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P50231

- CCL5_RAT

UniProt

P50231 - CCL5_RAT

Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: RGD
    2. heparin binding Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. cellular response to alkyl hydroperoxide Source: RGD
    3. cellular response to amino acid stimulus Source: RGD
    4. cellular response to cytokine stimulus Source: RGD
    5. cellular response to ethanol Source: RGD
    6. cellular response to high density lipoprotein particle stimulus Source: RGD
    7. cellular response to lipopolysaccharide Source: RGD
    8. cellular response to morphine Source: RGD
    9. cellular response to transforming growth factor beta stimulus Source: RGD
    10. cellular response to tumor necrosis factor Source: RGD
    11. cellular response to vitamin K Source: RGD
    12. chronic inflammatory response Source: RGD
    13. dibenzo-p-dioxin metabolic process Source: RGD
    14. inflammatory response Source: RGD
    15. lymphocyte chemotaxis Source: RGD
    16. negative regulation of cell death Source: RGD
    17. negative regulation of neuron death Source: RGD
    18. phosphatidylcholine metabolic process Source: RGD
    19. positive regulation of angiogenesis Source: RGD
    20. positive regulation of fever generation Source: RGD
    21. positive regulation of gene expression Source: RGD
    22. positive regulation of mast cell chemotaxis Source: RGD
    23. positive regulation of neuron differentiation Source: RGD
    24. positive regulation of osteoclast differentiation Source: RGD
    25. positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
    26. positive regulation of T cell chemotaxis Source: BHF-UCL
    27. pseudopodium assembly Source: BHF-UCL
    28. response to activity Source: RGD
    29. response to bacterium Source: RGD
    30. response to cholesterol Source: RGD
    31. response to cytokine Source: RGD
    32. response to drug Source: RGD
    33. response to estrogen Source: RGD
    34. response to glucocorticoid Source: RGD
    35. response to insulin Source: RGD
    36. response to interferon-gamma Source: BHF-UCL
    37. response to lipopolysaccharide Source: RGD
    38. response to nutrient levels Source: RGD
    39. response to organic cyclic compound Source: RGD
    40. response to salt stress Source: RGD
    41. response to virus Source: RGD
    42. T-helper 1 cell diapedesis Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    SIS-delta
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:Ccl5
    Synonyms:Scya5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69069. Ccl5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 9268C-C motif chemokine 5PRO_0000005180Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Gene expression databases

    GenevestigatoriP50231.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014865.

    Structurei

    3D structure databases

    ProteinModelPortaliP50231.
    SMRiP50231. Positions 25-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP50231.
    PhylomeDBiP50231.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE   50
    YFYTSSKCSN LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS 92
    Length:92
    Mass (Da):10,170
    Last modified:October 1, 1996 - v1
    Checksum:iB4FBEC2B4208ABC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06436 mRNA. Translation: AAA96499.1.
    UniGeneiRn.8019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06436 mRNA. Translation: AAA96499.1 .
    UniGenei Rn.8019.

    3D structure databases

    ProteinModelPortali P50231.
    SMRi P50231. Positions 25-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 69069. Ccl5.

    Phylogenomic databases

    eggNOGi NOG38896.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P50231.
    PhylomeDBi P50231.

    Miscellaneous databases

    PROi P50231.

    Gene expression databases

    Genevestigatori P50231.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jones M.L., Shanley T.P., Ward P.A.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Long Evans.
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL5_RAT
    AccessioniPrimary (citable) accession number: P50231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3