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Protein

Syntaxin-2

Gene

Stx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for epithelial morphogenesis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: RGD

GO - Biological processi

  • acrosome reaction Source: InterPro
  • digestive tract morphogenesis Source: RGD
  • epithelial cell differentiation Source: RGD
  • intracellular protein transport Source: GO_Central
  • intracellular transport Source: RGD
  • microvillus assembly Source: RGD
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: RGD
  • vesicle-mediated transport Source: RGD
  • vesicle targeting Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-2
Alternative name(s):
Epimorphin
Gene namesi
Name:Stx2
Synonyms:Epim
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2558 Stx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 266CytoplasmicSequence analysisAdd BLAST266
Transmembranei267 – 290Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002101981 – 290Syntaxin-2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50279
PRIDEiP50279

PTM databases

iPTMnetiP50279
PhosphoSitePlusiP50279

Expressioni

Tissue specificityi

Heart, spleen, liver, and testis.

Gene expression databases

GenevisibleiP50279 RN

Interactioni

Subunit structurei

Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent.

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: RGD

Protein-protein interaction databases

BioGridi247200, 3 interactors
CORUMiP50279
DIPiDIP-347N
STRINGi10116.ENSRNOP00000001242

Structurei

3D structure databases

ProteinModelPortaliP50279
SMRiP50279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 255t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili69 – 106Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiP50279
KOiK08486
PhylomeDBiP50279

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028671 STX2
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF36 PTHR19957:SF36, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 2A (identifier: P50279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRDRLPDLTA CRKSDDGDNA VIITVEKDHF MDAFFHQVEE IRSSIARIAQ
60 70 80 90 100
HVEDVKKNHS IILSAPNPEG KIKEELEDLN KEIKKTANRI RGKLKAIEQS
110 120 130 140 150
CDQDENGNRT SVDLRIRRTQ HSVLSRKFVD VMTEYNEAQI LFRERSKGRI
160 170 180 190 200
QRQLEITGRT TTDEELEEML ESGKPSIFIS DIISDSQITR QALNEIESRH
210 220 230 240 250
KDIMKLETSI RELHEMFMDM AMFVETQGEM VNNIERNVVN SVDYVEHAKE
260 270 280 290
ETKKAIKYQS KARRKKWIIA AVVVAVIAVL ALIIGLTVGK
Length:290
Mass (Da):33,359
Last modified:November 1, 1997 - v2
Checksum:i37FBAD7ADFDA3841
GO
Isoform 2B (identifier: P50279-2) [UniParc]FASTAAdd to basket
Also known as: 2'

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → KVMFVLICVVTLLVILGIILATALS

Show »
Length:289
Mass (Da):33,343
Checksum:iEB30916B2B85C873
GO
Isoform 2C (identifier: P50279-3) [UniParc]FASTAAdd to basket
Also known as: 2''

The sequence of this isoform differs from the canonical sequence as follows:
     265-290: KKWIIAAVVVAVIAVLALIIGLTVGK → GVLCALGRQC

Show »
Length:274
Mass (Da):31,719
Checksum:i1EB45C5B567EFA83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146S → R in AAC52908 (PubMed:8938452).Curated1
Sequence conflicti287T → S in AAC52908 (PubMed:8938452).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006336265 – 290KKWII…LTVGK → KVMFVLICVVTLLVILGIIL ATALS in isoform 2B. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_006337265 – 290KKWII…LTVGK → GVLCALGRQC in isoform 2C. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20823 mRNA Translation: AAA03044.1
L20889 mRNA Translation: AAA03049.1
L20888 mRNA Translation: AAA03048.1
AH006759 Genomic DNA Translation: AAC52908.1
PIRiC48213
RefSeqiNP_036880.1, NM_012748.1 [P50279-1]
XP_006249312.1, XM_006249250.3 [P50279-2]
UniGeneiRn.10623

Genome annotation databases

GeneIDi25130
KEGGirno:25130
UCSCiRGD:2558 rat [P50279-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX2_RAT
AccessioniPrimary (citable) accession number: P50279
Secondary accession number(s): Q08846, Q08847, Q08848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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