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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Apis florea (Dwarf honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi159Copper ACurated1
Metal bindingi194Copper ACurated1
Metal bindingi198Copper ACurated1
Metal bindingi202Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiApis florea (Dwarf honeybee)
Taxonomic identifieri7463 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25Mitochondrial intermembraneSequence analysisAdd BLAST25
Transmembranei26 – 47HelicalSequence analysisAdd BLAST22
Topological domaini48 – 62Mitochondrial matrixSequence analysisAdd BLAST15
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 225Mitochondrial intermembraneSequence analysisAdd BLAST143

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834971 – 225Cytochrome c oxidase subunit 2Add BLAST225

Structurei

3D structure databases

ProteinModelPortaliP50267.
SMRiP50267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR036257. Cyt_c_oxidase_su2_TM_sf.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

P50267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTWMMFMFQ ESNSLYADNL VSFHNMVMII VIMISTLTVY IIFDLFLNKF
60 70 80 90 100
SNLYLLKNHN IEIIWMIVPI VILLIICFPS LKILYLIDEI VNPFFSIKSI
110 120 130 140 150
GHQWYWSYEY PEFNNIEFYS YMLNYSDLNQ FRLLETDNRM IIPMKIPLRL
160 170 180 190 200
ITTSTDVIHS WTVPSLGIKV DAVPGRINQL NLISKRPGIF FGQCSEICGM
210 220
NHSFMPIMVE STSFKYFMNW IYKMN
Length:225
Mass (Da):26,694
Last modified:October 1, 1996 - v1
Checksum:iE823D1DD7D3550CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77211 Genomic DNA. Translation: AAA87246.1.

Similar proteinsi

Entry informationi

Entry nameiCOX2_APIFL
AccessioniPrimary (citable) accession number: P50267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families