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P50207 (HXC13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C13
Gene names
Name:Hoxc13
Synonyms:Hoxc-13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. Ref.1 Ref.4

Subcellular location

Nucleus.

Tissue specificity

Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment. Ref.1 Ref.4

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Homeobox protein Hox-C13
PRO_0000200198

Regions

DNA binding258 – 31760Homeobox
Compositional bias27 – 6034Gly-rich

Sequences

Sequence LengthMass (Da)Tools
P50207 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: AE363563B5AEF776

FASTA32835,193
        10         20         30         40         50         60 
MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG KAPSMDGLGG 

        70         80         90        100        110        120 
SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA RQCAPPPAPP TSSSATLGYG 

       130        140        150        160        170        180 
YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK YPEPSGALPG DDLSSRAKEF AFYPSFASSY 

       190        200        210        220        230        240 
QAMPGYLDVS VVPGISGHPE PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS 

       250        260        270        280        290        300 
PFPDVVPLQP EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER 

       310        320 
QVTIWFQNRR VKEKKVVSKS KAPHLHST 

« Hide

References

[1]"Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia."
Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D., Ito T., Ogawa M., Awgulewitsch A.
Development 128:1547-1558(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: FVB.
Tissue: Embryo.
[2]"Hoxc13 expression in mouse kidney development and reactivated expression during HIV-associated glomerulosclerosis."
Bruggeman L.A.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
[3]"Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes."
Bradshaw M.S., Ruddle F.H.
Genomics 22:234-236(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-309.
Strain: C57BL/6J.
[4]"Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation."
Potter C.S., Peterson R.L., Barth J.L., Pruett N.D., Jacobs D.F., Kern M.J., Argraves W.S., Sundberg J.P., Awgulewitsch A.
J. Biol. Chem. 281:29245-29255(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193796 mRNA. Translation: AAL09298.1.
AY349616 mRNA. Translation: AAQ54690.1.
U04838 Genomic DNA. Translation: AAA20229.1.
CCDSCCDS27890.1.
PIRI48924.
RefSeqNP_034594.1. NM_010464.2.
UniGeneMm.207062.

3D structure databases

ProteinModelPortalP50207.
SMRP50207. Positions 258-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP50207. 1 interaction.

PTM databases

PhosphoSiteP50207.

Proteomic databases

PaxDbP50207.
PRIDEP50207.

Protocols and materials databases

DNASU15422.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655.
GeneID15422.
KEGGmmu:15422.
UCSCuc007xwv.1. mouse.

Organism-specific databases

CTD3229.
MGIMGI:99560. Hoxc13.

Phylogenomic databases

eggNOGNOG276440.
GeneTreeENSGT00730000110374.
HOGENOMHOG000231176.
HOVERGENHBG106958.
InParanoidP50207.
KOK09298.
OMAKPCSYHP.
OrthoDBEOG7SJD53.
PhylomeDBP50207.
TreeFamTF330813.

Gene expression databases

BgeeP50207.
CleanExMM_HOXC13.
GenevestigatorP50207.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288162.
PROP50207.
SOURCESearch...

Entry information

Entry nameHXC13_MOUSE
AccessionPrimary (citable) accession number: P50207
Secondary accession number(s): Q53Z78, Q920I7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries