
PROi P50284.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50284.
Bgeei P50284.
CleanExi MM_LTBR.
Genevestigatori P50284.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PIRSFi PIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSi PR01920. TNFACTORR3.
SMARTi SM00208. TNFR. 3 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression."
    Force W.R., Walter B.N., Hession C., Tizard R., Kozak C.A., Browning J.L., Ware C.F.
    J. Immunol. 155:5280-5288(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CVB.
    Tissue: Lung.
  2. "The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping."
    Nakamura T., Tashiro K., Nazarea M., Nakano T., Sasayama S., Honjo T.
    Genomics 30:312-319(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
    Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K.
    J. Biol. Chem. 271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF5.
    Strain: BALB/c.

Entry informationi

Entry nameiTNR3_MOUSE
AccessioniPrimary (citable) accession number: P50284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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