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P50231

- CCL5_RAT

UniProt

P50231 - CCL5_RAT

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Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

  1. chemokine activity Source: RGD
  2. heparin binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to alkyl hydroperoxide Source: RGD
  3. cellular response to amino acid stimulus Source: RGD
  4. cellular response to cytokine stimulus Source: RGD
  5. cellular response to ethanol Source: RGD
  6. cellular response to high density lipoprotein particle stimulus Source: RGD
  7. cellular response to lipopolysaccharide Source: RGD
  8. cellular response to morphine Source: RGD
  9. cellular response to transforming growth factor beta stimulus Source: RGD
  10. cellular response to tumor necrosis factor Source: RGD
  11. cellular response to vitamin K Source: RGD
  12. chemokine-mediated signaling pathway Source: UniProtKB
  13. chronic inflammatory response Source: RGD
  14. dibenzo-p-dioxin metabolic process Source: RGD
  15. G-protein coupled receptor signaling pathway Source: UniProtKB
  16. inflammatory response Source: RGD
  17. lymphocyte chemotaxis Source: RGD
  18. negative regulation of cell death Source: RGD
  19. negative regulation of neuron death Source: RGD
  20. phosphatidylcholine metabolic process Source: RGD
  21. positive regulation of angiogenesis Source: RGD
  22. positive regulation of fever generation Source: RGD
  23. positive regulation of gene expression Source: RGD
  24. positive regulation of mast cell chemotaxis Source: RGD
  25. positive regulation of neuron differentiation Source: RGD
  26. positive regulation of osteoclast differentiation Source: RGD
  27. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  28. positive regulation of T cell chemotaxis Source: BHF-UCL
  29. pseudopodium assembly Source: BHF-UCL
  30. regulation of insulin secretion Source: UniProtKB
  31. regulation of neuron death Source: UniProtKB
  32. response to activity Source: RGD
  33. response to bacterium Source: RGD
  34. response to cholesterol Source: RGD
  35. response to cytokine Source: RGD
  36. response to drug Source: RGD
  37. response to estrogen Source: RGD
  38. response to glucocorticoid Source: RGD
  39. response to insulin Source: RGD
  40. response to interferon-gamma Source: BHF-UCL
  41. response to lipopolysaccharide Source: RGD
  42. response to nutrient levels Source: RGD
  43. response to organic cyclic compound Source: RGD
  44. response to salt stress Source: RGD
  45. response to virus Source: RGD
  46. T-helper 1 cell diapedesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:Ccl5
Synonyms:Scya5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69069. Ccl5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 9268C-C motif chemokine 5PRO_0000005180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP50231.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014865.

Structurei

3D structure databases

ProteinModelPortaliP50231.
SMRiP50231. Positions 25-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50231.
PhylomeDBiP50231.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE
60 70 80 90
YFYTSSKCSN LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS
Length:92
Mass (Da):10,170
Last modified:October 1, 1996 - v1
Checksum:iB4FBEC2B4208ABC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06436 mRNA. Translation: AAA96499.1.
UniGeneiRn.8019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06436 mRNA. Translation: AAA96499.1 .
UniGenei Rn.8019.

3D structure databases

ProteinModelPortali P50231.
SMRi P50231. Positions 25-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 69069. Ccl5.

Phylogenomic databases

eggNOGi NOG38896.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P50231.
PhylomeDBi P50231.

Miscellaneous databases

PROi P50231.

Gene expression databases

Genevestigatori P50231.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jones M.L., Shanley T.P., Ward P.A.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Lung.

Entry informationi

Entry nameiCCL5_RAT
AccessioniPrimary (citable) accession number: P50231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3