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Protein

Corticosteroid 11-beta-dehydrogenase isozyme 2

Gene

Hsd11b2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

Catalytic activityi

An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219SubstrateBy similarity1
Active sitei232Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 111NADBy similarityAdd BLAST30

GO - Molecular functioni

  • 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity Source: RGD
  • NAD binding Source: RGD
  • steroid binding Source: RGD

GO - Biological processi

  • female pregnancy Source: RGD
  • glucocorticoid metabolic process Source: RGD
  • regulation of blood volume by renal aldosterone Source: RGD
  • response to drug Source: RGD
  • response to food Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hypoxia Source: RGD
  • response to insulin Source: RGD
  • response to steroid hormone Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-RNO-194002 Glucocorticoid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 2
Short name:
11-DH2
Short name:
11-beta-HSD2
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Gene namesi
Name:Hsd11b2
Synonyms:Hsd11k
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2835 Hsd11b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2908

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546301 – 400Corticosteroid 11-beta-dehydrogenase isozyme 2Add BLAST400

Proteomic databases

PaxDbiP50233
PRIDEiP50233

PTM databases

PhosphoSitePlusiP50233

Expressioni

Tissue specificityi

Highly expressed in kidney, adrenal gland and distal colon. Detected at much lower levels in lung.

Gene expression databases

BgeeiENSRNOG00000017084
ExpressionAtlasiP50233 baseline and differential
GenevisibleiP50233 RN

Interactioni

Subunit structurei

Interacts with ligand-free cytoplasmic NR3C2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023130

Chemistry databases

BindingDBiP50233

Structurei

3D structure databases

ProteinModelPortaliP50233
SMRiP50233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00910000144025
HOVERGENiHBG005482
InParanoidiP50233
KOiK00071
OMAiGEDYIEH
OrthoDBiEOG091G0LMI
PhylomeDBiP50233
TreeFamiTF325617

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P50233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERWPWPSGG AWLLVAARAL LQLLRSDLRL GRPLLAALAL LAALDWLCQR
60 70 80 90 100
LLPPPAALVV LAGAGWIALS RLARPPRLPV ATRAVLITGC DTGFGKETAK
110 120 130 140 150
KLDAMGFTVL ATVLDLNGPG ALELRARCSP RLKLLQMDLT KPEDISRVLE
160 170 180 190 200
ITKAHTASTG LWGLVNNAGL NMVVADVELS PVVTFRECME VNFFGALELT
210 220 230 240 250
KGLLPLLRHS RGRIVTVGSP AGDMPYPCLA AYGTSKAAIA LLMDTFSCEL
260 270 280 290 300
LPWGIKVSII QPGCFKTEAV TNVNLWEKRK QLLLANLPRE LLQAYGEDYI
310 320 330 340 350
EHLHGQFLNS LRMALPDLSP VVDAIIDALL AAQPRSRYYT GRGLGLMYFI
360 370 380 390 400
HHYLPGGLRR RFLQNFFISH LLPRALRPGQ PGPVHDTTQD PNPSPTVSAL
Length:400
Mass (Da):43,726
Last modified:October 1, 1996 - v1
Checksum:iA1BAAA328E2F189D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22424 mRNA Translation: AAA87007.1
BC087023 mRNA Translation: AAH87023.1
RefSeqiNP_058777.1, NM_017081.2
UniGeneiRn.10186

Genome annotation databases

EnsembliENSRNOT00000023130; ENSRNOP00000023130; ENSRNOG00000017084
GeneIDi25117
KEGGirno:25117
UCSCiRGD:2835 rat

Similar proteinsi

Entry informationi

Entry nameiDHI2_RAT
AccessioniPrimary (citable) accession number: P50233
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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