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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton acceptorBy similarity
Binding sitei130 – 1301PAPSBy similarity
Binding sitei138 – 1381PAPSBy similarity
Binding sitei193 – 1931PAPSBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 536PAPSBy similarity
Nucleotide bindingi227 – 2326PAPSBy similarity
Nucleotide bindingi255 – 2595PAPSBy similarity

GO - Molecular functioni

  1. aryl sulfotransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: Ensembl

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. steroid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BRENDAi2.8.2.1. 908.
ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
REACT_211218. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase
Phenol sulfotransferase
Phenol-sulfating phenol sulfotransferase
Short name:
P-PST
Gene namesi
Name:SULT1A1
Synonyms:STP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Sulfotransferase 1A1PRO_0000085125Add
BLAST

Proteomic databases

PRIDEiP50227.

Expressioni

Tissue specificityi

Distal lung parenchyma.

Gene expression databases

ExpressionAtlasiP50227. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011388.

Structurei

3D structure databases

ProteinModelPortaliP50227.
SMRiP50227. Positions 7-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50227.
KOiK01014.
OMAiKMAGCKL.
OrthoDBiEOG7V49ZK.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P50227-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIQDTSRP PAKYVKGIPL IKYFAEALGP LESFEAWPDD LLISTYPKSG
60 70 80 90 100
TTWVSEILDL IYQEGDLEKC QRAPVFLRVP FLEFSAPGVP TGVELLKDTP
110 120 130 140 150
APRLLKTHLP LALLPKTLLD QKVKVIYIAR NAKDVAVSYY HFYRMAKVHP
160 170 180 190 200
DPGTWDSFLE KFMAGEVCYG SWYQHVQEWW ELSHTHPVLY LFYEDIKEDP
210 220 230 240 250
KREIQKILEF IGRSLPEETV DHIVQRTSFK EMKKNPMTNY STIPTAVMDH
260 270 280 290
SISAFMRKGI TGDWKSTFTV AQNELFEAHY AKKMAGCKLR FRWEL
Length:295
Mass (Da):34,184
Last modified:May 1, 2007 - v2
Checksum:i8F5B7F1E1094D6C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001P → S in AAI02275. 1 PublicationCurated
Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAA85510. (PubMed:7575456)Curated
Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAC48677. (PubMed:8890738)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35253 mRNA. Translation: AAA85510.1.
U34753 Genomic DNA. Translation: AAC48677.1.
BC102274 mRNA. Translation: AAI02275.1.
L33828 Genomic DNA. Translation: AAA56789.1.
PIRiJC5000.
RefSeqiNP_803487.1. NM_177521.2.
XP_005224892.1. XM_005224835.1.
XP_005224893.1. XM_005224836.1.
XP_005224894.1. XM_005224837.1.
XP_005224895.1. XM_005224838.1.
UniGeneiBt.3537.

Genome annotation databases

EnsembliENSBTAT00000011388; ENSBTAP00000011388; ENSBTAG00000008635.
GeneIDi282485.
KEGGibta:282485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35253 mRNA. Translation: AAA85510.1.
U34753 Genomic DNA. Translation: AAC48677.1.
BC102274 mRNA. Translation: AAI02275.1.
L33828 Genomic DNA. Translation: AAA56789.1.
PIRiJC5000.
RefSeqiNP_803487.1. NM_177521.2.
XP_005224892.1. XM_005224835.1.
XP_005224893.1. XM_005224836.1.
XP_005224894.1. XM_005224837.1.
XP_005224895.1. XM_005224838.1.
UniGeneiBt.3537.

3D structure databases

ProteinModelPortaliP50227.
SMRiP50227. Positions 7-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011388.

Proteomic databases

PRIDEiP50227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011388; ENSBTAP00000011388; ENSBTAG00000008635.
GeneIDi282485.
KEGGibta:282485.

Organism-specific databases

CTDi6817.

Phylogenomic databases

eggNOGiNOG260792.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50227.
KOiK01014.
OMAiKMAGCKL.
OrthoDBiEOG7V49ZK.
TreeFamiTF321745.

Enzyme and pathway databases

BRENDAi2.8.2.1. 908.
ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
REACT_211218. Cytosolic sulfonation of small molecules.

Miscellaneous databases

NextBioi20806249.

Gene expression databases

ExpressionAtlasiP50227. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of bovine tracheobronchial phenol sulphotransferase cDNA and detection of mRNA regulation by cortisol."
    Schauss S.J., Henry T., Palmatier R., Halvorson L., Dannenbring R., Beckmann J.D.
    Biochem. J. 311:209-217(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Tracheobronchial.
  2. "Isolation and characterization of a bovine gene encoding phenol sulfotransferase."
    Henry T., Kliewer B., Palmatier R., Ulphani J.S., Beckmann J.D.
    Gene 174:221-224(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  4. Nonneman D.J., Shibuya H., Johnson G.S.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-57.

Entry informationi

Entry nameiST1A1_BOVIN
AccessioniPrimary (citable) accession number: P50227
Secondary accession number(s): Q3T0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: January 7, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.