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P50267 (COX2_APIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismApis florea (Dwarf honeybee)
Taxonomic identifier7463 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Cytochrome c oxidase subunit 2
PRO_0000183497

Regions

Topological domain1 – 2525Mitochondrial intermembrane Potential
Transmembrane26 – 4722Helical; Potential
Topological domain48 – 6215Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 225143Mitochondrial intermembrane Potential

Sites

Metal binding1591Copper A Probable
Metal binding1941Copper A Probable
Metal binding1981Copper A Probable
Metal binding2021Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P50267 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E823D1DD7D3550CD

FASTA22526,694
        10         20         30         40         50         60 
MSTWMMFMFQ ESNSLYADNL VSFHNMVMII VIMISTLTVY IIFDLFLNKF SNLYLLKNHN 

        70         80         90        100        110        120 
IEIIWMIVPI VILLIICFPS LKILYLIDEI VNPFFSIKSI GHQWYWSYEY PEFNNIEFYS 

       130        140        150        160        170        180 
YMLNYSDLNQ FRLLETDNRM IIPMKIPLRL ITTSTDVIHS WTVPSLGIKV DAVPGRINQL 

       190        200        210        220 
NLISKRPGIF FGQCSEICGM NHSFMPIMVE STSFKYFMNW IYKMN 

« Hide

References

[1]"Phylogenetic relationships in the honeybee (genus Apis) as determined by the sequence of the cytochrome oxidase II region of mitochondrial DNA."
Willis L.G., Winston M.L., Honda B.M.
Mol. Phylogenet. Evol. 1:169-178(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M77211 Genomic DNA. Translation: AAA87246.1.

3D structure databases

ProteinModelPortalP50267.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_APIFL
AccessionPrimary (citable) accession number: P50267
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families