Cytochrome c oxidase subunit 2 - Drosophila simulans (Fruit fly)

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P50253 (COX2_DROSI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	mt:CoII
Synonyms:	CoII

Encoded on

Mitochondrion

Organism

Drosophila simulans (Fruit fly) [Complete proteome]

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
Sequence caution	The sequence AAD13956.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 228

228

Cytochrome c oxidase subunit 2

PRO_0000183585

Regions

Topological domain

1 – 26

Mitochondrial intermembrane Potential

Transmembrane

27 – 48

Helical; Potential

Topological domain

49 – 62

Mitochondrial matrix Potential

Transmembrane

63 – 82

Helical; Potential

Topological domain

83 – 228

146

Mitochondrial intermembrane Potential

Sites

Metal binding

161

Copper A Probable

Metal binding

196

Copper A Probable

Metal binding

200

Copper A Probable

Metal binding

204

Copper A Probable

Natural variations

Natural variant

D → A in strain: 14021-0251.0. Ref.2

Natural variant

115

N → S in strain: HW00, HW09, NC37, NC48, TT00 and TT01. Ref.5

Natural variant

118

F → Y in strain: MD106, MD225 and RU35. Ref.4 Ref.5

Natural variant

129

T → S in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.2 Ref.3 Ref.4 Ref.5

Natural variant

130

T → I in strain: 14021-0251.0, C167, AU023, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.2 Ref.3 Ref.4 Ref.5

Natural variant

165

V → I in strain: AU023, C167, DSR, DSW, KY007, KY045, KY201, KY215, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, RU00, RU01, RU07, RU35, RU259 and Sc00. Ref.3 Ref.4 Ref.5

Natural variant

218

H → N in strain: 14021-0251.0.

Sequences

Sequence

Length

Mass (Da)

Tools

P50253 [UniParc].

Last modified March 1, 2005. Version 2.
Checksum: E7C1A3EE91730B85
Show »

FASTA

228

26,148

        10         20         30         40         50         60 
MSTWANLGLQ DSASPLMEQL IFFHDHALLI LVMITVLVGY LMFMLFFNNY VNRFLLHGQL 

        70         80         90        100        110        120 
IEMIWTILPA IILLFIALPS LRLLYLLDEI NEPSVTLKSI GHQWYWSYEY SDFNNIEFDS 

       130        140        150        160        170        180 
YMIPTNELTT DGFRLLDVDN RVILPMNSQI RILVTAADVI HSWTVPALGV KVDGTPGRLN 

       190        200        210        220 
QTNFFINRPG LFYGQCSEIC GANHSFMPIV IESVPVNHFI KWISSNNS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster." Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I. Genet. Res. 61:195-204(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogeny of the subgenus sophophora (Diptera: drosophilidae) based on combined analysis of nuclear and mitochondrial sequences." O'Grady P.M., Kidwell M.G. Mol. Phylogenet. Evol. 22:442-453(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-25; SER-129 AND ILE-130. Strain: 14021-0251.0.
[3]	"Sequential evolution of a symbiont inferred from the host: Wolbachia and Drosophila simulans." Ballard J.W.O. Mol. Biol. Evol. 21:428-442(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-129; ILE-130 AND ILE-165. Strain: AU023, KY003, KY004, KY005, KY006, KY007, KY009, KY011, KY017, KY019, KY021, KY022, KY025, KY027, KY028, KY032, KY045, KY048, KY052, KY053, KY071, KY201, KY202, KY203, KY204, KY207, KY213, KY214, KY215, KY216, KY217, KY218, KY220, KY224, KY227, KY232, KY234, KY235, KY240, KY242, KY244, KY245, KY249, KY251, KY252, KY257, KY259, KY260, MW13, MW16, MW26, MW34, MW39, MW41, MW42, MW51, MW52, MW61, TZ03a, TZ05a, TZ06a, TZ07a, TZ08a, TZ09a, TZ13a, TZ15a, TZ17a, TZ23, TZ33, TZ35, TZ37, TZ38, TZ39, TZ40, TZ41, TZ42, TZ46 and TZ49.
[4]	"Distinguishing Drosophila melanogaster from Drosophila simulans using restriction digest of mitochondrial COII." Tarnowski H.E., Marshall K., Sinclair B.J. Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-118; SER-129; ILE-130 AND ILE-165.
[5]	Ballard J.W.O. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS SER-115; TYR-118; SER-129; ILE-130 AND ILE-165. Strain: C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD199, MD221, MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, Sc00, TT00 and TT01.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S64977 Genomic DNA. Translation: AAD13956.2. Different initiation. AF474082 Genomic DNA. Translation: AAL83266.1. AY370272 Genomic DNA. Translation: AAR21759.1. AY370273 Genomic DNA. Translation: AAR21760.1. AY370274 Genomic DNA. Translation: AAR21761.1. AY370275 Genomic DNA. Translation: AAR21762.1. AY370276 Genomic DNA. Translation: AAR21763.1. AY370277 Genomic DNA. Translation: AAR21764.1. AY370278 Genomic DNA. Translation: AAR21765.1. AY370279 Genomic DNA. Translation: AAR21766.1. AY370280 Genomic DNA. Translation: AAR21767.1. AY370281 Genomic DNA. Translation: AAR21768.1. AY370282 Genomic DNA. Translation: AAR21769.1. AY370283 Genomic DNA. Translation: AAR21770.1. AY370284 Genomic DNA. Translation: AAR21771.1. AY370285 Genomic DNA. Translation: AAR21772.1. AY370286 Genomic DNA. Translation: AAR21773.1. AY370287 Genomic DNA. Translation: AAR21774.1. AY370288 Genomic DNA. Translation: AAR21775.1. AY370289 Genomic DNA. Translation: AAR21776.1. AY370290 Genomic DNA. Translation: AAR21777.1. AY370291 Genomic DNA. Translation: AAR21778.1. AY370292 Genomic DNA. Translation: AAR21779.1. AY370293 Genomic DNA. Translation: AAR21780.1. AY370294 Genomic DNA. Translation: AAR21781.1. AY370295 Genomic DNA. Translation: AAR21782.1. AY370296 Genomic DNA. Translation: AAR21783.1. AY370297 Genomic DNA. Translation: AAR21784.1. AY370298 Genomic DNA. Translation: AAR21785.1. AY370299 Genomic DNA. Translation: AAR21786.1. AY370300 Genomic DNA. Translation: AAR21787.1. AY370301 Genomic DNA. Translation: AAR21788.1. AY370302 Genomic DNA. Translation: AAR21789.1. AY370303 Genomic DNA. Translation: AAR21790.1. AY370304 Genomic DNA. Translation: AAR21791.1. AY370305 Genomic DNA. Translation: AAR21792.1. AY370306 Genomic DNA. Translation: AAR21793.1. AY370307 Genomic DNA. Translation: AAR21794.1. AY370308 Genomic DNA. Translation: AAR21795.1. AY370309 Genomic DNA. Translation: AAR21796.1. AY370310 Genomic DNA. Translation: AAR21797.1. AY370311 Genomic DNA. Translation: AAR21798.1. AY370312 Genomic DNA. Translation: AAR21799.1. AY370313 Genomic DNA. Translation: AAR21800.1. AY370314 Genomic DNA. Translation: AAR21801.1. AY370315 Genomic DNA. Translation: AAR21802.1. AY370316 Genomic DNA. Translation: AAR21803.1. AY370317 Genomic DNA. Translation: AAR21804.1. AY370318 Genomic DNA. Translation: AAR21805.1. AY370319 Genomic DNA. Translation: AAR21806.1. AY370320 Genomic DNA. Translation: AAR21807.1. AY370321 Genomic DNA. Translation: AAR21808.1. AY370322 Genomic DNA. Translation: AAR21809.1. AY370323 Genomic DNA. Translation: AAR21810.1. AY370324 Genomic DNA. Translation: AAR21811.1. AY370325 Genomic DNA. Translation: AAR21812.1. AY370326 Genomic DNA. Translation: AAR21813.1. AY370327 Genomic DNA. Translation: AAR21814.1. AY370328 Genomic DNA. Translation: AAR21815.1. AY370329 Genomic DNA. Translation: AAR21816.1. AY370330 Genomic DNA. Translation: AAR21817.1. AY370331 Genomic DNA. Translation: AAR21818.1. AY370332 Genomic DNA. Translation: AAR21819.1. AY370333 Genomic DNA. Translation: AAR21820.1. AY370334 Genomic DNA. Translation: AAR21821.1. AY370335 Genomic DNA. Translation: AAR21822.1. AY370336 Genomic DNA. Translation: AAR21823.1. AY370337 Genomic DNA. Translation: AAR21824.1. AY370338 Genomic DNA. Translation: AAR21825.1. AY370339 Genomic DNA. Translation: AAR21826.1. AY370340 Genomic DNA. Translation: AAR21827.1. AY370341 Genomic DNA. Translation: AAR21828.1. AY370342 Genomic DNA. Translation: AAR21829.1. AY370343 Genomic DNA. Translation: AAR21830.1. AY370344 Genomic DNA. Translation: AAR21831.1. AY370345 Genomic DNA. Translation: AAR21832.1. AY370346 Genomic DNA. Translation: AAR21833.1. AY370347 Genomic DNA. Translation: AAR21834.1. AY370348 Genomic DNA. Translation: AAR21835.1. AY370349 Genomic DNA. Translation: AAR21836.1. AY370350 Genomic DNA. Translation: AAR21837.1. AY518670 Genomic DNA. Translation: AAR91395.1. AY518671 Genomic DNA. Translation: AAR91403.1. AY518672 Genomic DNA. Translation: AAR91416.1. AY518673 Genomic DNA. Translation: AAR91429.1. AY518674 Genomic DNA. Translation: AAR91442.1. GQ222022 Genomic DNA. Translation: ACT09365.1. AF200833 Genomic DNA. Translation: AAF77297.1. AF200834 Genomic DNA. Translation: AAF77311.1. AF200835 Genomic DNA. Translation: AAF77318.1. AF200836 Genomic DNA. Translation: AAF77331.1. AF200837 Genomic DNA. Translation: AAF77344.1. AF200838 Genomic DNA. Translation: AAF77357.1. AF200839 Genomic DNA. Translation: AAF77371.1. AF200840 Genomic DNA. Translation: AAF77383.1. AF200841 Genomic DNA. Translation: AAF77396.1. AF200842 Genomic DNA. Translation: AAF77414.1. AF200843 Genomic DNA. Translation: AAF77422.1. AF200844 Genomic DNA. Translation: AAF77435.1. AF200845 Genomic DNA. Translation: AAF77448.1. AF200846 Genomic DNA. Translation: AAF77461.1. AF200847 Genomic DNA. Translation: AAF77474.1. AF200848 Genomic DNA. Translation: AAF77487.1. AF200849 Genomic DNA. Translation: AAF77501.1. AF200850 Genomic DNA. Translation: AAF77513.1. AF200851 Genomic DNA. Translation: AAF77527.1. AF200852 Genomic DNA. Translation: AAF77539.1. AF200853 Genomic DNA. Translation: AAF77552.1. AF200854 Genomic DNA. Translation: AAF77565.1.
RefSeq	NP_982324.1. NC_005781.1.
3D structure databases
ProteinModelPortal	P50253.
SMR	P50253. Positions 1-225.
ModBase	Search...
Proteomic databases
PRIDE	P50253.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2760956.
KEGG	dsi:COX2.
Organism-specific databases
CTD	4513.
FlyBase	FBgn0012878. Dsim\mt:CoII.
Phylogenomic databases
KO	K02261.
ProtClustDB	MTH00154.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_DROSI

Accession

Primary (citable) accession number: P50253
Secondary accession number(s): C6KI55

Q9MDM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents