Reviewed, UniProtKB/Swiss-Prot P50208 (HXA5_AMBME)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Ambystoma mexicanum (Axolotl)

Taxonomic identifier

8296 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Caudata › Salamandroidea › Ambystomatidae › Ambystoma

Protein attributes

Sequence length	148 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 148	›148	Homeobox protein Hox-A5		PRO_0000200066
Regions
	DNA binding	73 – 132	60	Homeobox
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P50208-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C1893F0ED9BF5086	FASTA	148	16,758
	10 20 30 40 50 60 VAVGSSSHIS SRDGLGTSSG TEDDTPGAAG RREGKFTARS ERTLGRAGGG PPQIYPWMRK 70 80 90 100 110 120 LHISHDNIGG PRGKRARTAY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLSERQIKIW 130 140 FQNRRMKWKK DNKLKSMSMA AAGGAFRP

References

[1]	"Identification and expression of a homologue of the murine HoxA5 gene in the Mexican axolotl (Ambystoma mexicanum)." Gaur A.F., Lemanski L.F., Dube D.K. Gene 162:249-253(1995) [PubMed: 7557438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U19238 mRNA. Translation: AAA91634.1.
PIR	PC4071.
3D structure databases
HSSP	HSSP built from PDB template 1SAN based on UniProtKB P02833.
SMR	P50208. Positions 74-135.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P50208.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA5_AMBME

Accession

Primary (citable) accession number: P50208

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 22, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)