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P50253

- COX2_DROSI

UniProt

P50253 - COX2_DROSI

Protein

Cytochrome c oxidase subunit 2

Gene

mt:CoII

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:mt:CoII
    Synonyms:CoII
    Encoded oniMitochondrion
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002854: Mitochondrion

    Organism-specific databases

    FlyBaseiFBgn0012878. Dsim\mt:CoII.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183585Add
    BLAST

    Proteomic databases

    PRIDEiP50253.

    Structurei

    3D structure databases

    ProteinModelPortaliP50253.
    SMRiP50253. Positions 1-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 228146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02261.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY    50
    VNRFLLHGQL IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI 100
    GHQWYWSYEY SDFNNIEFDS YMIPTNELTT DGFRLLDVDN RVILPMNSQI 150
    RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFFINRPG LFYGQCSEIC 200
    GANHSFMPIV IESVPVNHFI KWISSNNS 228
    Length:228
    Mass (Da):26,148
    Last modified:March 1, 2005 - v2
    Checksum:iE7C1A3EE91730B85
    GO

    Sequence cautioni

    The sequence AAD13956.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251D → A in strain: 14021-0251.0. 1 Publication
    Natural varianti115 – 1151N → S in strain: HW00, HW09, NC37, NC48, TT00 and TT01. 1 Publication
    Natural varianti118 – 1181F → Y in strain: MD106, MD225 and RU35. 2 Publications
    Natural varianti129 – 1291T → S in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications
    Natural varianti130 – 1301T → I in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 4 Publications
    Natural varianti165 – 1651V → I in strain: AU023, C167, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. 3 Publications
    Natural varianti218 – 2181H → N in strain: 14021-0251.0.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64977 Genomic DNA. Translation: AAD13956.2. Different initiation.
    AF474082 Genomic DNA. Translation: AAL83266.1.
    AY370272 Genomic DNA. Translation: AAR21759.1.
    AY370273 Genomic DNA. Translation: AAR21760.1.
    AY370274 Genomic DNA. Translation: AAR21761.1.
    AY370275 Genomic DNA. Translation: AAR21762.1.
    AY370276 Genomic DNA. Translation: AAR21763.1.
    AY370277 Genomic DNA. Translation: AAR21764.1.
    AY370278 Genomic DNA. Translation: AAR21765.1.
    AY370279 Genomic DNA. Translation: AAR21766.1.
    AY370280 Genomic DNA. Translation: AAR21767.1.
    AY370281 Genomic DNA. Translation: AAR21768.1.
    AY370282 Genomic DNA. Translation: AAR21769.1.
    AY370283 Genomic DNA. Translation: AAR21770.1.
    AY370284 Genomic DNA. Translation: AAR21771.1.
    AY370285 Genomic DNA. Translation: AAR21772.1.
    AY370286 Genomic DNA. Translation: AAR21773.1.
    AY370287 Genomic DNA. Translation: AAR21774.1.
    AY370288 Genomic DNA. Translation: AAR21775.1.
    AY370289 Genomic DNA. Translation: AAR21776.1.
    AY370290 Genomic DNA. Translation: AAR21777.1.
    AY370291 Genomic DNA. Translation: AAR21778.1.
    AY370292 Genomic DNA. Translation: AAR21779.1.
    AY370293 Genomic DNA. Translation: AAR21780.1.
    AY370294 Genomic DNA. Translation: AAR21781.1.
    AY370295 Genomic DNA. Translation: AAR21782.1.
    AY370296 Genomic DNA. Translation: AAR21783.1.
    AY370297 Genomic DNA. Translation: AAR21784.1.
    AY370298 Genomic DNA. Translation: AAR21785.1.
    AY370299 Genomic DNA. Translation: AAR21786.1.
    AY370300 Genomic DNA. Translation: AAR21787.1.
    AY370301 Genomic DNA. Translation: AAR21788.1.
    AY370302 Genomic DNA. Translation: AAR21789.1.
    AY370303 Genomic DNA. Translation: AAR21790.1.
    AY370304 Genomic DNA. Translation: AAR21791.1.
    AY370305 Genomic DNA. Translation: AAR21792.1.
    AY370306 Genomic DNA. Translation: AAR21793.1.
    AY370307 Genomic DNA. Translation: AAR21794.1.
    AY370308 Genomic DNA. Translation: AAR21795.1.
    AY370309 Genomic DNA. Translation: AAR21796.1.
    AY370310 Genomic DNA. Translation: AAR21797.1.
    AY370311 Genomic DNA. Translation: AAR21798.1.
    AY370312 Genomic DNA. Translation: AAR21799.1.
    AY370313 Genomic DNA. Translation: AAR21800.1.
    AY370314 Genomic DNA. Translation: AAR21801.1.
    AY370315 Genomic DNA. Translation: AAR21802.1.
    AY370316 Genomic DNA. Translation: AAR21803.1.
    AY370317 Genomic DNA. Translation: AAR21804.1.
    AY370318 Genomic DNA. Translation: AAR21805.1.
    AY370319 Genomic DNA. Translation: AAR21806.1.
    AY370320 Genomic DNA. Translation: AAR21807.1.
    AY370321 Genomic DNA. Translation: AAR21808.1.
    AY370322 Genomic DNA. Translation: AAR21809.1.
    AY370323 Genomic DNA. Translation: AAR21810.1.
    AY370324 Genomic DNA. Translation: AAR21811.1.
    AY370325 Genomic DNA. Translation: AAR21812.1.
    AY370326 Genomic DNA. Translation: AAR21813.1.
    AY370327 Genomic DNA. Translation: AAR21814.1.
    AY370328 Genomic DNA. Translation: AAR21815.1.
    AY370329 Genomic DNA. Translation: AAR21816.1.
    AY370330 Genomic DNA. Translation: AAR21817.1.
    AY370331 Genomic DNA. Translation: AAR21818.1.
    AY370332 Genomic DNA. Translation: AAR21819.1.
    AY370333 Genomic DNA. Translation: AAR21820.1.
    AY370334 Genomic DNA. Translation: AAR21821.1.
    AY370335 Genomic DNA. Translation: AAR21822.1.
    AY370336 Genomic DNA. Translation: AAR21823.1.
    AY370337 Genomic DNA. Translation: AAR21824.1.
    AY370338 Genomic DNA. Translation: AAR21825.1.
    AY370339 Genomic DNA. Translation: AAR21826.1.
    AY370340 Genomic DNA. Translation: AAR21827.1.
    AY370341 Genomic DNA. Translation: AAR21828.1.
    AY370342 Genomic DNA. Translation: AAR21829.1.
    AY370343 Genomic DNA. Translation: AAR21830.1.
    AY370344 Genomic DNA. Translation: AAR21831.1.
    AY370345 Genomic DNA. Translation: AAR21832.1.
    AY370346 Genomic DNA. Translation: AAR21833.1.
    AY370347 Genomic DNA. Translation: AAR21834.1.
    AY370348 Genomic DNA. Translation: AAR21835.1.
    AY370349 Genomic DNA. Translation: AAR21836.1.
    AY370350 Genomic DNA. Translation: AAR21837.1.
    AY518670 Genomic DNA. Translation: AAR91395.1.
    AY518671 Genomic DNA. Translation: AAR91403.1.
    AY518672 Genomic DNA. Translation: AAR91416.1.
    AY518673 Genomic DNA. Translation: AAR91429.1.
    AY518674 Genomic DNA. Translation: AAR91442.1.
    GQ222022 Genomic DNA. Translation: ACT09365.1.
    AF200833 Genomic DNA. Translation: AAF77297.1.
    AF200834 Genomic DNA. Translation: AAF77311.1.
    AF200835 Genomic DNA. Translation: AAF77318.1.
    AF200836 Genomic DNA. Translation: AAF77331.1.
    AF200837 Genomic DNA. Translation: AAF77344.1.
    AF200838 Genomic DNA. Translation: AAF77357.1.
    AF200839 Genomic DNA. Translation: AAF77371.1.
    AF200840 Genomic DNA. Translation: AAF77383.1.
    AF200841 Genomic DNA. Translation: AAF77396.1.
    AF200842 Genomic DNA. Translation: AAF77414.1.
    AF200843 Genomic DNA. Translation: AAF77422.1.
    AF200844 Genomic DNA. Translation: AAF77435.1.
    AF200845 Genomic DNA. Translation: AAF77448.1.
    AF200846 Genomic DNA. Translation: AAF77461.1.
    AF200847 Genomic DNA. Translation: AAF77474.1.
    AF200848 Genomic DNA. Translation: AAF77487.1.
    AF200849 Genomic DNA. Translation: AAF77501.1.
    AF200850 Genomic DNA. Translation: AAF77513.1.
    AF200851 Genomic DNA. Translation: AAF77527.1.
    AF200852 Genomic DNA. Translation: AAF77539.1.
    AF200853 Genomic DNA. Translation: AAF77552.1.
    AF200854 Genomic DNA. Translation: AAF77565.1.
    RefSeqiNP_982324.1. NC_005781.1.

    Genome annotation databases

    GeneIDi2760956.
    KEGGidsi:COX2.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S64977 Genomic DNA. Translation: AAD13956.2 . Different initiation.
    AF474082 Genomic DNA. Translation: AAL83266.1 .
    AY370272 Genomic DNA. Translation: AAR21759.1 .
    AY370273 Genomic DNA. Translation: AAR21760.1 .
    AY370274 Genomic DNA. Translation: AAR21761.1 .
    AY370275 Genomic DNA. Translation: AAR21762.1 .
    AY370276 Genomic DNA. Translation: AAR21763.1 .
    AY370277 Genomic DNA. Translation: AAR21764.1 .
    AY370278 Genomic DNA. Translation: AAR21765.1 .
    AY370279 Genomic DNA. Translation: AAR21766.1 .
    AY370280 Genomic DNA. Translation: AAR21767.1 .
    AY370281 Genomic DNA. Translation: AAR21768.1 .
    AY370282 Genomic DNA. Translation: AAR21769.1 .
    AY370283 Genomic DNA. Translation: AAR21770.1 .
    AY370284 Genomic DNA. Translation: AAR21771.1 .
    AY370285 Genomic DNA. Translation: AAR21772.1 .
    AY370286 Genomic DNA. Translation: AAR21773.1 .
    AY370287 Genomic DNA. Translation: AAR21774.1 .
    AY370288 Genomic DNA. Translation: AAR21775.1 .
    AY370289 Genomic DNA. Translation: AAR21776.1 .
    AY370290 Genomic DNA. Translation: AAR21777.1 .
    AY370291 Genomic DNA. Translation: AAR21778.1 .
    AY370292 Genomic DNA. Translation: AAR21779.1 .
    AY370293 Genomic DNA. Translation: AAR21780.1 .
    AY370294 Genomic DNA. Translation: AAR21781.1 .
    AY370295 Genomic DNA. Translation: AAR21782.1 .
    AY370296 Genomic DNA. Translation: AAR21783.1 .
    AY370297 Genomic DNA. Translation: AAR21784.1 .
    AY370298 Genomic DNA. Translation: AAR21785.1 .
    AY370299 Genomic DNA. Translation: AAR21786.1 .
    AY370300 Genomic DNA. Translation: AAR21787.1 .
    AY370301 Genomic DNA. Translation: AAR21788.1 .
    AY370302 Genomic DNA. Translation: AAR21789.1 .
    AY370303 Genomic DNA. Translation: AAR21790.1 .
    AY370304 Genomic DNA. Translation: AAR21791.1 .
    AY370305 Genomic DNA. Translation: AAR21792.1 .
    AY370306 Genomic DNA. Translation: AAR21793.1 .
    AY370307 Genomic DNA. Translation: AAR21794.1 .
    AY370308 Genomic DNA. Translation: AAR21795.1 .
    AY370309 Genomic DNA. Translation: AAR21796.1 .
    AY370310 Genomic DNA. Translation: AAR21797.1 .
    AY370311 Genomic DNA. Translation: AAR21798.1 .
    AY370312 Genomic DNA. Translation: AAR21799.1 .
    AY370313 Genomic DNA. Translation: AAR21800.1 .
    AY370314 Genomic DNA. Translation: AAR21801.1 .
    AY370315 Genomic DNA. Translation: AAR21802.1 .
    AY370316 Genomic DNA. Translation: AAR21803.1 .
    AY370317 Genomic DNA. Translation: AAR21804.1 .
    AY370318 Genomic DNA. Translation: AAR21805.1 .
    AY370319 Genomic DNA. Translation: AAR21806.1 .
    AY370320 Genomic DNA. Translation: AAR21807.1 .
    AY370321 Genomic DNA. Translation: AAR21808.1 .
    AY370322 Genomic DNA. Translation: AAR21809.1 .
    AY370323 Genomic DNA. Translation: AAR21810.1 .
    AY370324 Genomic DNA. Translation: AAR21811.1 .
    AY370325 Genomic DNA. Translation: AAR21812.1 .
    AY370326 Genomic DNA. Translation: AAR21813.1 .
    AY370327 Genomic DNA. Translation: AAR21814.1 .
    AY370328 Genomic DNA. Translation: AAR21815.1 .
    AY370329 Genomic DNA. Translation: AAR21816.1 .
    AY370330 Genomic DNA. Translation: AAR21817.1 .
    AY370331 Genomic DNA. Translation: AAR21818.1 .
    AY370332 Genomic DNA. Translation: AAR21819.1 .
    AY370333 Genomic DNA. Translation: AAR21820.1 .
    AY370334 Genomic DNA. Translation: AAR21821.1 .
    AY370335 Genomic DNA. Translation: AAR21822.1 .
    AY370336 Genomic DNA. Translation: AAR21823.1 .
    AY370337 Genomic DNA. Translation: AAR21824.1 .
    AY370338 Genomic DNA. Translation: AAR21825.1 .
    AY370339 Genomic DNA. Translation: AAR21826.1 .
    AY370340 Genomic DNA. Translation: AAR21827.1 .
    AY370341 Genomic DNA. Translation: AAR21828.1 .
    AY370342 Genomic DNA. Translation: AAR21829.1 .
    AY370343 Genomic DNA. Translation: AAR21830.1 .
    AY370344 Genomic DNA. Translation: AAR21831.1 .
    AY370345 Genomic DNA. Translation: AAR21832.1 .
    AY370346 Genomic DNA. Translation: AAR21833.1 .
    AY370347 Genomic DNA. Translation: AAR21834.1 .
    AY370348 Genomic DNA. Translation: AAR21835.1 .
    AY370349 Genomic DNA. Translation: AAR21836.1 .
    AY370350 Genomic DNA. Translation: AAR21837.1 .
    AY518670 Genomic DNA. Translation: AAR91395.1 .
    AY518671 Genomic DNA. Translation: AAR91403.1 .
    AY518672 Genomic DNA. Translation: AAR91416.1 .
    AY518673 Genomic DNA. Translation: AAR91429.1 .
    AY518674 Genomic DNA. Translation: AAR91442.1 .
    GQ222022 Genomic DNA. Translation: ACT09365.1 .
    AF200833 Genomic DNA. Translation: AAF77297.1 .
    AF200834 Genomic DNA. Translation: AAF77311.1 .
    AF200835 Genomic DNA. Translation: AAF77318.1 .
    AF200836 Genomic DNA. Translation: AAF77331.1 .
    AF200837 Genomic DNA. Translation: AAF77344.1 .
    AF200838 Genomic DNA. Translation: AAF77357.1 .
    AF200839 Genomic DNA. Translation: AAF77371.1 .
    AF200840 Genomic DNA. Translation: AAF77383.1 .
    AF200841 Genomic DNA. Translation: AAF77396.1 .
    AF200842 Genomic DNA. Translation: AAF77414.1 .
    AF200843 Genomic DNA. Translation: AAF77422.1 .
    AF200844 Genomic DNA. Translation: AAF77435.1 .
    AF200845 Genomic DNA. Translation: AAF77448.1 .
    AF200846 Genomic DNA. Translation: AAF77461.1 .
    AF200847 Genomic DNA. Translation: AAF77474.1 .
    AF200848 Genomic DNA. Translation: AAF77487.1 .
    AF200849 Genomic DNA. Translation: AAF77501.1 .
    AF200850 Genomic DNA. Translation: AAF77513.1 .
    AF200851 Genomic DNA. Translation: AAF77527.1 .
    AF200852 Genomic DNA. Translation: AAF77539.1 .
    AF200853 Genomic DNA. Translation: AAF77552.1 .
    AF200854 Genomic DNA. Translation: AAF77565.1 .
    RefSeqi NP_982324.1. NC_005781.1.

    3D structure databases

    ProteinModelPortali P50253.
    SMRi P50253. Positions 1-225.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P50253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2760956.
    KEGGi dsi:COX2.

    Organism-specific databases

    CTDi 4513.
    FlyBasei FBgn0012878. Dsim\mt:CoII.

    Phylogenomic databases

    KOi K02261.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster."
      Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.
      Genet. Res. 61:195-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Phylogeny of the subgenus sophophora (Diptera: drosophilidae) based on combined analysis of nuclear and mitochondrial sequences."
      O'Grady P.M., Kidwell M.G.
      Mol. Phylogenet. Evol. 22:442-453(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-25; SER-129 AND ILE-130.
      Strain: 14021-0251.0.
    3. "Sequential evolution of a symbiont inferred from the host: Wolbachia and Drosophila simulans."
      Ballard J.W.O.
      Mol. Biol. Evol. 21:428-442(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-129; ILE-130 AND ILE-165.
      Strain: AU023, KY003, KY004, KY005, KY006, KY007, KY009, KY011, KY017, KY019, KY021, KY022, KY025, KY027, KY028, KY032, KY045, KY048, KY052, KY053, KY071, KY201, KY202, KY203, KY204, KY207, KY213, KY214, KY215, KY216, KY217, KY218, KY220, KY224, KY227, KY232, KY234, KY235, KY240, KY242, KY244, KY245, KY249, KY251, KY252, KY257, KY259, KY260, MW13, MW16, MW26, MW34, MW39, MW41, MW42, MW51, MW52, MW61, TZ03a, TZ05a, TZ06a, TZ07a, TZ08a, TZ09a, TZ13a, TZ15a, TZ17a, TZ23, TZ33, TZ35, TZ37, TZ38, TZ39, TZ40, TZ41, TZ42, TZ46 and TZ49.
    4. "Distinguishing Drosophila melanogaster from Drosophila simulans using restriction digest of mitochondrial COII."
      Tarnowski H.E., Marshall K., Sinclair B.J.
      Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-118; SER-129; ILE-130 AND ILE-165.
    5. "Comparative genomics of mitochondrial DNA in Drosophila simulans."
      Ballard J.W.
      J. Mol. Evol. 51:64-75(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS SER-115; TYR-118; SER-129; ILE-130 AND ILE-165.
      Strain: C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, Sc00, TT00 and TT01.

    Entry informationi

    Entry nameiCOX2_DROSI
    AccessioniPrimary (citable) accession number: P50253
    Secondary accession number(s): C6KI55
    , Q6UHJ8, Q6UHP0, Q8SGU5, Q9MD62, Q9MD70, Q9MDM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3