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P50215

- IDH_SPHYA

UniProt

P50215 - IDH_SPHYA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Sphingobium yanoikuyae (Sphingomonas yanoikuyae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateBy similarity
Binding sitei82 – 821NADPBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei132 – 1321SubstrateBy similarity
Sitei139 – 1391Critical for catalysisBy similarity
Sitei210 – 2101Critical for catalysisBy similarity
Metal bindingi250 – 2501Magnesium or manganeseBy similarity
Binding sitei258 – 2581NADPBy similarity
Metal bindingi273 – 2731Magnesium or manganeseBy similarity
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPBy similarity
Nucleotide bindingi308 – 3136NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. isocitrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2328-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:idhA
OrganismiSphingobium yanoikuyae (Sphingomonas yanoikuyae)
Taxonomic identifieri13690 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Isocitrate dehydrogenase [NADP]PRO_0000083567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP50215.

Structurei

3D structure databases

ProteinModelPortaliP50215.
SMRiP50215. Positions 3-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50215-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVKNPV VEIDGDEMTR IIWEWIRERL ILPYLDVDLK YYDLSVEKRD
60 70 80 90 100
ETSDQITIDA ANAIKEYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR
110 120 130 140 150
NILGGVVFRE PIVIKNVPRL VPGWTDPIVV GRHAFGDQYK ATDFKVPGAG
160 170 180 190 200
TLTMKWVGTN GEELEYEVFE FPSAGVAMGM YNLDESIRDF AKASFNYGLN
210 220 230 240 250
RGWPVYLSTK NTILKAYDGR FKDLFQEVFD AEFADKFKAA GIVYEHRLID
260 270 280 290 300
DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLLSPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRQHQQG KATSTNPIAS IFAWTQGLSF RGKFDDTPDV
360 370 380 390 400
VKFAETLEQV CIKTVEGGAM TKDLALLIGP DQAWMTTEQF FEAIRVNLEA

EMAKWA
Length:406
Mass (Da):45,483
Last modified:October 1, 1996 - v1
Checksum:i093F7E18303A89E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37523 Genomic DNA. Translation: AAC43640.1.
PIRiJC4600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37523 Genomic DNA. Translation: AAC43640.1 .
PIRi JC4600.

3D structure databases

ProteinModelPortali P50215.
SMRi P50215. Positions 3-404.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P50215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-2328-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and expression of an isocitrate dehydrogenase-encoding gene from a polycyclic aromatic hydrocarbon oxidizer, Sphingomonas yanoikuyae B1."
    Wang Y., Lau P.C.K.
    Gene 168:15-21(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 6900 / JCM 10274 / B1.

Entry informationi

Entry nameiIDH_SPHYA
AccessioniPrimary (citable) accession number: P50215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3