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P50283 (CD7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell antigen CD7
Alternative name(s):
CD_antigen=CD7
Gene names
Name:Cd7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not yet known.

Subunit structure

Interacts with SECTM1. Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 210187T-cell antigen CD7
PRO_0000014634

Regions

Topological domain24 – 150127Extracellular Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 21039Cytoplasmic Potential
Domain24 – 129106Ig-like

Amino acid modifications

Lipidation1681S-palmitoyl cysteine By similarity
Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential
Disulfide bond45 ↔ 111 Potential

Experimental info

Sequence conflict691F → L in AAB17482. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50283 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0EBD496B8302962B

FASTA21023,153
        10         20         30         40         50         60 
MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH LEGILMKKIW 

        70         80         90        100        110        120 
PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS LQLADTGDYT CEAVRKVSAR 

       130        140        150        160        170        180 
GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC 

       190        200        210 
ASGIKESPCV VYEDMSYSNR KTPCIPNQYQ 

« Hide

References

[1]"Isolation and characterization of mouse CD7 cDNA."
Yoshikawa K., Seto M., Ueda R., Obata Y., Fukatsu H., Segawa A., Takahashi T.
Immunogenetics 37:114-119(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Mouse Cd7 maps to chromosome 11."
Lee D.M., Watson M.L., Seldin M.F.
Immunogenetics 39:289-290(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[3]"Molecular cloning of the gene coding for the mouse T-cell antigen CD7."
Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.
Immunogenetics 41:159-161(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
Strain: BALB/c.
Tissue: Spleen.
[4]"Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SECTM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10329 mRNA. Translation: BAA01171.1.
U23462 Genomic DNA. Translation: AAB17482.1.
D31956 Genomic DNA. Translation: BAA06728.1.
CCDSCCDS25764.1.
PIRI49294.
RefSeqNP_033984.1. NM_009854.2.
UniGeneMm.4100.

3D structure databases

ProteinModelPortalP50283.
SMRP50283. Positions 28-112.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP50283.

Proteomic databases

PRIDEP50283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
GeneID12516.
KEGGmmu:12516.
UCSCuc007mvc.2. mouse.

Organism-specific databases

CTD924.
MGIMGI:88344. Cd7.

Phylogenomic databases

eggNOGNOG43963.
HOGENOMHOG000285979.
HOVERGENHBG005290.
InParanoidP50283.
KOK06457.
OMAYEDMSHS.
OrthoDBEOG7M0NSW.
PhylomeDBP50283.
TreeFamTF338565.

Gene expression databases

ArrayExpressP50283.
BgeeP50283.
CleanExMM_CD7.
GenevestigatorP50283.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281510.
PROP50283.
SOURCESearch...

Entry information

Entry nameCD7_MOUSE
AccessionPrimary (citable) accession number: P50283
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot