ID   CD7_MOUSE               Reviewed;         210 AA.
AC   P50283;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 166.
DE   RecName: Full=T-cell antigen CD7;
DE   AltName: CD_antigen=CD7;
DE   Flags: Precursor;
GN   Name=Cd7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7678579; DOI=10.1007/bf00216834;
RA   Yoshikawa K., Seto M., Ueda R., Obata Y., Fukatsu H., Segawa A.,
RA   Takahashi T.;
RT   "Isolation and characterization of mouse CD7 cDNA.";
RL   Immunogenetics 37:114-119(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=7509775; DOI=10.1007/bf00188794;
RA   Lee D.M., Watson M.L., Seldin M.F.;
RT   "Mouse Cd7 maps to chromosome 11.";
RL   Immunogenetics 39:289-290(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
RC   STRAIN=BALB/cJ; TISSUE=Spleen;
RX   PubMed=7528728; DOI=10.1007/bf00182331;
RA   Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.;
RT   "Molecular cloning of the gene coding for the mouse T-cell antigen CD7.";
RL   Immunogenetics 41:159-161(1995).
RN   [4]
RP   INTERACTION WITH SECTM1.
RX   PubMed=10652336; DOI=10.1074/jbc.275.5.3431;
RA   Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.;
RT   "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.";
RL   J. Biol. Chem. 275:3431-3437(2000).
CC   -!- FUNCTION: Not yet known.
CC   -!- SUBUNIT: Interacts with SECTM1. {ECO:0000269|PubMed:10652336}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; D10329; BAA01171.1; -; mRNA.
DR   EMBL; U23462; AAB17482.1; -; Genomic_DNA.
DR   EMBL; D31956; BAA06728.1; -; Genomic_DNA.
DR   CCDS; CCDS25764.1; -.
DR   PIR; I49294; I49294.
DR   RefSeq; NP_033984.1; NM_009854.2.
DR   AlphaFoldDB; P50283; -.
DR   SMR; P50283; -.
DR   BioGRID; 198609; 1.
DR   STRING; 10090.ENSMUSP00000026159; -.
DR   GlyCosmos; P50283; 3 sites, No reported glycans.
DR   GlyGen; P50283; 3 sites.
DR   iPTMnet; P50283; -.
DR   PhosphoSitePlus; P50283; -.
DR   PaxDb; 10090-ENSMUSP00000026159; -.
DR   ProteomicsDB; 265627; -.
DR   ABCD; P50283; 17 sequenced antibodies.
DR   Antibodypedia; 3610; 2219 antibodies from 54 providers.
DR   DNASU; 12516; -.
DR   Ensembl; ENSMUST00000026159.6; ENSMUSP00000026159.6; ENSMUSG00000025163.7.
DR   GeneID; 12516; -.
DR   KEGG; mmu:12516; -.
DR   UCSC; uc007mvc.2; mouse.
DR   AGR; MGI:88344; -.
DR   CTD; 924; -.
DR   MGI; MGI:88344; Cd7.
DR   VEuPathDB; HostDB:ENSMUSG00000025163; -.
DR   eggNOG; ENOG502SD5I; Eukaryota.
DR   GeneTree; ENSGT00390000013965; -.
DR   HOGENOM; CLU_115462_0_0_1; -.
DR   InParanoid; P50283; -.
DR   OMA; SACVVYE; -.
DR   OrthoDB; 5321775at2759; -.
DR   PhylomeDB; P50283; -.
DR   TreeFam; TF338565; -.
DR   BioGRID-ORCS; 12516; 3 hits in 80 CRISPR screens.
DR   PRO; PR:P50283; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P50283; Protein.
DR   Bgee; ENSMUSG00000025163; Expressed in animal zygote and 53 other cell types or tissues.
DR   ExpressionAtlas; P50283; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR039090; CD7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR15343; CD7; 1.
DR   PANTHER; PTHR15343:SF0; T-CELL ANTIGEN CD7; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   Genevisible; P50283; MM.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Disulfide bond; Glycoprotein; Immunity;
KW   Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..210
FT                   /note="T-cell antigen CD7"
FT                   /id="PRO_0000014634"
FT   TOPO_DOM        24..150
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..210
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..129
FT                   /note="Ig-like"
FT   LIPID           168
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        45..111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   CONFLICT        69
FT                   /note="F -> L (in Ref. 2; AAB17482)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  23153 MW;  0EBD496B8302962B CRC64;
     MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH LEGILMKKIW
     PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS LQLADTGDYT CEAVRKVSAR
     GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC
     ASGIKESPCV VYEDMSYSNR KTPCIPNQYQ
//