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P50279 (STX2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene names
Name:Stx2
Synonyms:Epim
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

Subunit structure

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.

Subcellular location

Membrane; Single-pass type IV membrane protein.

Tissue specificity

Heart, spleen, liver, and testis.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 2A (identifier: P50279-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2B (identifier: P50279-2)

Also known as: 2';

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → KVMFVLICVVTLLVILGIILATALS
Isoform 2C (identifier: P50279-3)

Also known as: 2'';

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → GVLCALGRQC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Syntaxin-2
PRO_0000210198

Regions

Topological domain1 – 266266Cytoplasmic Potential
Transmembrane267 – 29024Helical; Anchor for type IV membrane protein; Potential
Domain193 – 25563t-SNARE coiled-coil homology
Coiled coil69 – 10638 Potential

Natural variations

Alternative sequence265 – 29026KKWII…LTVGK → KVMFVLICVVTLLVILGIIL ATALS in isoform 2B.
VSP_006336
Alternative sequence265 – 29026KKWII…LTVGK → GVLCALGRQC in isoform 2C.
VSP_006337

Experimental info

Sequence conflict1461S → R in AAC52908. Ref.2
Sequence conflict2871T → S in AAC52908. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 2A [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 37FBAD7ADFDA3841

FASTA29033,359
        10         20         30         40         50         60 
MRDRLPDLTA CRKSDDGDNA VIITVEKDHF MDAFFHQVEE IRSSIARIAQ HVEDVKKNHS 

        70         80         90        100        110        120 
IILSAPNPEG KIKEELEDLN KEIKKTANRI RGKLKAIEQS CDQDENGNRT SVDLRIRRTQ 

       130        140        150        160        170        180 
HSVLSRKFVD VMTEYNEAQI LFRERSKGRI QRQLEITGRT TTDEELEEML ESGKPSIFIS 

       190        200        210        220        230        240 
DIISDSQITR QALNEIESRH KDIMKLETSI RELHEMFMDM AMFVETQGEM VNNIERNVVN 

       250        260        270        280        290 
SVDYVEHAKE ETKKAIKYQS KARRKKWIIA AVVVAVIAVL ALIIGLTVGK

« Hide

Isoform 2B (2') [UniParc].

Checksum: EB30916B2B85C873
Show »

FASTA28933,343
Isoform 2C (2'') [UniParc].

Checksum: 1EB45C5B567EFA83
Show »

FASTA27431,719

References

[1]"The syntaxin family of vesicular transport receptors."
Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K.E., Fleming A.M., Hazuka C.D., Scheller R.H.
Cell 74:863-873(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2B AND 2C).
[2]"The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12."
Zha H., Remmers E.F., Szpirer C., Szpirer J., Zhang H., Kozak C.A., Wilder R.L.
Genomics 37:386-389(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-290.
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L20823 mRNA. Translation: AAA03044.1.
L20889 mRNA. Translation: AAA03049.1.
L20888 mRNA. Translation: AAA03048.1.
AH006759 Genomic DNA. Translation: AAC52908.1.
IPIIPI00196568.
IPI00231128.
IPI00231129.
PIRC48213.
RefSeqNP_036880.1. NM_012748.1.
UniGeneRn.10623.

3D structure databases

ProteinModelPortalP50279.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-347N.

PTM databases

PhosphoSiteP50279.

Proteomic databases

PRIDEP50279.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000037296; ENSRNOP00000036115; ENSRNOG00000000936.
ENSRNOT00000037306; ENSRNOP00000036551; ENSRNOG00000000936.
GeneID25130.
KEGGrno:25130.
UCSCRGD:2558. rat.

Organism-specific databases

CTD2054.
RGD2558. Stx2.

Phylogenomic databases

eggNOGCOG5074.
GeneTreeENSGT00550000074334.
HOGENOMHOG000286023.
HOVERGENHBG000497.
InParanoidP50279.
KOK08486.

Gene expression databases

ArrayExpressP50279.
GenevestigatorP50279.
GermOnlineENSRNOG00000000936. Rattus norvegicus.

Family and domain databases

InterProIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMSSF47661. t-snare. 1 hit.
PROSITEPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605537.

Entry information

Entry nameSTX2_RAT
AccessionPrimary (citable) accession number: P50279
Secondary accession number(s): Q08846, Q08847, Q08848
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: April 3, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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