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Protein

Homeobox protein MOX-2

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi187 – 24660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • blood circulation Source: ProtInc
  • limb development Source: Ensembl
  • multicellular organismal development Source: ProtInc
  • neuron death Source: UniProtKB
  • palate development Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • skeletal muscle tissue development Source: Ensembl
  • somite specification Source: Ensembl
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
Gene namesi
Name:MEOX2
Synonyms:GAX, MOX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7014. MEOX2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nuclear speck Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi236 – 2361Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication

Organism-specific databases

PharmGKBiPA30748.

Polymorphism and mutation databases

BioMutaiMEOX2.
DMDMi93141286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Homeobox protein MOX-2PRO_0000049197Add
BLAST

Proteomic databases

PaxDbiP50222.
PRIDEiP50222.

PTM databases

PhosphoSiteiP50222.

Expressioni

Tissue specificityi

Embryo and placenta.

Gene expression databases

BgeeiP50222.
CleanExiHS_MEOX2.
GenevisibleiP50222. HS.

Organism-specific databases

HPAiHPA053793.

Interactioni

Subunit structurei

Interacts with RNF10.1 Publication

Protein-protein interaction databases

BioGridi110386. 212 interactions.
IntActiP50222. 12 interactions.
MINTiMINT-202865.
STRINGi9606.ENSP00000262041.

Structurei

3D structure databases

ProteinModelPortaliP50222.
SMRiP50222. Positions 194-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 476Poly-Ser
Compositional biasi68 – 8013Poly-HisAdd
BLAST
Compositional biasi81 – 866Poly-Gln

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG250192.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiP50222.
KOiK09322.
OMAiSWHIPQM.
OrthoDBiEOG7JDQZZ.
PhylomeDBiP50222.
TreeFamiTF351603.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP
110 120 130 140 150
PSAARHSLCL QPDSGGPPEL GSSPPVLCSN SSSLGSSTPT GAACAPGDYG
160 170 180 190 200
RQALSPAEAE KRSGGKRKSD SSDSQEGNYK SEVNSKPRKE RTAFTKEQIR
210 220 230 240 250
ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM KWKRVKGGQQ
260 270 280 290 300
GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE

HAHL
Length:304
Mass (Da):33,594
Last modified:April 18, 2006 - v2
Checksum:i0C008479D6995389
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581G → D in AAA58497 (PubMed:7713505).Curated

Polymorphismi

The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 802Missing .1 Publication
VAR_026040
Natural varianti80 – 801Missing .3 Publications
VAR_026041
Natural varianti287 – 2871I → L.
Corresponds to variant rs2237493 [ dbSNP | Ensembl ].
VAR_049585

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82629 mRNA. Translation: CAA57949.1.
L36328 mRNA. Translation: AAA58497.1.
AK313386 mRNA. Translation: BAG36184.1.
AC005550 Genomic DNA. Translation: AAC33152.1.
AC004452 Genomic DNA. Translation: AAC06184.1.
BC017021 mRNA. Translation: AAH17021.1.
CCDSiCCDS34605.1.
PIRiA55641.
A56837.
RefSeqiNP_005915.2. NM_005924.4.
UniGeneiHs.170355.

Genome annotation databases

EnsembliENST00000262041; ENSP00000262041; ENSG00000106511.
GeneIDi4223.
KEGGihsa:4223.
UCSCiuc003stc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82629 mRNA. Translation: CAA57949.1.
L36328 mRNA. Translation: AAA58497.1.
AK313386 mRNA. Translation: BAG36184.1.
AC005550 Genomic DNA. Translation: AAC33152.1.
AC004452 Genomic DNA. Translation: AAC06184.1.
BC017021 mRNA. Translation: AAH17021.1.
CCDSiCCDS34605.1.
PIRiA55641.
A56837.
RefSeqiNP_005915.2. NM_005924.4.
UniGeneiHs.170355.

3D structure databases

ProteinModelPortaliP50222.
SMRiP50222. Positions 194-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110386. 212 interactions.
IntActiP50222. 12 interactions.
MINTiMINT-202865.
STRINGi9606.ENSP00000262041.

PTM databases

PhosphoSiteiP50222.

Polymorphism and mutation databases

BioMutaiMEOX2.
DMDMi93141286.

Proteomic databases

PaxDbiP50222.
PRIDEiP50222.

Protocols and materials databases

DNASUi4223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262041; ENSP00000262041; ENSG00000106511.
GeneIDi4223.
KEGGihsa:4223.
UCSCiuc003stc.3. human.

Organism-specific databases

CTDi4223.
GeneCardsiGC07M015617.
H-InvDBHIX0006493.
HGNCiHGNC:7014. MEOX2.
HPAiHPA053793.
MIMi600535. gene.
neXtProtiNX_P50222.
PharmGKBiPA30748.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG250192.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiP50222.
KOiK09322.
OMAiSWHIPQM.
OrthoDBiEOG7JDQZZ.
PhylomeDBiP50222.
TreeFamiTF351603.

Miscellaneous databases

ChiTaRSiMEOX2. human.
GeneWikiiMEOX2.
GenomeRNAii4223.
NextBioi16667.
PROiP50222.
SOURCEiSearch...

Gene expression databases

BgeeiP50222.
CleanExiHS_MEOX2.
GenevisibleiP50222. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3."
    Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B., Pachnis V., Karagogeos D.
    Genomics 26:550-555(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-80 DEL.
    Tissue: Embryo.
  2. "Molecular cloning and localization of the human GAX gene to 7p21."
    Lepage D.F., Walsh K.
    Genomics 24:535-540(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 79-HIS-HIS-80 DEL.
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
    Tissue: Trachea.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
    Tissue: Skin.
  6. "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
    Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
    Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF10.
  7. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
    Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.
    PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells."
    Douville J.M., Cheung D.Y., Herbert K.L., Moffatt T., Wigle J.T.
    PLoS ONE 6:E29099-E29099(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-236.

Entry informationi

Entry nameiMEOX2_HUMAN
AccessioniPrimary (citable) accession number: P50222
Secondary accession number(s): B2R8I7, O75263, Q9UPL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: July 22, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.