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Protein

Sulfotransferase 1A2

Gene

SULT1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi255 – 259PAPS5

GO - Molecular functioni

  • aryl sulfotransferase activity Source: UniProtKB
  • flavonol 3-sulfotransferase activity Source: BHF-UCL
  • sulfotransferase activity Source: Reactome

GO - Biological processi

  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  • amine biosynthetic process Source: ProtInc
  • catecholamine metabolic process Source: UniProtKB-KW
  • phenol-containing compound metabolic process Source: UniProtKB
  • steroid metabolic process Source: UniProtKB-KW
  • sulfation Source: BHF-UCL
  • xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS11091-MONOMER.
ZFISH:HS11091-MONOMER.
BRENDAi2.8.2.1. 2681.
2.8.2.9. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.
SABIO-RKP50226.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A2 (EC:2.8.2.1)
Short name:
ST1A2
Alternative name(s):
Aryl sulfotransferase 2
Phenol sulfotransferase 2
Phenol-sulfating phenol sulfotransferase 2
Short name:
P-PST 2
Gene namesi
Name:SULT1A2
Synonyms:STP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11454. SULT1A2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6799.
OpenTargetsiENSG00000197165.
PharmGKBiPA341.

Chemistry databases

ChEMBLiCHEMBL1743292.

Polymorphism and mutation databases

BioMutaiSULT1A2.
DMDMi288558827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851281 – 295Sulfotransferase 1A2Add BLAST295

Proteomic databases

EPDiP50226.
MaxQBiP50226.
PaxDbiP50226.
PeptideAtlasiP50226.
PRIDEiP50226.

PTM databases

iPTMnetiP50226.
PhosphoSitePlusiP50226.

Expressioni

Gene expression databases

BgeeiENSG00000197165.
CleanExiHS_SULT1A2.
ExpressionAtlasiP50226. baseline and differential.
GenevisibleiP50226. HS.

Organism-specific databases

HPAiHPA049500.
HPA051051.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NIF3L1Q9GZT83EBI-6137631,EBI-740897

Protein-protein interaction databases

BioGridi112673. 9 interactors.
IntActiP50226. 1 interactor.
STRINGi9606.ENSP00000338742.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi18 – 20Combined sources3
Helixi22 – 26Combined sources5
Helixi30 – 32Combined sources3
Beta strandi41 – 46Combined sources6
Helixi51 – 62Combined sources12
Helixi75 – 78Combined sources4
Helixi92 – 95Combined sources4
Turni96 – 98Combined sources3
Beta strandi104 – 107Combined sources4
Turni111 – 113Combined sources3
Helixi116 – 120Combined sources5
Beta strandi124 – 129Combined sources6
Helixi132 – 145Combined sources14
Helixi155 – 163Combined sources9
Helixi172 – 182Combined sources11
Turni183 – 185Combined sources3
Beta strandi188 – 192Combined sources5
Helixi193 – 198Combined sources6
Helixi200 – 210Combined sources11
Helixi217 – 226Combined sources10
Helixi229 – 234Combined sources6
Turni236 – 238Combined sources3
Turni245 – 247Combined sources3
Turni250 – 252Combined sources3
Helixi263 – 266Combined sources4
Helixi270 – 283Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z29X-ray2.40A1-295[»]
ProteinModelPortaliP50226.
SMRiP50226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50226.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50226.
KOiK01014.
OMAiILEFVGH.
OrthoDBiEOG091G0D5F.
PhylomeDBiP50226.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P50226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIQDISRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKVPGIP SGMETLKNTP
110 120 130 140 150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVYP
160 170 180 190 200
HPGTWESFLE KFMAGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILEF VGRSLPEETV DLMVEHTSFK EMKKNPMTNY TTVRREFMDH
260 270 280 290
SISPFMRKGM AGDWKTTFTV AQNERFDADY AKKMAGCSLS FRSEL
Length:295
Mass (Da):34,310
Last modified:February 9, 2010 - v2
Checksum:iEB505BBDAA3A2E09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290S → T in AAC51149 (PubMed:9119390).Curated1
Sequence conflicti290S → T in ABX65442 (PubMed:9119390).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0074267I → T.3 PublicationsCorresponds to variant rs1136703dbSNPEnsembl.1
Natural variantiVAR_05734019P → L.1 PublicationCorresponds to variant rs10797300dbSNPEnsembl.1
Natural variantiVAR_05734162Y → F.Corresponds to variant rs4987024dbSNPEnsembl.1
Natural variantiVAR_007427235N → T.4 PublicationsCorresponds to variant rs1059491dbSNPEnsembl.1
Natural variantiVAR_057342239N → S.Corresponds to variant rs45472392dbSNPEnsembl.1
Natural variantiVAR_061887282K → E.6 PublicationsCorresponds to variant rs27742dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28170 mRNA. Translation: AAB09659.1.
U28169 mRNA. Translation: AAB09658.1.
X78282 mRNA. Translation: CAA55088.1.
U34804 Genomic DNA. Translation: AAB09758.1.
U72202
, U72196, U72197, U72198, U72199, U72200, U72201 Genomic DNA. Translation: AAB08970.1.
U76619 Genomic DNA. Translation: AAB18753.1.
U33886 Genomic DNA. Translation: AAC51149.1.
U33886 Genomic DNA. Translation: ABX65442.1.
AC020765 Genomic DNA. No translation available.
BC113727 mRNA. Translation: AAI13728.1.
BC113729 mRNA. Translation: AAI13730.1.
CCDSiCCDS10636.1.
PIRiG01843.
JC5249.
S52791.
RefSeqiNP_001045.1. NM_001054.3.
NP_803564.1. NM_177528.2.
UniGeneiHs.546304.

Genome annotation databases

EnsembliENST00000335715; ENSP00000338742; ENSG00000197165.
ENST00000395630; ENSP00000378992; ENSG00000197165.
GeneIDi6799.
KEGGihsa:6799.
UCSCiuc002dqg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28170 mRNA. Translation: AAB09659.1.
U28169 mRNA. Translation: AAB09658.1.
X78282 mRNA. Translation: CAA55088.1.
U34804 Genomic DNA. Translation: AAB09758.1.
U72202
, U72196, U72197, U72198, U72199, U72200, U72201 Genomic DNA. Translation: AAB08970.1.
U76619 Genomic DNA. Translation: AAB18753.1.
U33886 Genomic DNA. Translation: AAC51149.1.
U33886 Genomic DNA. Translation: ABX65442.1.
AC020765 Genomic DNA. No translation available.
BC113727 mRNA. Translation: AAI13728.1.
BC113729 mRNA. Translation: AAI13730.1.
CCDSiCCDS10636.1.
PIRiG01843.
JC5249.
S52791.
RefSeqiNP_001045.1. NM_001054.3.
NP_803564.1. NM_177528.2.
UniGeneiHs.546304.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z29X-ray2.40A1-295[»]
ProteinModelPortaliP50226.
SMRiP50226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112673. 9 interactors.
IntActiP50226. 1 interactor.
STRINGi9606.ENSP00000338742.

Chemistry databases

ChEMBLiCHEMBL1743292.

PTM databases

iPTMnetiP50226.
PhosphoSitePlusiP50226.

Polymorphism and mutation databases

BioMutaiSULT1A2.
DMDMi288558827.

Proteomic databases

EPDiP50226.
MaxQBiP50226.
PaxDbiP50226.
PeptideAtlasiP50226.
PRIDEiP50226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335715; ENSP00000338742; ENSG00000197165.
ENST00000395630; ENSP00000378992; ENSG00000197165.
GeneIDi6799.
KEGGihsa:6799.
UCSCiuc002dqg.3. human.

Organism-specific databases

CTDi6799.
DisGeNETi6799.
GeneCardsiSULT1A2.
HGNCiHGNC:11454. SULT1A2.
HPAiHPA049500.
HPA051051.
MIMi601292. gene.
neXtProtiNX_P50226.
OpenTargetsiENSG00000197165.
PharmGKBiPA341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50226.
KOiK01014.
OMAiILEFVGH.
OrthoDBiEOG091G0D5F.
PhylomeDBiP50226.
TreeFamiTF321745.

Enzyme and pathway databases

BioCyciMetaCyc:HS11091-MONOMER.
ZFISH:HS11091-MONOMER.
BRENDAi2.8.2.1. 2681.
2.8.2.9. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.
SABIO-RKP50226.

Miscellaneous databases

EvolutionaryTraceiP50226.
GeneWikiiSULT1A2.
GenomeRNAii6799.
PROiP50226.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197165.
CleanExiHS_SULT1A2.
ExpressionAtlasiP50226. baseline and differential.
GenevisibleiP50226. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiST1A2_HUMAN
AccessioniPrimary (citable) accession number: P50226
Secondary accession number(s): A9QY25, P78393, Q14CJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.