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Protein

Sulfotransferase 1A1

Gene

SULT1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorBy similarity1
Binding sitei130PAPS1
Binding sitei138PAPS1
Binding sitei193PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53PAPS6
Nucleotide bindingi227 – 232PAPS6
Nucleotide bindingi255 – 259PAPS5

GO - Molecular functioni

  • aryl sulfotransferase activity Source: UniProtKB
  • flavonol 3-sulfotransferase activity Source: BHF-UCL
  • steroid sulfotransferase activity Source: UniProtKB
  • sulfotransferase activity Source: MGI

GO - Biological processi

  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  • amine metabolic process Source: ProtInc
  • catecholamine metabolic process Source: UniProtKB-KW
  • estrogen metabolic process Source: UniProtKB
  • flavonoid metabolic process Source: BHF-UCL
  • steroid metabolic process Source: UniProtKB-KW
  • sulfation Source: BHF-UCL
  • xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Catecholamine metabolism, Lipid metabolism, Steroid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER.
ZFISH:HS09898-MONOMER.
BRENDAi2.8.2.1. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.
SABIO-RKP50225.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1A1 (EC:2.8.2.1)
Short name:
ST1A1
Alternative name(s):
Aryl sulfotransferase 1
HAST1/HAST2
Phenol sulfotransferase 1
Phenol-sulfating phenol sulfotransferase 1
Short name:
P-PST 1
ST1A3
Thermostable phenol sulfotransferase
Short name:
Ts-PST
Gene namesi
Name:SULT1A1
Synonyms:STP, STP1
ORF Names:OK/SW-cl.88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11453. SULT1A1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi70C → S: Increased sensitivity of enzyme activity to heat inactivation. 1 Publication1

Organism-specific databases

DisGeNETi6817.
OpenTargetsiENSG00000196502.
PharmGKBiPA343.

Chemistry databases

ChEMBLiCHEMBL1743291.
DrugBankiDB00316. Acetaminophen.
DB00675. Tamoxifen.

Polymorphism and mutation databases

BioMutaiSULT1A1.
DMDMi313104286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851271 – 295Sulfotransferase 1A1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50225.
MaxQBiP50225.
PaxDbiP50225.
PeptideAtlasiP50225.
PRIDEiP50225.

2D gel databases

OGPiP50225.

PTM databases

iPTMnetiP50225.
PhosphoSitePlusiP50225.

Expressioni

Tissue specificityi

Liver, lung, adrenal, brain, platelets and skin.

Gene expression databases

BgeeiENSG00000196502.
CleanExiHS_SULT1A1.
ExpressionAtlasiP50225. baseline and differential.
GenevisibleiP50225. HS.

Organism-specific databases

HPAiHPA049500.
HPA051051.

Interactioni

Subunit structurei

Homodimer.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SULT2B1O002043EBI-2814403,EBI-749441

Protein-protein interaction databases

BioGridi112686. 43 interactors.
IntActiP50225. 5 interactors.
STRINGi9606.ENSP00000321988.

Chemistry databases

BindingDBiP50225.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 15Combined sources3
Beta strandi18 – 20Combined sources3
Helixi22 – 31Combined sources10
Beta strandi41 – 46Combined sources6
Helixi51 – 62Combined sources12
Turni63 – 65Combined sources3
Helixi67 – 70Combined sources4
Helixi75 – 78Combined sources4
Beta strandi87 – 89Combined sources3
Helixi92 – 97Combined sources6
Beta strandi104 – 107Combined sources4
Turni111 – 113Combined sources3
Helixi116 – 120Combined sources5
Beta strandi124 – 129Combined sources6
Helixi132 – 145Combined sources14
Helixi155 – 164Combined sources10
Helixi172 – 182Combined sources11
Turni183 – 185Combined sources3
Beta strandi188 – 192Combined sources5
Helixi193 – 198Combined sources6
Helixi200 – 211Combined sources12
Helixi217 – 226Combined sources10
Helixi229 – 234Combined sources6
Turni236 – 238Combined sources3
Turni245 – 247Combined sources3
Turni250 – 252Combined sources3
Helixi263 – 266Combined sources4
Helixi270 – 283Combined sources14
Turni284 – 286Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS6X-ray1.90A1-295[»]
1Z28X-ray2.30A1-295[»]
2D06X-ray2.30A/B1-295[»]
3QVUX-ray2.50A/B1-295[»]
3QVVX-ray2.35A/B1-295[»]
3U3JX-ray2.70A/B1-294[»]
3U3KX-ray2.36A/B1-295[»]
3U3MX-ray2.30A1-295[»]
3U3OX-ray2.00A1-295[»]
3U3RX-ray2.36A1-295[»]
4GRAX-ray2.56A/B1-295[»]
ProteinModelPortaliP50225.
SMRiP50225.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50225.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate binding3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50225.
KOiK01014.
OMAiISAPPKC.
OrthoDBiEOG091G0D5F.
PhylomeDBiP50225.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG
60 70 80 90 100
TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP
110 120 130 140 150
APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP
160 170 180 190 200
EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP
210 220 230 240 250
KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH
260 270 280 290
SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Length:295
Mass (Da):34,165
Last modified:November 30, 2010 - v3
Checksum:i7D4362A603A29176
GO
Isoform 2 (identifier: P50225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: MELIQDTSRP...PQTLLDQKVK → MLAKLLCDQV...LKQKFWNTYM

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,388
Checksum:i8A6A935E4DD11A6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90P → L in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti146A → T in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti181E → G in CAA59147 (PubMed:7864863).Curated1
Sequence conflicti243V → A in AAA67895 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAA99892 (PubMed:8423770).Curated1
Sequence conflicti290S → T in AAC50480 (PubMed:8924211).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00930237R → Q.1 PublicationCorresponds to variant rs143283780dbSNPEnsembl.1
Natural variantiVAR_028721151E → D.Corresponds to variant rs1042014dbSNPEnsembl.1
Natural variantiVAR_057339151E → Q.Corresponds to variant rs1042011dbSNPEnsembl.1
Natural variantiVAR_007425213R → H in allele SULT1A1*2; common polymorphism; has a lower activity. 4 PublicationsCorresponds to variant rs9282861dbSNPEnsembl.1
Natural variantiVAR_009303223V → M.Combined sources14 PublicationsCorresponds to variant rs1801030dbSNPEnsembl.1
Natural variantiVAR_014889235N → T.Corresponds to variant rs35728980dbSNPEnsembl.1
Natural variantiVAR_061886282E → K.2 PublicationsCorresponds to variant rs36043491dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401011 – 124MELIQ…DQKVK → MLAKLLCDQVVGAPIAVSAF YAGMSILQGKDDIFLDLKQK FWNTYM in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA. Translation: AAA18613.1.
L19955 mRNA. Translation: AAA02935.1.
L10819 mRNA. Translation: AAA35562.1.
L19999 mRNA. Translation: AAA99892.1.
U26309 mRNA. Translation: AAA67895.1.
X84654 mRNA. Translation: CAA59147.1.
X78283 mRNA. Translation: CAA55089.1.
U71086 Genomic DNA. Translation: AAB09597.1.
U54701 Genomic DNA. Translation: AAC50480.1.
AJ007418 mRNA. Translation: CAA07495.1.
U52852 Genomic DNA. Translation: AAC51816.1.
AB062428 mRNA. Translation: BAB93491.1.
BT007324 mRNA. Translation: AAP35988.1.
CR608214 mRNA. No translation available.
AC020765 Genomic DNA. No translation available.
BC000923 mRNA. Translation: AAH00923.1.
BC110887 mRNA. Translation: AAI10888.1.
L15346 Genomic DNA. Translation: AAA60595.1.
CCDSiCCDS10637.1. [P50225-2]
CCDS32420.1. [P50225-1]
PIRiI57945.
JC2523.
JC5248.
S52399.
S52794.
RefSeqiNP_001046.2. NM_001055.3. [P50225-1]
NP_803565.1. NM_177529.2. [P50225-1]
NP_803566.1. NM_177530.2. [P50225-1]
NP_803878.1. NM_177534.2. [P50225-1]
NP_803880.1. NM_177536.3. [P50225-2]
XP_016879095.1. XM_017023606.1. [P50225-1]
XP_016879100.1. XM_017023611.1. [P50225-1]
XP_016879101.1. XM_017023612.1. [P50225-1]
XP_016879102.1. XM_017023613.1. [P50225-1]
UniGeneiHs.567342.
Hs.736805.

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502. [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502. [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502. [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502. [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502. [P50225-1]
GeneIDi6817.
KEGGihsa:6817.
UCSCiuc002dqi.4. human. [P50225-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09031 mRNA. Translation: AAA18613.1.
L19955 mRNA. Translation: AAA02935.1.
L10819 mRNA. Translation: AAA35562.1.
L19999 mRNA. Translation: AAA99892.1.
U26309 mRNA. Translation: AAA67895.1.
X84654 mRNA. Translation: CAA59147.1.
X78283 mRNA. Translation: CAA55089.1.
U71086 Genomic DNA. Translation: AAB09597.1.
U54701 Genomic DNA. Translation: AAC50480.1.
AJ007418 mRNA. Translation: CAA07495.1.
U52852 Genomic DNA. Translation: AAC51816.1.
AB062428 mRNA. Translation: BAB93491.1.
BT007324 mRNA. Translation: AAP35988.1.
CR608214 mRNA. No translation available.
AC020765 Genomic DNA. No translation available.
BC000923 mRNA. Translation: AAH00923.1.
BC110887 mRNA. Translation: AAI10888.1.
L15346 Genomic DNA. Translation: AAA60595.1.
CCDSiCCDS10637.1. [P50225-2]
CCDS32420.1. [P50225-1]
PIRiI57945.
JC2523.
JC5248.
S52399.
S52794.
RefSeqiNP_001046.2. NM_001055.3. [P50225-1]
NP_803565.1. NM_177529.2. [P50225-1]
NP_803566.1. NM_177530.2. [P50225-1]
NP_803878.1. NM_177534.2. [P50225-1]
NP_803880.1. NM_177536.3. [P50225-2]
XP_016879095.1. XM_017023606.1. [P50225-1]
XP_016879100.1. XM_017023611.1. [P50225-1]
XP_016879101.1. XM_017023612.1. [P50225-1]
XP_016879102.1. XM_017023613.1. [P50225-1]
UniGeneiHs.567342.
Hs.736805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS6X-ray1.90A1-295[»]
1Z28X-ray2.30A1-295[»]
2D06X-ray2.30A/B1-295[»]
3QVUX-ray2.50A/B1-295[»]
3QVVX-ray2.35A/B1-295[»]
3U3JX-ray2.70A/B1-294[»]
3U3KX-ray2.36A/B1-295[»]
3U3MX-ray2.30A1-295[»]
3U3OX-ray2.00A1-295[»]
3U3RX-ray2.36A1-295[»]
4GRAX-ray2.56A/B1-295[»]
ProteinModelPortaliP50225.
SMRiP50225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112686. 43 interactors.
IntActiP50225. 5 interactors.
STRINGi9606.ENSP00000321988.

Chemistry databases

BindingDBiP50225.
ChEMBLiCHEMBL1743291.
DrugBankiDB00316. Acetaminophen.
DB00675. Tamoxifen.

PTM databases

iPTMnetiP50225.
PhosphoSitePlusiP50225.

Polymorphism and mutation databases

BioMutaiSULT1A1.
DMDMi313104286.

2D gel databases

OGPiP50225.

Proteomic databases

EPDiP50225.
MaxQBiP50225.
PaxDbiP50225.
PeptideAtlasiP50225.
PRIDEiP50225.

Protocols and materials databases

DNASUi6817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314752; ENSP00000321988; ENSG00000196502. [P50225-1]
ENST00000350842; ENSP00000329399; ENSG00000196502. [P50225-2]
ENST00000395607; ENSP00000378971; ENSG00000196502. [P50225-1]
ENST00000395609; ENSP00000378972; ENSG00000196502. [P50225-1]
ENST00000569554; ENSP00000457912; ENSG00000196502. [P50225-1]
GeneIDi6817.
KEGGihsa:6817.
UCSCiuc002dqi.4. human. [P50225-1]

Organism-specific databases

CTDi6817.
DisGeNETi6817.
GeneCardsiSULT1A1.
H-InvDBHIX0017846.
HGNCiHGNC:11453. SULT1A1.
HPAiHPA049500.
HPA051051.
MIMi171150. gene.
neXtProtiNX_P50225.
OpenTargetsiENSG00000196502.
PharmGKBiPA343.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiP50225.
KOiK01014.
OMAiISAPPKC.
OrthoDBiEOG091G0D5F.
PhylomeDBiP50225.
TreeFamiTF321745.

Enzyme and pathway databases

BioCyciMetaCyc:HS09898-MONOMER.
ZFISH:HS09898-MONOMER.
BRENDAi2.8.2.1. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.
SABIO-RKP50225.

Miscellaneous databases

EvolutionaryTraceiP50225.
GeneWikiiSULT1A1.
GenomeRNAii6817.
PROiP50225.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196502.
CleanExiHS_SULT1A1.
ExpressionAtlasiP50225. baseline and differential.
GenevisibleiP50225. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiST1A1_HUMAN
AccessioniPrimary (citable) accession number: P50225
Secondary accession number(s): Q2NL71
, Q86U58, Q92818, Q9BVU6, Q9UGG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.