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P50214

- IDH_NOSS1

UniProt

P50214 - IDH_NOSS1

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, alr1827
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADP By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Sitei160 – 1601Critical for catalysis By similarity
Sitei237 – 2371Critical for catalysis By similarity
Metal bindingi362 – 3621Magnesium or manganese By similarity
Binding sitei407 – 4071NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei446 – 4461NADP By similarity
Binding sitei450 – 4501NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi394 – 4007NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:alr1827
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Isocitrate dehydrogenase [NADP]
PRO_0000083547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP50214.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi103690.alr1827.

Structurei

3D structure databases

ProteinModelPortaliP50214.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiAITIFRE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50214-1 [UniParc]FASTAAdd to Basket

« Hide

MYNKITPPTT GEKITFKNGE PVVPDNPIIP FIRGDGTGID IWPATEKVLD    50
AAVAKAYQGK RKISWFKVYA GDEACDLYGT YQYLPEDTLT AIREYGVAIK 100
GPLTTPVGGG IRSLNVALRQ IFDLYACVRP CRYYAGTPSP HKNPEKLDVI 150
VYRENTEDIY LGIEWKQGSE IGDRLISILN KELIPATPEH GKKQIPLDSG 200
IGIKPISKTG SQRLVRRAIK HALTLPKDKQ QVTLVHKGNI MKYTEGAFRD 250
WGYELATSEF RQETVTERES WILSNKEKNP NISLEDNARQ IDPGFDALTP 300
EKKAQIVKEV ETVLNSIWES HGNGKWKEKV LVNDRIADSI FQQIQTRPDE 350
YSILATMNLN GDYLSDAAAA IVGGLGMGPG ANIGDSCAVF EATHGTAPKH 400
AGLDRINPGS VILSGVMMLE YMGWQEAADL IKKGLSDAIA NSQVTYDLAR 450
LLEPPVEPLK CSEFADAIIK HFG 473
Length:473
Mass (Da):52,228
Last modified:October 1, 1996 - v1
Checksum:iD30941B992A38AAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77654 Genomic DNA. Translation: CAA54734.1.
BA000019 Genomic DNA. Translation: BAB73526.1.
PIRiA55591.
AE2034.
RefSeqiNP_485867.1. NC_003272.1.
WP_010995995.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73526; BAB73526; BAB73526.
GeneIDi1105419.
KEGGiana:alr1827.
PATRICi22773725. VBINosSp37423_2340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77654 Genomic DNA. Translation: CAA54734.1 .
BA000019 Genomic DNA. Translation: BAB73526.1 .
PIRi A55591.
AE2034.
RefSeqi NP_485867.1. NC_003272.1.
WP_010995995.1. NC_003272.1.

3D structure databases

ProteinModelPortali P50214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr1827.

Proteomic databases

PRIDEi P50214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB73526 ; BAB73526 ; BAB73526 .
GeneIDi 1105419.
KEGGi ana:alr1827.
PATRICi 22773725. VBINosSp37423_2340.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi AITIFRE.
OrthoDBi EOG6SNDTP.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NADP(+)-isocitrate dehydrogenase from the cyanobacterium Anabaena sp. strain PCC 7120: purification and characterization of the enzyme and cloning, sequencing, and disruption of the icd gene."
    Muro-Pastor M.I., Florencio F.J.
    J. Bacteriol. 176:2718-2726(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiIDH_NOSS1
AccessioniPrimary (citable) accession number: P50214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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