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P50205

- PHBB_RHIME

UniProt

P50205 - PHBB_RHIME

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Protein
Acetoacetyl-CoA reductase
Gene
phbB, R03261, SMc03878
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADP By similarity
Binding sitei88 – 881Substrate By similarity
Active sitei147 – 1471Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143NADP By similarity
Nucleotide bindingi82 – 865NADP By similarity
Nucleotide bindingi177 – 1804NADP By similarity

GO - Molecular functioni

  1. acetoacetyl-CoA reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PHB biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3352-MONOMER.
UniPathwayiUPA00917.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA reductase (EC:1.1.1.36)
Gene namesi
Name:phbB
Ordered Locus Names:R03261
ORF Names:SMc03878
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Acetoacetyl-CoA reductase
PRO_0000054750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03878.

Structurei

3D structure databases

ProteinModelPortaliP50205.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 1444Substrate binding By similarity
Regioni178 – 1792Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00023.
OMAiGINEHET.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50205-1 [UniParc]FASTAAdd to Basket

« Hide

MSRVALVTGG SRGIGAAICV ALKAAGYKVA ANYAGNDERA KAFEQESGIP    50
VYKWDVSSYQ ACVDGIARVE ADLGPVDILV NNAGITRDAM FHKMTPEQWG 100
EVIGTNLTGV FNMTHPLWSG MRDRGFGRIV NISSINGQKG QMGQVNYSAA 150
KAGDLGLTKA LAQEGAAKGI TVNAICPGYI GTEMVRAVPE KVLNERIIPQ 200
IPVGRLGEPE EVARCVVFLA SDDAGFITGS TISANGGQYF A 241
Length:241
Mass (Da):25,370
Last modified:October 1, 1996 - v1
Checksum:i025C43AF1900B1F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17226 Genomic DNA. Translation: AAA90983.1.
AL591688 Genomic DNA. Translation: CAC47840.1.
RefSeqiNP_387367.1. NC_003047.1.
WP_003535773.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47840; CAC47840; SMc03878.
GeneIDi1234955.
KEGGisme:SMc03878.
PATRICi23636186. VBISinMel96828_4815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17226 Genomic DNA. Translation: AAA90983.1 .
AL591688 Genomic DNA. Translation: CAC47840.1 .
RefSeqi NP_387367.1. NC_003047.1.
WP_003535773.1. NC_003047.1.

3D structure databases

ProteinModelPortali P50205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc03878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47840 ; CAC47840 ; SMc03878 .
GeneIDi 1234955.
KEGGi sme:SMc03878.
PATRICi 23636186. VBISinMel96828_4815.

Phylogenomic databases

eggNOGi COG1028.
KOi K00023.
OMAi GINEHET.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00917 .
BioCyci SMEL266834:GJF6-3352-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Poly-beta-hydroxybutyrate (PHB) biosynthetic genes in Rhizobium meliloti 41."
    Tombolini R., Povolo S., Buson A., Squartini A., Nuti M.P.
    Microbiology 141:2553-2559(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 41.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPHBB_RHIME
AccessioniPrimary (citable) accession number: P50205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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