Reviewed, UniProtKB/Swiss-Prot P50209 (HXA9_AMBME)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A9

Gene names

Name:

HOXA9

Organism

Ambystoma mexicanum (Axolotl)

Taxonomic identifier

8296 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Caudata › Salamandroidea › Ambystomatidae › Ambystoma

Protein attributes

Sequence length	143 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 143	›143	Homeobox protein Hox-A9		PRO_0000200089
Regions
	DNA binding	78 – 137	60	Homeobox
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P50209-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 83ED182CEE573773	FASTA	143	16,592
	10 20 30 40 50 60 RHYGIKPEPL PPGTRRGDCT TFDSSHTLSL SDYGSSPADK QSSEGAFPEA PAETEASGDK 70 80 90 100 110 120 PAIDPNNPAA NWLHARSTRK KRCPYTKHQT LELEKEFLFN MYLTRDRRYE VARLLNLTER 130 140 QVKIWFQNRR MKMKKINKDR PKE

References

[1]	"Regulation of HoxA expression in developing and regenerating axolotl limbs." Gardiner D.M., Blumberg B., Komine Y., Bryant S.V. Development 121:1731-1741(1995) [PubMed: 7600989] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Regenerating limb blastema.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U20941 mRNA. Translation: AAA86505.1.
3D structure databases
SMR	P50209. Positions 66-142.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P50209.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR006711. Hox9_act. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF04617. Hox9_act. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA9_AMBME

Accession

Primary (citable) accession number: P50209

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)