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P50215 (IDH_SPHYA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Synonyms:idhA
OrganismSphingobium yanoikuyae (Sphingomonas yanoikuyae)
Taxonomic identifier13690 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Isocitrate dehydrogenase [NADP]
PRO_0000083567

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity
Metal binding2731Magnesium or manganese By similarity
Binding site771Substrate By similarity
Binding site821NADP By similarity
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity
Site2101Critical for catalysis By similarity

Amino acid modifications

Modified residue941Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P50215 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 093F7E18303A89E7

FASTA40645,483
        10         20         30         40         50         60 
MAKIKVKNPV VEIDGDEMTR IIWEWIRERL ILPYLDVDLK YYDLSVEKRD ETSDQITIDA 

        70         80         90        100        110        120 
ANAIKEYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR NILGGVVFRE PIVIKNVPRL 

       130        140        150        160        170        180 
VPGWTDPIVV GRHAFGDQYK ATDFKVPGAG TLTMKWVGTN GEELEYEVFE FPSAGVAMGM 

       190        200        210        220        230        240 
YNLDESIRDF AKASFNYGLN RGWPVYLSTK NTILKAYDGR FKDLFQEVFD AEFADKFKAA 

       250        260        270        280        290        300 
GIVYEHRLID DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLSPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQHQQG KATSTNPIAS IFAWTQGLSF RGKFDDTPDV VKFAETLEQV 

       370        380        390        400 
CIKTVEGGAM TKDLALLIGP DQAWMTTEQF FEAIRVNLEA EMAKWA 

« Hide

References

[1]"Sequence and expression of an isocitrate dehydrogenase-encoding gene from a polycyclic aromatic hydrocarbon oxidizer, Sphingomonas yanoikuyae B1."
Wang Y., Lau P.C.K.
Gene 168:15-21(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 6900 / JCM 10274 / B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37523 Genomic DNA. Translation: AAC43640.1.
PIRJC4600.

3D structure databases

ProteinModelPortalP50215.
SMRP50215. Positions 3-404.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP50215.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-2328-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_SPHYA
AccessionPrimary (citable) accession number: P50215
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families