ID   CRIP1_HUMAN             Reviewed;          77 AA.
AC   P50238; H3BPI2; Q13628; Q53XY7; Q96J34;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   27-MAR-2024, entry version 180.
DE   RecName: Full=Cysteine-rich protein 1;
DE            Short=CRP-1;
DE   AltName: Full=Cysteine-rich heart protein;
DE            Short=CRHP;
DE            Short=hCRHP;
DE   AltName: Full=Cysteine-rich intestinal protein;
DE            Short=CRIP;
GN   Name=CRIP1; Synonyms=CRIP, CRP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=7999070; DOI=10.1006/bbrc.1994.2693;
RA   Tsui S.K.W., Yam N.Y., Lee C.-Y., Waye M.M.Y.;
RT   "Isolation and characterization of a cDNA that codes for a LIM-containing
RT   protein which is developmentally regulated in heart.";
RL   Biochem. Biophys. Res. Commun. 205:497-505(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=9126610; DOI=10.1006/prep.1996.0709;
RA   Khoo C., Blanchard R.K., Sullivan V.K., Cousins R.J.;
RT   "Human cysteine-rich intestinal protein: cDNA cloning and expression of
RT   recombinant protein and identification in human peripheral blood
RT   mononuclear cells.";
RL   Protein Expr. Purif. 9:379-387(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Seems to have a role in zinc absorption and may function as
CC       an intracellular zinc transport protein.
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DR   EMBL; U09770; AAA64537.1; -; mRNA.
DR   EMBL; U58630; AAB61158.1; -; mRNA.
DR   EMBL; BT007181; AAP35845.1; -; mRNA.
DR   EMBL; AL928654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC002738; AAH02738.1; -; mRNA.
DR   CCDS; CCDS10004.1; -.
DR   PIR; G02666; G02666.
DR   PIR; JC2431; JC2431.
DR   RefSeq; NP_001302.1; NM_001311.4.
DR   AlphaFoldDB; P50238; -.
DR   SMR; P50238; -.
DR   BioGRID; 107786; 51.
DR   IntAct; P50238; 8.
DR   STRING; 9606.ENSP00000332449; -.
DR   GlyGen; P50238; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P50238; -.
DR   PhosphoSitePlus; P50238; -.
DR   BioMuta; CRIP1; -.
DR   DMDM; 20981688; -.
DR   EPD; P50238; -.
DR   jPOST; P50238; -.
DR   MassIVE; P50238; -.
DR   MaxQB; P50238; -.
DR   PaxDb; 9606-ENSP00000332449; -.
DR   PeptideAtlas; P50238; -.
DR   ProteomicsDB; 56212; -.
DR   Pumba; P50238; -.
DR   TopDownProteomics; P50238; -.
DR   Antibodypedia; 47461; 148 antibodies from 23 providers.
DR   DNASU; 1396; -.
DR   Ensembl; ENST00000330233.11; ENSP00000332449.7; ENSG00000213145.10.
DR   Ensembl; ENST00000392531.4; ENSP00000376315.3; ENSG00000213145.10.
DR   Ensembl; ENST00000409393.6; ENSP00000386340.2; ENSG00000213145.10.
DR   GeneID; 1396; -.
DR   KEGG; hsa:1396; -.
DR   MANE-Select; ENST00000392531.4; ENSP00000376315.3; NM_001311.5; NP_001302.1.
DR   UCSC; uc001yri.5; human.
DR   AGR; HGNC:2360; -.
DR   CTD; 1396; -.
DR   DisGeNET; 1396; -.
DR   GeneCards; CRIP1; -.
DR   HGNC; HGNC:2360; CRIP1.
DR   HPA; ENSG00000213145; Low tissue specificity.
DR   MIM; 123875; gene.
DR   neXtProt; NX_P50238; -.
DR   OpenTargets; ENSG00000213145; -.
DR   PharmGKB; PA26878; -.
DR   VEuPathDB; HostDB:ENSG00000213145; -.
DR   eggNOG; KOG1700; Eukaryota.
DR   GeneTree; ENSGT00940000162342; -.
DR   HOGENOM; CLU_026811_4_1_1; -.
DR   InParanoid; P50238; -.
DR   OMA; PKCDKPV; -.
DR   OrthoDB; 7294at2759; -.
DR   PhylomeDB; P50238; -.
DR   PathwayCommons; P50238; -.
DR   SignaLink; P50238; -.
DR   BioGRID-ORCS; 1396; 9 hits in 1132 CRISPR screens.
DR   ChiTaRS; CRIP1; human.
DR   GeneWiki; CRIP1; -.
DR   GenomeRNAi; 1396; -.
DR   Pharos; P50238; Tbio.
DR   PRO; PR:P50238; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; P50238; Protein.
DR   Bgee; ENSG00000213145; Expressed in right coronary artery and 95 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042277; F:peptide binding; IDA:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IDA:UniProtKB.
DR   GO; GO:0071236; P:cellular response to antibiotic; IDA:UniProtKB.
DR   GO; GO:0071493; P:cellular response to UV-B; IDA:UniProtKB.
DR   GO; GO:0007507; P:heart development; TAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEP:UniProtKB.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:UniProtKB.
DR   GO; GO:0060741; P:prostate gland stromal morphogenesis; IEP:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; IEP:UniProtKB.
DR   GO; GO:0010033; P:response to organic substance; IEP:UniProtKB.
DR   GO; GO:0010043; P:response to zinc ion; IDA:UniProtKB.
DR   CDD; cd09478; LIM_CRIP; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR46074:SF3; CYSTEINE-RICH PROTEIN 1; 1.
DR   PANTHER; PTHR46074; CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER; 1.
DR   Pfam; PF00412; LIM; 1.
DR   SMART; SM00132; LIM; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR   Genevisible; P50238; HS.
PE   1: Evidence at protein level;
KW   Acetylation; LIM domain; Metal-binding; Methylation; Reference proteome;
KW   Zinc.
FT   CHAIN           1..77
FT                   /note="Cysteine-rich protein 1"
FT                   /id="PRO_0000075707"
FT   DOMAIN          2..63
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   MOD_RES         9
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0007744|PubMed:19608861"
FT   MOD_RES         22
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P63254"
FT   MOD_RES         68
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P63254"
FT   CONFLICT        58
FT                   /note="A -> V (in Ref. 1; AAA64537)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   77 AA;  8533 MW;  B342436418DBC021 CRC64;
     MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM
     FGPKGFGRGG AESHTFK
//