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P50227 (ST1A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfotransferase 1A1
Short name=ST1A1
EC=2.8.2.1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name=P-PST
Gene names
Name:SULT1A1
Synonyms:STP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.

Catalytic activity

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Distal lung parenchyma.

Sequence similarities

Belongs to the sulfotransferase 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Sulfotransferase 1A1
PRO_0000085125

Regions

Nucleotide binding48 – 536PAPS By similarity
Nucleotide binding227 – 2326PAPS By similarity
Nucleotide binding255 – 2595PAPS By similarity
Region106 – 1083Substrate binding By similarity

Sites

Active site1081Proton acceptor By similarity
Binding site1301PAPS By similarity
Binding site1381PAPS By similarity
Binding site1931PAPS By similarity

Experimental info

Sequence conflict2001P → S in AAI02275. Ref.3
Sequence conflict285 – 2917AGCKLRF → RAATPL in AAA85510. Ref.1
Sequence conflict285 – 2917AGCKLRF → RAATPL in AAC48677. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50227 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 8F5B7F1E1094D6C5

FASTA29534,184
        10         20         30         40         50         60 
MELIQDTSRP PAKYVKGIPL IKYFAEALGP LESFEAWPDD LLISTYPKSG TTWVSEILDL 

        70         80         90        100        110        120 
IYQEGDLEKC QRAPVFLRVP FLEFSAPGVP TGVELLKDTP APRLLKTHLP LALLPKTLLD 

       130        140        150        160        170        180 
QKVKVIYIAR NAKDVAVSYY HFYRMAKVHP DPGTWDSFLE KFMAGEVCYG SWYQHVQEWW 

       190        200        210        220        230        240 
ELSHTHPVLY LFYEDIKEDP KREIQKILEF IGRSLPEETV DHIVQRTSFK EMKKNPMTNY 

       250        260        270        280        290 
STIPTAVMDH SISAFMRKGI TGDWKSTFTV AQNELFEAHY AKKMAGCKLR FRWEL

« Hide

References

« Hide 'large scale' references
[1]"Characterization of bovine tracheobronchial phenol sulphotransferase cDNA and detection of mRNA regulation by cortisol."
Schauss S.J., Henry T., Palmatier R., Halvorson L., Dannenbring R., Beckmann J.D.
Biochem. J. 311:209-217(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Tracheobronchial.
[2]"Isolation and characterization of a bovine gene encoding phenol sulfotransferase."
Henry T., Kliewer B., Palmatier R., Ulphani J.S., Beckmann J.D.
Gene 174:221-224(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[4]Nonneman D.J., Shibuya H., Johnson G.S.
Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-57.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U35253 mRNA. Translation: AAA85510.1.
U34753 Genomic DNA. Translation: AAC48677.1.
BC102274 mRNA. Translation: AAI02275.1.
L33828 Genomic DNA. Translation: AAA56789.1.
IPIIPI00695563.
PIRJC5000.
RefSeqNP_803487.1. NM_177521.2.
UniGeneBt.3537.

3D structure databases

ProteinModelPortalP50227.
SMRP50227. Positions 7-295.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011388.

Proteomic databases

PRIDEP50227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011388; ENSBTAP00000011388; ENSBTAG00000008635.
GeneID282485.
KEGGbta:282485.

Organism-specific databases

CTD6817.

Phylogenomic databases

eggNOGNOG260792.
GeneTreeENSGT00560000076773.
HOGENOMHOG000037209.
HOVERGENHBG001195.
InParanoidP50227.
KOK01014.
OMAISAPPKC.
OrthoDBEOG4255T9.

Enzyme and pathway databases

BRENDA2.8.2.1. 908.

Gene expression databases

ArrayExpressP50227.

Family and domain databases

InterProIPR000863. Sulfotransferase_dom.
[Graphical view]
PfamPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806249.

Entry information

Entry nameST1A1_BOVIN
AccessionPrimary (citable) accession number: P50227
Secondary accession number(s): Q3T0S9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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