ID   CCL4_RAT                Reviewed;          92 AA.
AC   P50230; A1EC89;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   08-NOV-2023, entry version 125.
DE   RecName: Full=C-C motif chemokine 4;
DE   AltName: Full=Macrophage inflammatory protein 1-beta;
DE            Short=MIP-1-beta;
DE   AltName: Full=Small-inducible cytokine A4;
DE   Flags: Precursor;
GN   Name=Ccl4; Synonyms=Mip1b, Scya4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Long Evans; TISSUE=Lung;
RA   Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.;
RL   Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Dahl salt-sensitive, and Lewis;
RX   PubMed=17218081; DOI=10.1016/j.ygeno.2006.12.005;
RA   Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P.,
RA   Radecki T., Joe B.;
RT   "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous
RT   variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome
RT   10.";
RL   Genomics 89:343-353(2007).
CC   -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U06434; AAA96497.1; -; mRNA.
DR   EMBL; EF121996; ABL63435.1; -; mRNA.
DR   EMBL; EF121997; ABL63436.1; -; mRNA.
DR   RefSeq; NP_446310.1; NM_053858.1.
DR   AlphaFoldDB; P50230; -.
DR   SMR; P50230; -.
DR   STRING; 10116.ENSRNOP00000015199; -.
DR   PaxDb; 10116-ENSRNOP00000015199; -.
DR   GeneID; 116637; -.
DR   KEGG; rno:116637; -.
DR   AGR; RGD:620441; -.
DR   CTD; 6351; -.
DR   RGD; 620441; Ccl4.
DR   eggNOG; ENOG502S8M4; Eukaryota.
DR   InParanoid; P50230; -.
DR   OrthoDB; 4265193at2759; -.
DR   PhylomeDB; P50230; -.
DR   Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P50230; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0031730; F:CCR5 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISO:RGD.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030595; P:leukocyte chemotaxis; IDA:RGD.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:RGD.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISO:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:RGD.
DR   GO; GO:0043117; P:positive regulation of vascular permeability; IDA:RGD.
DR   GO; GO:0009636; P:response to toxic substance; ISO:RGD.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF103; C-C MOTIF CHEMOKINE 4-RELATED; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..92
FT                   /note="C-C motif chemokine 4"
FT                   /id="PRO_0000005167"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   92 AA;  10234 MW;  60B451EEEBC7103D CRC64;
     MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD YYETSSLCSQ
     PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN
//