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P50238 (CRIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich protein 1

Short name=CRP-1
Alternative name(s):
Cysteine-rich heart protein
Short name=CRHP
Short name=hCRHP
Cysteine-rich intestinal protein
Short name=CRIP
Gene names
Name:CRIP1
Synonyms:CRIP, CRP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length77 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Sequence similarities

Contains 1 LIM zinc-binding domain.

Ontologies

Keywords
   DomainLIM domain
   LigandMetal-binding
Zinc
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Traceable author statement Ref.2. Source: UniProtKB

cellular response to UV-B

Inferred from direct assay PubMed 20415737. Source: UniProtKB

cellular response to antibiotic

Inferred from direct assay PubMed 20415737. Source: UniProtKB

heart development

Traceable author statement Ref.1. Source: UniProtKB

immune response

Inferred from expression pattern PubMed 20415737. Source: UniProtKB

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from direct assay PubMed 20415737. Source: UniProtKB

prostate gland stromal morphogenesis

Inferred from expression pattern PubMed 9507743. Source: UniProtKB

regulation of gene expression

Inferred from expression pattern Ref.1. Source: UniProtKB

response to organic substance

Inferred from expression pattern PubMed 17486081. Source: UniProtKB

response to zinc ion

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 20415737Ref.2PubMed 9507743. Source: UniProtKB

   Molecular_functionAT DNA binding

Inferred from direct assay PubMed 20108983. Source: UniProtKB

DNA binding, bending

Inferred from direct assay PubMed 20108983. Source: UniProtKB

peptide binding

Inferred from direct assay PubMed 18670594. Source: UniProtKB

zinc ion binding

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 7776Cysteine-rich protein 1
PRO_0000075707

Regions

Domain2 – 6362LIM zinc-binding
Compositional bias62 – 709Gly-rich

Amino acid modifications

Modified residue91N6-acetyllysine Ref.6
Modified residue221N6-acetyllysine By similarity

Experimental info

Sequence conflict581A → V in AAA64537. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50238 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B342436418DBC021

FASTA778,533
        10         20         30         40         50         60 
MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM 

        70 
FGPKGFGRGG AESHTFK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart."
Tsui S.K.W., Yam N.Y., Lee C.-Y., Waye M.M.Y.
Biochem. Biophys. Res. Commun. 205:497-505(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells."
Khoo C., Blanchard R.K., Sullivan V.K., Cousins R.J.
Protein Expr. Purif. 9:379-387(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[6]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09770 mRNA. Translation: AAA64537.1.
U58630 mRNA. Translation: AAB61158.1.
BT007181 mRNA. Translation: AAP35845.1.
AL928654 Genomic DNA. No translation available.
BC002738 mRNA. Translation: AAH02738.1.
PIRG02666.
JC2431.
RefSeqNP_001302.1. NM_001311.4.
UniGeneHs.70327.

3D structure databases

ProteinModelPortalP50238.
SMRP50238. Positions 2-77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107786. 5 interactions.
IntActP50238. 3 interactions.
MINTMINT-3018274.
STRING9606.ENSP00000332449.

PTM databases

PhosphoSiteP50238.

Polymorphism databases

DMDM20981688.

Proteomic databases

PaxDbP50238.
PeptideAtlasP50238.
PRIDEP50238.

Protocols and materials databases

DNASU1396.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330233; ENSP00000332449; ENSG00000213145.
ENST00000392531; ENSP00000376315; ENSG00000213145.
ENST00000409393; ENSP00000386340; ENSG00000213145.
ENST00000603619; ENSP00000473914; ENSG00000270784.
ENST00000604460; ENSP00000474660; ENSG00000270784.
ENST00000604601; ENSP00000474287; ENSG00000270784.
GeneID1396.
KEGGhsa:1396.
UCSCuc001yri.4. human.

Organism-specific databases

CTD1396.
GeneCardsGC14P105952.
HGNCHGNC:2360. CRIP1.
HPAHPA042462.
MIM123875. gene.
neXtProtNX_P50238.
PharmGKBPA26878.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246818.
HOGENOMHOG000264233.
HOVERGENHBG051118.
InParanoidP50238.
OMACNKTLSA.
PhylomeDBP50238.

Gene expression databases

BgeeP50238.
CleanExHS_CRIP1.
GenevestigatorP50238.

Family and domain databases

Gene3D2.10.110.10. 1 hit.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 1 hit.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCRIP1.
GenomeRNAi1396.
NextBio5713.
PROP50238.
SOURCESearch...

Entry information

Entry nameCRIP1_HUMAN
AccessionPrimary (citable) accession number: P50238
Secondary accession number(s): H3BPI2 expand/collapse secondary AC list , Q13628, Q53XY7, Q96J34
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM