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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104NADPBy similarity1
Binding sitei113SubstrateBy similarity1
Binding sitei115SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei153SubstrateBy similarity1
Sitei160Critical for catalysisBy similarity1
Sitei237Critical for catalysisBy similarity1
Metal bindingi362Magnesium or manganeseBy similarity1
Binding sitei407NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei446NADPBy similarity1
Binding sitei450NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi394 – 400NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:alr1827
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835471 – 473Isocitrate dehydrogenase [NADP]Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP50214.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi103690.alr1827.

Structurei

3D structure databases

ProteinModelPortaliP50214.
SMRiP50214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTERESWI.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNKITPPTT GEKITFKNGE PVVPDNPIIP FIRGDGTGID IWPATEKVLD
60 70 80 90 100
AAVAKAYQGK RKISWFKVYA GDEACDLYGT YQYLPEDTLT AIREYGVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ IFDLYACVRP CRYYAGTPSP HKNPEKLDVI
160 170 180 190 200
VYRENTEDIY LGIEWKQGSE IGDRLISILN KELIPATPEH GKKQIPLDSG
210 220 230 240 250
IGIKPISKTG SQRLVRRAIK HALTLPKDKQ QVTLVHKGNI MKYTEGAFRD
260 270 280 290 300
WGYELATSEF RQETVTERES WILSNKEKNP NISLEDNARQ IDPGFDALTP
310 320 330 340 350
EKKAQIVKEV ETVLNSIWES HGNGKWKEKV LVNDRIADSI FQQIQTRPDE
360 370 380 390 400
YSILATMNLN GDYLSDAAAA IVGGLGMGPG ANIGDSCAVF EATHGTAPKH
410 420 430 440 450
AGLDRINPGS VILSGVMMLE YMGWQEAADL IKKGLSDAIA NSQVTYDLAR
460 470
LLEPPVEPLK CSEFADAIIK HFG
Length:473
Mass (Da):52,228
Last modified:October 1, 1996 - v1
Checksum:iD30941B992A38AAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77654 Genomic DNA. Translation: CAA54734.1.
BA000019 Genomic DNA. Translation: BAB73526.1.
PIRiA55591.
AE2034.
RefSeqiWP_010995995.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73526; BAB73526; BAB73526.
KEGGiana:alr1827.
PATRICi22773725. VBINosSp37423_2340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77654 Genomic DNA. Translation: CAA54734.1.
BA000019 Genomic DNA. Translation: BAB73526.1.
PIRiA55591.
AE2034.
RefSeqiWP_010995995.1. NC_003272.1.

3D structure databases

ProteinModelPortaliP50214.
SMRiP50214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1827.

Proteomic databases

PRIDEiP50214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73526; BAB73526; BAB73526.
KEGGiana:alr1827.
PATRICi22773725. VBINosSp37423_2340.

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTERESWI.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_NOSS1
AccessioniPrimary (citable) accession number: P50214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.