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Protein

Homeobox protein Hox-C13

Gene

Hoxc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi258 – 317HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • hair follicle development Source: MGI
  • nail development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • tongue morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C13
Gene namesi
Name:Hoxc13
Synonyms:Hoxc-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:99560 Hoxc13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001981 – 328Homeobox protein Hox-C13Add BLAST328

Proteomic databases

PaxDbiP50207
PRIDEiP50207

PTM databases

PhosphoSitePlusiP50207

Expressioni

Tissue specificityi

Expressed in differentiating keratinocytes. In the hair follicle lower matrix, expressed in all 3 hair shaft-forming compartments, i.e. cuticle, cortex and medulla. Expression stops sharply at the boundary with the germinal matrix compartment.2 Publications

Gene expression databases

BgeeiENSMUSG00000001655
CleanExiMM_HOXC13
GenevisibleiP50207 MM

Interactioni

Protein-protein interaction databases

IntActiP50207, 1 interactor
STRINGi10090.ENSMUSP00000001700

Structurei

3D structure databases

ProteinModelPortaliP50207
SMRiP50207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 60Gly-richAdd BLAST34

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231176
HOVERGENiHBG106958
InParanoidiP50207
KOiK09298
OMAiHSHNVNL
OrthoDBiEOG091G0E5Q
PhylomeDBiP50207
TreeFamiTF330813

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSLLLHPR WPESLMYVYE DSAAESGSGG GGGGGGAGGA GGGCSGASPG
60 70 80 90 100
KAPSMDGLGG SCPASHCRDL LPHPVLARPP APLGAPQGAV YTDIPAPEAA
110 120 130 140 150
RQCAPPPAPP TSSSATLGYG YPFGGSYYGC RLSHNVNLQQ KPCAYHPGDK
160 170 180 190 200
YPEPSGALPG DDLSSRAKEF AFYPSFASSY QAMPGYLDVS VVPGISGHPE
210 220 230 240 250
PRHDALIPVE GYQHWALSNG WDSQVYCSKE QSQSAHLWKS PFPDVVPLQP
260 270 280 290 300
EVSSYRRGRK KRVPYTKVQL KELEKEYAAS KFITKEKRRR ISATTNLSER
310 320
QVTIWFQNRR VKEKKVVSKS KAPHLHST
Length:328
Mass (Da):35,193
Last modified:January 23, 2002 - v2
Checksum:iAE363563B5AEF776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193796 mRNA Translation: AAL09298.1
AY349616 mRNA Translation: AAQ54690.1
U04838 Genomic DNA Translation: AAA20229.1
CCDSiCCDS27890.1
PIRiI48924
RefSeqiNP_034594.1, NM_010464.2
UniGeneiMm.207062

Genome annotation databases

EnsembliENSMUST00000001700; ENSMUSP00000001700; ENSMUSG00000001655
GeneIDi15422
KEGGimmu:15422
UCSCiuc007xwv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHXC13_MOUSE
AccessioniPrimary (citable) accession number: P50207
Secondary accession number(s): Q53Z78, Q920I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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