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Protein

T-cell antigen CD7

Gene

Cd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • homeostasis of number of cells within a tissue Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell antigen CD7
Alternative name(s):
CD_antigen: CD7
Gene namesi
Name:Cd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88344. Cd7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 150ExtracellularSequence analysisAdd BLAST127
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 210CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001463424 – 210T-cell antigen CD7Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi45 ↔ 111PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Lipidationi168S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP50283.
PRIDEiP50283.

PTM databases

iPTMnetiP50283.
PhosphoSitePlusiP50283.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025163.
CleanExiMM_CD7.
ExpressionAtlasiP50283. baseline and differential.
GenevisibleiP50283. MM.

Interactioni

Subunit structurei

Interacts with SECTM1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026159.

Structurei

3D structure databases

ProteinModelPortaliP50283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 129Ig-likeAdd BLAST106

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYNZ. Eukaryota.
ENOG41117EQ. LUCA.
GeneTreeiENSGT00390000013965.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP50283.
KOiK06457.
OMAiYEDMSHS.
OrthoDBiEOG091G0Q1Y.
PhylomeDBiP50283.
TreeFamiTF338565.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH
60 70 80 90 100
LEGILMKKIW PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS
110 120 130 140 150
LQLADTGDYT CEAVRKVSAR GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP
160 170 180 190 200
AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC ASGIKESPCV VYEDMSYSNR
210
KTPCIPNQYQ
Length:210
Mass (Da):23,153
Last modified:October 1, 1996 - v1
Checksum:i0EBD496B8302962B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → L in AAB17482 (PubMed:7509775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10329 mRNA. Translation: BAA01171.1.
U23462 Genomic DNA. Translation: AAB17482.1.
D31956 Genomic DNA. Translation: BAA06728.1.
CCDSiCCDS25764.1.
PIRiI49294.
RefSeqiNP_033984.1. NM_009854.2.
UniGeneiMm.4100.

Genome annotation databases

EnsembliENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
GeneIDi12516.
KEGGimmu:12516.
UCSCiuc007mvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10329 mRNA. Translation: BAA01171.1.
U23462 Genomic DNA. Translation: AAB17482.1.
D31956 Genomic DNA. Translation: BAA06728.1.
CCDSiCCDS25764.1.
PIRiI49294.
RefSeqiNP_033984.1. NM_009854.2.
UniGeneiMm.4100.

3D structure databases

ProteinModelPortaliP50283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026159.

PTM databases

iPTMnetiP50283.
PhosphoSitePlusiP50283.

Proteomic databases

PaxDbiP50283.
PRIDEiP50283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
GeneIDi12516.
KEGGimmu:12516.
UCSCiuc007mvc.2. mouse.

Organism-specific databases

CTDi924.
MGIiMGI:88344. Cd7.

Phylogenomic databases

eggNOGiENOG410IYNZ. Eukaryota.
ENOG41117EQ. LUCA.
GeneTreeiENSGT00390000013965.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP50283.
KOiK06457.
OMAiYEDMSHS.
OrthoDBiEOG091G0Q1Y.
PhylomeDBiP50283.
TreeFamiTF338565.

Miscellaneous databases

PROiP50283.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025163.
CleanExiMM_CD7.
ExpressionAtlasiP50283. baseline and differential.
GenevisibleiP50283. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD7_MOUSE
AccessioniPrimary (citable) accession number: P50283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.