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P50283

- CD7_MOUSE

UniProt

P50283 - CD7_MOUSE

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Protein

T-cell antigen CD7

Gene

Cd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Not yet known.

GO - Biological processi

  1. homeostasis of number of cells within a tissue Source: MGI
  2. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell antigen CD7
Alternative name(s):
CD_antigen: CD7
Gene namesi
Name:Cd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:88344. Cd7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 150127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 21039CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 210187T-cell antigen CD7PRO_0000014634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi45 ↔ 111PROSITE-ProRule annotation
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Lipidationi168 – 1681S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP50283.

PTM databases

PhosphoSiteiP50283.

Expressioni

Gene expression databases

BgeeiP50283.
CleanExiMM_CD7.
ExpressionAtlasiP50283. baseline and differential.
GenevestigatoriP50283.

Interactioni

Subunit structurei

Interacts with SECTM1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP50283.
SMRiP50283. Positions 28-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 129106Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43963.
HOGENOMiHOG000285979.
HOVERGENiHBG005290.
InParanoidiP50283.
KOiK06457.
OMAiYEDMSHS.
OrthoDBiEOG7M0NSW.
PhylomeDBiP50283.
TreeFamiTF338565.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH
60 70 80 90 100
LEGILMKKIW PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS
110 120 130 140 150
LQLADTGDYT CEAVRKVSAR GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP
160 170 180 190 200
AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC ASGIKESPCV VYEDMSYSNR
210
KTPCIPNQYQ
Length:210
Mass (Da):23,153
Last modified:October 1, 1996 - v1
Checksum:i0EBD496B8302962B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691F → L in AAB17482. (PubMed:7509775)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10329 mRNA. Translation: BAA01171.1.
U23462 Genomic DNA. Translation: AAB17482.1.
D31956 Genomic DNA. Translation: BAA06728.1.
CCDSiCCDS25764.1.
PIRiI49294.
RefSeqiNP_033984.1. NM_009854.2.
UniGeneiMm.4100.

Genome annotation databases

EnsembliENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
GeneIDi12516.
KEGGimmu:12516.
UCSCiuc007mvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10329 mRNA. Translation: BAA01171.1 .
U23462 Genomic DNA. Translation: AAB17482.1 .
D31956 Genomic DNA. Translation: BAA06728.1 .
CCDSi CCDS25764.1.
PIRi I49294.
RefSeqi NP_033984.1. NM_009854.2.
UniGenei Mm.4100.

3D structure databases

ProteinModelPortali P50283.
SMRi P50283. Positions 28-112.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P50283.

Proteomic databases

PRIDEi P50283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026159 ; ENSMUSP00000026159 ; ENSMUSG00000025163 .
GeneIDi 12516.
KEGGi mmu:12516.
UCSCi uc007mvc.2. mouse.

Organism-specific databases

CTDi 924.
MGIi MGI:88344. Cd7.

Phylogenomic databases

eggNOGi NOG43963.
HOGENOMi HOG000285979.
HOVERGENi HBG005290.
InParanoidi P50283.
KOi K06457.
OMAi YEDMSHS.
OrthoDBi EOG7M0NSW.
PhylomeDBi P50283.
TreeFami TF338565.

Miscellaneous databases

NextBioi 281510.
PROi P50283.
SOURCEi Search...

Gene expression databases

Bgeei P50283.
CleanExi MM_CD7.
ExpressionAtlasi P50283. baseline and differential.
Genevestigatori P50283.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "Molecular cloning of the gene coding for the mouse T-cell antigen CD7."
    Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.
    Immunogenetics 41:159-161(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
    Strain: BALB/c.
    Tissue: Spleen.
  4. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
    Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
    J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SECTM1.

Entry informationi

Entry nameiCD7_MOUSE
AccessioniPrimary (citable) accession number: P50283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3