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P50253 (COX2_DROSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt:CoII
Synonyms:CoII
Encoded onMitochondrion
OrganismDrosophila simulans (Fruit fly) [Complete proteome]
Taxonomic identifier7240 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence caution

The sequence AAD13956.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183585

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 228146Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Natural variations

Natural variant251D → A in strain: 14021-0251.0. Ref.2
Natural variant1151N → S in strain: HW00, HW09, NC37, NC48, TT00 and TT01. Ref.5
Natural variant1181F → Y in strain: MD106, MD225 and RU35. Ref.4 Ref.5
Natural variant1291T → S in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.2 Ref.3 Ref.4 Ref.5
Natural variant1301T → I in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.2 Ref.3 Ref.4 Ref.5
Natural variant1651V → I in strain: AU023, C167, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.3 Ref.4 Ref.5
Natural variant2181H → N in strain: 14021-0251.0.

Sequences

Sequence LengthMass (Da)Tools
P50253 [UniParc].

Last modified March 1, 2005. Version 2.
Checksum: E7C1A3EE91730B85

FASTA22826,148
        10         20         30         40         50         60 
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY VNRFLLHGQL 

        70         80         90        100        110        120 
IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI GHQWYWSYEY SDFNNIEFDS 

       130        140        150        160        170        180 
YMIPTNELTT DGFRLLDVDN RVILPMNSQI RILVTAADVI HSWTVPALGV KVDGTPGRLN 

       190        200        210        220 
QTNFFINRPG LFYGQCSEIC GANHSFMPIV IESVPVNHFI KWISSNNS 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster."
Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.
Genet. Res. 61:195-204(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Phylogeny of the subgenus sophophora (Diptera: drosophilidae) based on combined analysis of nuclear and mitochondrial sequences."
O'Grady P.M., Kidwell M.G.
Mol. Phylogenet. Evol. 22:442-453(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-25; SER-129 AND ILE-130.
Strain: 14021-0251.0.
[3]"Sequential evolution of a symbiont inferred from the host: Wolbachia and Drosophila simulans."
Ballard J.W.O.
Mol. Biol. Evol. 21:428-442(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-129; ILE-130 AND ILE-165.
Strain: AU023, KY003, KY004, KY005, KY006, KY007, KY009, KY011, KY017, KY019, KY021, KY022, KY025, KY027, KY028, KY032, KY045, KY048, KY052, KY053, KY071, KY201, KY202, KY203, KY204, KY207, KY213, KY214, KY215, KY216, KY217, KY218, KY220, KY224, KY227, KY232, KY234, KY235, KY240, KY242, KY244, KY245, KY249, KY251, KY252, KY257, KY259, KY260, MW13, MW16, MW26, MW34, MW39, MW41, MW42, MW51, MW52, MW61, TZ03a, TZ05a, TZ06a, TZ07a, TZ08a, TZ09a, TZ13a, TZ15a, TZ17a, TZ23, TZ33, TZ35, TZ37, TZ38, TZ39, TZ40, TZ41, TZ42, TZ46 and TZ49.
[4]"Distinguishing Drosophila melanogaster from Drosophila simulans using restriction digest of mitochondrial COII."
Tarnowski H.E., Marshall K., Sinclair B.J.
Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-118; SER-129; ILE-130 AND ILE-165.
[5]"Comparative genomics of mitochondrial DNA in Drosophila simulans."
Ballard J.W.
J. Mol. Evol. 51:64-75(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS SER-115; TYR-118; SER-129; ILE-130 AND ILE-165.
Strain: C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, Sc00, TT00 and TT01.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S64977 Genomic DNA. Translation: AAD13956.2. Different initiation.
AF474082 Genomic DNA. Translation: AAL83266.1.
AY370272 Genomic DNA. Translation: AAR21759.1.
AY370273 Genomic DNA. Translation: AAR21760.1.
AY370274 Genomic DNA. Translation: AAR21761.1.
AY370275 Genomic DNA. Translation: AAR21762.1.
AY370276 Genomic DNA. Translation: AAR21763.1.
AY370277 Genomic DNA. Translation: AAR21764.1.
AY370278 Genomic DNA. Translation: AAR21765.1.
AY370279 Genomic DNA. Translation: AAR21766.1.
AY370280 Genomic DNA. Translation: AAR21767.1.
AY370281 Genomic DNA. Translation: AAR21768.1.
AY370282 Genomic DNA. Translation: AAR21769.1.
AY370283 Genomic DNA. Translation: AAR21770.1.
AY370284 Genomic DNA. Translation: AAR21771.1.
AY370285 Genomic DNA. Translation: AAR21772.1.
AY370286 Genomic DNA. Translation: AAR21773.1.
AY370287 Genomic DNA. Translation: AAR21774.1.
AY370288 Genomic DNA. Translation: AAR21775.1.
AY370289 Genomic DNA. Translation: AAR21776.1.
AY370290 Genomic DNA. Translation: AAR21777.1.
AY370291 Genomic DNA. Translation: AAR21778.1.
AY370292 Genomic DNA. Translation: AAR21779.1.
AY370293 Genomic DNA. Translation: AAR21780.1.
AY370294 Genomic DNA. Translation: AAR21781.1.
AY370295 Genomic DNA. Translation: AAR21782.1.
AY370296 Genomic DNA. Translation: AAR21783.1.
AY370297 Genomic DNA. Translation: AAR21784.1.
AY370298 Genomic DNA. Translation: AAR21785.1.
AY370299 Genomic DNA. Translation: AAR21786.1.
AY370300 Genomic DNA. Translation: AAR21787.1.
AY370301 Genomic DNA. Translation: AAR21788.1.
AY370302 Genomic DNA. Translation: AAR21789.1.
AY370303 Genomic DNA. Translation: AAR21790.1.
AY370304 Genomic DNA. Translation: AAR21791.1.
AY370305 Genomic DNA. Translation: AAR21792.1.
AY370306 Genomic DNA. Translation: AAR21793.1.
AY370307 Genomic DNA. Translation: AAR21794.1.
AY370308 Genomic DNA. Translation: AAR21795.1.
AY370309 Genomic DNA. Translation: AAR21796.1.
AY370310 Genomic DNA. Translation: AAR21797.1.
AY370311 Genomic DNA. Translation: AAR21798.1.
AY370312 Genomic DNA. Translation: AAR21799.1.
AY370313 Genomic DNA. Translation: AAR21800.1.
AY370314 Genomic DNA. Translation: AAR21801.1.
AY370315 Genomic DNA. Translation: AAR21802.1.
AY370316 Genomic DNA. Translation: AAR21803.1.
AY370317 Genomic DNA. Translation: AAR21804.1.
AY370318 Genomic DNA. Translation: AAR21805.1.
AY370319 Genomic DNA. Translation: AAR21806.1.
AY370320 Genomic DNA. Translation: AAR21807.1.
AY370321 Genomic DNA. Translation: AAR21808.1.
AY370322 Genomic DNA. Translation: AAR21809.1.
AY370323 Genomic DNA. Translation: AAR21810.1.
AY370324 Genomic DNA. Translation: AAR21811.1.
AY370325 Genomic DNA. Translation: AAR21812.1.
AY370326 Genomic DNA. Translation: AAR21813.1.
AY370327 Genomic DNA. Translation: AAR21814.1.
AY370328 Genomic DNA. Translation: AAR21815.1.
AY370329 Genomic DNA. Translation: AAR21816.1.
AY370330 Genomic DNA. Translation: AAR21817.1.
AY370331 Genomic DNA. Translation: AAR21818.1.
AY370332 Genomic DNA. Translation: AAR21819.1.
AY370333 Genomic DNA. Translation: AAR21820.1.
AY370334 Genomic DNA. Translation: AAR21821.1.
AY370335 Genomic DNA. Translation: AAR21822.1.
AY370336 Genomic DNA. Translation: AAR21823.1.
AY370337 Genomic DNA. Translation: AAR21824.1.
AY370338 Genomic DNA. Translation: AAR21825.1.
AY370339 Genomic DNA. Translation: AAR21826.1.
AY370340 Genomic DNA. Translation: AAR21827.1.
AY370341 Genomic DNA. Translation: AAR21828.1.
AY370342 Genomic DNA. Translation: AAR21829.1.
AY370343 Genomic DNA. Translation: AAR21830.1.
AY370344 Genomic DNA. Translation: AAR21831.1.
AY370345 Genomic DNA. Translation: AAR21832.1.
AY370346 Genomic DNA. Translation: AAR21833.1.
AY370347 Genomic DNA. Translation: AAR21834.1.
AY370348 Genomic DNA. Translation: AAR21835.1.
AY370349 Genomic DNA. Translation: AAR21836.1.
AY370350 Genomic DNA. Translation: AAR21837.1.
AY518670 Genomic DNA. Translation: AAR91395.1.
AY518671 Genomic DNA. Translation: AAR91403.1.
AY518672 Genomic DNA. Translation: AAR91416.1.
AY518673 Genomic DNA. Translation: AAR91429.1.
AY518674 Genomic DNA. Translation: AAR91442.1.
GQ222022 Genomic DNA. Translation: ACT09365.1.
AF200833 Genomic DNA. Translation: AAF77297.1.
AF200834 Genomic DNA. Translation: AAF77311.1.
AF200835 Genomic DNA. Translation: AAF77318.1.
AF200836 Genomic DNA. Translation: AAF77331.1.
AF200837 Genomic DNA. Translation: AAF77344.1.
AF200838 Genomic DNA. Translation: AAF77357.1.
AF200839 Genomic DNA. Translation: AAF77371.1.
AF200840 Genomic DNA. Translation: AAF77383.1.
AF200841 Genomic DNA. Translation: AAF77396.1.
AF200842 Genomic DNA. Translation: AAF77414.1.
AF200843 Genomic DNA. Translation: AAF77422.1.
AF200844 Genomic DNA. Translation: AAF77435.1.
AF200845 Genomic DNA. Translation: AAF77448.1.
AF200846 Genomic DNA. Translation: AAF77461.1.
AF200847 Genomic DNA. Translation: AAF77474.1.
AF200848 Genomic DNA. Translation: AAF77487.1.
AF200849 Genomic DNA. Translation: AAF77501.1.
AF200850 Genomic DNA. Translation: AAF77513.1.
AF200851 Genomic DNA. Translation: AAF77527.1.
AF200852 Genomic DNA. Translation: AAF77539.1.
AF200853 Genomic DNA. Translation: AAF77552.1.
AF200854 Genomic DNA. Translation: AAF77565.1.
RefSeqNP_982324.1. NC_005781.1.

3D structure databases

ProteinModelPortalP50253.
SMRP50253. Positions 1-225.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP50253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2760956.
KEGGdsi:COX2.

Organism-specific databases

CTD4513.
FlyBaseFBgn0012878. Dsim\mt:CoII.

Phylogenomic databases

KOK02261.
ProtClustDBMTH00154.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_DROSI
AccessionPrimary (citable) accession number: P50253
Secondary accession number(s): C6KI55 expand/collapse secondary AC list , Q6UHJ8, Q6UHP0, Q8SGU5, Q9MD62, Q9MD70, Q9MDM7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase