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Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Molecular functioni

  • chemokine activity Source: RGD

GO - Biological processi

  • immune response Source: InterPro
  • inflammatory response Source: RGD
  • leukocyte chemotaxis Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of vascular permeability Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620441. Ccl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000005167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP50230.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP50230.
SMRiP50230. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50230.
KOiK12964.
PhylomeDBiP50230.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD
60 70 80 90
YYETSSLCSQ PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN
Length:92
Mass (Da):10,234
Last modified:October 1, 1996 - v1
Checksum:i60B451EEEBC7103D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06434 mRNA. Translation: AAA96497.1.
EF121996 mRNA. Translation: ABL63435.1.
EF121997 mRNA. Translation: ABL63436.1.
RefSeqiNP_446310.1. NM_053858.1.
UniGeneiRn.37880.

Genome annotation databases

GeneIDi116637.
KEGGirno:116637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06434 mRNA. Translation: AAA96497.1.
EF121996 mRNA. Translation: ABL63435.1.
EF121997 mRNA. Translation: ABL63436.1.
RefSeqiNP_446310.1. NM_053858.1.
UniGeneiRn.37880.

3D structure databases

ProteinModelPortaliP50230.
SMRiP50230. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116637.
KEGGirno:116637.

Organism-specific databases

CTDi6351.
RGDi620441. Ccl4.

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50230.
KOiK12964.
PhylomeDBiP50230.

Miscellaneous databases

NextBioi619347.
PROiP50230.

Gene expression databases

GenevestigatoriP50230.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Lung.
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.

Entry informationi

Entry nameiCCL4_RAT
AccessioniPrimary (citable) accession number: P50230
Secondary accession number(s): A1EC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.