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Protein

High-affinity methionine permease

Gene

MUP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High affinity permease for methionine.

GO - Molecular functioni

GO - Biological processi

  • cysteine transport Source: UniProtKB
  • methionine import Source: SGD
  • methionine transport Source: UniProtKB
  • sulfur amino acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30772-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity methionine permease
Gene namesi
Name:MUP1
Ordered Locus Names:YGR055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR055W.
SGDiS000003287. MUP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92ExtracellularSequence analysis10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 140CytoplasmicSequence analysisAdd BLAST27
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 182ExtracellularSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 207CytoplasmicSequence analysis4
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 293ExtracellularSequence analysisAdd BLAST65
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 340CytoplasmicSequence analysisAdd BLAST26
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 418ExtracellularSequence analysisAdd BLAST57
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 455CytoplasmicSequence analysisAdd BLAST16
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 490ExtracellularSequence analysisAdd BLAST14
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 574CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • integral component of plasma membrane Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966481 – 574High-affinity methionine permeaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei552PhosphothreonineCombined sources1
Modified residuei573PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP50276.
PRIDEiP50276.

PTM databases

iPTMnetiP50276.

Interactioni

Protein-protein interaction databases

BioGridi33300. 115 interactors.
DIPiDIP-7914N.
IntActiP50276. 57 interactors.
MINTiMINT-1357522.

Structurei

3D structure databases

ProteinModelPortaliP50276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast low affinity methionine permease (MUP3).Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119037.
HOGENOMiHOG000187297.
InParanoidiP50276.
OMAiNWNPPIK.
OrthoDBiEOG092C3NRL.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P50276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGRTFLSQ LNVFNKENYQ FSSSTTKKEV SNSTVDADNG ASDFEAGQQF
60 70 80 90 100
ATELDQGEKQ LGILSCIGLI CNRMLGTGVF AVSSTIYTLC GSVGLALIMW
110 120 130 140 150
AVGAIIAISG LYVYMEFGTA IPKNGGEKNY LEAIFRKPKF FITCMYAAYI
160 170 180 190 200
FFLGWAAGNS INTAIMFLTA ADTEVTKWNQ RGIGVAVVFF AFLINSLNVK
210 220 230 240 250
IGLYLQNILG IFKIGIVLFI SITGWVALGG GLKDGYQSHN FRNAFEGTET
260 270 280 290 300
ATAYGIVNAL YSVIWSFVGY SNVNYALGEV KNPVRTLKIA GPTSMVFLAI
310 320 330 340 350
IYIFVNIAYF AVVPKDKLIS SKLILAADFF DIVFGGQAKR AAAALVGLSA
360 370 380 390 400
LGNVLSVIFS QGRIIQQLGR EGVLPFSNFF ASSKPFNSPM VGLFQHFIVC
410 420 430 440 450
TVTILAPPPG DAYLLVQNLI SYPMNIINFA ISAGLLWIYW QRRQGKIEWN
460 470 480 490 500
PPIKAGVFVT GFFTLSNLYL IIAPYVPPSN GESVYSSMPY WIHCVIAWGI
510 520 530 540 550
FFFGGVYYVV WAQLLPRWGH YKLVSKDVLG EDGFWRVKIA KVYDDTIGDV
560 570
DTQEDGVIET NIIEHYKSEQ EKSL
Length:574
Mass (Da):63,221
Last modified:October 1, 1996 - v1
Checksum:iF95D342814710837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40316 Genomic DNA. Translation: AAB63529.1.
DQ115391 Genomic DNA. Translation: AAZ22468.1.
Z72840 Genomic DNA. Translation: CAA97055.1.
BK006941 Genomic DNA. Translation: DAA08151.1.
PIRiS61943.
RefSeqiNP_011569.1. NM_001181184.1.

Genome annotation databases

EnsemblFungiiYGR055W; YGR055W; YGR055W.
GeneIDi852946.
KEGGisce:YGR055W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40316 Genomic DNA. Translation: AAB63529.1.
DQ115391 Genomic DNA. Translation: AAZ22468.1.
Z72840 Genomic DNA. Translation: CAA97055.1.
BK006941 Genomic DNA. Translation: DAA08151.1.
PIRiS61943.
RefSeqiNP_011569.1. NM_001181184.1.

3D structure databases

ProteinModelPortaliP50276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33300. 115 interactors.
DIPiDIP-7914N.
IntActiP50276. 57 interactors.
MINTiMINT-1357522.

Protein family/group databases

TCDBi2.A.3.8.4. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP50276.

Proteomic databases

MaxQBiP50276.
PRIDEiP50276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR055W; YGR055W; YGR055W.
GeneIDi852946.
KEGGisce:YGR055W.

Organism-specific databases

EuPathDBiFungiDB:YGR055W.
SGDiS000003287. MUP1.

Phylogenomic databases

GeneTreeiENSGT00760000119037.
HOGENOMiHOG000187297.
InParanoidiP50276.
OMAiNWNPPIK.
OrthoDBiEOG092C3NRL.

Enzyme and pathway databases

BioCyciYEAST:G3O-30772-MONOMER.
ReactomeiR-SCE-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiP50276.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMUP1_YEAST
AccessioniPrimary (citable) accession number: P50276
Secondary accession number(s): D6VUJ0, Q45U31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.