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Protein

Homeobox protein Hox-C13

Gene

Hoxc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi258 – 31760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • hair follicle development Source: MGI
  • nail development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • tongue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C13
Gene namesi
Name:Hoxc13
Synonyms:Hoxc-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99560. Hoxc13.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Homeobox protein Hox-C13PRO_0000200198Add
BLAST

Proteomic databases

PaxDbiP50207.
PRIDEiP50207.

PTM databases

PhosphoSiteiP50207.

Expressioni

Tissue specificityi

Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment.2 Publications

Gene expression databases

BgeeiP50207.
CleanExiMM_HOXC13.
GenevestigatoriP50207.

Interactioni

Protein-protein interaction databases

IntActiP50207. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP50207.
SMRiP50207. Positions 258-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 6034Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP50207.
KOiK09298.
OMAiNGWDGQV.
OrthoDBiEOG7SJD53.
PhylomeDBiP50207.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG
60 70 80 90 100
KAPSMDGLGG SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA
110 120 130 140 150
RQCAPPPAPP TSSSATLGYG YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK
160 170 180 190 200
YPEPSGALPG DDLSSRAKEF AFYPSFASSY QAMPGYLDVS VVPGISGHPE
210 220 230 240 250
PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS PFPDVVPLQP
260 270 280 290 300
EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER
310 320
QVTIWFQNRR VKEKKVVSKS KAPHLHST
Length:328
Mass (Da):35,193
Last modified:January 23, 2002 - v2
Checksum:iAE363563B5AEF776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193796 mRNA. Translation: AAL09298.1.
AY349616 mRNA. Translation: AAQ54690.1.
U04838 Genomic DNA. Translation: AAA20229.1.
CCDSiCCDS27890.1.
PIRiI48924.
RefSeqiNP_034594.1. NM_010464.2.
UniGeneiMm.207062.

Genome annotation databases

EnsembliENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
GeneIDi15422.
KEGGimmu:15422.
UCSCiuc007xwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193796 mRNA. Translation: AAL09298.1.
AY349616 mRNA. Translation: AAQ54690.1.
U04838 Genomic DNA. Translation: AAA20229.1.
CCDSiCCDS27890.1.
PIRiI48924.
RefSeqiNP_034594.1. NM_010464.2.
UniGeneiMm.207062.

3D structure databases

ProteinModelPortaliP50207.
SMRiP50207. Positions 258-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50207. 1 interaction.

PTM databases

PhosphoSiteiP50207.

Proteomic databases

PaxDbiP50207.
PRIDEiP50207.

Protocols and materials databases

DNASUi15422.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
GeneIDi15422.
KEGGimmu:15422.
UCSCiuc007xwv.1. mouse.

Organism-specific databases

CTDi3229.
MGIiMGI:99560. Hoxc13.

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP50207.
KOiK09298.
OMAiNGWDGQV.
OrthoDBiEOG7SJD53.
PhylomeDBiP50207.
TreeFamiTF330813.

Miscellaneous databases

NextBioi288162.
PROiP50207.
SOURCEiSearch...

Gene expression databases

BgeeiP50207.
CleanExiMM_HOXC13.
GenevestigatoriP50207.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia."
    Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D., Ito T., Ogawa M., Awgulewitsch A.
    Development 128:1547-1558(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: FVB.
    Tissue: Embryo.
  2. "Hoxc13 expression in mouse kidney development and reactivated expression during HIV-associated glomerulosclerosis."
    Bruggeman L.A.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  3. "Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes."
    Bradshaw M.S., Ruddle F.H.
    Genomics 22:234-236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-309.
    Strain: C57BL/6J.
  4. "Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation."
    Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F., Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.
    J. Biol. Chem. 281:29245-29255(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHXC13_MOUSE
AccessioniPrimary (citable) accession number: P50207
Secondary accession number(s): Q53Z78, Q920I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: January 7, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.