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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei188NADUniRule annotation1
Binding sitei240NADUniRule annotation1
Binding sitei275NADUniRule annotation1
Binding sitei343NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 156NADUniRule annotation3
Nucleotide bindingi217 – 222NADUniRule annotation6
Nucleotide bindingi296 – 298NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi3.3.1.1. 5243.
UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:PF0343
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

P50251:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170111 – 421AdenosylhomocysteinaseAdd BLAST421

Proteomic databases

PRIDEiP50251.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0343.

Structurei

3D structure databases

ProteinModelPortaliP50251.
SMRiP50251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG093Z03XF.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P50251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCGKDYCVK DLSLAEEGWK KIDWVSRFMP VLQYIKREFE EKKPFKGVRI
60 70 80 90 100
AATLHLEMKT AFLLLTLKAG GAEVSAAASN PLSTQDDVVA ALAKAGVKVY
110 120 130 140 150
AIRGESREQY YEFMHKALDI RPNIIIDDGA DMISLVHKER QEMLDEIWGG
160 170 180 190 200
SEETTTGVIR LRAMEKAGIL KFPVIAVNDS YMKYLFDNRY GTGQSTWDGI
210 220 230 240 250
MRATNLLIAG KNVVVVGYGW CGRGIAMRAR GLGATVIVVE VDPIKALEAR
260 270 280 290 300
MDGFLVMDMK EAAKIGDIFV TATGNIKCIR REHFELMKDG AIMANAGHFD
310 320 330 340 350
VEIWKPDLEK LAVEINNPRP NVTEYKLKDG RRLYLLADGR LVNLVAADGH
360 370 380 390 400
PAEIMDMSFA LQAKAAEYIK DNHERLEPKV YILPREIDEM VARIKLESMG
410 420
IKIEELTEEQ KKYLESWEHG T
Length:421
Mass (Da):47,383
Last modified:September 26, 2001 - v2
Checksum:i4ED68F6313CB412B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80467.1.
X79777 Genomic DNA. Translation: CAA56173.1.
RefSeqiWP_011011458.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80467; AAL80467; PF0343.
GeneIDi1468178.
KEGGipfu:PF0343.
PATRICifig|186497.12.peg.357.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PYRFU
AccessioniPrimary (citable) accession number: P50251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 26, 2001
Last modified: October 25, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families