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P50279

- STX2_RAT

UniProt

P50279 - STX2_RAT

Protein

Syntaxin-2

Gene

Stx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. SNARE binding Source: RGD

    GO - Biological processi

    1. acrosome reaction Source: InterPro
    2. digestive tract morphogenesis Source: RGD
    3. epithelial cell differentiation Source: RGD
    4. intracellular protein transport Source: InterPro
    5. intracellular transport Source: RGD
    6. microvillus assembly Source: RGD
    7. vesicle fusion Source: RGD
    8. vesicle-mediated transport Source: RGD
    9. vesicle targeting Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-2
    Alternative name(s):
    Epimorphin
    Gene namesi
    Name:Stx2
    Synonyms:Epim
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi2558. Stx2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. midbody Source: RGD
    3. transport vesicle Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Syntaxin-2PRO_0000210198Add
    BLAST

    Proteomic databases

    PRIDEiP50279.

    PTM databases

    PhosphoSiteiP50279.

    Expressioni

    Tissue specificityi

    Heart, spleen, liver, and testis.

    Gene expression databases

    GenevestigatoriP50279.

    Interactioni

    Subunit structurei

    Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.

    Protein-protein interaction databases

    BioGridi247200. 3 interactions.
    DIPiDIP-347N.
    MINTiMINT-1509080.

    Structurei

    3D structure databases

    ProteinModelPortaliP50279.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 266266CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei267 – 29024Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini193 – 25563t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili69 – 10638Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5074.
    GeneTreeiENSGT00730000110552.
    HOGENOMiHOG000286023.
    HOVERGENiHBG000497.
    InParanoidiP50279.
    KOiK08486.
    OrthoDBiEOG7X9G7R.
    PhylomeDBiP50279.

    Family and domain databases

    InterProiIPR028671. STX2.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR19957:SF36. PTHR19957:SF36. 1 hit.
    PfamiPF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view]
    SMARTiSM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.
    PROSITEiPS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 2A (identifier: P50279-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRDRLPDLTA CRKSDDGDNA VIITVEKDHF MDAFFHQVEE IRSSIARIAQ    50
    HVEDVKKNHS IILSAPNPEG KIKEELEDLN KEIKKTANRI RGKLKAIEQS 100
    CDQDENGNRT SVDLRIRRTQ HSVLSRKFVD VMTEYNEAQI LFRERSKGRI 150
    QRQLEITGRT TTDEELEEML ESGKPSIFIS DIISDSQITR QALNEIESRH 200
    KDIMKLETSI RELHEMFMDM AMFVETQGEM VNNIERNVVN SVDYVEHAKE 250
    ETKKAIKYQS KARRKKWIIA AVVVAVIAVL ALIIGLTVGK 290
    Length:290
    Mass (Da):33,359
    Last modified:November 1, 1997 - v2
    Checksum:i37FBAD7ADFDA3841
    GO
    Isoform 2B (identifier: P50279-2) [UniParc]FASTAAdd to Basket

    Also known as: 2'

    The sequence of this isoform differs from the canonical sequence as follows:
         265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → KVMFVLICVVTLLVILGIILATALS

    Show »
    Length:289
    Mass (Da):33,343
    Checksum:iEB30916B2B85C873
    GO
    Isoform 2C (identifier: P50279-3) [UniParc]FASTAAdd to Basket

    Also known as: 2''

    The sequence of this isoform differs from the canonical sequence as follows:
         265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → GVLCALGRQC

    Show »
    Length:274
    Mass (Da):31,719
    Checksum:i1EB45C5B567EFA83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461S → R in AAC52908. (PubMed:8938452)Curated
    Sequence conflicti287 – 2871T → S in AAC52908. (PubMed:8938452)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei265 – 29026KKWII…LTVGK → KVMFVLICVVTLLVILGIIL ATALS in isoform 2B. 1 PublicationVSP_006336Add
    BLAST
    Alternative sequencei265 – 29026KKWII…LTVGK → GVLCALGRQC in isoform 2C. 1 PublicationVSP_006337Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20823 mRNA. Translation: AAA03044.1.
    L20889 mRNA. Translation: AAA03049.1.
    L20888 mRNA. Translation: AAA03048.1.
    AH006759 Genomic DNA. Translation: AAC52908.1.
    PIRiC48213.
    RefSeqiNP_036880.1. NM_012748.1. [P50279-1]
    XP_006249312.1. XM_006249250.1. [P50279-2]
    UniGeneiRn.10623.

    Genome annotation databases

    EnsembliENSRNOT00000037296; ENSRNOP00000036115; ENSRNOG00000000936. [P50279-3]
    ENSRNOT00000037306; ENSRNOP00000036551; ENSRNOG00000000936. [P50279-2]
    GeneIDi25130.
    KEGGirno:25130.
    UCSCiRGD:2558. rat. [P50279-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20823 mRNA. Translation: AAA03044.1 .
    L20889 mRNA. Translation: AAA03049.1 .
    L20888 mRNA. Translation: AAA03048.1 .
    AH006759 Genomic DNA. Translation: AAC52908.1 .
    PIRi C48213.
    RefSeqi NP_036880.1. NM_012748.1. [P50279-1 ]
    XP_006249312.1. XM_006249250.1. [P50279-2 ]
    UniGenei Rn.10623.

    3D structure databases

    ProteinModelPortali P50279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247200. 3 interactions.
    DIPi DIP-347N.
    MINTi MINT-1509080.

    PTM databases

    PhosphoSitei P50279.

    Proteomic databases

    PRIDEi P50279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037296 ; ENSRNOP00000036115 ; ENSRNOG00000000936 . [P50279-3 ]
    ENSRNOT00000037306 ; ENSRNOP00000036551 ; ENSRNOG00000000936 . [P50279-2 ]
    GeneIDi 25130.
    KEGGi rno:25130.
    UCSCi RGD:2558. rat. [P50279-1 ]

    Organism-specific databases

    CTDi 2054.
    RGDi 2558. Stx2.

    Phylogenomic databases

    eggNOGi COG5074.
    GeneTreei ENSGT00730000110552.
    HOGENOMi HOG000286023.
    HOVERGENi HBG000497.
    InParanoidi P50279.
    KOi K08486.
    OrthoDBi EOG7X9G7R.
    PhylomeDBi P50279.

    Miscellaneous databases

    NextBioi 605537.
    PROi P50279.

    Gene expression databases

    Genevestigatori P50279.

    Family and domain databases

    InterProi IPR028671. STX2.
    IPR006012. Syntaxin/epimorphin_CS.
    IPR006011. Syntaxin_N.
    IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR19957:SF36. PTHR19957:SF36. 1 hit.
    Pfami PF05739. SNARE. 1 hit.
    PF00804. Syntaxin. 1 hit.
    [Graphical view ]
    SMARTi SM00503. SynN. 1 hit.
    SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    PROSITEi PS00914. SYNTAXIN. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2B AND 2C).
    2. "The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12."
      Zha H., Remmers E.F., Szpirer C., Szpirer J., Zhang H., Kozak C.A., Wilder R.L.
      Genomics 37:386-389(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-290.
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiSTX2_RAT
    AccessioniPrimary (citable) accession number: P50279
    Secondary accession number(s): Q08846, Q08847, Q08848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3