ID STX2_RAT Reviewed; 290 AA. AC P50279; Q08846; Q08847; Q08848; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 24-JAN-2024, entry version 155. DE RecName: Full=Syntaxin-2; DE AltName: Full=Epimorphin; GN Name=Stx2; Synonyms=Epim; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2B AND 2C). RX PubMed=7690687; DOI=10.1016/0092-8674(93)90466-4; RA Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K.E., RA Fleming A.M., Hazuka C.D., Scheller R.H.; RT "The syntaxin family of vesicular transport receptors."; RL Cell 74:863-873(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-290. RC STRAIN=Sprague-Dawley; TISSUE=Liver; RX PubMed=8938452; DOI=10.1006/geno.1996.0574; RA Zha H., Remmers E.F., Szpirer C., Szpirer J., Zhang H., Kozak C.A., RA Wilder R.L.; RT "The epimorphin gene is highly conserved among humans, mice, and rats and RT maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12."; RL Genomics 37:386-389(1996). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22673903; DOI=10.1038/ncomms1871; RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., RA Olsen J.V.; RT "Quantitative maps of protein phosphorylation sites across 14 different rat RT organs and tissues."; RL Nat. Commun. 3:876-876(2012). CC -!- FUNCTION: Essential for epithelial morphogenesis. May mediate Ca(2+)- CC regulation of exocytosis acrosomal reaction in sperm. CC -!- SUBUNIT: Interacts with SYT6 and SYT8; the interaction is Ca(2+)- CC dependent. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Comment=Additional isoforms seem to exist.; CC Name=2A; CC IsoId=P50279-1; Sequence=Displayed; CC Name=2B; Synonyms=2'; CC IsoId=P50279-2; Sequence=VSP_006336; CC Name=2C; Synonyms=2''; CC IsoId=P50279-3; Sequence=VSP_006337; CC -!- TISSUE SPECIFICITY: Heart, spleen, liver, and testis. CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L20823; AAA03044.1; -; mRNA. DR EMBL; L20889; AAA03049.1; -; mRNA. DR EMBL; L20888; AAA03048.1; -; mRNA. DR EMBL; AH006759; AAC52908.1; -; Genomic_DNA. DR PIR; C48213; C48213. DR RefSeq; NP_036880.1; NM_012748.1. DR RefSeq; XP_006249312.1; XM_006249250.3. DR AlphaFoldDB; P50279; -. DR SMR; P50279; -. DR BioGRID; 247200; 3. DR CORUM; P50279; -. DR DIP; DIP-347N; -. DR STRING; 10116.ENSRNOP00000001242; -. DR iPTMnet; P50279; -. DR PhosphoSitePlus; P50279; -. DR PaxDb; 10116-ENSRNOP00000001242; -. DR Ensembl; ENSRNOT00000099417.1; ENSRNOP00000085955.1; ENSRNOG00000000936.7. [P50279-2] DR GeneID; 25130; -. DR KEGG; rno:25130; -. DR UCSC; RGD:2558; rat. [P50279-1] DR AGR; RGD:2558; -. DR CTD; 2054; -. DR RGD; 2558; Stx2. DR eggNOG; KOG0810; Eukaryota. DR GeneTree; ENSGT01030000234627; -. DR HOGENOM; CLU_042423_2_2_1; -. DR InParanoid; P50279; -. DR OrthoDB; 2876074at2759; -. DR PhylomeDB; P50279; -. DR PRO; PR:P50279; -. DR Proteomes; UP000002494; Chromosome 12. DR GO; GO:0016323; C:basolateral plasma membrane; ISO:RGD. DR GO; GO:0009986; C:cell surface; ISO:RGD. DR GO; GO:0005911; C:cell-cell junction; ISO:RGD. DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD. DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; ISO:RGD. DR GO; GO:0030027; C:lamellipodium; ISO:RGD. DR GO; GO:0045121; C:membrane raft; ISO:RGD. DR GO; GO:0030496; C:midbody; IDA:RGD. DR GO; GO:0005886; C:plasma membrane; ISO:RGD. DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central. DR GO; GO:0032991; C:protein-containing complex; ISO:RGD. DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central. DR GO; GO:0045202; C:synapse; IDA:SynGO. DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central. DR GO; GO:0048306; F:calcium-dependent protein binding; ISO:RGD. DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central. DR GO; GO:0000149; F:SNARE binding; IMP:RGD. DR GO; GO:0005198; F:structural molecule activity; ISO:RGD. DR GO; GO:0007340; P:acrosome reaction; ISO:RGD. DR GO; GO:0030154; P:cell differentiation; ISO:RGD. DR GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD. DR GO; GO:1903575; P:cornified envelope assembly; ISO:RGD. DR GO; GO:0048546; P:digestive tract morphogenesis; IMP:RGD. DR GO; GO:0030855; P:epithelial cell differentiation; IMP:RGD. DR GO; GO:0006887; P:exocytosis; IBA:GO_Central. DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central. DR GO; GO:0046907; P:intracellular transport; TAS:RGD. DR GO; GO:0030033; P:microvillus assembly; IDA:RGD. DR GO; GO:0061952; P:midbody abscission; IMP:CACAO. DR GO; GO:0000281; P:mitotic cytokinesis; IMP:CACAO. DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central. DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central. DR GO; GO:0006906; P:vesicle fusion; TAS:RGD. DR GO; GO:0006903; P:vesicle targeting; TAS:RGD. DR GO; GO:0016192; P:vesicle-mediated transport; TAS:RGD. DR CDD; cd15882; SNARE_syntaxin2; 1. DR CDD; cd00179; SynN; 1. DR Gene3D; 1.20.5.110; -; 1. DR Gene3D; 1.20.58.70; -; 1. DR InterPro; IPR010989; SNARE. DR InterPro; IPR028671; STX2_SNARE. DR InterPro; IPR045242; Syntaxin. DR InterPro; IPR006012; Syntaxin/epimorphin_CS. DR InterPro; IPR006011; Syntaxin_N. DR InterPro; IPR000727; T_SNARE_dom. DR PANTHER; PTHR19957; SYNTAXIN; 1. DR PANTHER; PTHR19957:SF36; SYNTAXIN-2; 1. DR Pfam; PF05739; SNARE; 1. DR Pfam; PF00804; Syntaxin; 1. DR SMART; SM00503; SynN; 1. DR SMART; SM00397; t_SNARE; 1. DR SUPFAM; SSF47661; t-snare proteins; 1. DR PROSITE; PS00914; SYNTAXIN; 1. DR PROSITE; PS50192; T_SNARE; 1. DR Genevisible; P50279; RN. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Membrane; Phosphoprotein; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..290 FT /note="Syntaxin-2" FT /id="PRO_0000210198" FT TOPO_DOM 1..266 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 267..290 FT /note="Helical; Anchor for type IV membrane protein" FT /evidence="ECO:0000255" FT DOMAIN 193..255 FT /note="t-SNARE coiled-coil homology" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202" FT COILED 69..106 FT /evidence="ECO:0000255" FT MOD_RES 14 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:22673903" FT VAR_SEQ 265..290 FT /note="KKWIIAAVVVAVIAVLALIIGLTVGK -> KVMFVLICVVTLLVILGIILAT FT ALS (in isoform 2B)" FT /evidence="ECO:0000303|PubMed:7690687" FT /id="VSP_006336" FT VAR_SEQ 265..290 FT /note="KKWIIAAVVVAVIAVLALIIGLTVGK -> GVLCALGRQC (in isoform FT 2C)" FT /evidence="ECO:0000303|PubMed:7690687" FT /id="VSP_006337" FT CONFLICT 146 FT /note="S -> R (in Ref. 2; AAC52908)" FT /evidence="ECO:0000305" FT CONFLICT 287 FT /note="T -> S (in Ref. 2; AAC52908)" FT /evidence="ECO:0000305" SQ SEQUENCE 290 AA; 33359 MW; 37FBAD7ADFDA3841 CRC64; MRDRLPDLTA CRKSDDGDNA VIITVEKDHF MDAFFHQVEE IRSSIARIAQ HVEDVKKNHS IILSAPNPEG KIKEELEDLN KEIKKTANRI RGKLKAIEQS CDQDENGNRT SVDLRIRRTQ HSVLSRKFVD VMTEYNEAQI LFRERSKGRI QRQLEITGRT TTDEELEEML ESGKPSIFIS DIISDSQITR QALNEIESRH KDIMKLETSI RELHEMFMDM AMFVETQGEM VNNIERNVVN SVDYVEHAKE ETKKAIKYQS KARRKKWIIA AVVVAVIAVL ALIIGLTVGK //