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P50284 (TNR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 3
Alternative name(s):
Lymphotoxin-beta receptor
Gene names
Name:Ltbr
Synonyms:Tnfcr, Tnfrsf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs By similarity.

Subunit structure

Self-associates By similarity. Associates with TRAF5. Associates with TRAF3 and TRAF4 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 4 TNFR-Cys repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 415385Tumor necrosis factor receptor superfamily member 3
PRO_0000034553

Regions

Topological domain31 – 223193Extracellular Potential
Transmembrane224 – 24421Helical; Potential
Topological domain245 – 415171Cytoplasmic Potential
Repeat42 – 8140TNFR-Cys 1
Repeat82 – 12443TNFR-Cys 2
Repeat125 – 17046TNFR-Cys 3
Repeat171 – 21343TNFR-Cys 4

Amino acid modifications

Modified residue3151Phosphoserine By similarity
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 58 By similarity
Disulfide bond59 ↔ 72 By similarity
Disulfide bond62 ↔ 80 By similarity
Disulfide bond83 ↔ 98 By similarity
Disulfide bond101 ↔ 116 By similarity
Disulfide bond104 ↔ 124 By similarity
Disulfide bond126 ↔ 132 By similarity
Disulfide bond139 ↔ 150 By similarity
Disulfide bond142 ↔ 169 By similarity
Disulfide bond172 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50284 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 29B326A566AEF661

FASTA41544,956
        10         20         30         40         50         60 
MRLPRASSPC GLAWGPLLLG LSGLLVASQP QLVPPYRIEN QTCWDQDKEY YEPMHDVCCS 

        70         80         90        100        110        120 
RCPPGEFVFA VCSRSQDTVC KTCPHNSYNE HWNHLSTCQL CRPCDIVLGF EEVAPCTSDR 

       130        140        150        160        170        180 
KAECRCQPGM SCVYLDNECV HCEEERLVLC QPGTEAEVTD EIMDTDVNCV PCKPGHFQNT 

       190        200        210        220        230        240 
SSPRARCQPH TRCEIQGLVE AAPGTSYSDT ICKNPPEPGA MLLLAILLSL VLFLLFTTVL 

       250        260        270        280        290        300 
ACAWMRHPSL CRKLGTLLKR HPEGEESPPC PAPRADPHFP DLAEPLLPMS GDLSPSPAGP 

       310        320        330        340        350        360 
PTAPSLEEVV LQQQSPLVQA RELEAEPGEH GQVAHGANGI HVTGGSVTVT GNIYIYNGPV 

       370        380        390        400        410 
LGGTRGPGDP PAPPEPPYPT PEEGAPGPSE LSTPYQEDGK AWHLAETETL GCQDL 

« Hide

References

[1]"Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression."
Force W.R., Walter B.N., Hession C., Tizard R., Kozak C.A., Browning J.L., Ware C.F.
J. Immunol. 155:5280-5288(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CVB.
Tissue: Lung.
[2]"The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping."
Nakamura T., Tashiro K., Nazarea M., Nakano T., Sasayama S., Honjo T.
Genomics 30:312-319(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K.
J. Biol. Chem. 271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRAF5.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29173 mRNA. Translation: AAA68964.1.
L38423 mRNA. Translation: AAB00846.1.
U30798 Genomic DNA. Translation: AAA81334.1.
CCDSCCDS20549.1.
RefSeqNP_034866.1. NM_010736.3.
UniGeneMm.3122.

3D structure databases

ProteinModelPortalP50284.
SMRP50284. Positions 43-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201222. 5 interactions.
DIPDIP-49695N.
IntActP50284. 2 interactions.
MINTMINT-4138161.

PTM databases

PhosphoSiteP50284.

Proteomic databases

PaxDbP50284.
PRIDEP50284.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032489; ENSMUSP00000032489; ENSMUSG00000030339.
GeneID17000.
KEGGmmu:17000.
UCSCuc009duj.1. mouse.

Organism-specific databases

CTD4055.
MGIMGI:104875. Ltbr.

Phylogenomic databases

eggNOGNOG38845.
GeneTreeENSGT00740000115372.
HOGENOMHOG000294180.
HOVERGENHBG023187.
InParanoidP50284.
KOK03159.
OMATVTGNIY.
OrthoDBEOG786H2Q.
PhylomeDBP50284.
TreeFamTF331157.

Gene expression databases

ArrayExpressP50284.
BgeeP50284.
CleanExMM_LTBR.
GenevestigatorP50284.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR017349. TNFR_3_LTBR.
[Graphical view]
PfamPF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFPIRSF037999. TNFR_3_LTBR. 1 hit.
PRINTSPR01920. TNFACTORR3.
SMARTSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLTBR. mouse.
NextBio291108.
PROP50284.
SOURCESearch...

Entry information

Entry nameTNR3_MOUSE
AccessionPrimary (citable) accession number: P50284
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot