Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine-rich protein 1

Gene

CRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

GO - Molecular functioni

  • AT DNA binding Source: UniProtKB
  • DNA binding, bending Source: UniProtKB
  • peptide binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • cellular response to antibiotic Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • heart development Source: UniProtKB
  • immune response Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
  • prostate gland stromal morphogenesis Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
  • response to organic substance Source: UniProtKB
  • response to zinc ion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 1
Short name:
CRP-1
Alternative name(s):
Cysteine-rich heart protein
Short name:
CRHP
Short name:
hCRHP
Cysteine-rich intestinal protein
Short name:
CRIP
Gene namesi
Name:CRIP1
Synonyms:CRIP, CRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:2360. CRIP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1396.
OpenTargetsiENSG00000213145.
ENSG00000257341.
PharmGKBiPA26878.

Polymorphism and mutation databases

BioMutaiCRIP1.
DMDMi20981688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000757072 – 77Cysteine-rich protein 1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9N6-acetyllysineCombined sources1
Modified residuei22N6-acetyllysineBy similarity1
Modified residuei68Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP50238.
MaxQBiP50238.
PaxDbiP50238.
PeptideAtlasiP50238.
PRIDEiP50238.
TopDownProteomicsiP50238.

PTM databases

iPTMnetiP50238.
PhosphoSitePlusiP50238.

Expressioni

Gene expression databases

BgeeiENSG00000213145.
CleanExiHS_CRIP1.
GenevisibleiP50238. HS.

Organism-specific databases

HPAiHPA042462.

Interactioni

Protein-protein interaction databases

BioGridi107786. 41 interactors.
IntActiP50238. 3 interactors.
MINTiMINT-3018274.
STRINGi9606.ENSP00000455329.

Structurei

3D structure databases

ProteinModelPortaliP50238.
SMRiP50238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 70Gly-rich9

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000264233.
HOVERGENiHBG051118.
InParanoidiP50238.
OMAiCNKTLSA.
OrthoDBiEOG091G11RX.
PhylomeDBiP50238.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP
60 70
YCNHPCYAAM FGPKGFGRGG AESHTFK
Length:77
Mass (Da):8,533
Last modified:January 23, 2007 - v3
Checksum:iB342436418DBC021
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58A → V in AAA64537 (PubMed:7999070).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09770 mRNA. Translation: AAA64537.1.
U58630 mRNA. Translation: AAB61158.1.
BT007181 mRNA. Translation: AAP35845.1.
AL928654 Genomic DNA. No translation available.
BC002738 mRNA. Translation: AAH02738.1.
CCDSiCCDS10004.1.
PIRiG02666.
JC2431.
RefSeqiNP_001302.1. NM_001311.4.
UniGeneiHs.70327.

Genome annotation databases

EnsembliENST00000330233; ENSP00000332449; ENSG00000213145.
ENST00000392531; ENSP00000376315; ENSG00000213145.
ENST00000409393; ENSP00000386340; ENSG00000213145.
GeneIDi1396.
KEGGihsa:1396.
UCSCiuc001yri.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09770 mRNA. Translation: AAA64537.1.
U58630 mRNA. Translation: AAB61158.1.
BT007181 mRNA. Translation: AAP35845.1.
AL928654 Genomic DNA. No translation available.
BC002738 mRNA. Translation: AAH02738.1.
CCDSiCCDS10004.1.
PIRiG02666.
JC2431.
RefSeqiNP_001302.1. NM_001311.4.
UniGeneiHs.70327.

3D structure databases

ProteinModelPortaliP50238.
SMRiP50238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107786. 41 interactors.
IntActiP50238. 3 interactors.
MINTiMINT-3018274.
STRINGi9606.ENSP00000455329.

PTM databases

iPTMnetiP50238.
PhosphoSitePlusiP50238.

Polymorphism and mutation databases

BioMutaiCRIP1.
DMDMi20981688.

Proteomic databases

EPDiP50238.
MaxQBiP50238.
PaxDbiP50238.
PeptideAtlasiP50238.
PRIDEiP50238.
TopDownProteomicsiP50238.

Protocols and materials databases

DNASUi1396.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330233; ENSP00000332449; ENSG00000213145.
ENST00000392531; ENSP00000376315; ENSG00000213145.
ENST00000409393; ENSP00000386340; ENSG00000213145.
GeneIDi1396.
KEGGihsa:1396.
UCSCiuc001yri.5. human.

Organism-specific databases

CTDi1396.
DisGeNETi1396.
GeneCardsiCRIP1.
HGNCiHGNC:2360. CRIP1.
HPAiHPA042462.
MIMi123875. gene.
neXtProtiNX_P50238.
OpenTargetsiENSG00000213145.
ENSG00000257341.
PharmGKBiPA26878.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1700. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000264233.
HOVERGENiHBG051118.
InParanoidiP50238.
OMAiCNKTLSA.
OrthoDBiEOG091G11RX.
PhylomeDBiP50238.

Miscellaneous databases

GeneWikiiCRIP1.
GenomeRNAii1396.
PROiP50238.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213145.
CleanExiHS_CRIP1.
GenevisibleiP50238. HS.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP1_HUMAN
AccessioniPrimary (citable) accession number: P50238
Secondary accession number(s): H3BPI2
, Q13628, Q53XY7, Q96J34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.