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P50207

- HXC13_MOUSE

UniProt

P50207 - HXC13_MOUSE

Protein

Homeobox protein Hox-C13

Gene

Hoxc13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi258 – 31760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    3. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anatomical structure morphogenesis Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. hair follicle development Source: MGI
    4. nail development Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. tongue morphogenesis Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C13
    Gene namesi
    Name:Hoxc13
    Synonyms:Hoxc-13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:99560. Hoxc13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Homeobox protein Hox-C13PRO_0000200198Add
    BLAST

    Proteomic databases

    PaxDbiP50207.
    PRIDEiP50207.

    PTM databases

    PhosphoSiteiP50207.

    Expressioni

    Tissue specificityi

    Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment.2 Publications

    Gene expression databases

    BgeeiP50207.
    CleanExiMM_HOXC13.
    GenevestigatoriP50207.

    Interactioni

    Protein-protein interaction databases

    IntActiP50207. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP50207.
    SMRiP50207. Positions 258-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 6034Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG276440.
    GeneTreeiENSGT00730000110374.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiP50207.
    KOiK09298.
    OMAiKPCSYHP.
    OrthoDBiEOG7SJD53.
    PhylomeDBiP50207.
    TreeFamiTF330813.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG    50
    KAPSMDGLGG SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA 100
    RQCAPPPAPP TSSSATLGYG YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK 150
    YPEPSGALPG DDLSSRAKEF AFYPSFASSY QAMPGYLDVS VVPGISGHPE 200
    PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS PFPDVVPLQP 250
    EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER 300
    QVTIWFQNRR VKEKKVVSKS KAPHLHST 328
    Length:328
    Mass (Da):35,193
    Last modified:January 23, 2002 - v2
    Checksum:iAE363563B5AEF776
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193796 mRNA. Translation: AAL09298.1.
    AY349616 mRNA. Translation: AAQ54690.1.
    U04838 Genomic DNA. Translation: AAA20229.1.
    CCDSiCCDS27890.1.
    PIRiI48924.
    RefSeqiNP_034594.1. NM_010464.2.
    UniGeneiMm.207062.

    Genome annotation databases

    EnsembliENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
    GeneIDi15422.
    KEGGimmu:15422.
    UCSCiuc007xwv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193796 mRNA. Translation: AAL09298.1 .
    AY349616 mRNA. Translation: AAQ54690.1 .
    U04838 Genomic DNA. Translation: AAA20229.1 .
    CCDSi CCDS27890.1.
    PIRi I48924.
    RefSeqi NP_034594.1. NM_010464.2.
    UniGenei Mm.207062.

    3D structure databases

    ProteinModelPortali P50207.
    SMRi P50207. Positions 258-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P50207. 1 interaction.

    PTM databases

    PhosphoSitei P50207.

    Proteomic databases

    PaxDbi P50207.
    PRIDEi P50207.

    Protocols and materials databases

    DNASUi 15422.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001700 ; ENSMUSP00000001700 ; ENSMUSG00000001655 .
    GeneIDi 15422.
    KEGGi mmu:15422.
    UCSCi uc007xwv.1. mouse.

    Organism-specific databases

    CTDi 3229.
    MGIi MGI:99560. Hoxc13.

    Phylogenomic databases

    eggNOGi NOG276440.
    GeneTreei ENSGT00730000110374.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi P50207.
    KOi K09298.
    OMAi KPCSYHP.
    OrthoDBi EOG7SJD53.
    PhylomeDBi P50207.
    TreeFami TF330813.

    Miscellaneous databases

    NextBioi 288162.
    PROi P50207.
    SOURCEi Search...

    Gene expression databases

    Bgeei P50207.
    CleanExi MM_HOXC13.
    Genevestigatori P50207.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia."
      Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D., Ito T., Ogawa M., Awgulewitsch A.
      Development 128:1547-1558(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: FVB.
      Tissue: Embryo.
    2. "Hoxc13 expression in mouse kidney development and reactivated expression during HIV-associated glomerulosclerosis."
      Bruggeman L.A.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
    3. "Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes."
      Bradshaw M.S., Ruddle F.H.
      Genomics 22:234-236(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-309.
      Strain: C57BL/6J.
    4. "Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation."
      Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F., Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.
      J. Biol. Chem. 281:29245-29255(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHXC13_MOUSE
    AccessioniPrimary (citable) accession number: P50207
    Secondary accession number(s): Q53Z78, Q920I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3