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Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt:CoII
Synonyms:CoII
Encoded oniMitochondrion
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0012878 Dsim\mt:CoII

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalSequence analysisAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Topological domaini83 – 228Mitochondrial intermembraneSequence analysisAdd BLAST146

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835851 – 228Cytochrome c oxidase subunit 2Add BLAST228

Proteomic databases

PRIDEiP50253

Structurei

3D structure databases

ProteinModelPortaliP50253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P50253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY
60 70 80 90 100
VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI
110 120 130 140 150
GHQWYWSYEY SDFNNIEFDS YMIPTNELTT DGFRLLDVDN RVILPMNSQI
160 170 180 190 200
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC
210 220
GANHSFMPIV IESVPVNHFI KWISSNNS
Length:228
Mass (Da):26,148
Last modified:March 1, 2005 - v2
Checksum:iE7C1A3EE91730B85
GO

Sequence cautioni

The sequence AAD13956 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25D → A in strain: 14021-0251.0. 1 Publication1
Natural varianti115N → S in strain: HW00, HW09, NC37, NC48, TT00 and TT01. 1 Publication1
Natural varianti118F → Y in strain: MD106, MD225 and RU35. 2 Publications1
Natural varianti129T → S in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications1
Natural varianti130T → I in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications1
Natural varianti165V → I in strain: AU023, C167, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 3 Publications1
Natural varianti218H → N in strain: 14021-0251.0. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64977 Genomic DNA Translation: AAD13956.2 Different initiation.
AF474082 Genomic DNA Translation: AAL83266.1
AY370272 Genomic DNA Translation: AAR21759.1
AY370273 Genomic DNA Translation: AAR21760.1
AY370274 Genomic DNA Translation: AAR21761.1
AY370275 Genomic DNA Translation: AAR21762.1
AY370276 Genomic DNA Translation: AAR21763.1
AY370277 Genomic DNA Translation: AAR21764.1
AY370278 Genomic DNA Translation: AAR21765.1
AY370279 Genomic DNA Translation: AAR21766.1
AY370280 Genomic DNA Translation: AAR21767.1
AY370281 Genomic DNA Translation: AAR21768.1
AY370282 Genomic DNA Translation: AAR21769.1
AY370283 Genomic DNA Translation: AAR21770.1
AY370284 Genomic DNA Translation: AAR21771.1
AY370285 Genomic DNA Translation: AAR21772.1
AY370286 Genomic DNA Translation: AAR21773.1
AY370287 Genomic DNA Translation: AAR21774.1
AY370288 Genomic DNA Translation: AAR21775.1
AY370289 Genomic DNA Translation: AAR21776.1
AY370290 Genomic DNA Translation: AAR21777.1
AY370291 Genomic DNA Translation: AAR21778.1
AY370292 Genomic DNA Translation: AAR21779.1
AY370293 Genomic DNA Translation: AAR21780.1
AY370294 Genomic DNA Translation: AAR21781.1
AY370295 Genomic DNA Translation: AAR21782.1
AY370296 Genomic DNA Translation: AAR21783.1
AY370297 Genomic DNA Translation: AAR21784.1
AY370298 Genomic DNA Translation: AAR21785.1
AY370299 Genomic DNA Translation: AAR21786.1
AY370300 Genomic DNA Translation: AAR21787.1
AY370301 Genomic DNA Translation: AAR21788.1
AY370302 Genomic DNA Translation: AAR21789.1
AY370303 Genomic DNA Translation: AAR21790.1
AY370304 Genomic DNA Translation: AAR21791.1
AY370305 Genomic DNA Translation: AAR21792.1
AY370306 Genomic DNA Translation: AAR21793.1
AY370307 Genomic DNA Translation: AAR21794.1
AY370308 Genomic DNA Translation: AAR21795.1
AY370309 Genomic DNA Translation: AAR21796.1
AY370310 Genomic DNA Translation: AAR21797.1
AY370311 Genomic DNA Translation: AAR21798.1
AY370312 Genomic DNA Translation: AAR21799.1
AY370313 Genomic DNA Translation: AAR21800.1
AY370314 Genomic DNA Translation: AAR21801.1
AY370315 Genomic DNA Translation: AAR21802.1
AY370316 Genomic DNA Translation: AAR21803.1
AY370317 Genomic DNA Translation: AAR21804.1
AY370318 Genomic DNA Translation: AAR21805.1
AY370319 Genomic DNA Translation: AAR21806.1
AY370320 Genomic DNA Translation: AAR21807.1
AY370321 Genomic DNA Translation: AAR21808.1
AY370322 Genomic DNA Translation: AAR21809.1
AY370323 Genomic DNA Translation: AAR21810.1
AY370324 Genomic DNA Translation: AAR21811.1
AY370325 Genomic DNA Translation: AAR21812.1
AY370326 Genomic DNA Translation: AAR21813.1
AY370327 Genomic DNA Translation: AAR21814.1
AY370328 Genomic DNA Translation: AAR21815.1
AY370329 Genomic DNA Translation: AAR21816.1
AY370330 Genomic DNA Translation: AAR21817.1
AY370331 Genomic DNA Translation: AAR21818.1
AY370332 Genomic DNA Translation: AAR21819.1
AY370333 Genomic DNA Translation: AAR21820.1
AY370334 Genomic DNA Translation: AAR21821.1
AY370335 Genomic DNA Translation: AAR21822.1
AY370336 Genomic DNA Translation: AAR21823.1
AY370337 Genomic DNA Translation: AAR21824.1
AY370338 Genomic DNA Translation: AAR21825.1
AY370339 Genomic DNA Translation: AAR21826.1
AY370340 Genomic DNA Translation: AAR21827.1
AY370341 Genomic DNA Translation: AAR21828.1
AY370342 Genomic DNA Translation: AAR21829.1
AY370343 Genomic DNA Translation: AAR21830.1
AY370344 Genomic DNA Translation: AAR21831.1
AY370345 Genomic DNA Translation: AAR21832.1
AY370346 Genomic DNA Translation: AAR21833.1
AY370347 Genomic DNA Translation: AAR21834.1
AY370348 Genomic DNA Translation: AAR21835.1
AY370349 Genomic DNA Translation: AAR21836.1
AY370350 Genomic DNA Translation: AAR21837.1
AY518670 Genomic DNA Translation: AAR91395.1
AY518671 Genomic DNA Translation: AAR91403.1
AY518672 Genomic DNA Translation: AAR91416.1
AY518673 Genomic DNA Translation: AAR91429.1
AY518674 Genomic DNA Translation: AAR91442.1
GQ222022 Genomic DNA Translation: ACT09365.1
AF200833 Genomic DNA Translation: AAF77297.1
AF200834 Genomic DNA Translation: AAF77311.1
AF200835 Genomic DNA Translation: AAF77318.1
AF200836 Genomic DNA Translation: AAF77331.1
AF200837 Genomic DNA Translation: AAF77344.1
AF200838 Genomic DNA Translation: AAF77357.1
AF200839 Genomic DNA Translation: AAF77371.1
AF200840 Genomic DNA Translation: AAF77383.1
AF200841 Genomic DNA Translation: AAF77396.1
AF200842 Genomic DNA Translation: AAF77414.1
AF200843 Genomic DNA Translation: AAF77422.1
AF200844 Genomic DNA Translation: AAF77435.1
AF200845 Genomic DNA Translation: AAF77448.1
AF200846 Genomic DNA Translation: AAF77461.1
AF200847 Genomic DNA Translation: AAF77474.1
AF200848 Genomic DNA Translation: AAF77487.1
AF200849 Genomic DNA Translation: AAF77501.1
AF200850 Genomic DNA Translation: AAF77513.1
AF200851 Genomic DNA Translation: AAF77527.1
AF200852 Genomic DNA Translation: AAF77539.1
AF200853 Genomic DNA Translation: AAF77552.1
AF200854 Genomic DNA Translation: AAF77565.1
RefSeqiNP_982324.1, NC_005781.1

Genome annotation databases

GeneIDi2760956
KEGGidsi:COX2

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOX2_DROSI
AccessioniPrimary (citable) accession number: P50253
Secondary accession number(s): C6KI55
, Q6UHJ8, Q6UHP0, Q8SGU5, Q9MD62, Q9MD70, Q9MDM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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