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P50283

- CD7_MOUSE

UniProt

P50283 - CD7_MOUSE

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Protein

T-cell antigen CD7

Gene
Cd7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

  1. homeostasis of number of cells within a tissue Source: MGI
  2. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell antigen CD7
Alternative name(s):
CD_antigen: CD7
Gene namesi
Name:Cd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:88344. Cd7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 150127Extracellular Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Topological domaini172 – 21039Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 210187T-cell antigen CD7PRO_0000014634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi45 ↔ 111 Reviewed prediction
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Lipidationi168 – 1681S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP50283.

PTM databases

PhosphoSiteiP50283.

Expressioni

Gene expression databases

ArrayExpressiP50283.
BgeeiP50283.
CleanExiMM_CD7.
GenevestigatoriP50283.

Interactioni

Subunit structurei

Interacts with SECTM1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP50283.
SMRiP50283. Positions 28-112.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 129106Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43963.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP50283.
KOiK06457.
OMAiYEDMSHS.
OrthoDBiEOG7M0NSW.
PhylomeDBiP50283.
TreeFamiTF338565.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50283-1 [UniParc]FASTAAdd to Basket

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MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH    50
LEGILMKKIW PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS 100
LQLADTGDYT CEAVRKVSAR GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP 150
AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC ASGIKESPCV VYEDMSYSNR 200
KTPCIPNQYQ 210
Length:210
Mass (Da):23,153
Last modified:October 1, 1996 - v1
Checksum:i0EBD496B8302962B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691F → L in AAB17482. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10329 mRNA. Translation: BAA01171.1.
U23462 Genomic DNA. Translation: AAB17482.1.
D31956 Genomic DNA. Translation: BAA06728.1.
CCDSiCCDS25764.1.
PIRiI49294.
RefSeqiNP_033984.1. NM_009854.2.
UniGeneiMm.4100.

Genome annotation databases

EnsembliENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
GeneIDi12516.
KEGGimmu:12516.
UCSCiuc007mvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10329 mRNA. Translation: BAA01171.1 .
U23462 Genomic DNA. Translation: AAB17482.1 .
D31956 Genomic DNA. Translation: BAA06728.1 .
CCDSi CCDS25764.1.
PIRi I49294.
RefSeqi NP_033984.1. NM_009854.2.
UniGenei Mm.4100.

3D structure databases

ProteinModelPortali P50283.
SMRi P50283. Positions 28-112.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P50283.

Proteomic databases

PRIDEi P50283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026159 ; ENSMUSP00000026159 ; ENSMUSG00000025163 .
GeneIDi 12516.
KEGGi mmu:12516.
UCSCi uc007mvc.2. mouse.

Organism-specific databases

CTDi 924.
MGIi MGI:88344. Cd7.

Phylogenomic databases

eggNOGi NOG43963.
HOGENOMi HOG000285979.
HOVERGENi HBG005290.
InParanoidi P50283.
KOi K06457.
OMAi YEDMSHS.
OrthoDBi EOG7M0NSW.
PhylomeDBi P50283.
TreeFami TF338565.

Miscellaneous databases

NextBioi 281510.
PROi P50283.
SOURCEi Search...

Gene expression databases

ArrayExpressi P50283.
Bgeei P50283.
CleanExi MM_CD7.
Genevestigatori P50283.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "Molecular cloning of the gene coding for the mouse T-cell antigen CD7."
    Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.
    Immunogenetics 41:159-161(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
    Strain: BALB/c.
    Tissue: Spleen.
  4. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
    Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
    J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SECTM1.

Entry informationi

Entry nameiCD7_MOUSE
AccessioniPrimary (citable) accession number: P50283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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