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P50227

- ST1A1_BOVIN

UniProt

P50227 - ST1A1_BOVIN

Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Proton acceptorBy similarity
    Binding sitei130 – 1301PAPSBy similarity
    Binding sitei138 – 1381PAPSBy similarity
    Binding sitei193 – 1931PAPSBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 536PAPSBy similarity
    Nucleotide bindingi227 – 2326PAPSBy similarity
    Nucleotide bindingi255 – 2595PAPSBy similarity

    GO - Molecular functioni

    1. aryl sulfotransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: Ensembl

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. steroid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Lipid metabolism, Steroid metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.1. 908.
    ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
    REACT_211218. Cytosolic sulfonation of small molecules.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfotransferase 1A1 (EC:2.8.2.1)
    Short name:
    ST1A1
    Alternative name(s):
    Aryl sulfotransferase
    Phenol sulfotransferase
    Phenol-sulfating phenol sulfotransferase
    Short name:
    P-PST
    Gene namesi
    Name:SULT1A1
    Synonyms:STP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Sulfotransferase 1A1PRO_0000085125Add
    BLAST

    Proteomic databases

    PRIDEiP50227.

    Expressioni

    Tissue specificityi

    Distal lung parenchyma.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011388.

    Structurei

    3D structure databases

    ProteinModelPortaliP50227.
    SMRiP50227. Positions 7-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1083Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the sulfotransferase 1 family.Curated

    Phylogenomic databases

    eggNOGiNOG260792.
    GeneTreeiENSGT00740000115442.
    HOGENOMiHOG000037209.
    HOVERGENiHBG001195.
    InParanoidiP50227.
    KOiK01014.
    OMAiWESFLEK.
    OrthoDBiEOG7V49ZK.
    TreeFamiTF321745.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P50227-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIQDTSRP PAKYVKGIPL IKYFAEALGP LESFEAWPDD LLISTYPKSG    50
    TTWVSEILDL IYQEGDLEKC QRAPVFLRVP FLEFSAPGVP TGVELLKDTP 100
    APRLLKTHLP LALLPKTLLD QKVKVIYIAR NAKDVAVSYY HFYRMAKVHP 150
    DPGTWDSFLE KFMAGEVCYG SWYQHVQEWW ELSHTHPVLY LFYEDIKEDP 200
    KREIQKILEF IGRSLPEETV DHIVQRTSFK EMKKNPMTNY STIPTAVMDH 250
    SISAFMRKGI TGDWKSTFTV AQNELFEAHY AKKMAGCKLR FRWEL 295
    Length:295
    Mass (Da):34,184
    Last modified:May 1, 2007 - v2
    Checksum:i8F5B7F1E1094D6C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti200 – 2001P → S in AAI02275. 1 PublicationCurated
    Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAA85510. (PubMed:7575456)Curated
    Sequence conflicti285 – 2917AGCKLRF → RAATPL in AAC48677. (PubMed:8890738)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35253 mRNA. Translation: AAA85510.1.
    U34753 Genomic DNA. Translation: AAC48677.1.
    BC102274 mRNA. Translation: AAI02275.1.
    L33828 Genomic DNA. Translation: AAA56789.1.
    PIRiJC5000.
    RefSeqiNP_803487.1. NM_177521.2.
    XP_005224892.1. XM_005224835.1.
    XP_005224893.1. XM_005224836.1.
    XP_005224894.1. XM_005224837.1.
    XP_005224895.1. XM_005224838.1.
    UniGeneiBt.3537.

    Genome annotation databases

    EnsembliENSBTAT00000011388; ENSBTAP00000011388; ENSBTAG00000008635.
    GeneIDi282485.
    KEGGibta:282485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35253 mRNA. Translation: AAA85510.1 .
    U34753 Genomic DNA. Translation: AAC48677.1 .
    BC102274 mRNA. Translation: AAI02275.1 .
    L33828 Genomic DNA. Translation: AAA56789.1 .
    PIRi JC5000.
    RefSeqi NP_803487.1. NM_177521.2.
    XP_005224892.1. XM_005224835.1.
    XP_005224893.1. XM_005224836.1.
    XP_005224894.1. XM_005224837.1.
    XP_005224895.1. XM_005224838.1.
    UniGenei Bt.3537.

    3D structure databases

    ProteinModelPortali P50227.
    SMRi P50227. Positions 7-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011388.

    Proteomic databases

    PRIDEi P50227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011388 ; ENSBTAP00000011388 ; ENSBTAG00000008635 .
    GeneIDi 282485.
    KEGGi bta:282485.

    Organism-specific databases

    CTDi 6817.

    Phylogenomic databases

    eggNOGi NOG260792.
    GeneTreei ENSGT00740000115442.
    HOGENOMi HOG000037209.
    HOVERGENi HBG001195.
    InParanoidi P50227.
    KOi K01014.
    OMAi WESFLEK.
    OrthoDBi EOG7V49ZK.
    TreeFami TF321745.

    Enzyme and pathway databases

    BRENDAi 2.8.2.1. 908.
    Reactomei REACT_211201. XBP1(S) activates chaperone genes.
    REACT_211218. Cytosolic sulfonation of small molecules.

    Miscellaneous databases

    NextBioi 20806249.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of bovine tracheobronchial phenol sulphotransferase cDNA and detection of mRNA regulation by cortisol."
      Schauss S.J., Henry T., Palmatier R., Halvorson L., Dannenbring R., Beckmann J.D.
      Biochem. J. 311:209-217(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Tracheobronchial.
    2. "Isolation and characterization of a bovine gene encoding phenol sulfotransferase."
      Henry T., Kliewer B., Palmatier R., Ulphani J.S., Beckmann J.D.
      Gene 174:221-224(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    4. Nonneman D.J., Shibuya H., Johnson G.S.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-57.

    Entry informationi

    Entry nameiST1A1_BOVIN
    AccessioniPrimary (citable) accession number: P50227
    Secondary accession number(s): Q3T0S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3