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P50210 (HXA13_AMBME) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A13
Gene names
Name:HOXA13
OrganismAmbystoma mexicanum (Axolotl)
Taxonomic identifier8296 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaAmbystomatidaeAmbystoma

Protein attributes

Sequence length107 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 107›107Homeobox protein Hox-A13
PRO_0000200106

Regions

DNA binding41 – 10060Homeobox

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P50210 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 005AA4982C8C79E3

FASTA10712,746
        10         20         30         40         50         60 
TNGWNGQVYC SKEQGQPPHL WKSSLPDVVW HPSDANSYRR GRKKRVPYTK VQLKELEREY 

        70         80         90        100 
ATNKFITKDK RRRISATTNL SERQVTIWFQ NRRVKEKKVI NKLKTTS 

« Hide

References

[1]"Regulation of HoxA expression in developing and regenerating axolotl limbs."
Gardiner D.M., Blumberg B., Komine Y., Bryant S.V.
Development 121:1731-1741(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Regenerating limb blastema.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20942 mRNA. Translation: AAA86506.1.

3D structure databases

ProteinModelPortalP50210.
SMRP50210. Positions 41-98.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106958.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXA13_AMBME
AccessionPrimary (citable) accession number: P50210
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries