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P50207

- HXC13_MOUSE

UniProt

P50207 - HXC13_MOUSE

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Protein

Homeobox protein Hox-C13

Gene
Hoxc13, Hoxc-13
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi258 – 31760HomeoboxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. hair follicle development Source: MGI
  4. nail development Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. tongue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C13
Gene namesi
Name:Hoxc13
Synonyms:Hoxc-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:99560. Hoxc13.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Homeobox protein Hox-C13PRO_0000200198Add
BLAST

Proteomic databases

PaxDbiP50207.
PRIDEiP50207.

PTM databases

PhosphoSiteiP50207.

Expressioni

Tissue specificityi

Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment.2 Publications

Gene expression databases

BgeeiP50207.
CleanExiMM_HOXC13.
GenevestigatoriP50207.

Interactioni

Protein-protein interaction databases

IntActiP50207. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP50207.
SMRiP50207. Positions 258-321.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 6034Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00730000110374.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP50207.
KOiK09298.
OMAiKPCSYHP.
OrthoDBiEOG7SJD53.
PhylomeDBiP50207.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50207-1 [UniParc]FASTAAdd to Basket

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MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG    50
KAPSMDGLGG SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA 100
RQCAPPPAPP TSSSATLGYG YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK 150
YPEPSGALPG DDLSSRAKEF AFYPSFASSY QAMPGYLDVS VVPGISGHPE 200
PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS PFPDVVPLQP 250
EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER 300
QVTIWFQNRR VKEKKVVSKS KAPHLHST 328
Length:328
Mass (Da):35,193
Last modified:January 23, 2002 - v2
Checksum:iAE363563B5AEF776
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193796 mRNA. Translation: AAL09298.1.
AY349616 mRNA. Translation: AAQ54690.1.
U04838 Genomic DNA. Translation: AAA20229.1.
CCDSiCCDS27890.1.
PIRiI48924.
RefSeqiNP_034594.1. NM_010464.2.
UniGeneiMm.207062.

Genome annotation databases

EnsembliENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
GeneIDi15422.
KEGGimmu:15422.
UCSCiuc007xwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193796 mRNA. Translation: AAL09298.1 .
AY349616 mRNA. Translation: AAQ54690.1 .
U04838 Genomic DNA. Translation: AAA20229.1 .
CCDSi CCDS27890.1.
PIRi I48924.
RefSeqi NP_034594.1. NM_010464.2.
UniGenei Mm.207062.

3D structure databases

ProteinModelPortali P50207.
SMRi P50207. Positions 258-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P50207. 1 interaction.

PTM databases

PhosphoSitei P50207.

Proteomic databases

PaxDbi P50207.
PRIDEi P50207.

Protocols and materials databases

DNASUi 15422.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001700 ; ENSMUSP00000001700 ; ENSMUSG00000001655 .
GeneIDi 15422.
KEGGi mmu:15422.
UCSCi uc007xwv.1. mouse.

Organism-specific databases

CTDi 3229.
MGIi MGI:99560. Hoxc13.

Phylogenomic databases

eggNOGi NOG276440.
GeneTreei ENSGT00730000110374.
HOGENOMi HOG000231176.
HOVERGENi HBG106958.
InParanoidi P50207.
KOi K09298.
OMAi KPCSYHP.
OrthoDBi EOG7SJD53.
PhylomeDBi P50207.
TreeFami TF330813.

Miscellaneous databases

NextBioi 288162.
PROi P50207.
SOURCEi Search...

Gene expression databases

Bgeei P50207.
CleanExi MM_HOXC13.
Genevestigatori P50207.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia."
    Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D., Ito T., Ogawa M., Awgulewitsch A.
    Development 128:1547-1558(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: FVB.
    Tissue: Embryo.
  2. "Hoxc13 expression in mouse kidney development and reactivated expression during HIV-associated glomerulosclerosis."
    Bruggeman L.A.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  3. "Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes."
    Bradshaw M.S., Ruddle F.H.
    Genomics 22:234-236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-309.
    Strain: C57BL/6J.
  4. "Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation."
    Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F., Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.
    J. Biol. Chem. 281:29245-29255(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHXC13_MOUSE
AccessioniPrimary (citable) accession number: P50207
Secondary accession number(s): Q53Z78, Q920I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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