P50238 (CRIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine-rich protein 1
Short name=CRP-1

Alternative name(s):
Cysteine-rich heart protein
Short name=CRHP
Short name=hCRHP
Cysteine-rich intestinal protein
Short name=CRIP

Gene names

Name:	CRIP1
Synonyms:	CRIP, CRP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Sequence similarities	Contains 1 LIM zinc-binding domain.

Ontologies

Keywords
Domain	LIM domain
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from direct assay PubMed 20415737. Source: UniProtKB cell proliferation Traceable author statement Ref.2. Source: UniProtKB cellular response to UV-B Inferred from direct assay PubMed 20415737. Source: UniProtKB cellular response to antibiotic Inferred from direct assay PubMed 20415737. Source: UniProtKB heart development Traceable author statement Ref.1. Source: UniProtKB immune response Inferred from expression pattern PubMed 20415737. Source: UniProtKB prostate gland stromal morphogenesis Inferred from expression pattern PubMed 9507743. Source: UniProtKB regulation of gene expression Inferred from expression pattern Ref.1. Source: UniProtKB response to organic substance Inferred from expression pattern PubMed 17486081. Source: UniProtKB response to zinc ion Inferred from direct assay Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 20415737Ref.2PubMed 9507743. Source: UniProtKB
Molecular_function	AT DNA binding Inferred from direct assay PubMed 20108983. Source: UniProtKB DNA binding, bending Inferred from direct assay PubMed 20108983. Source: UniProtKB peptide binding Inferred from direct assay PubMed 18670594. Source: UniProtKB zinc ion binding Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 77	76	Cysteine-rich protein 1		PRO_0000075707
Regions
	Domain	2 – 63	62	LIM zinc-binding
	Compositional bias	62 – 70	9	Gly-rich
Amino acid modifications
	Modified residue	9	1	N6-acetyllysine Ref.6
Experimental info
	Sequence conflict	58	1	A → V in AAA64537. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P50238 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B342436418DBC021	FASTA	77	8,533
	10 20 30 40 50 60 MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM 70 FGPKGFGRGG AESHTFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart." Tsui S.K.W., Yam N.Y., Lee C.-Y., Waye M.M.Y. Biochem. Biophys. Res. Commun. 205:497-505(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells." Khoo C., Blanchard R.K., Sullivan V.K., Cousins R.J. Protein Expr. Purif. 9:379-387(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Small intestine.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9, MASS SPECTROMETRY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09770 mRNA. Translation: AAA64537.1. U58630 mRNA. Translation: AAB61158.1. BT007181 mRNA. Translation: AAP35845.1. AL928654 Genomic DNA. No translation available. BC002738 mRNA. Translation: AAH02738.1.
IPI	IPI00215611.
PIR	G02666. JC2431.
RefSeq	NP_001302.1. NM_001311.4.
UniGene	Hs.70327.
3D structure databases
ProteinModelPortal	P50238.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50238. 3 interactions.
STRING	9606.ENSP00000332449.
PTM databases
PhosphoSite	P50238.
Polymorphism databases
DMDM	20981688.
Proteomic databases
PaxDb	P50238.
PeptideAtlas	P50238.
PRIDE	P50238.
Protocols and materials databases
DNASU	1396.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330233; ENSP00000332449; ENSG00000213145. ENST00000392531; ENSP00000376315; ENSG00000213145. ENST00000409393; ENSP00000386340; ENSG00000213145.
GeneID	1396.
KEGG	hsa:1396.
UCSC	uc001yri.4. human.
Organism-specific databases
CTD	1396.
GeneCards	GC14P105952.
HGNC	HGNC:2360. CRIP1.
HPA	HPA042462.
MIM	123875. gene.
neXtProt	NX_P50238.
PharmGKB	PA26878.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246818.
HOGENOM	HOG000264233.
HOVERGEN	HBG051118.
InParanoid	P50238.
OMA	CNKTLSA.
OrthoDB	EOG4R23WD.
PhylomeDB	P50238.
Gene expression databases
Bgee	P50238.
CleanEx	HS_CRIP1.
Genevestigator	P50238.
GermOnline	ENSG00000182351. Homo sapiens.
Family and domain databases
Gene3D	2.10.110.10. 1 hit.
InterPro	IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 1 hit. [Graphical view]
SMART	SM00132. LIM. 1 hit. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 1 hit. PS50023. LIM_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1396.
NextBio	5713.
SOURCE	Search...

Entry information

Entry name

CRIP1_HUMAN

Accession

Primary (citable) accession number: P50238
Secondary accession number(s): H3BPI2 , Q13628, Q53XY7, Q96J34

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.