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Protein

Acetoacetyl-CoA reductase

Gene

phaB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH.

Pathwayi: poly-(R)-3-hydroxybutanoate biosynthesis

This protein is involved in the pathway poly-(R)-3-hydroxybutanoate biosynthesis, which is part of Biopolymer metabolism.
View all proteins of this organism that are known to be involved in the pathway poly-(R)-3-hydroxybutanoate biosynthesis and in Biopolymer metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NADPBy similarity1
Binding sitei88SubstrateBy similarity1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14NADPBy similarity3
Nucleotide bindingi82 – 86NADPBy similarity5
Nucleotide bindingi177 – 180NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPHB biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00917

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA reductase (EC:1.1.1.36)
Gene namesi
Name:phaB1 Publication
Ordered Locus Names:R03261
ORF Names:SMc03878
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547501 – 241Acetoacetyl-CoA reductaseAdd BLAST241

Proteomic databases

PRIDEiP50205

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03878

Structurei

3D structure databases

ProteinModelPortaliP50205
SMRiP50205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni141 – 144Substrate bindingBy similarity4
Regioni178 – 179Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00023
OMAiICDKDES

Family and domain databases

InterProiView protein in InterPro
IPR011283 Acetoacetyl-CoA_reductase
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01829 AcAcCoA_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P50205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVALVTGG SRGIGAAICV ALKAAGYKVA ANYAGNDERA KAFEQESGIP
60 70 80 90 100
VYKWDVSSYQ ACVDGIARVE ADLGPVDILV NNAGITRDAM FHKMTPEQWG
110 120 130 140 150
EVIGTNLTGV FNMTHPLWSG MRDRGFGRIV NISSINGQKG QMGQVNYSAA
160 170 180 190 200
KAGDLGLTKA LAQEGAAKGI TVNAICPGYI GTEMVRAVPE KVLNERIIPQ
210 220 230 240
IPVGRLGEPE EVARCVVFLA SDDAGFITGS TISANGGQYF A
Length:241
Mass (Da):25,370
Last modified:October 1, 1996 - v1
Checksum:i025C43AF1900B1F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17226 Genomic DNA Translation: AAA90983.1
AL591688 Genomic DNA Translation: CAC47840.1
RefSeqiNP_387367.1, NC_003047.1
WP_003535773.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC47840; CAC47840; SMc03878
GeneIDi1234955
KEGGisme:SMc03878
PATRICifig|266834.11.peg.4815

Similar proteinsi

Entry informationi

Entry nameiPHAB_RHIME
AccessioniPrimary (citable) accession number: P50205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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