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P50230 (CCL4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name=MIP-1-beta
Small-inducible cytokine A4
Gene names
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9269C-C motif chemokine 4
PRO_0000005167

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50230 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 60B451EEEBC7103D

FASTA9210,234
        10         20         30         40         50         60 
MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD YYETSSLCSQ 

        70         80         90 
PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN 

« Hide

References

[1]Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Long Evans.
Tissue: Lung.
[2]"Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Dahl salt-sensitive and Lewis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06434 mRNA. Translation: AAA96497.1.
EF121996 mRNA. Translation: ABL63435.1.
EF121997 mRNA. Translation: ABL63436.1.
RefSeqNP_446310.1. NM_053858.1.
UniGeneRn.37880.

3D structure databases

ProteinModelPortalP50230.
SMRP50230. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID116637.
KEGGrno:116637.

Organism-specific databases

CTD6351.
RGD620441. Ccl4.

Phylogenomic databases

eggNOGNOG124416.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP50230.
KOK12964.
PhylomeDBP50230.

Gene expression databases

GenevestigatorP50230.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619347.
PROP50230.

Entry information

Entry nameCCL4_RAT
AccessionPrimary (citable) accession number: P50230
Secondary accession number(s): A1EC89
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families