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P50222 (MEOX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein MOX-2
Alternative name(s):
Growth arrest-specific homeobox
Mesenchyme homeobox 2
Gene names
Name:MEOX2
Synonyms:GAX, MOX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle By similarity.

Subunit structure

Interacts with RNF10. Ref.5

Subcellular location

Nucleus. Nucleus speckle Ref.6.

Tissue specificity

Embryo and placenta.

Domain

The polyhistidine repeat may act as a targeting signal to nuclear speckles (Ref.6).

Polymorphism

The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Homeobox protein MOX-2
PRO_0000049197

Regions

DNA binding187 – 24660Homeobox
Compositional bias42 – 476Poly-Ser
Compositional bias68 – 8013Poly-His
Compositional bias81 – 866Poly-Gln

Natural variations

Natural variant79 – 802Missing.
VAR_026040
Natural variant801Missing. Ref.1 Ref.2 Ref.4
VAR_026041
Natural variant2871I → L.
Corresponds to variant rs2237493 [ dbSNP | Ensembl ].
VAR_049585

Experimental info

Sequence conflict581G → D in AAA58497. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50222 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: 0C008479D6995389

FASTA30433,594
        10         20         30         40         50         60 
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 

        70         80         90        100        110        120 
ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL 

       130        140        150        160        170        180 
GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK 

       190        200        210        220        230        240 
SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM 

       250        260        270        280        290        300 
KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE 


HAHL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3."
Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B., Pachnis V., Karagogeos D.
Genomics 26:550-555(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-80 DEL.
Tissue: Embryo.
[2]"Molecular cloning and localization of the human GAX gene to 7p21."
Lepage D.F., Walsh K.
Genomics 24:535-540(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 79-HIS-HIS-80 DEL.
Tissue: Heart.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
Tissue: Skin.
[5]"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RNF10.
[6]"Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.
PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X82629 mRNA. Translation: CAA57949.1.
L36328 mRNA. Translation: AAA58497.1.
AC005550 Genomic DNA. Translation: AAC33152.1.
AC004452 Genomic DNA. Translation: AAC06184.1.
BC017021 mRNA. Translation: AAH17021.1.
PIRA55641.
A56837.
RefSeqNP_005915.2. NM_005924.4.
UniGeneHs.170355.

3D structure databases

ProteinModelPortalP50222.
SMRP50222. Positions 194-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110386. 19 interactions.
IntActP50222. 12 interactions.
MINTMINT-202865.
STRING9606.ENSP00000262041.

PTM databases

PhosphoSiteP50222.

Polymorphism databases

DMDM93141286.

Proteomic databases

PaxDbP50222.
PRIDEP50222.

Protocols and materials databases

DNASU4223.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262041; ENSP00000262041; ENSG00000106511.
GeneID4223.
KEGGhsa:4223.
UCSCuc003stc.3. human.

Organism-specific databases

CTD4223.
GeneCardsGC07M015617.
H-InvDBHIX0006493.
HGNCHGNC:7014. MEOX2.
HPAHPA053793.
MIM600535. gene.
neXtProtNX_P50222.
PharmGKBPA30748.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG250192.
HOGENOMHOG000230987.
HOVERGENHBG052456.
InParanoidP50222.
KOK09322.
OMASQDGNYK.
OrthoDBEOG7JDQZZ.
PhylomeDBP50222.
TreeFamTF351603.

Gene expression databases

ArrayExpressP50222.
BgeeP50222.
CleanExHS_MEOX2.
GenevestigatorP50222.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMEOX2.
GenomeRNAi4223.
NextBio16667.
PROP50222.
SOURCESearch...

Entry information

Entry nameMEOX2_HUMAN
AccessionPrimary (citable) accession number: P50222
Secondary accession number(s): O75263, Q9UPL6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 18, 2006
Last modified: February 19, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM