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P50227

- ST1A1_BOVIN

UniProt

P50227 - ST1A1_BOVIN

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Protein
Sulfotransferase 1A1
Gene
SULT1A1, STP
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton acceptor By similarity
Binding sitei130 – 1301PAPS By similarity
Binding sitei138 – 1381PAPS By similarity
Binding sitei193 – 1931PAPS By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 536PAPS By similarity
Nucleotide bindingi227 – 2326PAPS By similarity
Nucleotide bindingi255 – 2595PAPS By similarity

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: Ensembl

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 908.
ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
REACT_211218. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name:
P-PST
Gene namesi
Name:SULT1A1
Synonyms:STP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Sulfotransferase 1A1
PRO_0000085125Add
BLAST

Proteomic databases

PRIDEiP50227.

Expressioni

Tissue specificityi

Distal lung parenchyma.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011388.

Structurei

3D structure databases

ProteinModelPortaliP50227.
SMRiP50227. Positions 7-295.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00740000115442.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50227.
KOiK01014.
OMAiWESFLEK.
OrthoDBiEOG7V49ZK.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P50227-1 [UniParc]FASTAAdd to Basket

« Hide

MELIQDTSRP PAKYVKGIPL IKYFAEALGP LESFEAWPDD LLISTYPKSG    50
TTWVSEILDL IYQEGDLEKC QRAPVFLRVP FLEFSAPGVP TGVELLKDTP 100
APRLLKTHLP LALLPKTLLD QKVKVIYIAR NAKDVAVSYY HFYRMAKVHP 150
DPGTWDSFLE KFMAGEVCYG SWYQHVQEWW ELSHTHPVLY LFYEDIKEDP 200
KREIQKILEF IGRSLPEETV DHIVQRTSFK EMKKNPMTNY STIPTAVMDH 250
SISAFMRKGI TGDWKSTFTV AQNELFEAHY AKKMAGCKLR FRWEL 295
Length:295
Mass (Da):34,184
Last modified:May 1, 2007 - v2
Checksum:i8F5B7F1E1094D6C5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001P → S in AAI02275. 1 Publication
Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAA85510. 1 Publication
Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAC48677. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35253 mRNA. Translation: AAA85510.1.
U34753 Genomic DNA. Translation: AAC48677.1.
BC102274 mRNA. Translation: AAI02275.1.
L33828 Genomic DNA. Translation: AAA56789.1.
PIRiJC5000.
RefSeqiNP_803487.1. NM_177521.2.
XP_005224892.1. XM_005224835.1.
XP_005224893.1. XM_005224836.1.
XP_005224894.1. XM_005224837.1.
XP_005224895.1. XM_005224838.1.
UniGeneiBt.3537.

Genome annotation databases

EnsembliENSBTAT00000011388; ENSBTAP00000011388; ENSBTAG00000008635.
GeneIDi282485.
KEGGibta:282485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35253 mRNA. Translation: AAA85510.1 .
U34753 Genomic DNA. Translation: AAC48677.1 .
BC102274 mRNA. Translation: AAI02275.1 .
L33828 Genomic DNA. Translation: AAA56789.1 .
PIRi JC5000.
RefSeqi NP_803487.1. NM_177521.2.
XP_005224892.1. XM_005224835.1.
XP_005224893.1. XM_005224836.1.
XP_005224894.1. XM_005224837.1.
XP_005224895.1. XM_005224838.1.
UniGenei Bt.3537.

3D structure databases

ProteinModelPortali P50227.
SMRi P50227. Positions 7-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000011388.

Proteomic databases

PRIDEi P50227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011388 ; ENSBTAP00000011388 ; ENSBTAG00000008635 .
GeneIDi 282485.
KEGGi bta:282485.

Organism-specific databases

CTDi 6817.

Phylogenomic databases

eggNOGi NOG260792.
GeneTreei ENSGT00740000115442.
HOGENOMi HOG000037209.
HOVERGENi HBG001195.
InParanoidi P50227.
KOi K01014.
OMAi WESFLEK.
OrthoDBi EOG7V49ZK.
TreeFami TF321745.

Enzyme and pathway databases

BRENDAi 2.8.2.1. 908.
Reactomei REACT_211201. XBP1(S) activates chaperone genes.
REACT_211218. Cytosolic sulfonation of small molecules.

Miscellaneous databases

NextBioi 20806249.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of bovine tracheobronchial phenol sulphotransferase cDNA and detection of mRNA regulation by cortisol."
    Schauss S.J., Henry T., Palmatier R., Halvorson L., Dannenbring R., Beckmann J.D.
    Biochem. J. 311:209-217(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Tracheobronchial.
  2. "Isolation and characterization of a bovine gene encoding phenol sulfotransferase."
    Henry T., Kliewer B., Palmatier R., Ulphani J.S., Beckmann J.D.
    Gene 174:221-224(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  4. Nonneman D.J., Shibuya H., Johnson G.S.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-57.

Entry informationi

Entry nameiST1A1_BOVIN
AccessioniPrimary (citable) accession number: P50227
Secondary accession number(s): Q3T0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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