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Protein

Syntaxin-2

Gene

Stx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: RGD

GO - Biological processi

  • acrosome reaction Source: InterPro
  • digestive tract morphogenesis Source: RGD
  • epithelial cell differentiation Source: RGD
  • exocytosis Source: GO_Central
  • intracellular protein transport Source: GO_Central
  • intracellular transport Source: RGD
  • microvillus assembly Source: RGD
  • synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: RGD
  • vesicle-mediated transport Source: RGD
  • vesicle targeting Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:Stx2
Synonyms:Epim
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2558. Stx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 266266CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei267 – 29024Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endomembrane system Source: GO_Central
  • integral component of membrane Source: RGD
  • midbody Source: RGD
  • plasma membrane Source: GO_Central
  • SNARE complex Source: GO_Central
  • synaptic vesicle Source: GO_Central
  • transport vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Syntaxin-2PRO_0000210198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP50279.

PTM databases

PhosphoSiteiP50279.

Expressioni

Tissue specificityi

Heart, spleen, liver, and testis.

Gene expression databases

ExpressionAtlasiP50279. baseline.
GenevisibleiP50279. RN.

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.

Protein-protein interaction databases

BioGridi247200. 3 interactions.
DIPiDIP-347N.
MINTiMINT-1509080.
STRINGi10116.ENSRNOP00000001242.

Structurei

3D structure databases

ProteinModelPortaliP50279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 25563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili69 – 10638Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP50279.
KOiK08486.
OrthoDBiEOG7X9G7R.
PhylomeDBiP50279.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 2A (identifier: P50279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRDRLPDLTA CRKSDDGDNA VIITVEKDHF MDAFFHQVEE IRSSIARIAQ
60 70 80 90 100
HVEDVKKNHS IILSAPNPEG KIKEELEDLN KEIKKTANRI RGKLKAIEQS
110 120 130 140 150
CDQDENGNRT SVDLRIRRTQ HSVLSRKFVD VMTEYNEAQI LFRERSKGRI
160 170 180 190 200
QRQLEITGRT TTDEELEEML ESGKPSIFIS DIISDSQITR QALNEIESRH
210 220 230 240 250
KDIMKLETSI RELHEMFMDM AMFVETQGEM VNNIERNVVN SVDYVEHAKE
260 270 280 290
ETKKAIKYQS KARRKKWIIA AVVVAVIAVL ALIIGLTVGK
Length:290
Mass (Da):33,359
Last modified:November 1, 1997 - v2
Checksum:i37FBAD7ADFDA3841
GO
Isoform 2B (identifier: P50279-2) [UniParc]FASTAAdd to basket

Also known as: 2'

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → KVMFVLICVVTLLVILGIILATALS

Show »
Length:289
Mass (Da):33,343
Checksum:iEB30916B2B85C873
GO
Isoform 2C (identifier: P50279-3) [UniParc]FASTAAdd to basket

Also known as: 2''

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → GVLCALGRQC

Show »
Length:274
Mass (Da):31,719
Checksum:i1EB45C5B567EFA83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461S → R in AAC52908 (PubMed:8938452).Curated
Sequence conflicti287 – 2871T → S in AAC52908 (PubMed:8938452).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei265 – 29026KKWII…LTVGK → KVMFVLICVVTLLVILGIIL ATALS in isoform 2B. 1 PublicationVSP_006336Add
BLAST
Alternative sequencei265 – 29026KKWII…LTVGK → GVLCALGRQC in isoform 2C. 1 PublicationVSP_006337Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20823 mRNA. Translation: AAA03044.1.
L20889 mRNA. Translation: AAA03049.1.
L20888 mRNA. Translation: AAA03048.1.
AH006759 Genomic DNA. Translation: AAC52908.1.
PIRiC48213.
RefSeqiNP_036880.1. NM_012748.1. [P50279-1]
XP_006249312.1. XM_006249250.2. [P50279-2]
UniGeneiRn.10623.

Genome annotation databases

GeneIDi25130.
KEGGirno:25130.
UCSCiRGD:2558. rat. [P50279-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20823 mRNA. Translation: AAA03044.1.
L20889 mRNA. Translation: AAA03049.1.
L20888 mRNA. Translation: AAA03048.1.
AH006759 Genomic DNA. Translation: AAC52908.1.
PIRiC48213.
RefSeqiNP_036880.1. NM_012748.1. [P50279-1]
XP_006249312.1. XM_006249250.2. [P50279-2]
UniGeneiRn.10623.

3D structure databases

ProteinModelPortaliP50279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247200. 3 interactions.
DIPiDIP-347N.
MINTiMINT-1509080.
STRINGi10116.ENSRNOP00000001242.

PTM databases

PhosphoSiteiP50279.

Proteomic databases

PRIDEiP50279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25130.
KEGGirno:25130.
UCSCiRGD:2558. rat. [P50279-1]

Organism-specific databases

CTDi2054.
RGDi2558. Stx2.

Phylogenomic databases

eggNOGiCOG5074.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiP50279.
KOiK08486.
OrthoDBiEOG7X9G7R.
PhylomeDBiP50279.

Miscellaneous databases

NextBioi605537.
PROiP50279.

Gene expression databases

ExpressionAtlasiP50279. baseline.
GenevisibleiP50279. RN.

Family and domain databases

InterProiIPR028671. STX2.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2B AND 2C).
  2. "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12."
    Zha H., Remmers E.F., Szpirer C., Szpirer J., Zhang H., Kozak C.A., Wilder R.L.
    Genomics 37:386-389(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-290.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiSTX2_RAT
AccessioniPrimary (citable) accession number: P50279
Secondary accession number(s): Q08846, Q08847, Q08848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.