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P50222

- MEOX2_HUMAN

UniProt

P50222 - MEOX2_HUMAN

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Protein

Homeobox protein MOX-2

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi187 – 24660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. blood circulation Source: ProtInc
  3. limb development Source: Ensembl
  4. multicellular organismal development Source: ProtInc
  5. neuron death Source: UniProt
  6. palate development Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  8. skeletal muscle tissue development Source: Ensembl
  9. somite specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
Gene namesi
Name:MEOX2
Synonyms:GAX, MOX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7014. MEOX2.

Subcellular locationi

Nucleus 2 Publications. Nucleus speckle 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi236 – 2361Q → E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A. 1 Publication

Organism-specific databases

PharmGKBiPA30748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Homeobox protein MOX-2PRO_0000049197Add
BLAST

Proteomic databases

PaxDbiP50222.
PRIDEiP50222.

PTM databases

PhosphoSiteiP50222.

Expressioni

Tissue specificityi

Embryo and placenta.

Gene expression databases

BgeeiP50222.
CleanExiHS_MEOX2.
ExpressionAtlasiP50222. baseline and differential.
GenevestigatoriP50222.

Organism-specific databases

HPAiHPA053793.

Interactioni

Subunit structurei

Interacts with RNF10.1 Publication

Protein-protein interaction databases

BioGridi110386. 38 interactions.
IntActiP50222. 12 interactions.
MINTiMINT-202865.
STRINGi9606.ENSP00000262041.

Structurei

3D structure databases

ProteinModelPortaliP50222.
SMRiP50222. Positions 194-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 476Poly-Ser
Compositional biasi68 – 8013Poly-HisAdd
BLAST
Compositional biasi81 – 866Poly-Gln

Domaini

The polyhistidine repeat may act as a targeting signal to nuclear speckles.1 Publication

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG250192.
GeneTreeiENSGT00760000119211.
HOGENOMiHOG000230987.
HOVERGENiHBG052456.
InParanoidiP50222.
KOiK09322.
OMAiPADFGRQ.
OrthoDBiEOG7JDQZZ.
PhylomeDBiP50222.
TreeFamiTF351603.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50222-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP
110 120 130 140 150
PSAARHSLCL QPDSGGPPEL GSSPPVLCSN SSSLGSSTPT GAACAPGDYG
160 170 180 190 200
RQALSPAEAE KRSGGKRKSD SSDSQEGNYK SEVNSKPRKE RTAFTKEQIR
210 220 230 240 250
ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM KWKRVKGGQQ
260 270 280 290 300
GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE

HAHL
Length:304
Mass (Da):33,594
Last modified:April 18, 2006 - v2
Checksum:i0C008479D6995389
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581G → D in AAA58497. (PubMed:7713505)Curated

Polymorphismi

The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 802Missing.1 Publication
VAR_026040
Natural varianti80 – 801Missing.3 Publications
VAR_026041
Natural varianti287 – 2871I → L.
Corresponds to variant rs2237493 [ dbSNP | Ensembl ].
VAR_049585

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82629 mRNA. Translation: CAA57949.1.
L36328 mRNA. Translation: AAA58497.1.
AK313386 mRNA. Translation: BAG36184.1.
AC005550 Genomic DNA. Translation: AAC33152.1.
AC004452 Genomic DNA. Translation: AAC06184.1.
BC017021 mRNA. Translation: AAH17021.1.
CCDSiCCDS34605.1.
PIRiA55641.
A56837.
RefSeqiNP_005915.2. NM_005924.4.
UniGeneiHs.170355.

Genome annotation databases

EnsembliENST00000262041; ENSP00000262041; ENSG00000106511.
GeneIDi4223.
KEGGihsa:4223.
UCSCiuc003stc.3. human.

Polymorphism databases

DMDMi93141286.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82629 mRNA. Translation: CAA57949.1 .
L36328 mRNA. Translation: AAA58497.1 .
AK313386 mRNA. Translation: BAG36184.1 .
AC005550 Genomic DNA. Translation: AAC33152.1 .
AC004452 Genomic DNA. Translation: AAC06184.1 .
BC017021 mRNA. Translation: AAH17021.1 .
CCDSi CCDS34605.1.
PIRi A55641.
A56837.
RefSeqi NP_005915.2. NM_005924.4.
UniGenei Hs.170355.

3D structure databases

ProteinModelPortali P50222.
SMRi P50222. Positions 194-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110386. 38 interactions.
IntActi P50222. 12 interactions.
MINTi MINT-202865.
STRINGi 9606.ENSP00000262041.

PTM databases

PhosphoSitei P50222.

Polymorphism databases

DMDMi 93141286.

Proteomic databases

PaxDbi P50222.
PRIDEi P50222.

Protocols and materials databases

DNASUi 4223.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262041 ; ENSP00000262041 ; ENSG00000106511 .
GeneIDi 4223.
KEGGi hsa:4223.
UCSCi uc003stc.3. human.

Organism-specific databases

CTDi 4223.
GeneCardsi GC07M015617.
H-InvDB HIX0006493.
HGNCi HGNC:7014. MEOX2.
HPAi HPA053793.
MIMi 600535. gene.
neXtProti NX_P50222.
PharmGKBi PA30748.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250192.
GeneTreei ENSGT00760000119211.
HOGENOMi HOG000230987.
HOVERGENi HBG052456.
InParanoidi P50222.
KOi K09322.
OMAi PADFGRQ.
OrthoDBi EOG7JDQZZ.
PhylomeDBi P50222.
TreeFami TF351603.

Miscellaneous databases

GeneWikii MEOX2.
GenomeRNAii 4223.
NextBioi 16667.
PROi P50222.
SOURCEi Search...

Gene expression databases

Bgeei P50222.
CleanExi HS_MEOX2.
ExpressionAtlasi P50222. baseline and differential.
Genevestigatori P50222.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3."
    Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B., Pachnis V., Karagogeos D.
    Genomics 26:550-555(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-80 DEL.
    Tissue: Embryo.
  2. "Molecular cloning and localization of the human GAX gene to 7p21."
    Lepage D.F., Walsh K.
    Genomics 24:535-540(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 79-HIS-HIS-80 DEL.
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
    Tissue: Trachea.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
    Tissue: Skin.
  6. "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
    Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
    Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF10.
  7. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
    Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.
    PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells."
    Douville J.M., Cheung D.Y., Herbert K.L., Moffatt T., Wigle J.T.
    PLoS ONE 6:E29099-E29099(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLN-236.

Entry informationi

Entry nameiMEOX2_HUMAN
AccessioniPrimary (citable) accession number: P50222
Secondary accession number(s): B2R8I7, O75263, Q9UPL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3