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P50205

- PHBB_RHIME

UniProt

P50205 - PHBB_RHIME

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Protein

Acetoacetyl-CoA reductase

Gene

phbB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADPBy similarity
Binding sitei88 – 881SubstrateBy similarity
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143NADPBy similarity
Nucleotide bindingi82 – 865NADPBy similarity
Nucleotide bindingi177 – 1804NADPBy similarity

GO - Molecular functioni

  1. acetoacetyl-CoA reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PHB biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3352-MONOMER.
UniPathwayiUPA00917.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA reductase (EC:1.1.1.36)
Gene namesi
Name:phbB
Ordered Locus Names:R03261
ORF Names:SMc03878
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Acetoacetyl-CoA reductasePRO_0000054750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03878.

Structurei

3D structure databases

ProteinModelPortaliP50205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni141 – 1444Substrate bindingBy similarity
Regioni178 – 1792Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00023.
OMAiGINEHET.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVALVTGG SRGIGAAICV ALKAAGYKVA ANYAGNDERA KAFEQESGIP
60 70 80 90 100
VYKWDVSSYQ ACVDGIARVE ADLGPVDILV NNAGITRDAM FHKMTPEQWG
110 120 130 140 150
EVIGTNLTGV FNMTHPLWSG MRDRGFGRIV NISSINGQKG QMGQVNYSAA
160 170 180 190 200
KAGDLGLTKA LAQEGAAKGI TVNAICPGYI GTEMVRAVPE KVLNERIIPQ
210 220 230 240
IPVGRLGEPE EVARCVVFLA SDDAGFITGS TISANGGQYF A
Length:241
Mass (Da):25,370
Last modified:October 1, 1996 - v1
Checksum:i025C43AF1900B1F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17226 Genomic DNA. Translation: AAA90983.1.
AL591688 Genomic DNA. Translation: CAC47840.1.
RefSeqiNP_387367.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47840; CAC47840; SMc03878.
GeneIDi1234955.
KEGGisme:SMc03878.
PATRICi23636186. VBISinMel96828_4815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17226 Genomic DNA. Translation: AAA90983.1 .
AL591688 Genomic DNA. Translation: CAC47840.1 .
RefSeqi NP_387367.1. NC_003047.1.

3D structure databases

ProteinModelPortali P50205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc03878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47840 ; CAC47840 ; SMc03878 .
GeneIDi 1234955.
KEGGi sme:SMc03878.
PATRICi 23636186. VBISinMel96828_4815.

Phylogenomic databases

eggNOGi COG1028.
KOi K00023.
OMAi GINEHET.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00917 .
BioCyci SMEL266834:GJF6-3352-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Poly-beta-hydroxybutyrate (PHB) biosynthetic genes in Rhizobium meliloti 41."
    Tombolini R., Povolo S., Buson A., Squartini A., Nuti M.P.
    Microbiology 141:2553-2559(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 41.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiPHBB_RHIME
AccessioniPrimary (citable) accession number: P50205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3