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P50222

- MEOX2_HUMAN

UniProt

P50222 - MEOX2_HUMAN

Protein

Homeobox protein MOX-2

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi187 – 24660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    6. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. blood circulation Source: ProtInc
    3. limb development Source: Ensembl
    4. multicellular organismal development Source: ProtInc
    5. neuron death Source: UniProt
    6. palate development Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    8. skeletal muscle tissue development Source: Ensembl
    9. somite specification Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein MOX-2
    Alternative name(s):
    Growth arrest-specific homeobox
    Mesenchyme homeobox 2
    Gene namesi
    Name:MEOX2
    Synonyms:GAX, MOX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7014. MEOX2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Nucleus speckle 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30748.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Homeobox protein MOX-2PRO_0000049197Add
    BLAST

    Proteomic databases

    PaxDbiP50222.
    PRIDEiP50222.

    PTM databases

    PhosphoSiteiP50222.

    Expressioni

    Tissue specificityi

    Embryo and placenta.

    Gene expression databases

    ArrayExpressiP50222.
    BgeeiP50222.
    CleanExiHS_MEOX2.
    GenevestigatoriP50222.

    Organism-specific databases

    HPAiHPA053793.

    Interactioni

    Subunit structurei

    Interacts with RNF10.1 Publication

    Protein-protein interaction databases

    BioGridi110386. 19 interactions.
    IntActiP50222. 12 interactions.
    MINTiMINT-202865.
    STRINGi9606.ENSP00000262041.

    Structurei

    3D structure databases

    ProteinModelPortaliP50222.
    SMRiP50222. Positions 194-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 476Poly-Ser
    Compositional biasi68 – 8013Poly-HisAdd
    BLAST
    Compositional biasi81 – 866Poly-Gln

    Domaini

    The polyhistidine repeat may act as a targeting signal to nuclear speckles.1 Publication

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG250192.
    HOGENOMiHOG000230987.
    HOVERGENiHBG052456.
    InParanoidiP50222.
    KOiK09322.
    OMAiPADFGRQ.
    OrthoDBiEOG7JDQZZ.
    PhylomeDBiP50222.
    TreeFamiTF351603.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50222-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII    50
    AGYPNEEGMF ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP 100
    PSAARHSLCL QPDSGGPPEL GSSPPVLCSN SSSLGSSTPT GAACAPGDYG 150
    RQALSPAEAE KRSGGKRKSD SSDSQEGNYK SEVNSKPRKE RTAFTKEQIR 200
    ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM KWKRVKGGQQ 250
    GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE 300
    HAHL 304
    Length:304
    Mass (Da):33,594
    Last modified:April 18, 2006 - v2
    Checksum:i0C008479D6995389
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581G → D in AAA58497. (PubMed:7713505)Curated

    Polymorphismi

    The poly-His region of MEOX2 is polymorphic and the number of His varies in the population.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 802Missing.1 Publication
    VAR_026040
    Natural varianti80 – 801Missing.3 Publications
    VAR_026041
    Natural varianti287 – 2871I → L.
    Corresponds to variant rs2237493 [ dbSNP | Ensembl ].
    VAR_049585

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82629 mRNA. Translation: CAA57949.1.
    L36328 mRNA. Translation: AAA58497.1.
    AK313386 mRNA. Translation: BAG36184.1.
    AC005550 Genomic DNA. Translation: AAC33152.1.
    AC004452 Genomic DNA. Translation: AAC06184.1.
    BC017021 mRNA. Translation: AAH17021.1.
    CCDSiCCDS34605.1.
    PIRiA55641.
    A56837.
    RefSeqiNP_005915.2. NM_005924.4.
    UniGeneiHs.170355.

    Genome annotation databases

    EnsembliENST00000262041; ENSP00000262041; ENSG00000106511.
    GeneIDi4223.
    KEGGihsa:4223.
    UCSCiuc003stc.3. human.

    Polymorphism databases

    DMDMi93141286.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82629 mRNA. Translation: CAA57949.1 .
    L36328 mRNA. Translation: AAA58497.1 .
    AK313386 mRNA. Translation: BAG36184.1 .
    AC005550 Genomic DNA. Translation: AAC33152.1 .
    AC004452 Genomic DNA. Translation: AAC06184.1 .
    BC017021 mRNA. Translation: AAH17021.1 .
    CCDSi CCDS34605.1.
    PIRi A55641.
    A56837.
    RefSeqi NP_005915.2. NM_005924.4.
    UniGenei Hs.170355.

    3D structure databases

    ProteinModelPortali P50222.
    SMRi P50222. Positions 194-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110386. 19 interactions.
    IntActi P50222. 12 interactions.
    MINTi MINT-202865.
    STRINGi 9606.ENSP00000262041.

    PTM databases

    PhosphoSitei P50222.

    Polymorphism databases

    DMDMi 93141286.

    Proteomic databases

    PaxDbi P50222.
    PRIDEi P50222.

    Protocols and materials databases

    DNASUi 4223.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262041 ; ENSP00000262041 ; ENSG00000106511 .
    GeneIDi 4223.
    KEGGi hsa:4223.
    UCSCi uc003stc.3. human.

    Organism-specific databases

    CTDi 4223.
    GeneCardsi GC07M015617.
    H-InvDB HIX0006493.
    HGNCi HGNC:7014. MEOX2.
    HPAi HPA053793.
    MIMi 600535. gene.
    neXtProti NX_P50222.
    PharmGKBi PA30748.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250192.
    HOGENOMi HOG000230987.
    HOVERGENi HBG052456.
    InParanoidi P50222.
    KOi K09322.
    OMAi PADFGRQ.
    OrthoDBi EOG7JDQZZ.
    PhylomeDBi P50222.
    TreeFami TF351603.

    Miscellaneous databases

    GeneWikii MEOX2.
    GenomeRNAii 4223.
    NextBioi 16667.
    PROi P50222.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50222.
    Bgeei P50222.
    CleanExi HS_MEOX2.
    Genevestigatori P50222.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3."
      Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B., Pachnis V., Karagogeos D.
      Genomics 26:550-555(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-80 DEL.
      Tissue: Embryo.
    2. "Molecular cloning and localization of the human GAX gene to 7p21."
      Lepage D.F., Walsh K.
      Genomics 24:535-540(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 79-HIS-HIS-80 DEL.
      Tissue: Heart.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
      Tissue: Trachea.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-80 DEL.
      Tissue: Skin.
    6. "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
      Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.
      Mol. Cell. Biochem. 275:75-84(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF10.
    7. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
      Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.
      PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMEOX2_HUMAN
    AccessioniPrimary (citable) accession number: P50222
    Secondary accession number(s): B2R8I7, O75263, Q9UPL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3