Polyamine oxidase FMS1 - Saccharomyces cerevisiae (Baker's yeast)

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Reviewed, UniProtKB/Swiss-Prot P50264 (FMS1_YEAST)

Last modified June 16, 2009. Version 68. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Polyamine oxidase FMS1
    EC=1.5.3.n9
Alternative name(s):
    Fenpropimorph resistance multicopy suppressor 1

Gene names

Name:	FMS1
Ordered Locus Names:	YMR020W
ORF Names:	YM9711.09

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance. Ref.3 Ref.5
Catalytic activity	N(8)-acetylspermidine + O₂ + H₂O = 4-acetamidobutanal + trimethylenediamine + H₂O₂.
Cofactor	Binds 1 FAD per subunit. Ref.3
Miscellaneous	Present with 6960 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the flavin monoamine oxidase family.

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Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pantothenate biosynthetic process Inferred from mutant phenotype. Source: SGD polyamine catabolic process Inferred from genetic interaction. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD
Molecular function	amine oxidase activity Ref.3 Inferred from direct assay. Source: SGD electron carrier activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 508

508

Polyamine oxidase FMS1

PRO_0000087317

Secondary structure

508

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P50264-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8E135295301EB3CF
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FASTA

508

57,806

        10         20         30         40         50         60 
MNTVSPAKKK VIIIGAGIAG LKAASTLHQN GIQDCLVLEA RDRVGGRLQT VTGYQGRKYD 

        70         80         90        100        110        120 
IGASWHHDTL TNPLFLEEAQ LSLNDGRTRF VFDDDNFIYI DEERGRVDHD KELLLEIVDN 

       130        140        150        160        170        180 
EMSKFAELEF HQHLGVSDCS FFQLVMKYLL QRRQFLTNDQ IRYLPQLCRY LELWHGLDWK 

       190        200        210        220        230        240 
LLSAKDTYFG HQGRNAFALN YDSVVQRIAQ SFPQNWLKLS CEVKSITREP SKNVTVNCED 

       250        260        270        280        290        300 
GTVYNADYVI ITVPQSVLNL SVQPEKNLRG RIEFQPPLKP VIQDAFDKIH FGALGKVIFE 

       310        320        330        340        350        360 
FEECCWSNES SKIVTLANST NEFVEIVRNA ENLDELDSML EREDSQKHTS VTCWSQPLFF 

       370        380        390        400        410        420 
VNLSKSTGVA SFMMLMQAPL TNHIESIRED KERLFSFFQP VLNKIMKCLD SEDVIDGMRP 

       430        440        450        460        470        480 
IENIANANKP VLRNIIVSNW TRDPYSRGAY SACFPGDDPV DMVVAMSNGQ DSRIRFAGEH 

       490        500 
TIMDGAGCAY GAWESGRREA TRISDLLK

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the Saccharomyces cerevisiae FMS1 gene related to Candida albicans corticosteroid-binding protein 1." Joets J., Pousset D., Marcireau C., Karst F. Curr. Genet. 30:115-120(1996) [PubMed: 8660467] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"Yeast Fms1 is a FAD-utilizing polyamine oxidase." Landry J., Sternglanz R. Biochem. Biophys. Res. Commun. 303:771-776(2003) [PubMed: 12670477] [Abstract] Cited for: FUNCTION, COFACTOR.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase." Chattopadhyay M.K., Tabor C.W., Tabor H. Proc. Natl. Acad. Sci. U.S.A. 100:13869-13874(2003) [PubMed: 14617780] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

X81848 Genomic DNA. Translation: CAA57442.1.
Z49211 Genomic DNA. Translation: CAA89122.1.

PIR

S54021.

RefSeq

NP_013733.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RSG	X-ray	1.90	A/B	1-508	[»]
1XPQ	X-ray	2.60	A/B/C/D	1-508	[»]
1YY5	X-ray	2.30	A/B	1-508	[»]
1Z6L	X-ray	2.50	A/B	1-508	[»]
3BI2	X-ray	2.30	A/B	1-508	[»]
3BI4	X-ray	2.20	A/B	1-508	[»]
3BI5	X-ray	2.50	A/B	1-508	[»]
3BNM	X-ray	2.20	A/B	1-508	[»]
3BNU	X-ray	2.20	A/B	1-508	[»]
3CN8	X-ray	2.40	A/B	1-508	[»]
3CND	X-ray	2.50	A/B	1-508	[»]
3CNP	X-ray	2.50	A/B	1-508	[»]
3CNS	X-ray	2.40	A/B	1-508	[»]
3CNT	X-ray	2.70	A/B	1-508	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:3959N.

IntAct

P50264. 3 interactions.

Genome annotation databases

Ensembl

YMR020W. Saccharomyces cerevisiae. [Contig view]

GeneID

855034.

GenomeReviews

Gene locus YMR020W in contig Z71257_GR.

KEGG

sce:YMR020W.

NMPDR

fig|4932.3.peg.4779.

Organism-specific databases

CYGD

YMR020w.

SGD

S000004622. FMS1.

Yeast-GFP

Search...

Phylogenomic databases

HOGENOM

P50264.

OMA

P50264. GASWHHD.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-13663.

BRENDA

1.5.3.11. 250.

Gene expression databases

GermOnline

YMR020W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR002937. Amino_oxidase.
[Graphical view]

Pfam

PF01593. Amino_oxidase. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

978242.

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Entry information

Entry name

FMS1_YEAST

Accession

Primary (citable) accession number: P50264

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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