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P50231 (CCL5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene names
Name:Ccl5
Synonyms:Scya5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 1 cell diapedesis

Inferred from direct assay PubMed 10477596. Source: BHF-UCL

aging

Inferred from expression pattern PubMed 16369869. Source: RGD

cellular response to alkyl hydroperoxide

Inferred from expression pattern PubMed 18478184. Source: RGD

cellular response to amino acid stimulus

Inferred from expression pattern PubMed 20560880. Source: RGD

cellular response to cytokine stimulus

Inferred from expression pattern PubMed 19111021. Source: RGD

cellular response to ethanol

Inferred from expression pattern PubMed 19828633. Source: RGD

cellular response to high density lipoprotein particle stimulus

Inferred from expression pattern PubMed 20623482. Source: RGD

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 20578038. Source: RGD

cellular response to morphine

Inferred from expression pattern PubMed 20578038. Source: RGD

cellular response to transforming growth factor beta stimulus

Inferred from expression pattern PubMed 20429874. Source: RGD

cellular response to tumor necrosis factor

Inferred from expression pattern PubMed 20663893. Source: RGD

cellular response to vitamin K

Inferred from expression pattern PubMed 19291322. Source: RGD

chronic inflammatory response

Inferred from expression pattern PubMed 17164972. Source: RGD

dibenzo-p-dioxin metabolic process

Inferred from expression pattern PubMed 20059583. Source: RGD

inflammatory response

Inferred from expression pattern PubMed 12144807. Source: RGD

lymphocyte chemotaxis

Inferred from direct assay PubMed 11069838PubMed 11104723. Source: RGD

negative regulation of cell death

Inferred from mutant phenotype PubMed 19497618. Source: RGD

negative regulation of neuron death

Inferred from mutant phenotype PubMed 20578038. Source: RGD

phosphatidylcholine metabolic process

Inferred from expression pattern PubMed 20638371. Source: RGD

positive regulation of T cell chemotaxis

Inferred from direct assay PubMed 10477596. Source: BHF-UCL

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 18392345. Source: RGD

positive regulation of fever generation

Inferred from direct assay PubMed 15066130. Source: RGD

positive regulation of gene expression

Inferred from direct assay PubMed 19497618. Source: RGD

positive regulation of mast cell chemotaxis

Inferred from direct assay PubMed 18052723. Source: RGD

positive regulation of neuron differentiation

Inferred from mutant phenotype PubMed 19559698. Source: RGD

positive regulation of osteoclast differentiation

Inferred from direct assay PubMed 9920817. Source: RGD

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 10477596. Source: BHF-UCL

pseudopodium assembly

Inferred from direct assay PubMed 10477596. Source: BHF-UCL

response to activity

Inferred from expression pattern PubMed 18464247. Source: RGD

response to bacterium

Inferred from expression pattern PubMed 18390738. Source: RGD

response to cholesterol

Inferred from expression pattern PubMed 20435353. Source: RGD

response to cytokine

Inferred from expression pattern PubMed 16251240. Source: RGD

response to drug

Inferred from expression pattern PubMed 16987901PubMed 17666800PubMed 18469848. Source: RGD

response to estrogen

Inferred from expression pattern PubMed 20435353. Source: RGD

response to glucocorticoid

Inferred from expression pattern PubMed 18476425. Source: RGD

response to insulin

Inferred from expression pattern PubMed 12435855. Source: RGD

response to interferon-gamma

Inferred from direct assay PubMed 10477596. Source: BHF-UCL

response to lipopolysaccharide

Inferred from expression pattern PubMed 19104678. Source: RGD

response to nutrient levels

Inferred from expression pattern PubMed 19194968. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 18375833. Source: RGD

response to salt stress

Inferred from expression pattern PubMed 20232302. Source: RGD

response to virus

Inferred from expression pattern PubMed 20007359. Source: RGD

   Cellular_componentextracellular space

Inferred from direct assay PubMed 18208670. Source: RGD

   Molecular_functionchemokine activity

Inferred from direct assay PubMed 11069838PubMed 11104723. Source: RGD

heparin binding

Inferred from direct assay PubMed 21052646. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 9268C-C motif chemokine 5
PRO_0000005180

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50231 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B4FBEC2B4208ABC6

FASTA9210,170
        10         20         30         40         50         60 
MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE YFYTSSKCSN 

        70         80         90 
LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS 

« Hide

References

[1]Jones M.L., Shanley T.P., Ward P.A.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Long Evans.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06436 mRNA. Translation: AAA96499.1.
UniGeneRn.8019.

3D structure databases

ProteinModelPortalP50231.
SMRP50231. Positions 25-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD69069. Ccl5.

Phylogenomic databases

eggNOGNOG38896.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP50231.
PhylomeDBP50231.

Gene expression databases

GenevestigatorP50231.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP50231.

Entry information

Entry nameCCL5_RAT
AccessionPrimary (citable) accession number: P50231
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families