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P50230

- CCL4_RAT

UniProt

P50230 - CCL4_RAT

Protein

C-C motif chemokine 4

Gene

Ccl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.

    GO - Molecular functioni

    1. chemokine activity Source: RGD

    GO - Biological processi

    1. immune response Source: InterPro
    2. inflammatory response Source: RGD
    3. leukocyte chemotaxis Source: RGD
    4. positive regulation of tumor necrosis factor production Source: RGD
    5. positive regulation of vascular permeability Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Macrophage inflammatory protein 1-beta
    Short name:
    MIP-1-beta
    Small-inducible cytokine A4
    Gene namesi
    Name:Ccl4
    Synonyms:Mip1b, Scya4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620441. Ccl4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000005167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Gene expression databases

    GenevestigatoriP50230.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP50230.
    SMRiP50230. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP50230.
    KOiK12964.
    PhylomeDBiP50230.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50230-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD   50
    YYETSSLCSQ PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN 92
    Length:92
    Mass (Da):10,234
    Last modified:October 1, 1996 - v1
    Checksum:i60B451EEEBC7103D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06434 mRNA. Translation: AAA96497.1.
    EF121996 mRNA. Translation: ABL63435.1.
    EF121997 mRNA. Translation: ABL63436.1.
    RefSeqiNP_446310.1. NM_053858.1.
    UniGeneiRn.37880.

    Genome annotation databases

    GeneIDi116637.
    KEGGirno:116637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06434 mRNA. Translation: AAA96497.1 .
    EF121996 mRNA. Translation: ABL63435.1 .
    EF121997 mRNA. Translation: ABL63436.1 .
    RefSeqi NP_446310.1. NM_053858.1.
    UniGenei Rn.37880.

    3D structure databases

    ProteinModelPortali P50230.
    SMRi P50230. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116637.
    KEGGi rno:116637.

    Organism-specific databases

    CTDi 6351.
    RGDi 620441. Ccl4.

    Phylogenomic databases

    eggNOGi NOG124416.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P50230.
    KOi K12964.
    PhylomeDBi P50230.

    Miscellaneous databases

    NextBioi 619347.
    PROi P50230.

    Gene expression databases

    Genevestigatori P50230.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Long Evans.
      Tissue: Lung.
    2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
      Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
      Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Dahl salt-sensitive and Lewis.

    Entry informationi

    Entry nameiCCL4_RAT
    AccessioniPrimary (citable) accession number: P50230
    Secondary accession number(s): A1EC89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3