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Protein

High-affinity methionine permease

Gene

MUP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity permease for methionine.

GO - Molecular functioni

GO - Biological processi

  • cysteine transport Source: UniProtKB
  • methionine import across plasma membrane Source: SGD
  • methionine transport Source: UniProtKB
  • sulfur amino acid transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30772-MONOMER

Protein family/group databases

TCDBi2.A.3.8.4 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity methionine permease
Gene namesi
Name:MUP1
Ordered Locus Names:YGR055W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR055W
SGDiS000003287 MUP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92ExtracellularSequence analysis10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 140CytoplasmicSequence analysisAdd BLAST27
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 182ExtracellularSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 207CytoplasmicSequence analysis4
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 293ExtracellularSequence analysisAdd BLAST65
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 340CytoplasmicSequence analysisAdd BLAST26
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 418ExtracellularSequence analysisAdd BLAST57
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 455CytoplasmicSequence analysisAdd BLAST16
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 490ExtracellularSequence analysisAdd BLAST14
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 574CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966481 – 574High-affinity methionine permeaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei552PhosphothreonineCombined sources1
Modified residuei573PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP50276
PaxDbiP50276
PRIDEiP50276

PTM databases

iPTMnetiP50276

Interactioni

Protein-protein interaction databases

BioGridi33300, 249 interactors
DIPiDIP-7914N
IntActiP50276, 59 interactors
MINTiP50276
STRINGi4932.YGR055W

Structurei

3D structure databases

ProteinModelPortaliP50276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast low affinity methionine permease (MUP3).Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000146412
HOGENOMiHOG000187297
InParanoidiP50276
OMAiGLFEHWL
OrthoDBiEOG092C3NRL

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

Sequencei

Sequence statusi: Complete.

P50276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGRTFLSQ LNVFNKENYQ FSSSTTKKEV SNSTVDADNG ASDFEAGQQF
60 70 80 90 100
ATELDQGEKQ LGILSCIGLI CNRMLGTGVF AVSSTIYTLC GSVGLALIMW
110 120 130 140 150
AVGAIIAISG LYVYMEFGTA IPKNGGEKNY LEAIFRKPKF FITCMYAAYI
160 170 180 190 200
FFLGWAAGNS INTAIMFLTA ADTEVTKWNQ RGIGVAVVFF AFLINSLNVK
210 220 230 240 250
IGLYLQNILG IFKIGIVLFI SITGWVALGG GLKDGYQSHN FRNAFEGTET
260 270 280 290 300
ATAYGIVNAL YSVIWSFVGY SNVNYALGEV KNPVRTLKIA GPTSMVFLAI
310 320 330 340 350
IYIFVNIAYF AVVPKDKLIS SKLILAADFF DIVFGGQAKR AAAALVGLSA
360 370 380 390 400
LGNVLSVIFS QGRIIQQLGR EGVLPFSNFF ASSKPFNSPM VGLFQHFIVC
410 420 430 440 450
TVTILAPPPG DAYLLVQNLI SYPMNIINFA ISAGLLWIYW QRRQGKIEWN
460 470 480 490 500
PPIKAGVFVT GFFTLSNLYL IIAPYVPPSN GESVYSSMPY WIHCVIAWGI
510 520 530 540 550
FFFGGVYYVV WAQLLPRWGH YKLVSKDVLG EDGFWRVKIA KVYDDTIGDV
560 570
DTQEDGVIET NIIEHYKSEQ EKSL
Length:574
Mass (Da):63,221
Last modified:October 1, 1996 - v1
Checksum:iF95D342814710837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40316 Genomic DNA Translation: AAB63529.1
DQ115391 Genomic DNA Translation: AAZ22468.1
Z72840 Genomic DNA Translation: CAA97055.1
BK006941 Genomic DNA Translation: DAA08151.1
PIRiS61943
RefSeqiNP_011569.1, NM_001181184.1

Genome annotation databases

EnsemblFungiiYGR055W; YGR055W; YGR055W
GeneIDi852946
KEGGisce:YGR055W

Similar proteinsi

Entry informationi

Entry nameiMUP1_YEAST
AccessioniPrimary (citable) accession number: P50276
Secondary accession number(s): D6VUJ0, Q45U31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health