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P50230

- CCL4_RAT

UniProt

P50230 - CCL4_RAT

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Protein

C-C motif chemokine 4

Gene
Ccl4, Mip1b, Scya4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. immune response Source: InterPro
  2. inflammatory response Source: RGD
  3. leukocyte chemotaxis Source: RGD
  4. positive regulation of tumor necrosis factor production Source: RGD
  5. positive regulation of vascular permeability Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:Ccl4
Synonyms:Mip1b, Scya4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620441. Ccl4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000005167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58 By similarity
Disulfide bondi35 ↔ 74 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

GenevestigatoriP50230.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP50230.
SMRiP50230. Positions 24-92.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP50230.
KOiK12964.
PhylomeDBiP50230.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50230-1 [UniParc]FASTAAdd to Basket

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MKLCVSAFSL LLLVAAFCDS VLSAPIGSDP PTSCCFSYTS RKIHRNFVMD   50
YYETSSLCSQ PAVVFLTKKG RQICADPSEP WVNEYVNDLE LN 92
Length:92
Mass (Da):10,234
Last modified:October 1, 1996 - v1
Checksum:i60B451EEEBC7103D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06434 mRNA. Translation: AAA96497.1.
EF121996 mRNA. Translation: ABL63435.1.
EF121997 mRNA. Translation: ABL63436.1.
RefSeqiNP_446310.1. NM_053858.1.
UniGeneiRn.37880.

Genome annotation databases

GeneIDi116637.
KEGGirno:116637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06434 mRNA. Translation: AAA96497.1 .
EF121996 mRNA. Translation: ABL63435.1 .
EF121997 mRNA. Translation: ABL63436.1 .
RefSeqi NP_446310.1. NM_053858.1.
UniGenei Rn.37880.

3D structure databases

ProteinModelPortali P50230.
SMRi P50230. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 116637.
KEGGi rno:116637.

Organism-specific databases

CTDi 6351.
RGDi 620441. Ccl4.

Phylogenomic databases

eggNOGi NOG124416.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P50230.
KOi K12964.
PhylomeDBi P50230.

Miscellaneous databases

NextBioi 619347.
PROi P50230.

Gene expression databases

Genevestigatori P50230.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jones M.L., Shanley T.P., Schmal H., Friedl H.P., Ward P.A.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Lung.
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.

Entry informationi

Entry nameiCCL4_RAT
AccessioniPrimary (citable) accession number: P50230
Secondary accession number(s): A1EC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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