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P50205

- PHBB_RHIME

UniProt

P50205 - PHBB_RHIME

Protein

Acetoacetyl-CoA reductase

Gene

phbB

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391NADPBy similarity
    Binding sitei88 – 881SubstrateBy similarity
    Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 143NADPBy similarity
    Nucleotide bindingi82 – 865NADPBy similarity
    Nucleotide bindingi177 – 1804NADPBy similarity

    GO - Molecular functioni

    1. acetoacetyl-CoA reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. poly-hydroxybutyrate biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    PHB biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-3352-MONOMER.
    UniPathwayiUPA00917.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetoacetyl-CoA reductase (EC:1.1.1.36)
    Gene namesi
    Name:phbB
    Ordered Locus Names:R03261
    ORF Names:SMc03878
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Acetoacetyl-CoA reductasePRO_0000054750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc03878.

    Structurei

    3D structure databases

    ProteinModelPortaliP50205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni141 – 1444Substrate bindingBy similarity
    Regioni178 – 1792Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK00023.
    OMAiGINEHET.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011283. Acetoacetyl-CoA_reductase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRVALVTGG SRGIGAAICV ALKAAGYKVA ANYAGNDERA KAFEQESGIP    50
    VYKWDVSSYQ ACVDGIARVE ADLGPVDILV NNAGITRDAM FHKMTPEQWG 100
    EVIGTNLTGV FNMTHPLWSG MRDRGFGRIV NISSINGQKG QMGQVNYSAA 150
    KAGDLGLTKA LAQEGAAKGI TVNAICPGYI GTEMVRAVPE KVLNERIIPQ 200
    IPVGRLGEPE EVARCVVFLA SDDAGFITGS TISANGGQYF A 241
    Length:241
    Mass (Da):25,370
    Last modified:October 1, 1996 - v1
    Checksum:i025C43AF1900B1F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17226 Genomic DNA. Translation: AAA90983.1.
    AL591688 Genomic DNA. Translation: CAC47840.1.
    RefSeqiNP_387367.1. NC_003047.1.
    WP_003535773.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC47840; CAC47840; SMc03878.
    GeneIDi1234955.
    KEGGisme:SMc03878.
    PATRICi23636186. VBISinMel96828_4815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17226 Genomic DNA. Translation: AAA90983.1 .
    AL591688 Genomic DNA. Translation: CAC47840.1 .
    RefSeqi NP_387367.1. NC_003047.1.
    WP_003535773.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali P50205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc03878.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC47840 ; CAC47840 ; SMc03878 .
    GeneIDi 1234955.
    KEGGi sme:SMc03878.
    PATRICi 23636186. VBISinMel96828_4815.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K00023.
    OMAi GINEHET.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    UniPathwayi UPA00917 .
    BioCyci SMEL266834:GJF6-3352-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011283. Acetoacetyl-CoA_reductase.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01829. AcAcCoA_reduct. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Poly-beta-hydroxybutyrate (PHB) biosynthetic genes in Rhizobium meliloti 41."
      Tombolini R., Povolo S., Buson A., Squartini A., Nuti M.P.
      Microbiology 141:2553-2559(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 41.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiPHBB_RHIME
    AccessioniPrimary (citable) accession number: P50205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3