P50222 (MEOX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein MOX-2

Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2

Gene names

Name:	MEOX2
Synonyms:	GAX, MOX2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle By similarity.
Subunit structure	Interacts with RNF10. Ref.5
Subcellular location	Nucleus. Nucleus speckle Ref.6.
Tissue specificity	Embryo and placenta.
Domain	The polyhistidine repeat may act as a targeting signal to nuclear speckles (Ref.6).
Polymorphism	The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara blood circulation Traceable author statement Ref.2. Source: ProtInc limb development Inferred from electronic annotation. Source: Compara multicellular organismal development Traceable author statement Ref.2. Source: ProtInc palate development Inferred from electronic annotation. Source: Compara skeletal muscle tissue development Inferred from electronic annotation. Source: Compara somite specification Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay Ref.5. Source: UniProtKB nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 9073066. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Homeobox protein MOX-2		PRO_0000049197
Regions
	DNA binding	187 – 246	60	Homeobox
	Compositional bias	42 – 47	6	Poly-Ser
	Compositional bias	68 – 80	13	Poly-His
	Compositional bias	81 – 86	6	Poly-Gln
Natural variations
	Natural variant	79 – 80	2	Missing.		VAR_026040
	Natural variant	80	1	Missing. Ref.1 Ref.2 Ref.4		VAR_026041
	Natural variant	287	1	I → L. Corresponds to variant rs2237493 [ dbSNP | Ensembl ].		VAR_049585
Experimental info
	Sequence conflict	58	1	G → D in AAA58497. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P50222 [UniParc]. Last modified April 18, 2006. Version 2. Checksum: 0C008479D6995389	FASTA	304	33,594
	10 20 30 40 50 60 MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 70 80 90 100 110 120 ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL 130 140 150 160 170 180 GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK 190 200 210 220 230 240 SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM 250 260 270 280 290 300 KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE HAHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3." Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B., Pachnis V., Karagogeos D. Genomics 26:550-555(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-80 DEL. Tissue: Embryo.
[2]	"Molecular cloning and localization of the human GAX gene to 7p21." Lepage D.F., Walsh K. Genomics 24:535-540(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 79-HIS-HIS-80 DEL. Tissue: Heart.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL. Tissue: Skin.
[5]	"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10." Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T. Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RNF10.
[6]	"Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment." Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S. PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82629 mRNA. Translation: CAA57949.1. L36328 mRNA. Translation: AAA58497.1. AC005550 Genomic DNA. Translation: AAC33152.1. AC004452 Genomic DNA. Translation: AAC06184.1. BC017021 mRNA. Translation: AAH17021.1.
IPI	IPI00030729.
PIR	A55641. A56837.
RefSeq	NP_005915.2. NM_005924.4.
UniGene	Hs.170355.
3D structure databases
ProteinModelPortal	P50222.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50222. 12 interactions.
MINT	MINT-202865.
STRING	9606.ENSP00000262041.
PTM databases
PhosphoSite	P50222.
Polymorphism databases
DMDM	93141286.
Proteomic databases
PaxDb	P50222.
PRIDE	P50222.
Protocols and materials databases
DNASU	4223.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262041; ENSP00000262041; ENSG00000106511.
GeneID	4223.
KEGG	hsa:4223.
UCSC	uc003stc.3. human.
Organism-specific databases
CTD	4223.
GeneCards	GC07M015617.
H-InvDB	HIX0006493.
HGNC	HGNC:7014. MEOX2.
HPA	HPA053793.
MIM	600535. gene.
neXtProt	NX_P50222.
PharmGKB	PA30748.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG250192.
HOGENOM	HOG000230987.
HOVERGEN	HBG052456.
InParanoid	P50222.
KO	K09322.
OMA	DHTLFGC.
OrthoDB	EOG4PZJ7H.
PhylomeDB	P50222.
Gene expression databases
ArrayExpress	P50222.
Bgee	P50222.
CleanEx	HS_MEOX2.
Genevestigator	P50222.
GermOnline	ENSG00000106511. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4223.
NextBio	16667.
SOURCE	Search...

Entry information

Entry name

MEOX2_HUMAN

Accession

Primary (citable) accession number: P50222
Secondary accession number(s): O75263, Q9UPL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 18, 2006
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.