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Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

  • chemokine activity Source: RGD
  • heparin binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to alkyl hydroperoxide Source: RGD
  • cellular response to amino acid stimulus Source: RGD
  • cellular response to cytokine stimulus Source: RGD
  • cellular response to ethanol Source: RGD
  • cellular response to high density lipoprotein particle stimulus Source: RGD
  • cellular response to lipid Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to morphine Source: RGD
  • cellular response to transforming growth factor beta stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • cellular response to vitamin K Source: RGD
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chronic inflammatory response Source: RGD
  • dibenzo-p-dioxin metabolic process Source: RGD
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • inflammatory response Source: RGD
  • lymphocyte chemotaxis Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of neuron death Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of fever generation Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of mast cell chemotaxis Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of osteoclast differentiation Source: RGD
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  • positive regulation of T cell chemotaxis Source: BHF-UCL
  • pseudopodium assembly Source: BHF-UCL
  • regulation of insulin secretion Source: UniProtKB
  • regulation of neuron death Source: UniProtKB
  • response to activity Source: RGD
  • response to bacterium Source: RGD
  • response to cholesterol Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to glucocorticoid Source: RGD
  • response to insulin Source: RGD
  • response to interferon-gamma Source: BHF-UCL
  • response to lipopolysaccharide Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to salt stress Source: RGD
  • response to virus Source: RGD
  • T-helper 1 cell diapedesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:Ccl5
Synonyms:Scya5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69069. Ccl5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 9268C-C motif chemokine 5PRO_0000005180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014865.

Structurei

3D structure databases

ProteinModelPortaliP50231.
SMRiP50231. Positions 25-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50231.
PhylomeDBiP50231.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE
60 70 80 90
YFYTSSKCSN LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS
Length:92
Mass (Da):10,170
Last modified:October 1, 1996 - v1
Checksum:iB4FBEC2B4208ABC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06436 mRNA. Translation: AAA96499.1.
UniGeneiRn.8019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06436 mRNA. Translation: AAA96499.1.
UniGeneiRn.8019.

3D structure databases

ProteinModelPortaliP50231.
SMRiP50231. Positions 25-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi69069. Ccl5.

Phylogenomic databases

eggNOGiNOG38896.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50231.
PhylomeDBiP50231.

Miscellaneous databases

PROiP50231.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Jones M.L., Shanley T.P., Ward P.A.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Lung.

Entry informationi

Entry nameiCCL5_RAT
AccessioniPrimary (citable) accession number: P50231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.