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P50214

- IDH_NOSS1

UniProt

P50214 - IDH_NOSS1

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041NADPBy similarity
    Binding sitei113 – 1131SubstrateBy similarity
    Binding sitei115 – 1151SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei153 – 1531SubstrateBy similarity
    Sitei160 – 1601Critical for catalysisBy similarity
    Sitei237 – 2371Critical for catalysisBy similarity
    Metal bindingi362 – 3621Magnesium or manganeseBy similarity
    Binding sitei407 – 4071NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei446 – 4461NADPBy similarity
    Binding sitei450 – 4501NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi394 – 4007NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:alr1827
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Isocitrate dehydrogenase [NADP]PRO_0000083547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei113 – 1131PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP50214.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi103690.alr1827.

    Structurei

    3D structure databases

    ProteinModelPortaliP50214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiAITIFRE.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 2 hits.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50214-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNKITPPTT GEKITFKNGE PVVPDNPIIP FIRGDGTGID IWPATEKVLD    50
    AAVAKAYQGK RKISWFKVYA GDEACDLYGT YQYLPEDTLT AIREYGVAIK 100
    GPLTTPVGGG IRSLNVALRQ IFDLYACVRP CRYYAGTPSP HKNPEKLDVI 150
    VYRENTEDIY LGIEWKQGSE IGDRLISILN KELIPATPEH GKKQIPLDSG 200
    IGIKPISKTG SQRLVRRAIK HALTLPKDKQ QVTLVHKGNI MKYTEGAFRD 250
    WGYELATSEF RQETVTERES WILSNKEKNP NISLEDNARQ IDPGFDALTP 300
    EKKAQIVKEV ETVLNSIWES HGNGKWKEKV LVNDRIADSI FQQIQTRPDE 350
    YSILATMNLN GDYLSDAAAA IVGGLGMGPG ANIGDSCAVF EATHGTAPKH 400
    AGLDRINPGS VILSGVMMLE YMGWQEAADL IKKGLSDAIA NSQVTYDLAR 450
    LLEPPVEPLK CSEFADAIIK HFG 473
    Length:473
    Mass (Da):52,228
    Last modified:October 1, 1996 - v1
    Checksum:iD30941B992A38AAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77654 Genomic DNA. Translation: CAA54734.1.
    BA000019 Genomic DNA. Translation: BAB73526.1.
    PIRiA55591.
    AE2034.
    RefSeqiNP_485867.1. NC_003272.1.
    WP_010995995.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB73526; BAB73526; BAB73526.
    GeneIDi1105419.
    KEGGiana:alr1827.
    PATRICi22773725. VBINosSp37423_2340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77654 Genomic DNA. Translation: CAA54734.1 .
    BA000019 Genomic DNA. Translation: BAB73526.1 .
    PIRi A55591.
    AE2034.
    RefSeqi NP_485867.1. NC_003272.1.
    WP_010995995.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali P50214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr1827.

    Proteomic databases

    PRIDEi P50214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB73526 ; BAB73526 ; BAB73526 .
    GeneIDi 1105419.
    KEGGi ana:alr1827.
    PATRICi 22773725. VBINosSp37423_2340.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi AITIFRE.
    OrthoDBi EOG6SNDTP.

    Family and domain databases

    Gene3Di 3.40.718.10. 2 hits.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NADP(+)-isocitrate dehydrogenase from the cyanobacterium Anabaena sp. strain PCC 7120: purification and characterization of the enzyme and cloning, sequencing, and disruption of the icd gene."
      Muro-Pastor M.I., Florencio F.J.
      J. Bacteriol. 176:2718-2726(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiIDH_NOSS1
    AccessioniPrimary (citable) accession number: P50214
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3