Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modification methylase DsaV

Gene

dsaVM

Organism
Dactylococcopsis salina (Myxobaktron salinum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CCNGG, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the DsaV endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3361 M.DsaV

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase DsaV (EC:2.1.1.37)
Short name:
M.DsaV
Alternative name(s):
Cytosine-specific methyltransferase DsaV
Gene namesi
Name:dsaVM
OrganismiDactylococcopsis salina (Myxobaktron salinum)
Taxonomic identifieri292566 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeDactylococcopsis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878721 – 351Modification methylase DsaVAdd BLAST351

Structurei

3D structure databases

ProteinModelPortaliP50185
SMRiP50185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 312SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST307

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P50185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKQLKFID LFAGIGGMRI PFEELGGKCV FSSEIDKHCQ RTYEANFGEM
60 70 80 90 100
PTGDITKLSA DSIPYHDLLL AGFPCQAFSQ GGRKQGFQDE RGQLFFQVAK
110 120 130 140 150
ILNDHRPQAI LLENVKGLRG HDKGRTLQMI LYVLEKLNYV VSWKIISATD
160 170 180 190 200
FNLPQKRERI FIVGFQDKNN KNLIFDFPKP IELTAKVGDL LEKEVDEKYT
210 220 230 240 250
ITDRMWEGHQ NRKKAHRKRG NGFGFSLVNR NSSYTRTISA RYYKDGSEVL
260 270 280 290 300
VEQANKNPRV LTPRECARLQ GFPESFVIPV SDCQAWRQFG NSVPVSVIRA
310 320 330 340 350
IAQKMLSYID LTEQQKEFKK VDLDQVITQK KKQLYPEDYQ EQFIQKELAL

L
Length:351
Mass (Da):40,499
Last modified:October 1, 1996 - v1
Checksum:i68B048AC0B8B2E5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10528 Genomic DNA Translation: AAA86046.1
PIRiS50098

Similar proteinsi

Entry informationi

Entry nameiMTD5_DACSA
AccessioniPrimary (citable) accession number: P50185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health