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P50283

- CD7_MOUSE

UniProt

P50283 - CD7_MOUSE

Protein

T-cell antigen CD7

Gene

Cd7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Not yet known.

    GO - Biological processi

    1. homeostasis of number of cells within a tissue Source: MGI
    2. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell antigen CD7
    Alternative name(s):
    CD_antigen: CD7
    Gene namesi
    Name:Cd7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:88344. Cd7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 210187T-cell antigen CD7PRO_0000014634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi45 ↔ 111PROSITE-ProRule annotation
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Lipidationi168 – 1681S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP50283.

    PTM databases

    PhosphoSiteiP50283.

    Expressioni

    Gene expression databases

    ArrayExpressiP50283.
    BgeeiP50283.
    CleanExiMM_CD7.
    GenevestigatoriP50283.

    Interactioni

    Subunit structurei

    Interacts with SECTM1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP50283.
    SMRiP50283. Positions 28-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 150127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini172 – 21039CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 129106Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43963.
    HOGENOMiHOG000285979.
    HOVERGENiHBG005290.
    InParanoidiP50283.
    KOiK06457.
    OMAiYEDMSHS.
    OrthoDBiEOG7M0NSW.
    PhylomeDBiP50283.
    TreeFamiTF338565.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50283-1 [UniParc]FASTAAdd to Basket

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    MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH    50
    LEGILMKKIW PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS 100
    LQLADTGDYT CEAVRKVSAR GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP 150
    AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC ASGIKESPCV VYEDMSYSNR 200
    KTPCIPNQYQ 210
    Length:210
    Mass (Da):23,153
    Last modified:October 1, 1996 - v1
    Checksum:i0EBD496B8302962B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691F → L in AAB17482. (PubMed:7509775)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10329 mRNA. Translation: BAA01171.1.
    U23462 Genomic DNA. Translation: AAB17482.1.
    D31956 Genomic DNA. Translation: BAA06728.1.
    CCDSiCCDS25764.1.
    PIRiI49294.
    RefSeqiNP_033984.1. NM_009854.2.
    UniGeneiMm.4100.

    Genome annotation databases

    EnsembliENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
    GeneIDi12516.
    KEGGimmu:12516.
    UCSCiuc007mvc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10329 mRNA. Translation: BAA01171.1 .
    U23462 Genomic DNA. Translation: AAB17482.1 .
    D31956 Genomic DNA. Translation: BAA06728.1 .
    CCDSi CCDS25764.1.
    PIRi I49294.
    RefSeqi NP_033984.1. NM_009854.2.
    UniGenei Mm.4100.

    3D structure databases

    ProteinModelPortali P50283.
    SMRi P50283. Positions 28-112.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P50283.

    Proteomic databases

    PRIDEi P50283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026159 ; ENSMUSP00000026159 ; ENSMUSG00000025163 .
    GeneIDi 12516.
    KEGGi mmu:12516.
    UCSCi uc007mvc.2. mouse.

    Organism-specific databases

    CTDi 924.
    MGIi MGI:88344. Cd7.

    Phylogenomic databases

    eggNOGi NOG43963.
    HOGENOMi HOG000285979.
    HOVERGENi HBG005290.
    InParanoidi P50283.
    KOi K06457.
    OMAi YEDMSHS.
    OrthoDBi EOG7M0NSW.
    PhylomeDBi P50283.
    TreeFami TF338565.

    Miscellaneous databases

    NextBioi 281510.
    PROi P50283.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50283.
    Bgeei P50283.
    CleanExi MM_CD7.
    Genevestigatori P50283.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "Molecular cloning of the gene coding for the mouse T-cell antigen CD7."
      Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.
      Immunogenetics 41:159-161(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
      Strain: BALB/c.
      Tissue: Spleen.
    4. "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."
      Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.
      J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SECTM1.

    Entry informationi

    Entry nameiCD7_MOUSE
    AccessioniPrimary (citable) accession number: P50283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3