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P50238

- CRIP1_HUMAN

UniProt

P50238 - CRIP1_HUMAN

Protein

Cysteine-rich protein 1

Gene

CRIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

    GO - Molecular functioni

    1. AT DNA binding Source: UniProtKB
    2. DNA binding, bending Source: UniProtKB
    3. peptide binding Source: UniProtKB
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. cellular response to antibiotic Source: UniProtKB
    3. cellular response to UV-B Source: UniProtKB
    4. heart development Source: UniProtKB
    5. immune response Source: UniProtKB
    6. intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
    7. prostate gland stromal morphogenesis Source: UniProtKB
    8. regulation of gene expression Source: UniProtKB
    9. response to organic substance Source: UniProtKB
    10. response to zinc ion Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich protein 1
    Short name:
    CRP-1
    Alternative name(s):
    Cysteine-rich heart protein
    Short name:
    CRHP
    Short name:
    hCRHP
    Cysteine-rich intestinal protein
    Short name:
    CRIP
    Gene namesi
    Name:CRIP1
    Synonyms:CRIP, CRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:2360. CRIP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26878.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7776Cysteine-rich protein 1PRO_0000075707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91N6-acetyllysine1 Publication
    Modified residuei22 – 221N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP50238.
    PaxDbiP50238.
    PeptideAtlasiP50238.
    PRIDEiP50238.

    PTM databases

    PhosphoSiteiP50238.

    Expressioni

    Gene expression databases

    BgeeiP50238.
    CleanExiHS_CRIP1.
    GenevestigatoriP50238.

    Organism-specific databases

    HPAiHPA042462.

    Interactioni

    Protein-protein interaction databases

    BioGridi107786. 5 interactions.
    IntActiP50238. 3 interactions.
    MINTiMINT-3018274.
    STRINGi9606.ENSP00000332449.

    Structurei

    3D structure databases

    ProteinModelPortaliP50238.
    SMRiP50238. Positions 2-77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 6362LIM zinc-bindingPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 709Gly-rich

    Sequence similaritiesi

    Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain

    Phylogenomic databases

    eggNOGiNOG246818.
    HOGENOMiHOG000264233.
    HOVERGENiHBG051118.
    InParanoidiP50238.
    OMAiCNKTLSA.
    PhylomeDBiP50238.

    Family and domain databases

    Gene3Di2.10.110.10. 1 hit.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 1 hit.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50238-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP   50
    YCNHPCYAAM FGPKGFGRGG AESHTFK 77
    Length:77
    Mass (Da):8,533
    Last modified:January 23, 2007 - v3
    Checksum:iB342436418DBC021
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581A → V in AAA64537. (PubMed:7999070)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09770 mRNA. Translation: AAA64537.1.
    U58630 mRNA. Translation: AAB61158.1.
    BT007181 mRNA. Translation: AAP35845.1.
    AL928654 Genomic DNA. No translation available.
    BC002738 mRNA. Translation: AAH02738.1.
    CCDSiCCDS10004.1.
    PIRiG02666.
    JC2431.
    RefSeqiNP_001302.1. NM_001311.4.
    UniGeneiHs.70327.

    Genome annotation databases

    EnsembliENST00000330233; ENSP00000332449; ENSG00000213145.
    ENST00000392531; ENSP00000376315; ENSG00000213145.
    ENST00000409393; ENSP00000386340; ENSG00000213145.
    GeneIDi1396.
    KEGGihsa:1396.
    UCSCiuc001yri.4. human.

    Polymorphism databases

    DMDMi20981688.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09770 mRNA. Translation: AAA64537.1 .
    U58630 mRNA. Translation: AAB61158.1 .
    BT007181 mRNA. Translation: AAP35845.1 .
    AL928654 Genomic DNA. No translation available.
    BC002738 mRNA. Translation: AAH02738.1 .
    CCDSi CCDS10004.1.
    PIRi G02666.
    JC2431.
    RefSeqi NP_001302.1. NM_001311.4.
    UniGenei Hs.70327.

    3D structure databases

    ProteinModelPortali P50238.
    SMRi P50238. Positions 2-77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107786. 5 interactions.
    IntActi P50238. 3 interactions.
    MINTi MINT-3018274.
    STRINGi 9606.ENSP00000332449.

    PTM databases

    PhosphoSitei P50238.

    Polymorphism databases

    DMDMi 20981688.

    Proteomic databases

    MaxQBi P50238.
    PaxDbi P50238.
    PeptideAtlasi P50238.
    PRIDEi P50238.

    Protocols and materials databases

    DNASUi 1396.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330233 ; ENSP00000332449 ; ENSG00000213145 .
    ENST00000392531 ; ENSP00000376315 ; ENSG00000213145 .
    ENST00000409393 ; ENSP00000386340 ; ENSG00000213145 .
    GeneIDi 1396.
    KEGGi hsa:1396.
    UCSCi uc001yri.4. human.

    Organism-specific databases

    CTDi 1396.
    GeneCardsi GC14P105952.
    HGNCi HGNC:2360. CRIP1.
    HPAi HPA042462.
    MIMi 123875. gene.
    neXtProti NX_P50238.
    PharmGKBi PA26878.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246818.
    HOGENOMi HOG000264233.
    HOVERGENi HBG051118.
    InParanoidi P50238.
    OMAi CNKTLSA.
    PhylomeDBi P50238.

    Miscellaneous databases

    GeneWikii CRIP1.
    GenomeRNAii 1396.
    NextBioi 5713.
    PROi P50238.
    SOURCEi Search...

    Gene expression databases

    Bgeei P50238.
    CleanExi HS_CRIP1.
    Genevestigatori P50238.

    Family and domain databases

    Gene3Di 2.10.110.10. 1 hit.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 1 hit.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 1 hit.
    PS50023. LIM_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart."
      Tsui S.K.W., Yam N.Y., Lee C.-Y., Waye M.M.Y.
      Biochem. Biophys. Res. Commun. 205:497-505(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells."
      Khoo C., Blanchard R.K., Sullivan V.K., Cousins R.J.
      Protein Expr. Purif. 9:379-387(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Small intestine.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCRIP1_HUMAN
    AccessioniPrimary (citable) accession number: P50238
    Secondary accession number(s): H3BPI2
    , Q13628, Q53XY7, Q96J34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3