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Protein

C-X-C motif chemokine 5

Gene

Cxcl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 5
Alternative name(s):
Cytokine LIX
Small-inducible cytokine B5
Cleaved into the following 2 chains:
Gene namesi
Name:Cxcl5
Synonyms:Scyb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1096868. Cxcl5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 40401 PublicationAdd
BLAST
Chaini41 – 13292C-X-C motif chemokine 5PRO_0000005078Add
BLAST
Chaini41 – 11878GCP-2(1-78)PRO_0000005079Add
BLAST
Chaini49 – 11870GCP-2(9-78)PRO_0000005080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 79By similarity
Disulfide bondi55 ↔ 95By similarity

Post-translational modificationi

GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states.2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP50228.
PRIDEiP50228.

PTM databases

iPTMnetiP50228.
PhosphoSiteiP50228.

Miscellaneous databases

PMAP-CutDBP50228.

Expressioni

Inductioni

By lipopolysaccharide (LPS).

Gene expression databases

BgeeiENSMUSG00000029371.
CleanExiMM_CXCL5.
GenevisibleiP50228. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031318.

Structurei

3D structure databases

ProteinModelPortaliP50228.
SMRiP50228. Positions 50-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP50228.
KOiK05506.
OMAiTELRCTC.
OrthoDBiEOG091G132U.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQLRSSAR IPSGSISPFM RMAPLAFLLL FTLPQHLAEA APSSVIAATE
60 70 80 90 100
LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA
110 120 130
PVIKKIIQKI LGSDKKKAKR NALAVERTAS VQ
Length:132
Mass (Da):14,235
Last modified:October 3, 2012 - v2
Checksum:iB7E9C4E6094DE365
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101R → H in AAC52238 (PubMed:7622488).Curated
Sequence conflicti10 – 101R → H in AAH24392 (PubMed:15489334).Curated
Sequence conflicti16 – 161I → S in AAC52238 (PubMed:7622488).Curated
Sequence conflicti16 – 161I → S in AAH24392 (PubMed:15489334).Curated
Sequence conflicti81 – 822TV → N AA sequence (PubMed:8759763).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27267 mRNA. Translation: AAC52238.1.
AY100019 Genomic DNA. Translation: AAM48589.1.
AC105995 Genomic DNA. No translation available.
BC024392 mRNA. Translation: AAH24392.1.
CCDSiCCDS19414.1.
PIRiA57325.
RefSeqiNP_033167.2. NM_009141.3.
UniGeneiMm.4660.

Genome annotation databases

EnsembliENSMUST00000031318; ENSMUSP00000031318; ENSMUSG00000029371.
GeneIDi20311.
KEGGimmu:20311.
UCSCiuc008ybg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27267 mRNA. Translation: AAC52238.1.
AY100019 Genomic DNA. Translation: AAM48589.1.
AC105995 Genomic DNA. No translation available.
BC024392 mRNA. Translation: AAH24392.1.
CCDSiCCDS19414.1.
PIRiA57325.
RefSeqiNP_033167.2. NM_009141.3.
UniGeneiMm.4660.

3D structure databases

ProteinModelPortaliP50228.
SMRiP50228. Positions 50-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031318.

PTM databases

iPTMnetiP50228.
PhosphoSiteiP50228.

Proteomic databases

PaxDbiP50228.
PRIDEiP50228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031318; ENSMUSP00000031318; ENSMUSG00000029371.
GeneIDi20311.
KEGGimmu:20311.
UCSCiuc008ybg.2. mouse.

Organism-specific databases

CTDi6374.
MGIiMGI:1096868. Cxcl5.

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP50228.
KOiK05506.
OMAiTELRCTC.
OrthoDBiEOG091G132U.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PMAP-CutDBP50228.
PROiP50228.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029371.
CleanExiMM_CXCL5.
GenevisibleiP50228. MM.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL5_MOUSE
AccessioniPrimary (citable) accession number: P50228
Secondary accession number(s): Q8K3I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.